Skin color clue to nicotine dependence
Higher concentrations of melanin -- the color pigment in skin and hair -- may be placing darker pigmented smokers at increased susceptibility to nicotine
dependence and tobacco-related carcinogens than lighter skinned smokers, according to scientists.
"We have found that the concentration of mel...
Researchers find link between nicotine addiction and autism
COLUMBUS, Ohio Scientists have identified a relationship between two proteins in the brain that has links to both nicotine
addiction and autism. The finding has led to speculation that existing drugs used to curb nicotine
addiction might serve as the basis for potential therapies to alleviate the...
Study links nicotine with breast cancer growth and spread
PHILADELPHIA A study published in Cancer Research , a journal of the American Association for Cancer Research, suggests a possible role for nicotine
in breast tumor development and metastases.
The study, conducted by researchers at the Beth Israel Deaconess Medical Center, is among the first...
New genetic research into nicotine addiction shows promise for personalized treatment
Whether a smoking-cessation drug will enable you to quit smoking may depend on your genes, according to new genotyping research from the Centre for Addiction and Mental Health (CAMH). The study, published in the September issue of the journal Biological Psychiatry, found that the enzyme known to m...
Children of smokers have more than 5 times higher levels of a nicotine toxin
Children who have at least one parent who smokes have 5.5 times higher levels of cotinine, a byproduct of nicotine, in their urine, according to a study by researchers from Warwick Medical School at the the University of Warwick, and the University of Leicester, published online ahead of print in...
Re-analysis of cigarettes confirms tobacco companies increased addictive nicotine 11 percent
A reanalysis of nicotine
yield from major brand name cigarettes sold in Massachusetts from 1997 to 2005 has confirmed that manufacturers have steadily increased the levels of this agent in cigarettes. This independent analysis, based on data submitted to the Massachusetts Department of Public Healt...
Successful lung cancer surgery not enough to break nicotine dependence in many smokers
A new study has found that close to half of 154 smokers who had surgery to remove early stage lung cancer picked up a cigarette again within 12 months of their potentially curative operation, and more than one-third were smoking at the one year mark. Sixty percent of patients who started smoking a...
Smokers invite to test vaccine against nicotine addiction
UCSF's Habit Abatement Clinic is testing a vaccine that enlists help from the immune system to keep nicotine
away from the brain. The vaccine is designed to help smokers quit and to limit the urge to start smoking again.
Called NicVax, the investigational vaccine is being developed by Nabi Bioph...
Blood test predicts success of quitting smoking using the nicotine patch
A blood test may enable doctors to predict which smokers using the nicotine
patch are likely to experience the least amount of cravings and have the highest probability of success in quitting cigarettes, according to the results of a study in the June issus of the Journal of Clinical Pharmacology a...
Prenatal nicotine exposure reduces breathing response of newborns...
A 37-year-old-mother, who gave birth to a low-weight preemie at 24 weeks, exhibited the first-found link in a human between bacteria found in the mouth and the amniotic fluid of a woman in preterm labor.
Using new DNA finger-printing techniques to find bacteria that cannot be cultured and grown ...
Simple drug treatment may prevent nicotine-induced SIDS: Study
...s at McMaster University, exposure of the fetus to nicotine
results in the inability to respond to decreases i...ication 'glibenclamide' can reverse the effects of nicotine
exposure, increasing the newborn's ability to resp...ng moments of apnea or asphyxia is impaired due to nicotine
During those episodes, specific prote...
Simulating pharmaceutical and personal care product transport
...luded non-equilibrium sorption in macropores using data from experiments on the transport of three PPCPs (atenolol, carbamazepine, and triclosan), the nicotine
metabolite cotinine, and the strongly sorbing dye rhodamine WT applied in LMB. The study was financed by grants from the European Union (ERAPharm, pro...
New mediator of smoking recruits
...opontin expression could be stimulated directly by nicotine
treatment. In addition, expressing osteopontin in...article from Prasse et al "suggest[s] that chronic nicotine
stimulation induced by cigarette smoking promotes ...oduction]." Osteopontin and cellular receptors for nicotine
may therefore be new targets for treating smoking ...
