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New method separates cancer cells from normal cells

The vast majority of cancer deaths are due to metastasis, the spread of cancer cells from its primary site to other parts of the body. These metastatic cells tend to move more than their non-metastatic variants but this movement is poorly understood. Scientists are studying cancer cells intently w...

New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease

Imagine being forced to say no to a child crying for more food at supper. Sadly, Margie Fischer doesn't have to imagine it; that was normal life at her family's dinner table for years. Her daughter Maggie, now 20, suffers from phenylketonuria (PKU), a genetic disease that means her body can't tole...

In lung cancer, silencing one crucial gene disrupts normal functioning of genome

PHILADELPHIA While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. They say that "silencing" of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contribu...

Seemingly suicidal stunt is normal rite of passage for immune cells

St. Louis, Oct.20, 2008 Researchers have shown that self-induced breaks in the DNA of immune cells known as lymphocytes activate genes that cause the cells to travel from where they're made to where they help the body fight invaders. Scientists have known for two decades or more that lymphocy...

Using nanotechnology, UCLA researchers discover cancer cells 'feel' much softer than normal cells

A multidisciplinary team of UCLA scientists were able to differentiate metastatic cancer cells from normal cells in patient samples using leading-edge nanotechnology that measures the softness of the cells. The study, published Dec. 2, 2007 in the advance online edition of the journal Nature N...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

LOS ANGELES, Oct. 28 Gene therapy administered intravenously could be an effective agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb, according to an animal study presented today by University ...

Study identifies pathway required for normal reproductive development

Massachusetts General Hospital (MGH) clinical researchers, in collaboration with basic scientists from the University of California, Irvine (UC Irvine) have identified a new molecular pathway required for normal development of the reproductive, olfactory and circadian systems in both humans and mi...

3 to 6 months to lose weight gained in pregnancy is normal

This release is available in German . Kilos often melt away by themselves but there is no guarantee Gaining weight in pregnancy is not only normal, it is necessary. The mother's body has to nourish the growing baby. Her body needs to take on more fluid to support the extra circulati...

Cancer stem cells similar to normal stem cells can thwart anti-cancer agents

Current cancer therapies often succeed at initially eliminating the bulk of the disease, including all rapidly proliferating cells, but are eventually thwarted because they cannot eliminate a small reservoir of multiple-drug-resistant tumor cells, called cancer stem cells, which ultimately become ...

Renegade RNA -- Clues to cancer and normal growth

Researchers at Johns Hopkins have discovered that a tiny piece of genetic code apparently goes where no bit of it has gone before, and it gets there under its own internal code. A report on the renegade ribonucleic acid, and the code that directs its movement, will be published Jan. 5 in Science....

Reversing cancer cells to normal cells

In earlier work, Northwestern University scientist Mary J.C. Hendrix and colleagues discovered that aggressive melanoma cells (but not normal skin cells nor less aggressive melanoma cells) contain specific proteins similar to those found in embryonic stem cells. This groundbreaking work led to the...

Intravenous gene therapy protects normal tissue of mice during whole-body radiation

therapy administered intravenously could be used as an agent to protect vital organs and tissues from the effects of ionizing radiation in the event of large-scale exposure from a radiological or nuclear bomb, according to an animal study presented today by University of Pittsburgh researchers at t...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

Scientists have discovered that a stem cell factor overexpressed both in brain tumor cells and in neurons following brain injury promotes tumor survival by inducing angiogenesis. The research study, published in the April issue of Cancer Cell, examines the interaction between tumor cells and surrou...

Tumor cells that border normal tissue are told to leave

The thin, single-cell boundary where a tumor meets normal tissue is the most dangerous part of a cancer according to a new study by scientists at Washington University School of Medicine in St. Louis. The researchers found that tumor cells bordering normal tissue receive signals that tell them to w...

