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Microscope in Biological News

Underwater microscope helps prevent shellfish poisoning along Gulf Coast of Texas

Through the use of an automated, underwater cell analyzer developed at the Woods Hole Oceanographic Institution (WHOI), researchers and coastal managers were recently able to detect a bloom of harmful marine algae in the Gulf of Mexico and prevent human consumption of tainted shellfish. Shellfish ...

Oosight microscope enables embryonic stem cell breakthrough

MBL, WOODS HOLE, MA A noninvasive, polarized light microscope invented at the Marine Biological Laboratory (MBL) played a crucial role in a recent breakthrough in embryonic stem-cell research aimed at developing medical therapies. A team led by Shoukhrat Mitalipov, Ph.D., of Oregon Health & Sc...

Nanoscale microscope sheds first light on gene repair

Proteins called H2AX act as "first aid" to DNA, among other roles. For the first time, scientists using the world's most powerful light microscope (the only one of its kind in the Americas) have seen how H2AX is distributed in the cell nucleus: in clusters, directing the first aid/repair after ...

New light microscope sharpens scientists' focus

A new light microscope so powerful that it allows scientists peering inside cells to discern the precise location of nearly each individual protein they are studying has been developed and successfully demonstrated by scientists at the Howard Hughes Medical Institute's Janelia Farm Research Campus ...

High-resolution light microscope reveals the fundamental mechanisms of nerve communication

In a simultaneous publication (Science Express, 13th April 2006), STED microscopy revealed the spatial distribution of the bruchpilot protein and aided neurobiologists from the European Neuroscience Institute and the University of W├╝rzburgin understanding the protein's central role in the formation...

New, unique microscope for nanotech

UC Davis researchers in nanotechnology, chemistry and biology now have access to one of the most advanced microscopes of its type in the world. The new Spectral Imaging Facility, opened this fall, is a combination of an atomic force microscope and a laser scanning confocal microscope, the first com...

New stem cell research could reduce number of animal experiments

...r Subramanian, allowing her to focus on her research, and a research assistant to work on the project. It will also fund a state-of-the-art high power microscope that will allow the researchers to observe the movements and growth of neurones in real time. The project is one of 13 receiving a share of a 4.5 m...

DOE-funded research projects win 46 R&D 100 Awards for 2009

...y with Veeco Instruments, Inc.) TEAM Electron microscope Stage The TEAM Stage will make one of the world's... Medical Products LLC.) FemtoScope This time microscope dramatically improves the performance of tradition... Sandia's Hyperspectral Confocal Fluorescence microscope System - This system rapidly finds all emitting fl...

Early initiation of Arctic sea-ice formation

...ng to the genus Synedropsis . "We were astonished by this", said team member Richard Pearce of NOCS, who imaged the samples using a scanning electron microscope at the NOCS: "Weakly silicified diatoms are preserved only under exceptional circumstances, so to find fossilised Synedropsis species so well preser...

Arctic climate under greenhouse conditions in the Late Cretaceous

...ted electron microscopy techniques. In the modern ocean, scientists use floating sediment traps to collect and study settling material. These electron microscope techniques that have been pioneered by Professor Kemp's group at Southampton have unlocked a 'palaeo-sediment trap' to reveal information about Late C...

Scientists track chemical changes in cells as they endure extreme conditions

...ing approach, they used a beamline equipped with a high-resolution infrared microscope to detect the molecular signatures of a cell's biochemical and metabolic ac...in levels of free radicals and organic acids. Specifically, the infrared microscope tracks the instantaneous response of hydrogen bond structures in cellular w...

The sound of light: Innovative technology shatters the barriers of modern light microscopy

... "listening to light". In the future this technology may facilitate the examination of tumors or coronary vessels in humans. Since the dawn of the microscope scientists have been using light to scrutinize thin sections of tissue to ascertain whether they are healthy or diseased or to investigate cell functi...

University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease

...ientist Luca Quaroni and Dr. Alan Casson, Head of the Department of Surgery at the University of Saskatchewan (U of S) used the synchrotron's infrared microscope to identify tissue afflicted with a condition known as Barrett's Esophagus from chemical fingerprints associated with the disease, which can lead to e...