Free online toolkit provides standard measures for genome and population studies
... as height, weight and waist circumference; and alcohol, tobacco and other substances, with measures such as alcohol maximum drinks in 24 hours , and nicotine
In addition to measures under each category, the toolkit includes information about each measure such as the rationale for its selectio...
Genetic irregularities linked to higher risk of COPD among smokers
..., only two single letter changes in DNA - (called single nucleotide polymorphisms, SNPs, or "snips") emerged as significant. Both were located near a nicotine
receptor on chromosome 15 that has already been associated with lung cancer and other respiratory disorders. The SNPs also appeared with significant f...
1 drug may help people both lay down the drink and put out the cigarette
...co use are the leading causes of death in alcoholics.
"A medication such as varenicline, which may target shared biological systems in alcohol and nicotine
use, holds promise as a treatment for individuals with both disorders" according to McKee.
McKee said that 80% of participants receiving vareniclin...
Nicotine activates more than just the brain's pleasure pathways
...ystem activity in mice, the researchers found that nicotine
sends signals directly to the brain's sensory syst...ings complement what is known about the effects of nicotine
in the dopamine pathway. This is the classic pleas...r study in no way contradicts prior findings about nicotine
and dopamine," Oliveira-Maia said. "Our findings a...
Caltech scientists engineer supersensitive receptor, gain better understanding of dopamine system
...holine receptor" to make it more sensitive to both nicotine
and acetylcholine. (Acetylcholine is another of th...or is kicked into action by the presence of either nicotine
or acetylcholine--two of the keys that fit its bio...ctive. In fact, the researchers note, low doses of nicotine
affect mice with these hypersensitive receptors in...
Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
...volved in inflammation, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, the effect of general anesthetics and addiction to alcohol, nicotine
Moreover, the results apply to closely related receptors that bind serotonin and GABA, which are neurotransmitters directly involved i...
Bitter-tasting nectar and floral odors optimize outcrossing for plants
...r herbivores. But given the right timing and dose, nicotine
in the nectar and the attractant, benzyl acetone, ...d tests, the researchers showed that the amount of nicotine
in the floral nectar of wild tobacco influenced po...A interference) that were unable to produce either nicotine
or benzyl acetone; the latter has a sweet odor we ...
If your first cigarette gave you a buzz and you now smoke, a gene may be to blame
...rts an association between a variant in the CHRNA5 nicotine
receptor gene, initial smoking experiences, and cu... of Michigan Medical School and founder of the U-M nicotine
"If cigarette smoking is sustained, nicotine
addiction can occur in a few days to a few months,...
Michael J. Fox Foundation Funds $1.1 Million for Cutting-edge Approaches to Parkinson's Disease
...otect against PD. The researchers hope to elucidate the mechanisms by which nicotine
may protect dopamine neurons through development and validation of a screening test for small molecules that could increase nicotine
receptor expression in the brain.
Marcus Unger, MD, and Wolfgang Oertel...
Scripps Research Institute awarded patent for remarkable chemical technology
...ts. Using copper-catalyzed azide-alkyne cycloaddition, Scripps Research scientists have already identified molecules with potential for fighting AIDS, nicotine
addiction, and other conditions. The reactions' gluing powers have also proven extremely effective at binding fluorescent alkyne dyes to proteins and ...
Hunger hormone: Makes food more attractive
...dvertisements geared towards children, in the same way that results proving nicotine
to be addictive spurred the current public policy towards nicotine
Researchers 'see' structure of open nicotinic acetylcholine ion channels
...tion, in the form of charged particles, or ions, across the cell membrane. Although normally closed, when the ion channel encounters acetylcholine or nicotine
on the surface of the cell the interaction causes the gate to open, allowing positively charged ions (called cations) to flow into the cell.
Protein protects lung cancer cells from efforts to fix or kill them
...healthy cells ability to fix themselves when radiation or chemicals such as nicotine
damage their DNA, according to a University of Florida study to be publishe...s of lung cancer patients who smoke.
Previous UF research has shown that nicotine
activates the protein, which helps tumor cells live long past their natural...
New research explains link between smoking and SIDS
... episodeis dramatically compromised by exposure to nicotine
in the womb, even light to moderate amounts.
