Small molecules mimic natural gene regulators
ANN ARBOR, Mich.---In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
Scientists at the Un...
Implants mimic infection to rally immune system against tumors
CAMBRIDGE, Mass., Jan. 22, 2009 -- Bioengineers at Harvard University have shown that small plastic disks impregnated with tumor-specific antigens and implanted under the skin can reprogram the mammalian immune system to attack tumors.
The research -- which ridded 90 percent of mice of an aggre...
Gene mutations in mice mimic human-like sleep disorder, UT Southwestern researchers find
DALLAS May 20, 2008 Mutations in two genes that control electrical excitability in a portion of the brain involved in sleep create a human-like insomnia disorder in mice, UT Southwestern Medical Center researchers have found. The findings may help scientists better understand the disorder and pr...
Researchers mimic bacteria to produce magnetic nanoparticles
When it comes to designing something, its hard to find a better source of inspiration than Mother Nature. Using that principle, a diverse, interdisciplinary group of researchers at the U.S. Department of Energys Ames Laboratory is mimicking bacteria to synthesize magnetic nanoparticles that could...
Zoologists challenge longstanding theory that 'eyespots' mimic the eyes of predators' enemies
Circular markings on creatures such as butterflies are effective against predators because they are conspicuous features, not because they mimic
the eyes of the predators own enemies, according to research published today in the journal, Behavioral Ecology. Zoologists based at the University of...
Now, self-healing materials can mimic human skin, healing again and again
The next generation of self-healing materials, invented by researchers at the University of Illinois, mimics human skin by healing itself time after time. The new materials rely upon embedded, three-dimensional microvascular networks that emulate biological circulatory systems.
“In the same mann...
Moths mimic sounds to survive
In a night sky filled with hungry bats, good-tasting moths increase their chances of survival by mimicking the sounds of their bad-tasting cousins, according to a new Wake Forest University study.
Published in the May 29 issue of the Proceedings of the National Academy of Sciences, the study is ...
New synthetic self-assembling macromolecules mimic nature
We take "self-assembly" for granted when it is carried out by the biopolymers which are our hair, teeth, or skin. But when scientists devise new ways for molecules to self assemble into new materials, it is an important achievement.
Researchers with the Macromolecules and Interfaces Institute (MI...
Researchers make nanosheets that mimic protein formation
How to direct and control the self-assembly of nanoparticles is a fundamental question in nanotechnology.
University of Michigan researchers have discovered a way to make nanocrystals in a fluid assemble into free-floating sheets the same way some protein structures form in living organisms.
Scientists to mimic nature for newest cancer drugs
The North Atlantic right whale's future looks grim if the current mortality rates continue, according to Florida State University assistant professor of oceanography Douglas Nowacek and a group of fellow scientists from across the nation.
They have co-authored a paper titled "North Atlantic Right...
Mouse brain tumors mimic those in human genetic disorder
A recently developed mouse model of brain
tumors common in the genetic disorder neurofibromatosis 1 (NF1)
successfully mimics the human condition and provides unique insight
into tumor development, diagnosis and treatment, according to
researchers at Washington University School of Medicine in St. ...
Animal and plant communication at the ESA Annual Meeting
...ed the bugs' exoskeletal chemicals with that of the ants.
"The chemicals in the bugs' cuticle matched that of the ants," says Whitehead. "The bugs mimic
the hydrocarbons that the ants produce, so the ants don't recognize them as something foreign."
Even if this chemical camouflage is energetically c...
The way you eat may affect your risk for breast cancer
...vention," she said. "We hope these studies will identify biomarkers and/or pathways that could be used in human studies to determine agents that would mimic
UCSF researchers identify new drug target for Kaposi's sarcoma
Using high-throughput screening, the team screened a library of 182 compounds that it had specifically and rationally designed to mimic
the protease interface. The work identified six molecules that inhibited the Kaposi's sarcoma virus protease activity by at least 50 percent, includin...
New windows opened on cell-to-cell interactions
...ules are oriented on their cell membranes to allow for cell-to-cell interactions.