Exhibition showcases the 'art of science'

...ike Gaevski, Joe Palmer, and Conrad Sylvestre of Princeton's Micro/Nanofabrication Laboratory (MNFL) for their entry Desert Butte, a scanning electron microscope image. Third Prize went to Maria Ciocca, a 2005 alumna now at the University of Pennsylvania School of Medicine, for Worm Love, an image taken using i...

Focus on the formation of bones, teeth and shells

...bones, teeth and sea shells. They used the world's most modern electron microscope to capture a three-dimensional image of the nanoparticles that form the bas...tion process to be studied. Using this approach, as well as the electron microscope mentioned above, Sommerdijk's research group at the TU/e Faculty of Chemica...

Milestone in live microscopy focus of $2 million NIH grant

...s scientists to develop the world's first electron microscope capable of filming live biological processes has b...ging tool called the dynamic transmission electron microscope or DTEM. These instruments can snap 10 to 100 imag...biological processes at the molecular level. "A microscope with these capabilities will allow us to make mile...

Non-wovens as scaffolds for artificial tissue

...the scientists in Halle etched approximately 50 "microtesting machines". They then placed and fastened the fibers over the testing machines. Under the microscope the researchers were able to observe how the fibers behave when they are pulled, how far they stretch and when they snap. As fiber-like structures are...

Neuroscientists discover long-term potentiation in the olfactory bulb

...ctory bulb does in fact have LTP. This specialized microscope used an advanced imaging technique called "2-photo...s made by higher-order brain regions. The 2-photon microscope used in this study is an ideal tool to ask what th... National Institutes of Health. The 2-photon laser microscope used in the study was constructed with support fro...

Findings uncover new details about mysterious virus

...nstructed picture of the virus matched features seen using the atomic force microscope picture, Rossmann said. The starfish-shaped feature apparently opens up ...fish-shaped feature and how it functions. The paper was written by Xiao; microscope expert Yurii G. Kuznetsov in the Department of Molecular Biology and Bioche...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

...ological system, but to the development of new agents that will enhance effectiveness in treatment. Previous immunohistochemical and immunoelectron microscope studies have detected OGF and OGFr in both the cytoplasmic and the nuclear compartments. The OGF-OGFr axis is known to regulate cell proliferation by...

New data on the breakdown of the KRas protein

... responsible for breaking down proteins; this breakdown pathway was unknown in the case of KRas. Thanks to videomicroscopy techniques using a confocal microscope and the fluorescence, resonance energy transfer (FRET) technique, the researchers have observed how the protein is brought inside the cell and transpo...

TGen researchers discover possible way to block the spread of deadly brain tumors

...pathology Fellow at Barrow Neurological Institute, who examined tumors for the study. "As a pathologist, I examined expression of NHERF-1 under the microscope in tumor sections, including both invading edges of tumor and cellular tumor cores. We found NHERF-1 to be robustly expressed by invading tumors cells...

Home tooth bleaching slightly reduces enamel strength

... scientists used a specialized tool to apply force to test the enamel hardness and stiffness (the surface ability to bounce back), and an atomic force microscope to observe the tiny nanometer-scale effects on the teeth. The average loss of enamel ranged from 1.2 to 2 nanometers on the treated teeth. The cont...

Alzheimer cell death in Zebrafish: Demise of neurons observed live for the first time

...loss of neurons. They were even able to observe this while it was happening. "The translucent larvae of the zebrafish can be studied under a laser microscope over an extended period of time," reports Haass. "If you add a color dye to the water to specifically stain dying cells, you can even directly watch t...

Mollusks taste memories to build shells

...f both shape and pattern that we see in the natural world," Boettiger said. To build their model, the UC Berkeley scientists first studied electron microscope images of mollusk mantles in order to understand the network of neurons connecting the sensing cells in the mantle with the secretory cells that produ...

Montana State grad's work helps diagnose skin cancer without a biopsy

...ical Center in Tennessee to build a handheld laser microscope that could someday reduce the number of biopsies n... of cancers -- come back negative. The handheld microscope could help doctors get a better idea when biopsies...money covered, among other things, the cost of the microscope itself and Arrasmith's graduate tuition. David...

Making a point: Picoscale stability in a room-temperature AFM

...he University of Colorado (CU) has shown how to detect and monitor the tiny amount of light reflected directly off the needle point of an atomic force microscope probe, and in so doing has demonstrated a 100-fold improvement in the stability of the instruments measurements under ambient conditions. Their recent...

