Preimplantation genetic diagnosis may pose neurological risks
Preimplantation genetic diagnosis (PGD) has helped many couples conceive healthy children and is generally considered a safe practice. However, a new long-term analysis of PGD in mice suggests that this procedure may increase risks of weight gain and memory decline in adulthood.
PGD is used al...
A new mouse model provides insight into genetic neurological disorders
Neurosensory diseases are difficult to model in mice because their symptoms are complex and diverse. The genetic causes identified are often lethal when transferred to a mouse. The lack of animal models slows progress in understanding and treating the diseases. By strategically altering a protein-...
Cell's split personality is a major discovery into neurological diseases
Researchers at the Universit de Montreal (UdeM) and the Montreal Neurological
Institute (MNI), McGill University have discovered that cells which normally support nerve cell (neuron) survival also play an active and major role in the death of neurons in the eye. The findings, published this week i...
Biologists discover link between CGG repeats in DNA and neurological disorders
MEDFORD/SOMERVILLE, Mass. Researchers have long known that some repetitive DNA sequences can make human chromosomes "fragile," i.e. appearing constricted or even broken during cell divisions. Scientists at Tufts University have found that one such DNA repeat not only stalls the cell's replication...
'Deranged calcium signaling' contributes to neurological disorder, UT Southwestern researchers find
DALLAS Nov. 25, 2008 Defective calcium metabolism in nerve cells may play a major role in a fatal genetic neurological
disorder that resembles Huntington's disease, researchers at UT Southwestern Medical Center have found in a mouse study.
The disease, called spinocerebellar ataxia 3 also kn...
MNI researchers locate neurological basis of depression following sports concussion
This release is also available in French . Researchers at the Montreal Neurological
Institute of McGill University have identified the neurological
basis of depression in male athletes with persisting post-concussion symptoms. The study, published in this weeks issue of Archives of General P...
Mechanism identified for promising neurological drug
Researchers at the San Francisco VA Medical Center have identified the mechanism by which minocycline, a medication currently being studied for the treatment of neurodegenerative diseases including Parkinson's disease and Huntington's disease, protects brain and nerve cells from damage.
In the st...
Cell therapy slows progression of an inherited neurological disease; Improves motor skills in mice
In an important discovery, scientists have demonstrated that the progression of a type of genetic brain disease is slowed and symptoms are improved in mice that received cell transplants.
The new study, published in the March 22 issue of The Journal of Neuroscience , may have implications for de...
UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders
Experts in bioengineering, imaging, molecular genetics, immunology, ethics, hematology/oncology and cellular biology to collaborate on Proposition 71 research
Drawing together experts from fields as diverse as engineering to molecular biology, UCLA officials announced March 16 the formation of t...
Use of Insecticides Linked to Lasting Neurological Problems for Farmers
New research shows that farmers who used agricultural insecticides experienced increased neurological
symptoms, even when they were no longer using the products. Data from 18,782 North Carolina and Iowa farmers linked use of insecticides, including organophosphates and organochlorines, to reports o...
Antibiotic might fight HIV-induced neurological problems
By studying animals, Johns Hopkins researchers have discovered that the antibiotic minocycline might help alleviate HIV's negative effects on the brain and central nervous system, problems that can develop even though antiretroviral therapy controls the virus elsewhere in the body.
Five monkeys ...
First 'atlas' of key brain genes could speed research on cancer, neurological diseases
Researchers at Dana-Farber Cancer Institute
have compiled the first atlas showing the locations of crucial gene
regulators, or switches that determine how different parts of the brain
develop ?and, in some cases, develop abnormally or malfunction.
The scientists say the map will accelerate research...
New stem cell research could reduce number of animal experiments
...ramanian, from the University's Department of Biology & Biochemistry, will be developing a technique using human stem cells to study this debilitating neurological
disease, greatly reducing the number of animals used in research.
Stem cells are the precursor cells that are able to develop into more specialised...
Holding breath for several minutes elevates marker for brain damage
...dividuals training and competing in static apnea diving events, could cause neurological
damage over time. The researchers recommended further research on free dive...uld begin early in their careers and follow them for years to monitor their neurological
The study is "Increased serum levels of the brain damage marke...
