Neurons

First real-time view of developing neurons reveals surprises, say Stanford researchers

Scientists have believed that neurons need a long period of fine-tuning and training with other neurons before they take on their adult role. But after using new technology for the first time to watch these cells develop, a team of researchers at the Stanford University School of Medicine found that neurons come into this world with a good idea about what they'll become as adults. The work...

One gene links newborn neurons with those that die in diseases such as Alzheimer's

In certain parts of the brain, cells called neurons go through a cycle of death and replenishment. New research from Rockefeller University's Fernando Nottebohm, Ph.D., shows that these replaceable neurons share something in common with the neurons that die in people with diseases such as Alzheimer's and Parkinson's: both have unusually low levels of a protein called UCHL1. "It would be ir...

Researchers make surprise discovery that some neurons can transmit three signals at once

Generations of neuroscientists have been indoctrinated into believing that our senses, thoughts, feelings and movements are orchestrated by a communication network of brain cells, or neurons, each responsible for relaying one specific chemical message called a neurotransmitter. Either neurons release a neurotransmitter that excites a neighboring cell, thereby triggering an electrical discharge an...

Speak up: Louder neurons form more connections

As the brain develops, neurons reach out helter-skelter forming new connections, only a small number of which take hold. How the brain chooses which connections to keep and which to prune back appears to be governed by which branches have the most electrical activity—a finding that could help to explain how early experiences guide brain development. The work, published in the April 21 issu...

Most important actors in the growth process of neurons identified

Defects in the growth process of our neurons often underlie brain or nerve diseases, such as Alzheimer's disease or multiple sclerosis. Scientists from the Flanders Interuniversity Institute for Biotechnology (VIB) connected to the Katholieke Universiteit Leuven, led by Bassem Hassan, have achieved a major step in unraveling the growth process of axons, the offshoots of neurons. They have identif...

Eating, body weight regulated by specific neurons

In findings with implications for pandemic influenza, a new study reports for the first time that a less-virulent strain of avian influenza virus can spread from poultry to humans. The research appears in the October 1 issue of The Journal of Infectious Diseases, now available online. Crossing the species barrier is an important step in the development of a flu virus with pandemic potenti...

New neurons take baby steps in the adult brain

In experiments with mice, scientists from Johns Hopkins' Institute for Cell Engineering have discovered the steps required to integrate new neurons into the brain's existing operations. For more than a century, scientists thought the adult brain could only lose nerve cells, not gain them, but in fact, new neurons do form during adulthood in all mammals, including humans, and become a worki...

Neurons generated in the adult brain learn to respond to novel stimuli

New brain cells that develop in the olfactory system of adult mice appear to play a role in the brain different from that of older neurons. The new olfactory neurons are especially sensitive to novel stimuli, preferentially learning to respond to new odors. This level of flexibility suggests that such newly-generated neurons could be induced to adapt to and integrate into other regions of the b...

Algal protein in worm neurons allows remote control of behavior by light

By introducing expression of a special green-algae gene into neurons of the tiny, transparent nematode C. elegans, researchers have been able to elicit specific behavioral responses by simply illuminating animals with blue light. The work paves the way for better understanding of how neurons communicate with each other, and with muscles, to regulate behavior in intact, living organisms. Generally...

Neurons find their place in the developing nervous system with the help of a sticky molecule

The brain, that exquisite network of billions of communicating cells, starts to take form with the genesis of nerve cells. Most newborn nerve cells, also called neurons, must travel from their birthplace to the position they will occupy in the adult brain. Researchers at the Salk Institute for Biological Studies have identified a molecule expressed on the surface of certain migrating neurons that...

Picking apart how neurons learn

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells. The findings, published in the March 16 issue of Neuron, pull together a growing body of evidence from the...

Researchers get neurons and silicon talking

The ultimate applications are potentially limitless. In the long term it will possibly enable the creation of very sophisticated neural prostheses to combat neurological disorders. What's more, it could allow the creation of organic computers that use living neurons as their CPU. Those applications are potentially decades away, but in the much nearer term the new technology could enable ve...

Mechanism for memory revealed in neurons of electric fish

Researchers from The University of Texas at Austin studying electric fish have gained new insight into how memory is stored at the level of neurons. Dr. Harold Zakon, Dr. Jörg Oestreich and colleagues show that when electr...

Attention shoppers: Researchers find neurons that encode the value of different goods

Researchers at Harvard Medical School (HMS) report in the April 23 issue of Nature that they have identified neurons that encode the values that subjects assign to different items. The activity of these neurons might facilitate the process of decision-making that occurs when someone chooses between different goods. "We have long known that different neurons in various parts of the brain re...

Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons

Scientists have discovered that a stem cell factor overexpressed both in brain tumor cells and in neurons following brain injury promotes tumor survival by inducing angiogenesis. The research study, published in the April issue of Cancer Cell, examines the interaction between tumor cells and surrounding tissues and may have substantial significance for design of more effective therapeutics for on...

Nanowire arrays can detect signals along individual neurons

Opening a whole new interface between nanotechnology and neuroscience, scientists at Harvard University have used slender silicon nanowires to detect, stimulate, and inhibit nerve signals along the axons and dendrites of live mammalian neurons. "We d...

Long-term changes in experience cause neurons to sprout new long-lasting connections

Howard Hughes Medical Institute researchers have discovered that neurons in the brains of mice sprout robust new connections when the animals are adjusting to new experiences. The new connections alter the circuitry of the brain by changing communication between neurons. The researchers said their findings aid understanding of how procedural learning induces long-term rewiring of the brain...

