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NIAID in Biological News

AVAC comments on NIAID decision not to move forward with PAVE 100 Trial

New York, NY The AIDS Vaccine Advocacy Coalition (AVAC) today urged Dr. Anthony Fauci and the U.S. National Institute of Allergy and Infectious Diseases (NIAID) to act swiftly to clarify the path ahead suggested by the announcement that NIAID would not go forward with the proposed PAVE 100 AIDS v...

New NIAID grants strengthen national biodefense and emerging infectious diseases research network

The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, today announced four-year grants totaling approximately $80 million for two new Regional Centers of Excellence for Biodefense and Emerging Infectious Diseases Research (RCE). The grants to ...

UCI awarded $45 million for infectious disease research

...g Infectious Diseases Research and its director, Dr. Alan Barbour, a UCI infectious disease expert. Created in May 2005 with a four-year, $40 million niaid grant, the center and is one of only 11 federally funded research sites dedicated to countering threats from bioterrorism agents and emerging infectio...

NIH funds development of resistance-breaking insecticides to reduce malaria transmission

... use on nets and effective against pyrethroid-resistant mosquitoes. The niaid award builds on results from three years (2005-2008) of research funded by ... However, the team made two important advances which form the basis for the niaid grant for "Development of vector-specific, resistance breaking insecticides...

NIAID scientists to speak on range of infectious disease topics at major scientific meeting

...ding the Human Microbiome Project, which is exploring how the billions of bacteria that inhabit our bodies contribute to health and illness. Other niaid scientists are scheduled to present findings during the four-day meeting as well. The range of topics covered reflects the broad scope of NIAID's rese...

New Systems Biology Awards enable detailed study of microbes

...eractions of those components with human cells. Their work will build upon and expand the data, technologies and other resources generated through the niaid microbial genomics program and complement Institute-supported systems biology research in human immunology. The new awards represent NIAID's strong co...

NIAID announces 25 new awards to develop radiation countermeasures

...ject Bioshield Authority, legislation that enables niaid within the Department of Health and Human Services...to HHS specifically for this purpose. HHS assigned niaid the leadership role in managing basic research eff...l treatments and diagnostics for CBRN threats, and niaid and the Biodefense Advanced Research and Developme...

American Society for Microbiology honors Arturo Casadevall

...2007 NIH Merit Award. He is also President of the Medical Mycology Society of America, Chair of the ASM Career Development Committee, Co-Chair of the niaid Board of Scientific Counselors, a member of the American Association of Physicians, a Fellow of the American Association for the Advancement of Scienc...

NIAID announces grants to stimulate food allergy research

...ne of the key objectives of this initiative," says niaid Director Anthony S. Fauci, M.D., whose institute i...ort food allergy research. Since fiscal year 2003, niaid has increased its food allergy research spending f...ted $13.4 million in fiscal year 2008. For more on niaid Food Allergy Research see http://www3.niaid.nih.g...

NIH launches Human Microbiome Project

...t of information about these microbial communities, which in turn will bolster the development and refinement of analytical tools and strategies, said niaid Director Anthony S. Fauci, M.D., co-chair of the Human Microbiome Projects Implementation Group. Following the precedents set by other large-scale...

NIH selects LIAI for major study on allergy molecular causes and possible treatments

...gest research database on how the immune system responds to infectious diseases, allergens and other agents. The database, developed by LIAI under an niaid contract, is a public health tool designed to speed the development of vaccines and treatments by sharing important research data with scientists arou...

Anthony S. Fauci awarded Lasker Award for Public Service

...ore deserving of this award. Dr. Faucis tenure as niaid director began in 1984. For nearly 23 years, he has overseen the extensive niaid research portfolio of basic and applied research t...and treat infectious and immunologic diseases. The niaid budget for fiscal year 2007 is approximately $4.4 ...

Newly found sensing system enables certain bacteria to resist human immune defenses

... problems with drug resistance, and these findings may help chart a path to designing new drugs to bolster our antimicrobial treatment options,” notes niaid Director Anthony S. Fauci, M.D. Led by Michael Otto, Ph.D., of NIAID’s Rocky Mountain Laboratories (RML), the scientists used the gram-positive b...

The quest for an effective HIV vaccine presents new possibilities, challenges

... antiretroviral drugs. These vaccines may also reduce the chance that a person infected with HIV would pass the virus on to other people, according to niaid Director Anthony S. Fauci, M.D., and Margaret I. Johnston, Ph.D., director of NIAID’s Vaccine Research Program in the Division of AIDS. In a review ...