Structure of protective protein in the eye lens revealed
...e tissue. In the eye lens, they counteract diseases like cataracts. Malfunctions of the αB-crystallin in tissue cells can give rise to cancer and neurological
defects, including Alzheimer's disease.
Many research groups have focused their work on the α-crystallins due to their medical relevance. Des...
Experimental treatment halts hypoxic-ischemic brain injury in newborns
...emic encephalopathy an important cause of perinatal mortality and permanent neurological
morbidities, but there are no specific medications against HIE in current m...poxic-ischemia die and 25 percent of those who survive suffer from lifelong neurological
Scientists track impact of DNA damage in the developing brain
...targeted for DNA damage and are a likely source of neurological
problems in humans. The cerebellum coordinates mov...e role the DNA damage response plays in preventing neurological
disease," the investigators wrote.
The study al...and offers a new focus for tracking the origins of neurological
The research also reflects growing sci...
A 'heart healthy' diet and ongoing, moderate physical activity may protect against cognitive decline
... 90 women aged 50-63 years, one to 10 years post natural menopause, with no history of breast cancer, HRT use, psychiatric disorder, dementia or other neurological
condition. Participants gave details on the amount of their strenuous and moderate physical recreational activities from high school to menopause. Eig...
22nd Congress of the European College of Neuropsychopharmacology, Sept. 12-16, 2009, Turkey
...tuation worse is that the prevalence of mental and neurological
disorders is expected to grow for a variety of rea... increased risk for age-related mental illness and neurological
disorders, especially dementia and Parkinsons dise...n are seen as the main cause of mental and certain neurological
disorders. The essential knowledge of central feat...
MS study offers theory for why repair of brain's wiring fails
...t processes, however, Rowitch cautioned that targeting Wnt could cause unintended side effects.
The new work may also have implications for another neurological
disease, periventricular leukomalacia, which can lead to cerebral palsy in extremely premature infants, says Rowitch. Recent studies by Rowitch and co...
Further gene mutations linked to autism risk
...en with ASDs, the study also uncovered two novel genes where variations were found, BZRAP1 and MDGA2 thought to be important in synaptic function and neurological
development, respectively. Interestingly, key variants on these genes were passed down in some, but not all, of the affected individuals in families. ...
Scripps Research scientists observe human neurodegenerative disorder in fruit flies
...treat the disease.
Named for the three physicians who first identified the disease in 1886, Charcot-Marie-Tooth is one of the most common inherited neurological
disorders in the United States today. When people have this disease, some lose the protective covering on their nerves called myelin. This causes a ho...
Mouse model provides clues to human language development
...xp2 mice by screening for more than 300 parameters, including the ability to see and hear, bone density, important metabolic functions and a number of neurological
functions. The mice carrying the humanized Foxp2 gene showed no physiological abnormalities. However, behavioral tests showed an altered exploratory b...
Scientists capture the first image of memories being made
...h new memories is essential to our daily existence and identity; enabling us to navigate through the world. A new study by researchers at the Montreal neurological
Institute and Hospital (The Neuro), McGill University and University of California, Los Angeles has captured an image for the first time of a mechanis...
The downside of microtubule stability
... Stalled microtubules might be responsible for some cases of the neurological
disorder Charcot-Marie-Tooth (CMT) disease, Tanabe and Takei report in the June 15, 2009 issue of the Journal of Cell Biology ( www.jcb.org ). A mut...
Protein regulates movement of mitochondria in brain cells
...our understanding of the molecular and cell biology of mitochondria have the potential to lead to novel approaches for the prevention and treatment of neurological
disorders," said Rempe.
Rutgers research tackles childhood epilepsy
... rapamycin, originally used to prevent rejection in organ transplants, suppressed epileptic seizures in the mice.
Epilepsy is the third most common neurological
disorder in the United States after Alzheimer's disease and stroke. It currently affects more than 326,000 children under age 15. More than 90,000 of ...