Th...nism doesnt work as it should in babies exposed to nicotine
The research, which was condu...ptation of life outside the wombis impaired due to nicotine
At birth, the nervous control of the...
American Chemical Society's Weekly PressPac -- Dec. 19, 2007
...acks the combustion products. However, moist snuff products still contain significant levels of carcinogens, and users should stop, perhaps via use of nicotine
replacement therapy, rather than switch from one risky product to another, the paper advises. MTS
ARTICLE #3 FOR IMMEDIATE RELEASE
Progress and ...
Overexcited neurons not good for cell health
...s on protein folding were found to occur upon exposure to the common toxins nicotine
and lindane (a pesticide).
Whether due to genetic mutation or exposure ...gregation.
The effects were similar when the researchers introduced both nicotine
(a neurostimulant) and lindane (an inhibitor of GABA, causing overstimulate...
New studies on schizophrenia, depression, trauma and autism highlight annual meeting
...irls. (Embargoed until 9:00 a.m. EST December 8)
Addiction Might be Controlled by Influencing Pleas...us system that inhibits neurons in the brain and nicotine
dependence. Researchers discovered that nicotine
has significant effects on brain GABA, a finding w...
How does the opioid system control pain, reward and addictive behavior?
...e activities of this compound (Matthes 1996). Importantly, a series of studies has shown that the reinforcing properties of alcohol, cannabinoids, and nicotine
each of which acts at a different receptor are also strongly diminished in these mutant mice. The genetic approach therefore highlights mu-receptors...
Nicotine may accelerate atherosclerosis, may be as dangerous as tar
...erosclerosis in mice correlated with the levels of nicotine
-- the higher the nicotine, the more disease.
...s that the problem with cigarettes is tar and that nicotine
is safe. That's why you can buy nicotine
gum or patches to help you stop smoking. Our study...
American Chemical Society's Weekly Presspac -- Aug. 29, 2007
...mise for the treatment of Alzheimers, Parkinsons, stroke and schizophrenia. In the continuing search for better drugs, even familiar compounds such as nicotine
and coffee are being explored for their potential memory-enhancing effects, Rovner notes.
Despite their promise, theres growing regulatory and ethi...
Nicotine rush hinges on sugar in neurons
... When nicotine
binds to a neuron, how does the cell know to send the signal that announces...anding one.
Some researchers had suggested that when a chemical such as nicotine
binds to an ion channel protein on the cell surface, the protein starts a “...
NIDA study identifies genes that might help some people abstain from smoking
...m and a team led by Dr. Jed Rose at the Center for nicotine
and Smoking Cessation Research at Duke University ...es in dependence to other drugs also contribute to nicotine
Genes that harbor variants that c...bruary 2007 meeting of the Society for Research on nicotine
“These findings provide ample ju...
Mechanism of nicotine's learning effects explored
... While nicotine
is highly addictive, researchers have also shown t...le was known about the detailed mechanism by which nicotine
exerts its learning-enhancing effects.
Now, r...searchers have discovered important details of how nicotine
adjusts the signaling properties of neuronal wirin...
Indicators for risk of heart disease are higher in passive smokers
...nd-hand smoke. Cotinine is the major metabolite of nicotine
that indicates levels of nicotine
intake. Since nicotine
is highly specific for tobacco smoke, blood serum ...
Bioluminescence at the service of a novel cerebral imaging technique
Because of these characteristics, the new tracer can demonstrate new physiological phenomena related to calcium activity. Thus the activation by nicotine
of pedunculate bodies (an important structure for learning and olfactory memory in the Drosophila) induces a secondary response which is delayed by ab...
Smokers quit after damage to brain region
The finding that one small region could be the Achilles' heel of smoking addiction is especially surprising, given the brain-wide effects of nicotine
on the nervous system.
The study considered smokers with damage that did not include the insula, but the likelihood of disrupting the smoking add...
New research identifies gene important for nicotine's effects on the brain
... and her colleagues at Yale University, found that nicotine
can increase activity of a molecule called CREB in...ocks CREB activity in the nucleus accumbens blocks nicotine
reward. "We and other researchers have begun to m...rk explored how the brain changes when it receives nicotine
and, therefore, focused on the dopamine system in ...