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Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

This release is available in Chinese . Researchers at Iowa State University have found that increased expression of a form of cytochrome P-450 (CYP4B1) is a key marker of inhibition of colitis in mice by ca...

A new mouse model provides insight into genetic neurological disorders

Neurosensory diseases are difficult to model in mice because their symptoms are complex and diverse. The genetic causes identified are often lethal when transferred to a mouse. The lack of animal models slows progress in understanding and treating the diseases. By strategically altering a protein-...

Diminuendo -- New mouse model for understanding cause of progressive hearing loss

The respective microRNA seed region influences the production of sensory hair cells in the inner ear, both in the mouse and in humans. The findings have been published ahead of print in the current online issue of Nature Genetics . This study represents a major step forward in elucidating the com...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

Cold Spring Harbor, N.Y. Being able to accurately predict how a given cancer will respond to chemotherapy would spare patients with non-responsive tumors the burden of undergoing toxic and ultimately unhelpful treatment. Just as important, knowing which of a patient's cancer-causing genetic lesi...

Brain building: Study shows brain growth tied to cell division in mouse embryos

How your brain grows might come down to how your cells divide. In the April 6 issue of the Journal of Cell Biology ( JCB ), Lake and Sokol report that mouse protein Vangl2 controls the asymmetrical cell division and developmental fate of progenitor neurons. Vangl2 (aka Strabismus in flies) is...

Salk researchers develop novel glioblastoma mouse model

LA JOLLA, CAResearchers at the Salk Institute for Biological Studies have developed a versatile mouse model of glioblastomathe most common and deadly brain cancer in humansthat closely resembles the development and progression of human brain tumors that arise naturally. "Mouse models of human ...

Peering inside the skull of a mouse to solve meningitis mystery

NEW YORK, Dec. 22, 2008 NYU Langone Medical Center scientists and their collaborators at the Scripps Research Institute in La Jolla, Calif., have discovered an unexpected cause for the fatal seizures seen in mice with viral meningitis, an infection of the central nervous system, according to a st...

Multiple sclerosis research charges ahead with new mouse model of disease

November 6, 2008, Cambridge, UK A new study highlights the role of a charge-switching enzyme in nervous system deficits characteristic of multiple sclerosis and other related neurological illness. Multiple sclerosis (MS) is one of several diseases in which myelin the insulator for electrica...

Anti-cancer drug prevents, reverses cardiovascular damage in mouse model of premature aging disorder

An experimental anti-cancer drug can prevent -- and even reverse -- potentially fatal cardiovascular damage in a mouse model of progeria, a rare genetic disorder that causes the most dramatic form of human premature aging, National Institutes of Health (NIH) researchers reported today. In a s...

Anything but modest: The mouse continues to contribute to humankind

Cambridge, UK, 07 August 2008 - "Big things come in small packages," the saying goes, and it couldn't be more true when discussing the mouse. This little creature has become a crucial part of human history through its contributions in understanding human genetics and disease. In a review publish...

Disabling mouse enzyme increases fertility

St. Louis, May 16, 2008 Changing the sugars attached to a hormone produced in the pituitary gland increased fertility levels in mice nearly 50 percent, a research group at Washington University School of Medicine in St. Louis has found. The change appears to alter a reproductive "thermostat," unv...

Negligent, attentive mouse mothers show biological differences

MADISON - In mice, child neglect is a product of both nature and nurture, according to a new study. Writing in the journal PLoS ONE on April 9, researchers from the University of Wisconsin-Madison describe a strain of mice that exhibit unusually high rates of maternal neglect, with approximatel...

Scientists successfully treat new mouse model of inflammatory bowel disease

March 6, 2008 -- Researchers trying to improve cancer immune therapy have made an unexpected find: They've produced the most accurate mouse model to date of inflammatory bowel disease (IBD), a cluster of conditions that afflict approximately 1.4 million Americans with abdominal pain, constipation ...