Covering the bases: Quantum effect may hold promise for low-cost DNA sequencing, sensor applications

...sadenine with thymine and cytosine with guanine. The scanning tunneling microscope used in the present study features a delicate electrode tip held very close... By measuring the current drop in the electrical circuit formed between the microscope probe and the substrate as the hydrogen bonds are gently pulled apart, a po...

Microscope reveals how bacteria 'breathe' toxic metals

...udy, Lower and his colleagues used an atomic force microscope (AFM) to test how the bacterium responded to the m...material. They combined the AFM with an optical microscope to get a precise map of the bacteria's location on... times bigger than the tip of an AFM probe. So the microscope was able to slide over the surface of individual b...

Vanderbilt scientists invent world's smallest periscopes

...-organisms from several sides at once. "With an off-the-shelf laboratory microscope you only see cells from one side, the top," says team member Chris Janetopo... According to Ron Reiserer, "This could easily become as ubiquitous as the microscope slide and could replace more expensive methods currently used to position i...

DNA evidence is in, newly discovered species of fish dubbed H. psychedelica

...ved in ethanol. The flesh of the preserved specimen looks white, but with a microscope one can still see the striping, Pietsch discovered. This got him thinkin... Pietsch retrieved the old specimens from the collection, put them under a microscope and found the striping distinctive to H. psychedelica . He'd had two speci...

Tension in the nanoworld

...akes use of extreme light concentration at the sharp tip of an Atomic Force microscope (AFM), yielding nanoscale resolved images at visible, infrared and terahert...mond tip into the surface of a Silicon Carbide crystal. With the near-field microscope the researchers were able to visualize the nanoscopic strain field around t...

Peering inside the skull of a mouse to solve meningitis mystery

...Gan, Ph.D., the microscopy produces time-lapse "movies," capturing activity that is not evident in still images made from slices of tissue viewed on a microscope slide. "A series of frozen images gave the misleading impression that the T-cells were engaging with the infected cells, but intravital microscopy...

Tiny MIT ecosystem may shed light on climate change

...essor of Ocean Utilization in CEE, and MIT mechanical engineering graduate student Marcos devised a clear plastic device about the size and shape of a microscope slide. Depending on the organism being studied, nutrients or prey are injected with a syringe-based pump into the device's microfluidic channel, w...

Breast cancer genome shows evolution, instability of cancer

...refined the understanding of aberrant genomic rearrangements to the base pair level of resolution, said Milosavljevic. "It was like working with a microscope and for the first time looking at the ultimate level of resolution. We found a number of genes that were rearranged that were known to be involved in ...

The Burnham buzz

...r New Cures Jeff Price, M.D., Ph.D. has created a next generation robotic microscope which can be used for high-throughput cellular image analysis to discover n...olors of light in optical systemsto simplify and speed auto-focusing of the microscope via digital color cameras. This advancement will increase screening from th...

Scientists film inner workings of the immune system

...tential for refining current interventions against disease." Centenary Institute Executive Director, Professor Mathew Vadas, says the multi-photon microscope used to film this immune process is the Hubble telescope of medical research. "The Hubble allowed the universe to be seen with absolute clarity, w...

Cell movements totally modular, Stanford study shows

...o see the movements of individual cells and overall sheet movements as cells filled the open space. "We stained the nuclei and took a movie under a microscope and watched what they did over a 15- to 20-hour period," said Vitorino. "That's when we noticed the cells moving inside the sheet, even in the absence...

December 2008 Geology and GSA Today media highlights

...have tackled this conundrum by analyzing the composition and internal structure of granules at very fine scales using several newly developed electron microscope techniques. Their results have revealed that the granules form in a complex sequence of events involving several episodes of crystallization of differ...

Caltech scientists develop 'barcode chip' for cheap, fast blood tests

...tems Biology in Seattle, Washington. An IBBC, described in a paper in the advance online edition of Nature Biotechnology , is about the size of a microscope slide and is made out of a glass substrate covered with silicone rubber. The chip's surface is molded to contain a microfluidics circuit--a system of ...
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(Date:4/17/2014)... In the April issue of Experimental Biology ... by Drs. Rex Gaskins and Paul Kenis in ... campus of the University of Illinois Urbana-Champaign describe ... reduction-oxidation reactions underlie a variety of cell functions ... to these crucial roles in regulating normal cellular ...
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