Small molecules mimic natural gene regulators
ANN ARBOR, Mich.---In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
Scientists at the Un...
Small molecules might block mutant protein production in Huntington's disease
DALLAS May 3, 2009 Molecules
that selectively interfere with protein production can stop human cells from making the abnormal molecules
that cause Huntington's disease, researchers at UT Southwestern Medical Center have found.
These man-made molecules
also were effective against the abnormal ...
Dancing 'adatoms' help chemists understand how water molecules split
RICHLAND, Wash. -- Single oxygen atoms dancing on a metal oxide slab, glowing brighter here and dimmer there, have helped chemists better understand how water splits into oxygen and hydrogen. In the process, the scientists have visualized a chemical reaction that had previously only been talked ab...
Small molecules block cancer gene
HOUSTON (March 10, 2009) Finding molecules
that block the activity of the oncogene Stat 3 (signal transducer and activator of transcription) required screening literally millions of compounds, using computers that compared the structure of the cancer-causing gene to those of the small molecules, ...
Scripps research team identifies key molecules that inhibit viral production
The research, led by Professor Donny Strosberg of Scripps Florida, was published on March 4, 2009, in the Journal of General Virology 's advance, online edition, Papers in Press.
In the new study, Strosberg and his colleagues describe peptides (molecules of two or more amino acids) derived fr...
New models question old assumptions about how many molecules it takes to control cell division
Blacksburg, Va. -- A single cell whether a yeast cell or one of your cells is exquisitely sensitive to its surroundings. It receives input signals, processes the information, makes decisions, and issues commands for making the proper response. As with any control system, noise errors, slip-ups,...
Engineers create intelligent molecules that seek-and-destroy diseased cells
Current treatments for diseases like cancer typically destroy nasty malignant cells, while also hammering the healthy ones. Using new advances in synthetic biology, researchers are designing molecules
intelligent enough to recognize diseased cells, leaving the healthy cells alone.
"We basically ...
Measuring molecules to improve drug design
CSIRO has patented an improved microscopy method for measuring the shapes and sizes of proteins which could help scientists create new pharmaceuticals that are a better match for the proteins they target.
The method, called Differential Aberration Correction (DAC) microscopy, measures distances ...
Researchers 'unzip' molecules to measure interactions keeping DNA packed in cells
ITHACA, N.Y. Anyone who has ever battled a stuck zipper knows it's a good idea to see what's stuck, where and how badly -- and then to pull hard.
A Cornell research team's experiments involve the "unzipping" of single DNA molecules. By mapping the hiccups, stoppages and forces along the way, th...
Shape changes in aroma-producing molecules determine the fragrances we detect
NEW YORK, December 22, 2008 - Shakespeare wrote "a rose by any other name
would smell as sweet." But would it if the molecules
that generate its
fragrance were to change their shape?
That's what Dr. Kevin Ryan, Assistant Professor of Chemistry at The City
College of New York (CCNY) and collabor...
Linking Proteins, Wires, Dots, and Molecules into Useful Devices
Through contemporary art, historical artifacts, and large-scale models, Molecules
That Matter showcases ten organic molecules
that profoundly altered modern life. In conjunction with this fascinating exhibition, five speakersall leaders in their fieldswill address the science in everyday experienc...
Do 68 molecules hold the key to understanding disease?
Why is it that the origins of many serious diseases remain a mystery? In considering that question, a scientist at the University of California, San Diego School of Medicine has come up with a unified molecular view of the indivisible unit of life, the cell, which may provide an answer.
Synthetic molecules emulate enzyme behavior for the first time
COLUMBUS, Ohio -- When chemists want to produce a lot of a substance -- such as a newly designed drug -- they often turn to catalysts, molecules
that speed chemical reactions. Many jobs require highly specialized catalysts, and finding one in just the right shape to connect with certain molecules
Two suppressor molecules affect 70 genes in leukemia
COLUMBUS, Ohio By restoring two small molecules
that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model.