Book is the first high-resolution digital mouse brain atlas designed for Web applications

Mouse and rat brain atlases have long been used to investigate human neurology. However, traditional brain atlases offer an incomplete map the brain and its function. The Allen Reference Atlas: A Digital Color Brain Atlas of the C57BL/6J Male Mouse (Wiley-Blackwell; Book/CD-ROM Edition; January 20...

Dissecting the genetic components of adaptation of E. coli to the mouse gut

New insights into the evolutionary mechanisms that facilitate the remarkably fast adaptation of intestinal bacteria within their natural environment are provided in the January issue of PLoS Genetics by researchers from INSERM and INRA at University Paris Descartes. Using germ-free mice a simp...

CSHL scientists identify and repress breast cancer stem cells in mouse tissue

Cold Spring Harbor, NY By manipulating highly specific gene-regulating molecules called microRNAs, scientists at Cold Spring Harbor Laboratory (CSHL) report that they have succeeded in singling out and repressing stem-like cells in mouse breast tissue cells that are widely thought to give rise t...

New chimeric mouse model for human liver diseases, drug testing

La Jolla, CA Cells cultured in the lab are like a fish out of water. Often, their behavior does not reflect their biological function within an entire organ or organism, which, for example, turns studying human liver cells into a big challenge. One way to get around the altered properties of ...

Cancer-resistant mouse discovered

LEXINGTON, Ky. (November 27, 2007) − A mouse resistant to cancer, even highly-aggressive types, has been created by researchers at the University of Kentucky. The breakthrough stems from a discovery by UK College of Medicine professor of radiation medicine Vivek Rangnekar and a team of rese...

Immune cells promote blood vessel formation in mouse endometriosis

A discovery in mice of immune cells that promote the formation of new blood vessels could lead to new treatments for endometriosis, a painful condition associated with infertility that affects up to 15 percent of women of reproductive age. The formation of new blood vessels, or angiogenesis, i...

Let the cat keep chasing the mouse

This release is available in German . Leipzig. For the first time an international researcher team has developed a model, which identifies potential habitats and corridors for the European wildcat ( Felis silvestris silvestris ). Using Rheinland-Pfalz as an example, it was demonstrate...

Statin treatment improves spatial memory in mouse models of Alzheimer's

Treatment with Simvastatin, one of the statin drugs widely used for lowering cholesterol in humans, significantly improved spatial memory - how to navigate a water maze - in mice genetically bred to have an Alzheimer’s like disease. Although statin improved memory in both males and females, the res...

Researchers create mouse lacking key inflammation gene

In a paper published yesterday in The Proceedings of the National Academy of Science (PNAS), researchers from Boston University School of Dental Medicine generated a mouse model exhibiting reduced inflammation. The Boston University researchers found that the transcription factor LITAF (Lipopol...

Mapping the mouse genome

In a new study published online this week in the open access journal PLoS Biology, Sagiv Shifman, Jonathan Flint, and colleagues present a high resolution genetic map for the mouse genome--one of the most detailed genetic maps now available aside from that for humans. To create this map, they u...

Knockout Mouse Project

Children's Hospital & Research Center Oakland is leading one of two teams in an international effort to produce thousands of genetically altered mice for a study to understand the role of individual genes in human health. Other members of the team represent the School of Veterinary Science at ...

Mutant mouse provides insights into breast cancer

By discovering a mutant mouse that is highly susceptible to mammary tumors, Cornell researchers have found a novel potential link between genetic defects in DNA replication (copying) and breast cancer. The mouse contains a mutation in a gene essential for replicating DNA in both humans and mice t...

MRSA vaccine shows promise in mouse study

By combining the four bacterial surface proteins that generate the strongest immune response in mice, researchers at the University of Chicago have created a vaccine that significantly protects immunized animals from multiple disease-causing, drug-resistant strains of Staphylococcus aureus, the mos...

Stem cells found in adult skin can be transplanted and function in mouse models of disease

Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease. This research is reported in the June 14, 2006 issue of The J...

