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Metastasis in Biological News

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

NEW YORK CITY (February 5, 2009)Scientists have long wondered how melanoma cells travel from primary tumors on the surface of the skin to the brain, liver and lungs, where they become more aggressive, resistant to therapy, and deadly. Now, scientists from NYU Langone Medical Center have identifi...

Newly identified gene powerful predictor of colon cancer metastasis

Cancer Researchers at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and the Charit Universitts Medizin Berlin (Germany) have identified a gene which enables them to predict for the first time with high probability if colon cancer is going to metastasize. Assistant Professor Dr. ...

It is important to demonstrate the influence of the microenvironment in the process of metastasis

In the work defended at the University of the Basque Country (UPV/EHU), an in vitro culture model of human colon cancer was created in order to reproduce the gene regulation that is expressed in these cancer cells during their growth as metastasis in the liver of patients. This in vitro culture mo...

A gene for metastasis

Colorectal cancer is one of the most prevalent cancers in the Western world. The tumor starts off as a polyp but then turns into an invasive and violent cancer, which often spreads to the liver. In an article recently published in the journal Cancer Research, Prof. Avri Ben-Zeev and Dr. Nancy Gave...

Inflammation may play role in metastasis of prostate cancer

Many would assume that "mounting an immune response" or "having your body fight the cancer" is a good thing. Now, research at the University of California, San Diego (UCSD) School of Medicine strongly suggests that inflammation associated with the progression of tumors actually plays a key role in...

'Trojan Horse' agent halts bone metastasis in mice

A novel vascular targeting agent completely prevented the development of bone tumors in 50 percent of the mice tested in a preclinical study, providing early evidence that it could treat, or thwart, growth of tumors in bone, a common destination for a number of cancers when they start to spread. ...

Two-faced protein can stop metastasis or promote it, researchers say

A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found. The study, published in the Sept. 18 online issue of the ...

Advances in lung cancer research announced at conference

...rain. In non-small cell lung cancer (NSCLC), brain metastasis is a devastating complication that occurs in as ma...ity to identify those at risk for developing brain metastasis may guide new therapies. A team led by Dr. Weis...ues to predict, treat and ultimately prevent brain metastasis in patients with non-small cell lung cancer," Dr. ...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...rophin (PTN), are both also over-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors. "We have found that PTN drives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in those cancers," Wellstein says. Researchers at Lombardi/Georgeto...

Colorectal cancer

...ne BAMBI is associated with two import signaling pathways and thus promotes metastasis formation," Dr. Fritzmann said. "These signaling pathways (Wnt and TGF-beta...4 genes more closely, in order to better understand the individual steps of metastasis formation. Aim To predict at an early stage whether the tumor will spre...

LSUHSC research describes function of key protein in cancer spread

...ncer cells acquire the ability to detach from their neighboring cells and move to and invade tissue at distant points in the body. "Because tumor metastasis leads to a poor prognosis and tremendously complicates treatment, it is of utmost importance that we understand, at a molecular level, the processes t...

3-D research model tackles prostate cancer spread

...en bones and cancer cells," Ms Sieh said. "Tissue-engineered bone provides the 3D architecture for the cancer cells which more closely resemble bone metastasis instead of growing the cancer cells and bone cells on a flat Petrie dish. "I am growing prostate cancer cells on the tissue-engineered bone to obser...

UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs

...ssive properties. For example, Muc4 is also expressed in pancreatic, lung and ovarian tumor cells. "Muc4 is likely a central cellular mechanism for metastasis of many cancers, and we will be continuing this important work to prove that," he said. ...

Skin cancer study uncovers new tumor suppressor gene

...cer development known as anchorage-independent growth. Likewise, cells with MMP-8 mutations had a greater ability to migrate -- a key aspect of cancer metastasis -- than normal cells. The researchers found that mice injected with cells expressing normal MMP-8 did not develop skin ulcers, which are one of the...

Researchers identify genetic markers for aggressive head and neck cancer

...particular microRNAs─miR-205 and let-7d─in their tumor tissue. Specifically, these patients were four times more likely to have an earlier metastasis or local-regional recurrence of their cancer than patients with higher levels of miR-205 and let-7d in tumor tissue. These findings may eventually...

Metastatic bone disease patients can walk in Lazarus' footsteps

...ed, bone metastases can eventually cause the bone to fracture and seriously affect a patient's quality of life. Each year, about 100,000 cases of bone metastasis are reported in the United States. In treating cancer patients with painful bone metastases, interventional radiologists may also use radiofrequenc...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 13 top young investigators

...Ruslan M. Medzhitov, PhD, at Yale University, New Haven, Connecticut, is studying the role of immune cells called macrophages in tumor progression and metastasis (cancer spread). His goal is to identify and characterize molecular pathways critical to metastatic cancers, particularly lung, breast, and skin canc...

Physics, math provide clues to unraveling cancer

...mits information not just in a forward direction, but also backwards. That implies new considerations for developing drugs to inhibit major growth and metastasis pathways in cancer. This crosstalk was missed by conventional methods. Typically, when scientists begin to look at a cell, they must make assumptio...

JCI online early table of contents: Jan. 19, 2009

...nd Yuliya Pylayeva, at Memorial Sloan-Kettering Cancer Center, New York, has provided new insight into the initiation, maintenance, and progression to metastasis of a specific subset of human and mouse breast cancers. A marked proportion of breast cancers are associated with excessive activation of either Ra...