NIAID expands capability for influenza research and surveillance

...e of concern for the public health community,?says niaid Director Anthony S. Fauci, M.D. “The new niaid Centers of Excellence for Influenza Research and S...n’s Research Hospital in Memphis, TN, initiated by niaid after the 1997 Hong Kong outbreak of highly pathog...

NIH researchers discover protein that appears to regulate bone mass loss, the cause of osteoporosis

...turation of immune cells, and without it people with X-linked Hyper IgM Syndrome are susceptible to a range of opportunistic infections. Last year, an niaid doctor treating children with this disease observed that several of them sustained unexplained rib fractures that he hypothesized could be, like osteo...

New details on how the immune system recognizes influenza

..."This study is interesting for what it shows we know and do not know," says niaid Director Anthony S. Fauci, M.D. "It reveals many gaps in our knowledge of i... Epitope Database and Analysis Resources Program, which began in 2004 after niaid awarded LIAI a $25 million contract to create a single repository of immune...

LIAI completes world's most comprehensive analysis on influenza virus data

...d's largest repository of scientific data on how the body's immune system responds to infectious agents -- under a $25 million contract awarded by the niaid in 2004. The database places particular emphasis on emerging infectious diseases, such as West Nile virus, along with those diseases considered ...

Discovery could lead to better control of hemorrhagic fever viruses

...ural areas of South America, the viruses are of U.S. government interest because of their potential as bioterrorism agents. All four are classified as niaid Category A Priority Pathogens and must be handled in Biosafety Level 4 containment facilities. The researchers, led by Hyeryun Choe, PhD, of Chil...

NIAID DNA vaccine for H5N1 avian influenza enters human trial

...ing advance against a global health threat," notes niaid Director Anthony S. Fauci, M.D. "More broadly, de...ne trial is further evidence of the ability of the niaid Vaccine Research Center to rapidly translate basic...new solutions to pandemic influenza is part of the niaid commitment to respond to new emerging infectious d...

Scientists sequence genome of parasite responsible for common sexually transmitted infection

...rget our efforts to developing the most effective medicines to treat the infection and potentially create a way to prevent infection altogether," says niaid Director Anthony S. Fauci, M.D. Trichomoniasis is a sexually transmitted infection that affects both men and women and results in roughly 7.4 mil...

Scientists unveil piece of HIV protein that may be key to AIDS vaccine development

...ne Research Center (VRC). His collaborators included other scientists from niaid and the National Cancer Institute, NIH, as well as investigators from the D...between the HIV gp120 surface protein and this neutralizing antibody," says niaid Director Anthony S. Fauci, M.D. "This finding could help in the development...

2,000 influenza virus genomes now completed and publicly accessible

...ulence, and look for new therapeutic, vaccine and diagnostic targets," says niaid Director Anthony S. Fauci, M.D. The Influenza Genome Sequencing Projec...uence data was incomplete," says Maria Y. Giovanni, Ph.D., who oversees the niaid Microbial Sequencing Centers. "The Influenza Genome Sequencing Project has ...

MRSA toxin acquitted: Study clears suspected key to severe bacterial illness

... But new evidence strongly suggests that is not the case. A study led by niaid researchers at Rocky Mountain Laboratories (RML) in Hamilton, MT, shows tha...pid spread from hospital settings into communities of healthy people," says niaid Director Anthony S. Fauci, M.D. "This is an evolving pathogen that in recen...

Experimental vaccine protects mice against deadly 1918 flu virus

...ent microorganisms from entering the environment. "Understanding why this influenza virus was so deadly is an extremely important question," says niaid Director Anthony S. Fauci, M.D. "By building upon earlier research where scientists successfully reconstructed the 1918 pandemic flu strain, Dr. Nabel...

H9N2 avian flu vaccine paired with adjuvant provokes strong human immune response at low doses

...nstrating the potential value of adjuvanted avian influenza vaccines," says niaid Director Anthony S. Fauci, M.D. An adjuvant is a substance that is added to...erson, an influenza pandemic could result, health experts say. In 2004, niaid directed Novartis Vaccines and Diagnostics (formerly Chiron Corporation) to...

Mouse study reveals new clues about virulence of 1918 influenza virus

... "This elegant research gives a detailed picture of the overzealous host reaction to infection by a fully reconstructed 1918 influenza virus," says niaid Director Anthony S. Fauci, M.D. "The research provides clues as to why the flu of 1918 was so deadly, and may also help us better understand the disea...