Neurons grown from embryonic stem cells restore function in paralyzed rats

For the first time, researchers have enticed transplants of embryonic stem cell-derived motor neurons in the spinal cord to connect with muscles and partially restore function in paralyzed animals. The study suggests that similar techniques may be useful for treating such disorders as spinal cord injury, transverse myelitis, amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy. The st...

Autistic brain has fewer neurons for processing emotion

For the first time, research has shown that the autistic brain has fewer neurons in an area related to emotion and social behavior, according to a new study published in the July 19 issue of This study provides quantitative evidence linking autism to an abnormality of the amygdala, especially the lateral nucleus—a major emotion-processing area with con...

Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent

The brain's septum helps prevent epileptic seizures by inducing rhythmical electrical activity in the circuits of another area of the brain known as the hippocampus, according to a new study in the Journal of Neurophysiology. The researchers found that, by imposing a normal "theta" rhythm on chronically epileptic rats, they could reduce epileptic seizures by 86-97 percent. The study "Septo...

Life and death in the hippocampus: what young neurons need to survive

Whether newborn nerve cells in adult brains live or die depends on whether they can muscle their way into networks occupied by mature neurons. Neuroscientists at the Salk Institute for Biological Studies pin-pointed the molecular survival gear required for a young neuron to successfully jump into the fray and hook up with other cells. In a study published in a forthcoming issue of Nature...

Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's

In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases....

New neurons could act to alleviate epilepsy

The new neurons generated as a result of neural damage due to epilepsy show a reduced excitability that could alleviate the disorder, researchers have found. The researchers said their results suggest that therapies for epilepsy aimed at inducing neurogenesis could prove effective in alleviating the disorder. In an article in the December 21, 2006, issue of the journal Neuron, published by...

Parkinson's mutation stunts neurons

Mutations in a key brain protein known to underlie a form of Parkinson's disease (PD) wreaks its damage by stunting the normal growth and branching of neurons, researchers have found. They have pinpointed the malfunction of the protein made by mutant forms of the gene called LRRK2 and how it affects neurons, ultimately leading to their death. The loss of dopamine-producing neurons is central to t...

Researchers identify neurons that assign value during learning

By using an experimental trick to activate certain sets of neurons and effectively substitute activation of these cells for positive or negative experiences, researchers have been able to identify neurons in the fruit fly Drosophila that are responsible for assigning value to stimuli during so-called associative learning. The findings, which advance our understanding of how, at the cellular level...

Growth factor stimulates rapid extension of key motor neurons in brain

A growth factor known to be important for the survival of many types of cells stimulates rapid extension of corticospinal motor neurons ?critical brain cells that connect the cerebral cortex with the spinal cord and that die in motor neuron diseases like amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). In the November 2006 issue of Nature Neuroscience, two investigators from Massachu...

MIT: Pulsing light silences overactive neurons

Scientists at the MIT Media Lab have invented a way to reversibly silence brain cells using pulses of yellow light, offering the prospect of controlling the haywire neuron activity that occurs in diseases such as epilepsy and Parkinson's disease. Such diseases often must be treated by removing neurons that fire incorrectly. The new MIT research could lead to the development of optical brai...

Motor protein plays key role in connecting neurons

A motor protein called myosin X runs the main road of a developing neuron, delivering to its tip a receptor that enables it to communicate with other neurons, scientists say. In another piece of the puzzle of how neurons form connections, researchers have found myosin X travels a portion of a neuron's backbone called the actin filament, a sort of two-way highway in the cell's highest tr...

Scientists produce neurons from human skin

Scientists from Université Laval’s Faculty of Medicine have succeeded in producing neurons in vitro using stem cells extracted from adult human skin. This is the first time such an advanced state of nerve cell differentiation has been achieved from human skin, according to lead researcher Professor François Berthod. This breakthrough could eventually lead to revolutionary advances in the treatmen...

Racing neurons control whether we stop or go

In the children’s game "red light green light," winners are able to stop, and take off running again, more quickly than their comrades. New research reveals that a similar race goes on in our brains, with impulse control being the big winner. "The research provides new insights into how the brain controls movements, which helps explain the impulsivity of people with attention deficit and h...

A 'traffic light' for neurons means 'go' for improving brain research

Every thought, feeling and action originates from the electrical signals emitted by diverse brain cells enmeshed in a tangle of circuits. At this fundamental level, scientists struggle to explain the mind. Worse yet, they have lacked tools to understand what's going wrong in patients with ailments such as depression or Parkinson's disease. New Stanford-led research published in the April 5 issue...

Newborn neurons like to hang with the 'in' crowd

Like any new kid on the block that tries to fit in, newborn brain cells need to find their place within the existing network of neurons. The newcomers jump right into the fray and preferentially reach out to mature brain cells that are already well connected within the established circuitry, report scientists at the Salk Institute for Biological Studies in the online edition of Nature Neuroscienc...

Role of noise in neurons

Addressing a current issue in neuroscience, Aldo Faisal and Simon Laughlin from Cambridge University investigate the reliability of thin axons for transmitting information. They show that noise effects in ion channels in the brain are much larger than previously assumed ?meaning the fidelity of transmission is compromised. Neurons in the cerebral cortex of the brain can have a wiring dens...

Turn-ons and turn-offs for neurons

Our brain consists of billions of nerve cells enabling to learn, remember and reason. Every time we think and experience, touch, smell or fear, millions of neurons in our brain becomes active. These nerve cells communicate with each other by chemical and electrical impulses to compute incoming sensory information and integrate it via distinct brain regions. With 20,000 - 25,000 genes in our ge...

Nicotine rush hinges on sugar in neurons

A University of Southern California study appearing with a commentary in Nature Neuroscience online proposes a role for sugar as the hinge that opens a gate in the cell membrane and brings...