The six-member research team built tiny artificial molecules that mimic
brush-like membrane proteins and contain tiny fluorescent probes at the outer end. These miniscule polymers were incorporated into artificial membrane...
Skin-like tissue developed from human embryonic stem cells
...hESC) to generate complex, multilayer tissues that mimic
human skin and the oral mucosa (the moist tissue t...ering techniques to produce skin-like tissues that mimic
the lining tissues found in the oral cavity," said...here they were grown at an air-liquid interface to mimic
their growth environment in the oral cavity. Withi...
Flexible neck in cell-receptor DC-SIGN targets more pathogens
...ght together and then pulled apart. In the current work, the surfaces were cell receptor DC-SIGN and a target membrane decorated with carbohydrates to mimic
a pathogen surface.
The forces were measured as a function of the distance between the two surfaces, which was measured with single-angstrom resolut...
Robo-bats with metal muscles may be next generation of remote control flyers
So Bunget, a doctoral student in mechanical engineering at NC State, and his advisor Dr. Stefan Seelecke looked to nature. "We are trying to mimic
nature as closely as possible," Seelecke says, "because it is very efficient. And, at the MAV scale, nature tells us that flapping flight like that o...
Biological warfare in bacteria offers hope for new antibiotics
...by Professor Colin Kleanthous, from the University of York's Department of Biology, will develop earlier research that suggests colicins use decoys to mimic
key parts of the cells' own protein machinery to evade their defences.
Professor Kleanthous said: "Colicins are the weapon used in the biological w...
Can a new implant coating technique create a new six million dollar man?
...t his method of coating circumvents the disadvantages of plasma- spraying. The electrochemical process allows synthetic hydroxyapatite to more closely mimic
the real material. Examined under a microscope, it is virtually indistinguishable from the body's own material ― which helps the body accept a n...
Beetle shell inspires brilliant white paper
...e to south-east Asia, it is believed that the beetle's whiteness evolved to mimic
local white fungi as a form of camouflage.
New research, now published ...wn that through careful mineral selection and processing, it is possible to mimic
some of the structure of the white beetle's shell to produce an enhanced br...
American Chemical Society's Weekly PressPac -- June 3, 2009
...iptional activation domains, these small molecules mimic
natural activators and could provide insights on h...ses. "Evidence suggests that these small molecules mimic
the function and mechanism of their natural counte...OR IMMEDIATE RELEASE
"Amphipathic Small Molecules mimic
the Binding Mode and Function of Endogenous Transc...
MIT: New tissue scaffold regrows cartilage and bone
...arted with an existing method to produce a skin scaffold, made of collagen (from bovine tendon) and glycosaminoglycan, a long polysaccharide chain. To mimic
the structure of bone, they developed a technique to mineralize the collagen scaffold by adding sources of calcium and phosphate.
Once that was don...
Songbird study from CSHL, CCNY provides concrete measure of biology's impact on culture
... their song to their progeny, which in turn tutored the next generation, and so on. The tutors were either paired one-on-one with their progeny, or to mimic
a more natural social setting, introduced into a colony of females (who, as it happens, do not sing) and allowed to breed for a few generations.
Synthetic chemical offers solution for crops facing drought
...o. "We screened thousands of chemicals for one that
mimics ABA. We found pyrabactin activates some of the ABA receptors in
plants and is an excellent mimic
of ABA. Moreover, unlike ABA, it is stable
and easy to make. It therefore suggests a highly effective chemical strategy
for improving plants' ability...
Some vocal-mimicking animals, particularly parrots, can move to a musical beat
...The research team found that only species that can mimic
sound seem to be able to keep a beat, implying an ...s had something in common: an excellent ability to mimic
"It had recently been theorized that v... really specific prediction: Only animals that can mimic
sound should be able to keep a beat."
To test t...
Avian flu research sheds light on swine flu outbreak
...nd the pathogenesis of the virus.
A virus vaccine is derived from the virus itself. The vaccine consists of virus components or killed viruses that mimic
the presence of the virus without causing disease. These prime the body's immune system to recognize and fight against the virus. The immune system p...