AIDS vaccine research offers new insights on survival

...C, professor of Medicine at Harvard Medical School, and investigator at the niaid VRC. "These latest findings now provide us with an important new way of loo...rti, M.D., Srinivas Rao, D.V.M., Ph.D., and Gary Nabel, M.D., Ph.D., of the niaid VRC; David Montefiori, Ph.D., of Duke University Medical Center; and Fred B...

Radiation-killed bacteria vaccine induces broad immune response in mice

...ned the possibility of making a variety of bacterial vaccines that combine the best features of both killed-agent and live, attenuated vaccines," says niaid Director Anthony S. Fauci, M.D. Earlier research in Dr. Raz's laboratory had shown that irradiated probiotics (bacteria that are beneficial to h...

Landmark discovery of a Kaposi's sarcoma-associated herpesvirus receptor

...esions. In the March 31, 2006 issue of Science, niaid research fellow Johnan Kaleeba, Ph.D. and senior i... is a landmark achievement in and of itself," says niaid director Anthony S. Fauci, M.D. "But the connectio...can make cells permissive for KSHV fusion. The niaid discovery may lead to new avenues for treating KSH...

Chemical guidance of T cells leads to immunologic memory and long-term immunity

...ther with antibodies, long-lasting protection following vaccinations," says niaid Director Anthony S. Fauci, M.D. The body contains hundreds of millions o...ess receptors that allow them to detect and follow these chemokines. The niaid team also showed that when dendritic cells interact in specific fashion wit...

International HIV/AIDS trial finds continuous antiretroviral therapy superior to episodic therapy

... AIDS or death), the major outcome of the study. niaid made the decision to halt enrollment in collaborat...ngs to date, and the SMART Executive Committee and niaid agreed with the recommendation. Upon reviewing the...t HIV/AIDS treatment trials ever conducted," notes niaid Director Anthony S. Fauci, M.D. "The study reflect...

Defective immune system response to smallpox vaccine detailed in new study

...hanism leading to eczema vaccinatum and improves our understanding of the immune responses to smallpox vaccine of people with atopic dermatitis," says niaid Director Anthony S. Fauci, M.D. Published in this month's issue of Immunity, the study details how the overproduction in skin cells of inflammation...

Scientists design potent anthrax toxin inhibitor

...the April 23 online edition of the journal Nature Biotechnology. Led by niaid grantees Ravi S. Kane, Ph.D., of Rensselaer Polytechnic Institute, in Troy,... standard antibiotic therapy for the treatment of inhalation anthrax," says niaid Director Anthony S. Fauci, M.D. The spore-forming bacterium Bacillus ant...

Mice studies illustrate potential of chimp/human antibodies to protect against smallpox

...s A. Zerhouni, M.D. "It is imperative that we have effective treatments available that everyone could use in the event of a bioterror attack," says niaid Director Anthony S. Fauci, M.D. "This study shows that there are potential alternatives to existing treatments and perhaps to existing vaccines that w...

H5N1 avian flu virus vaccine induces immune responses in healthy adults

... Elias A. Zerhouni, M.D. "We are working hard to address the many challenges that remain with regard to the development of an H5N1 vaccine," adds niaid Director Anthony S. Fauci, M.D. "For example, potentially protective immune responses were seen most frequently at the highest dose of this vaccine. W...

Synthetic Protein Eases Arthritis Symptoms in Mice

...ch avenue to better understand and, perhaps, to treat rheumatoid arthritis, a condition that causes suffering in more than two million Americans,?says niaid Director Anthony S. Fauci, M.D. Investigators from NIAID’s Laboratory of Immunology, led by Michael Lenardo, M.D., published their findings in the ...

NIAID researchers show how promising TB drug works

..., which is currently cumbersome and lengthy," says niaid Director Anthony S. Fauci, M.D. "This new finding ... protein was the target of PA-824's action," says niaid scientist Clifton Barry, III, Ph.D., who headed th...first clinical trial of PA-824, see June 14, 2005, niaid press release: http://www3.niaid.nih.gov/news/new...

Agricultural workers at increased risk for infection with animal flu viruses

...ors assert. The paper appears online this week in Clinical Infectious Diseases. "Pigs play a role in transmitting influenza virus to humans," says niaid Director Anthony S. Fauci, M.D. "The worry is that if a pig were to become simultaneously infected with both a human and an avian influenza virus, gen...

Emerging staph strains found to be increasingly deadly and deceptive

... "Each day physicians around the world are stymied by the inability to effectively treat patients suffering from severe S. aureus infections," says niaid Director Anthony S. Fauci, M.D. "There is a critical need to develop new treatments against late-stage disease caused by antibiotic-resistant strains,...
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