Researchers show key protein necessary for normal development of red blood cells

Virginia Commonwealth University researchers studying hemoglobin genes, mutations of which play a role in genetic blood disorders like sickle cell anemia and beta-thalassemia, have shown in studies with mice that the KLF2 protein is crucial for making young red blood cells. The findings may poin...

Model identifies genes that induce normal skin cells to become abnormal

Northwestern University researchers have developed a novel, three-dimensional model that allows scientists to observe how interacting with the microenvironment of metastatic melanoma cells induces normal skin cells to become similar to aggressive cancer cells that migrate and spread throughout the ...

Gene therapy may protect normal tissues during radiation retreatment for lung cancer

The ice ages made massive changes to the Earth's landscape The ice ages made massive changes to the Earth's landscape. But what was happening below the ice in the oceans? Research by marine scientists reveals that it was a time of mass destruction as whole communities of animals were wiped out...

Leptin-signaling Protein Maintains Normal Body Weight And Energy Balance In Mice

32% increase of African fish supply needed by 2020 just to maintain consumption levels Calling fisheries critical for nourishing the poor and for helping Africa cope with the health, economic and social devastation of problems like HIV and AIDS, the New Partnership for Africa's Development (NEPA...

Stem cells grown in lab mirror normal developmental steps

Assistant Professor Mark Pagani in the Department of Geology and Geophysics at Yale and his colleagues mapped the first detailed history of atmospheric carbon dioxide between 45 - 25 million years ago based on stable isotopes of carbon in a National Science Foundation study reported in Science Expr...

Gov't Creates Gene Database of Normal Human Tissues

Researchers at the National Cancer Institute, part of the National Institutes of Health, have built the largest open-source database for normal tissue from human organs. Scientists searching for genes that go awry and cause disease can use the NCI database as a crucial point of reference because it...

Highest ever winter water temperatures recorded

... Tasmania's east coast is recording its highest-ever winter water temperatures of more than 13C up to 1.5C above normal due to a strengthening of an ocean current originating north of Australia. Satellites have given oceanographers an insight into a remarkable pheno...

Protein handlers should be effective treatment target for cancer and Alzheimer's

... an increased risk of neurodegenerative disease or vice versa. "A lot of drugs, such as chemotherapeutic agents, can kill cancer but they also kill normal tissue. That is a limiting factor. We are looking for better drugs," she says. The MCG center is among the first to study molecular chaperones and...

Abnormal brain circuits may prevent movement disorder

...n the United States alone. The brains of people with inherited dystonia are normal at autopsy and the exact cause of their movement abnormality is unknown. ... will develop the involuntary movements that can prevent them from living a normal life, according to Dr. Eidelberg. The puzzle was why. In the latest...

Holding breath for several minutes elevates marker for brain damage

...nine divers. The controls showed no change in S100B On average, S100B rose 37% within 10 minutes after the apnea ended. S100B levels returned to normal within two hours for all the participants. The divers showed signs of asphyxia, that is, blood oxygen levels fell, while carbon dioxide levels rose....

Scientists open doors to diagnosis of emphysema

...ak down the extracellular matrix (the complex network of proteins and fibers that surround and support the cells of the body), a process important for normal wound healing. However, over-stimulation of macrophages by irritants leads to build up of excess MMP12, which starts to damage the delicate structure ...

Stem cell 'daughters' lead to breast cancer

...vealed that BRCA1 breast tissue and basal breast tumors are more similar to normal luminal progenitor cells than any other cell type in the breast. This place...ehave from the outset. "We also know that the BRCA1 gene is required for normal DNA repair. There may therefore be a triple whammy effect faulty growth co...

Drug-proof zebrafish reveal secrets of addiction

... drug in the fish's brain) but that appeared to be normal in all other ways. As amphetamine is experienced a...paring these drug-proof nad mutants to fish with a normal response, Webb and her colleagues discovered a set...tamine in nad mutants, without being altered under normal conditions in either genotype. In addition to gene...