Specific genetic cause of fetal alcohol-related developmental disorders found
...rmones and, therefore, fetal thyroid hormones.
"Specific concentrations of thyroid hormones must be available in the fetal brain to support normal neurological
development," Sittig said.
One of the enzymes that control thyroid hormone levels in the fetal brain is the iodothyronine deiodinase type III, or D...
Protein linked to mental retardation controls synapse maturation, plasticity, CSHL team finds
...nd in the mechanisms through which the strength, or plasticity, of their connections are regulated -- are thought to contribute to numerous mental and neurological
"Great progress has been made in recent years in the identification of chromosomal abnormalities and genetic changes involved in mental ...
One size does not fit all
A new study by researchers at the Montreal neurological
Institute (MNI), McGill University, demonstrates t...t cell types that are postulated to be targeted in neurological
disease processes and that are implicated in any b...ty of life for people who suffer from a variety of neurological
Skip this cocktail party
...ontie, Reddy, Hahn, and their coauthors provides tools to ask deeper questions about how the ever-growing list of contaminants in the ocean affect the neurological
development of marine mammals.
And what sort of results does Montie expect this new field of neuro-ecotoxicology to produce? "I think we don't rea...
Bull's-eye electrode helps interpret thoughts, deliver stimulus to aid paralyzed, epileptic patients
... precise location in the brain to control epileptic seizures or treat other neurological
disorders. He has been awarded a $397,000 grant from the National Institut...re most beneficial," Besio said. "We hope to use the electrode to detect a neurological
disorder like a seizure, and then use the electrode to determine exactly wh...
Cocaine: Perceived as a reward by the brain?
... little about its effects on the human brain or the mechanisms that lead to cocaine addiction. The latest article by Dr. Marco Leyton, of the Montreal neurological
Institute (MNI), McGill University and the McGill University Health Centre, which was published in the journal Biological Psychiatry on May 15, 2009...
Protein identified as critical to insulating the body's wiring could also become treatment target
...euregulin 1 sitting there but they can't do anything without the receptor."
Impaired myelin formation and maintenance is implicated in a variety of neurological
and psychiatric diseases including schizophrenia, multiple sclerosis and Charcot-Marie-Tooth neuropathy, a genetic, progressive disease that weakens m...
BIO 2009 -- R&D session: New stem cell research unlocks unknown therapies
... other devastating diseases.
He is also the scientific founder of NeuroNova, a biopharmaceutical company, developing stem cell-based therapies for neurological
disorders in the central nervous system. NeuroNova has two drug candidates in clinical development, one for Parkinson's disease and one for ALS.
Drug prevents seizure progression in model of epilepsy
...eing able to target them with a simple treatment, represents a significant advance in our ability to understand and treat epilepsy."
Epilepsy is a neurological
disorder marked by abnormal electrical activity in the brain that leads to recurring seizures. A person who has a first seizure is statistically much ...
Lithium may help radiation target cancer, spare healthy tissue
...for both primary and metastatic brain tumors. However, as with all treatment modalities, radiation often causes long-term side effects. In particular, neurological
impairments including lowered IQ, learning difficulties and memory loss have been reported, especially in children treated for brain cancers. Radiat...
Genetic study confirms the immune system's role in narcolepsy
...y. Current findings leave little doubt that autoimmunity plays a role," says Merrill Mitler, Ph.D., a program director with the National Institute of neurological
Disorders and Stroke (NINDS). The study was funded principally by NINDS, with additional support from the National Institute of Mental Health (NIMH),...
Small molecules might block mutant protein production in Huntington's disease
...hwestern Medical Center have found.
These man-made molecules also were effective against the abnormal protein that causes Machado-Joseph disease, a neurological
condition similar to Huntington's.
The work has been done only in cultured cells, and it will take years before the effectiveness of this process c...
First neuroimaging study examining motor execution in children with autism reveals new insights
...tute have uncovered important new insight into the neurological
basis of autism. The study, published online in th...the brain to communicate with each other forms the neurological
basis of autism.
Researchers used fMRI scans to...ientists to measure and quantify. In contrast, the neurological
processes behind motor skills are well understood,...