The research, using human chronic lymphocytic leukemia (CLL) cells, also showed that loss of the two molecules
affects 70 genes, most of whic...
Synthetic molecules may be less expensive alternative to therapeutic antibodies, researchers find
DALLAS April 4, 2008 Researchers at UT Southwestern Medical Center have developed a simple and inexpensive method to screen small synthetic molecules
and pull out a handful that might treat cancer and other diseases less expensively than current methods.
In one screen of more than 300,000 suc...
Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth
A team led by the University of Colorado at Boulder and the University of Milan has discovered some unexpected forms of liquid crystals of ultrashort DNA molecules
immersed in water, providing a new scenario for a key step in the emergence of life on Earth.
CU-Boulder physics Professor Noel Cl...
Curry-derived molecules might be too spicy for colorectal cancers
SINGAPORE -- Curcumin, the yellowish component of turmeric that gives curry its flavor, has long been noted for its potential anti-cancer properties. Researchers from Tohoku University in Sendai, Japan, report on an apparent improvement upon nature: two molecular analogues of curcumin that demon...
New molecules discovered that block cancer cells from modifying cell DNA
Lake Tahoe, CA, October 11, 2007 Researchers have discovered new small molecules
that may prevent prostate cancer cells from turning off normal genes in a process that transforms normal cells into cancer cells. This significant discovery in the field of epigenetics has immediate implications in t...
Clemson scientists shed light on molecules in living cells
CLEMSON, S.C. Clemson University chemists have developed a method to dramatically improve the longevity of fluorescent nanoparticles that may someday help researchers track the motion of a single molecule as it travels through a living cell.
The chemists are exploiting a process called reson...
Navigating in the ocean of molecules
This release is available in German .
Tracking down new active agents for cancer or malaria treatment could soon become easier - thanks to a computer program with which researchers from the Max Planck Institute of Molecular Physiology in Dortmund aim to facilitate the search for suitable ...
NTU professor discovers method to efficiently produce less toxic drugs using organic molecules
Nanyang Technological University (NTU)'s Associate Professor Zhong Guofu has made a significant contribution to the field of organic chemistry, in particular the study of using small organic molecules
as catalysts, in the synthesis process called organocatalysis. Such synthesis process takes place...
Argonne scientists discover possible mechanism for creating 'handedness' in biological molecules
ARGONNE, Ill. (December 1, 2008) The basic molecules
that make up all living things have a predetermined chirality or "handedness," similar to the way people are right- or left-handed. This chirality has a profound influence on the chemistry and molecular interactions of living organisms. The inc...
Improving our ability to peek inside molecules
LIVERMORE -- It's not easy to see a single molecule inside a living cell.
Nevertheless, researchers at Lawrence Livermore National Laboratory are helping to develop a new technique that will enable them to create detailed high-resolution images, giving scientists an unprecedented look at the at...
'Nanoglassblowing' seen as boon to study of individual molecules
While the results may not rival the artistry of glassblowers in Europe and Latin America, researchers at the National Institute of Standards and Technology (NIST) and Cornell University have found beauty in a new fabrication technique called "nanoglassblowing" that creates nanoscale (billionth of ...
Researchers observe spontaneous 'ratcheting' of single ribosome molecules
Researchers report this week that they are the first to observe the dynamic, ratchet-like movements of single ribosomal molecules
in the act of building proteins from genetic blueprints.
Their study, published in the journal Molecular Cell, reveals a key mechanism in the interplay of molecules...
Argonne scientists use lasers to align molecules
ARGONNE, Ill. (May 13, 2008) Protein crystallographers have only scratched the surface of the human proteins important for drug interactions because of difficulties crystallizing the molecules
for synchrotron x-ray diffraction.
Scientists at the U.S. Department of Energy's (DOE) Argonne Nation...
New book presents methods to poke and prod individual molecules
COLD SPRING HARBOR, N.Y. Single-molecule biologythe revolutionary field that deals with the study of individual macromoleculesis undergoing rapid growth. Tremendous technical advances have made it possible to probe molecules
one by one, and to produce dynamic images as they twist, twirl, wobbl...