Parasites ready to jump

...l target for transposons, since these cells pass their genetic material together with integrated mobile elements on to all cells of the progeny. But normal body (somatic) cells can also be attacked by transposons. For example, certain viruses carry transposons in their genomes and introduce them into the ...

Study links virus to some cases of common skin cancer

...rcent, tested positive for the virus. By sequencing the viral DNA from 31 normal and tumor samples, the researchers showed that the same mutation was presen...ay a role in causing the cancer," Toland says. Next, Toland wants to test normal skin in healthy individuals to learn how common this virus is in people gen...

Little-known protein found to be key player

... cells with extra atlastin had an overdeveloped endoplasmic reticulum (ER), a system of interconnected membrane tubes and chambers that's critical for normal cell function. The tests also showed too little atlastin led to a fragmented ER. Flies with defective atlastin were sterile and short-lived. "The e...

Research shows rates of severe childhood obesity have tripled

...red severely obese, Skelton said, whereas in an adult, that is considered a normal BMI. An expert committee convened by the American Medical Association, the ...r heart attack, stroke and diabetes. These risk factors include higher-than normal blood pressure, cholesterol and insulin levels. "These findings demonst...

Fujitsu Expands Support for Ethernet Networks With New Additions to XG Switch Product Line

...ibilities are Infinite is a trademark of Fujitsu Ltd. All other trademarks are the property of their respective owners. Statements herein are based on normal operating conditions and are not intended to create any implied warranty of merchantability or fitness for a particular purpose. Fujitsu Computer Prod...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

...esearchers from Fox Chase Cancer Center. Since the DLX5 gene is inactive in normal adults, it may be an ideal target for future anti-cancer drugs, they reason...e MYC has a definite role in cancer, MYC also has an important place in the normal functioning of cells, so it may be difficult to target without killing heal...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...mmitted myeloid progenitors to convert them from a normal cell to AML," the authors noted, referring to seve...light questions about what it takes to transform a normal cell into a cancer cell. "The complement of geneti... to chart the genetic changes that free cells from normal controls and allow the uncontrolled cell division ...

Nanodiamonds deliver insulin for wound healing

...nt. In their studies, Ho and his colleagues showed that the insulin was very tightly bound to the nanodiamonds when in an aqueous solution near the normal physiological pH level. Measurements of insulin function revealed that the protein was virtually inactive when bound to the nanodiamonds -- a benefici...

Placenta-derived stem cells may help sufferers of lung diseases

...monary fibrosis and fibrotic diseases caused by tuberculosis, chemical exposure, radiation or pathogens. These diseases can ultimately lead to loss of normal lung tissue and organ failure. No known therapy effectively reverses or stops the fibrotic process. Placenta-derived stem cells are known to be abl...

ISU researchers find possible treatment for spinal muscular atrophy

...ied from junk DNA. SMN2 normally doesn't produce normal protein because of the presence of a specific intr...en the intronic sequence is blocked, SMN2 produces normal proteins and acts, in effect, like SMN1. "The si... you think about it." The resulting proteins are normal just like a regular cell - free from Spinal Muscul...

Smaller than expected, but severe, dead zone in Gulf of Mexico

...ls developed by R. Eugene Turner, Ph. D. of Louisiana State University and Donald Scavia, Ph.D. of the University of Michigan, predicted a larger than normal dead zone area of between 7,450 8,456 square miles. The forecast was driven primarily by the high nitrate loads and high freshwater flows from the Mi...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...stand how this method of gene regulation fits into normal development, aging, learning and memory as well as... we found in cancer are not naturally expressed in normal cells. So there are a lot of things we don't know,...t going to become cancer. They have to slip by the normal surveillance to survive and grow." To find the ...

Common allergy drug reduces obesity and diabetes in mice

...ant in fat tissue from obese and diabetic humans and mice than they were in normal weight fat tissue. This led to an obvious question: by regulating mast cell...om what we've just seen, that Tregs are keeping the macrophages in check in normal fat tissue, thus preventing inflammation." For over a decade, Tregs have...
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