Two-pronged model could help foil tough cystic fibrosis infections
...ed iron chelators, deferoxamine and deferasirox, that can remove excess iron from the system by binding to the metal in a process called chelation. To mimic
the clinical environment, they stuck to the maximum possible tobramycin dose of 1,000 micrograms per milliliter, mixed with a chelator.
New method developed by UC San Diego bioengineers gives regenerative medicine a boost
...s of information and instructions on top of the genetic code," he said. "This method will help determine whether artificial stem cells can 100 percent mimic
natural stem cells. This method helps you determine if, by doing this trick, you can generate a stem cell similar to a natural stem cell. If it is no...
UT Southwestern researchers probe kidney damage, protection in lupus
In the first study, which appears in the April issue of The Journal of Immunology, the researchers examined several strains of mice that mimic
human lupus. They found that immune cells in those mice overproduced a particular molecule called CXCR4. In fact, the mice had up to twice as much CXC...
ASBMB Annual Meeting to feature talks on the biochemistry of aging
...Rapamycin (TOR) pathway, involved in nutrient sensing, can block the detrimental effects of a HFD. They also found that reducing the levels of TOR can mimic
a calorie-restricted diet and improve metabolism, heart function and longevity. Thus, in addition to potentially linking HFD-obesity to diabetes and h...
Yale researchers uncover secrets of salmonella's stealth attack
... track using its own specialized "nano-syringe" called a type III secretion system. Using this structure, Salmonella injects bacterial proteins that mimic
proteins of the host cell and help the pathogen avoid destruction.
The Yale study describes the crucial role a bacterial protein called SopB plays ...
CSHL team develops mouse models of leukemia that predict response to chemotherapy
...Lowe and colleagues report in the April 1st issue of the journal Genes and Development , their models, which include treatment protocols that closely mimic
current AML therapy in people, precisely recapitulate genetic associations that have been linked to favorable or adverse treatment responses in patien...
Researchers develop flow sensors based on hair structures of blind cavefish
...tend from their bodies. Their ability to detect underwater objects and navigate through their lightless environment inspired a group of researchers to mimic
the hairs of these blind cavefish in the laboratory.
While the fish use these hairs to detect obstacles, avoid predators and localize prey, resear...
CEL-SCI Corporation to Launch Aseptic Filling for Stem Cell Produced Therapies and Other Biological Products
...tical and Pharmaceutical market is the area of biologics, and most recently the area of stem cells. These compounds and therapies are derived from or mimic
human cells or proteins and other molecules (e.g., hormones, etc.) Nearly all of the major new billion dollar drugs developed for unmet medical needs...
A natural approach for HIV vaccine
...ntage over a single super antibody that focuses on only one part of the virus, which can mutate. The findings suggest that research into vaccines that mimic
this natural antibody response could pay off.
Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone
...e with rhesus TRIM5-alpha to overcome HIV. Understanding these additional cooperative functions may serve as the basis of new therapeutics that either mimic
or enhance the blockade of the virus that occurs in monkeys.
Dana Gabuzda, M.D.
Dana-Farber Cancer Institute, Inc., Boston, MA
Spun-sugar fibers spawn sweet technique for nerve repair
...laments are coated with a corn-based degradable polymer, and then the sugar is dissolved in water, leaving behind bundles of hollow polymer tubes that mimic
those found in nerves, said Riyi Shi, an associate professor in Purdue's Weldon School of Biomedical Engineering and Department of Basic Medical Scien...
Study finds life-saving trend among seagulls
...ws that Herring and Ring-billed gulls not only watch their neighbours they mimic
their behaviour to assure their survival. Contrary to previous beliefs, thi... we know now that they are judging the level of vigilance of their peers to mimic
it. This adds a new complexity to understanding animal behaviour."
Researcher seeks to turn stem cells into blood vessels
...he amount of oxygen to which the stem cells are exposed. Reducing the oxygen these cells require creates a condition called hypoxia. "We are trying to mimic
this condition in the lab," Gerecht said, "because some research indicates that a lack of oxygen causes stem cells to form blood vessels in order to d...