Early exposure to indoor fungus molecules may protect infants against future allergies
Maybe being a fussy housekeeper isn’t such a good thing after all.
Environmental health scientists at the University of Cincinnati (UC) say they have confirmed what other scientists have only suspected: early-life exposure to certain indoor fungal components (molecules) can help build stronger i...
Technique monitors thousands of molecules simultaneously
A chemist at Washington University in St. Louis is making molecules
the new-fashioned way ?selectively harnessing thousands of minuscule electrodes on a tiny computer chip that do chemical reactions and yield molecules
that bind to receptor sites. Kevin Moeller, Ph.D., Washington University profess...
Minuscule molecules pack a powerful punch
A role for a microRNA in the immune system has been shown by study of one of the world’s first microRNA knockout mouse, reported Friday 27 April in Science. The microRNA acts as a lynchpin to balance the response of immune defences and the researchers suggest the corresponding human gene will have ...
Pair of microRNA molecules controls major oncogene in most common leukemia
Researchers at Ohio State University have discovered that two microRNA (miRNA) molecules
help control the oncogene responsible for a dangerous form of B-cell chronic lymphocytic leukemia (B-CLL), the most common human leukemia in the world.
Their findings, published in the December 15 issue of C...
Biological motors sort molecules one by one on a chip
Researchers from Delft University of Technology's Kavli Institute of Nanoscience have discovered how to use the motors of biological cells in extremely small channels on a chip. Based on this, they built a transport system that uses electrical charges to direct the molecules
individually. To demons...
Convergent evolution of molecules in electric fish
Having a set of extra genes gave fish on separate continents the ability to evolve electric organs, report researchers from The University of Texas at Austin.
Dr. Harold Zakon and colleagues, in a paper recently published in Proceedings of the National Academy of Sciences, show that African and S...
Tiny RNA molecules fine-tune the brain's synapses
Non-coding regions of the genome ?those that don't code for proteins ?are now known to include important elements that regulate gene activity. Among those elements are microRNAs, tiny, recently discovered RNA molecules
that suppress gene expression.
Increasing evidence indicates a role for microR...
Scientists discover new way to look at how molecules twist and turn on water
Findings by Geri Richmond's team provide insight for environmental challenges
Chemists have discovered details about how the tadpole-shaped molecules
found in many soaps and detergents bury their heads into the top-most surface of water, an insight expected to yield benefits such as better meth...
Physical and functional interaction of key cell growth molecules linked to cancer
Scientists have uncovered new information about a specific mechanism involved in the biology of malignant human tumor cells. The findings, published in the June issue of Cancer Cell, significantly advance knowledge about epidermal growth factor receptor (EGFR).
EGFR is a well-studied cell surface...
Scientists discover that three molecules may be developed into new Alzheimer's drugs
A team of scientists has discovered three molecules
–?from a search of 58,000 compounds –?that appear to inhibit a key perpetrator of Alzheimer's disease.
Each of the three molecules
protects the protein called "tau," which becomes hopelessly tangled in the brains of patients with Alzheimer's. Th...
Touching Molecules With Your Bare Hands
For a virus to survive, it must elude the ever vigilant immune sentinels of its host. A latent virus can escape immune detection if it resides in nondividing cells and doesn’t produce any proteins. No viral proteins means no red flags for immune cells. If the virus targets one of the many cell type...
Medical molecules designed to respond to visible light that can penetrate tissue
If you have ever covered a flashlight with your hand and seen the red light that still comes through, then you have seen light in the therapeutic window ?that magic wavelength that is not absorbed or reflected away by tissue. Scientists believe that they can use light at that wavelength to signal m...
Duke Chemists Isolating Individual Molecules Of Toxic Protein In Alzheimer's, Parkinson's Disease
To understand the formation of the brain-clogging deposits that cause such disorders as Alzheimer's and Parkinson's diseases, Duke University chemists have figured out how to capture and "micromanipulate" the single molecular building blocks of the deposits.
Their aim is to understand the detaile...