Nobelist discovers antidepressant protein in mouse brain

A protein that seems to be pivotal in lifting depression has been discovered by a Nobel Laureate researcher funded by the National Institutes of Health's National Institute of Mental Health (NIMH). "Mice deficient in this protein, called p11, display depression-like behaviors, while those with s...

Engineered mouse mimics cognitive aspects of schizophrenia

Researchers have developed a mouse strain in which the abnormal activity of the dopamine machinery in a specific part of the brain causes cognitive and behavioral impairments mimicking those in human schizophrenics. The achievement is important, because creating an animal model of any schizophren...

Technique makes it easier to see mouse embryo in all its glory

A fast, high-resolution, 3D mouse embryo visualization technique developed by collaborators at the University of Texas Health Science Center at San Antonio and the University of Utah will revolutionize the way birth defects and cancer genes are studied in animal models. That's the prediction of the...

Interactive 3-D atlas of mouse brain now available on web

Researchers at the U.S. Department of Energy's Brookhaven National Laboratory have just launched a web-based 3-D digital atlas browser and database of the brain of a popular laboratory mouse (see http://www.bnl.gov/CTN/mouse/ ). "Neuroscientists around the world can now download these extremely...

The nude mouse tale: Omega-3 fats save the life of a terminal cancer patient

Ron Pardini is not a medical doctor. Yet he is seen as a hero by his cancer-stricken neighbor, "D.H." Pardini helped the 78-year-old after D.H. was diagnosed with terminal lung cancer. "In 2000 he was told by his doctor he had only a few months to live," said Pardini, a professor of biochemistry ...

Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke

Researchers at Johns Hopkins have discovered how to block a molecular switch that triggers brain damage caused by the lack of oxygen during a stroke. The Hopkins study, conducted on mice, is believed to be the first to demonstrate that a protein on the surface of nerve cells called the EP1 receptor...

Chemical compound inhibits tumor growth, size in new mouse study

Penn State food scientists have shown that the amount of health-linked polyphenols present during roasting or baking influences the toasty aroma developed by oats and might be used to limit the generation of off-flavors in oat products. Polyphenols are a large family of naturally occurring plant ...

Building a better mouse model of lung cancer: FHIT counts

Scientists have identified some of the very earliest genetic changes involved in the development of lung cancer and have incorporated them into a new strain of mouse that develops the disease in much the same way that humans do. The discoveries, reported in the August 1 issue of Cancer Research, ...

New technique could alter field of mouse genetics

Howard Hughes Medical Institute researchers have harnessed a mobile gene from the cabbage looper moth and modified it for routine use in mice and other vertebrates. If the new tool works as they expect, it will speed understanding of genes involved in human biology and disease and accelerate the se...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

Silencing Alzheimer's: targeting a key enzyme with gene therapy reversed course of disease in mouse modelsIn mice, that had been genetically engineered to develop Alzheimer's disease, scientists were able to reverse the rodents' memory loss by reducing the amount of an enzyme that is crucial for th...

Agilent Technologies Introduces First Commercial Mouse Microarray for Comparative Genomic Hybridization Research

Tuberculosis remains a major global health threat. Although more than 3 billion doses of the BCG vaccine have been administered to fight tuberculosis, the ability of the BCG vaccine to protect adults is very limited, as is its efficacy against newly emerging isolates. In a study appearing online ...

Gene therapy advance treats hemophilia in mouse models

Vector improved in two ways creates a sustained, partial correction to bleeding problems in mice A virus that typically infects insects could help with the development of gene therapy treatment for Hemophilia A, a condition in which even a bump on the knee can cause serious internal bleeding in ...

Researchers extend mouse lifespan by protecting against free radicals

Scientists at the University of Washington and their colleagues at other research centers have found a way to significantly extend the lifespan of mice while reducing the impact of the aging process. Their study, which will be published online by the journal Science on May 5, lends more credence to...
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