Team finds breast cancer gene linked to disease spread

... 8 and appears to be crucial to cancer's spread or metastasis because it helps tumor cells stick tightly to bloo...n identifying the genetic mechanism at play in the metastasis of breast cancer, the scientists may have answered...ood Johnson Medical School. "Not only has a new metastasis gene been identified, but this also is one of a fe...

Modified gene targets cancer cells a thousand times more often than healthy cells

...are successful, Gorbunova hopes the process might be someday given as a simple shot-in-the-arm, which might travel throughout the bloodstream and stop metastasis in its tracks. ...

Massague honored with inaugural AACR Distinguished Leadership Award in Breast Cancer Research

...ified the role of transforming growth hormone factor-Beta (TGF-Beta) in the metastasis of breast cancer cells to the lung, has been selected to receive the inaugu...cells. These investigations demonstrated that a genetic predisposition for metastasis can sometimes be identified in primary malignancies before the cancer has b...

Mechanisms of cardiovascular disease and cancer give clues to new therapies

...ls. Some tumour cells, for example in ovarian carcinoma, exploit endothelins to suppress their death while migrating to other parts of the body in the metastasis process, enabling the tumour to spread, usually with fatal results. Understanding the endothelin axis and its role in both cancer and cardiovascular...

Mayo researchers identify dangerous 'two-faced' protein crucial to breast cancer spread and growth

...er, p120 catenin induces invasion and metastasis," Dr. Anastasiadis says. In this study, the researchers discovered that not only does p120 promote metastasis when it is not bound to E-cadherin, it also turns on growth-promoting genes and proteins. In laboratory and animal experiments, they found that "free"...

Einstein researchers develop a new way to study how breast cancer spreads

...o how cancer cells move during the early stages of metastasis may help scientists develop more effective cancer ...umor itself. We can now look at the early steps of metastasis in high resolution and specific regions of the tum...earch provides a powerful tool for studying cancer metastasis and is part of a growing body of Einstein cancer r...

Study links nicotine with breast cancer growth and spread

...nal carcinogen, but rather it combines with other yet to be determined factors to enable tumorigenesis. "In vitro and in vivo tests showed that no metastasis occurs when the administration of nicotine alone," said Chen. "At this point we can only suggest that nicotine potentiates the growth-related process....

LSUHSC awarded patent for compound inhibiting cancer and other diseases

...genesisthe process of developing new blood vessels. Studies have demonstrated that the level of vascularization in a tumor is strongly associated with metastasis in melanoma, breast, and lung carcinomas. "This patent was based on the observation that lipid droplets are critical to the formation o...

Vaccine against HER2-positive breast cancer offers complete protection in lab

...ceptors and destroy them, are a mainstay of treatment for this cancer, but a significant proportion of patients develop a resistance to them or cancer metastasis that is hard to treat. This treatment relied on activated, own-immunity to wipe out the cancer, says the study's lead investigator, Wei-Zen Wei, Ph...

Dense tissue promotes aggressive cancers

...ually been tied to matrix degradation, which is thought to be important for metastasis and spread of cells through the body." Because metastasis is often what makes cancers deadly, new leads on how to block it are critic...

TG2 identified as potential therapeutic target in chemo-resistant ovarian cancer

...tic melanoma, breast cancer and pancreatic cancer. "Drug resistance and metastasis are major impediments to the successful treatment of ovarian cancer and unt...howed that silencing TG2 with the siRNA liposome reduced tumor size, slowed metastasis and enhanced the effect of gemcitabine chemotherapy. "This aberrant prot...

Research at Argonne's Advanced Photon Source reveals structure and behavior of collagen

..., a class of enzymes which when working properly help to regulate the normal growth and development of animals but when malfunctioning can lead to the metastasis of cancerous tumors or rheumatoid arthritis. The visualization of this interaction could help drug developers to create an inhibitor to prevent the p...

CSHL scientists identify and repress breast cancer stem cells in mouse tissue

... these therapies in model systems to see if the effects we see in cell culture are mirrored in real tumors and then, to gauge what effect that has on metastasis and relapse following therapy. It has been known for some time that stem and progenitor cells possess unique defenses, as compared with mature, or ...

OHSU turns innovations into commercial opportunities at record pace

...om the laboratory of Cheryl Maslen, Ph.D., OHSU professor of medicine and molecular and medical genetics. A major focus of Maslens lab is the study of metastasis of cancer cells. A mutation in the CRELD1 gene, which codes for a cell surface adhesion protein, has been identified by Maslen as a potential indicato...

AACR, BCRF award inaugural grants in translational breast cancer research

...f the MSP pathway as a biomarker for poor prognosis and to carry out preclinical tests of three MSP pathway inhibitors in order to block growth and/or metastasis of breast cancer. Yee will look at Gene Expression Profiling to Predict Response to anti-IGF Therapy. This research builds upon his long-term goa...

$2.7 million awarded for metastatic colon cancer research

...hile colon cancer in its earliest stages is often treatable, the spread, or metastasis of the disease to other parts of the body makes for a more complicated cour... the knowledge and understanding of the connection between inflammation and metastasis of colon cancer will be the focus of Karin and his team of researchers at U...

Interleukin-8, key marker for colorectal cancer treatment

... Although IL-8 expression has been recently correlated with the tumorpathology of various carcinoma types, the role of IL-8 in tumor development and metastasis is still not fully understood and often discussed controversially. Moreover, it remains unclear whether IL-8 expression is related to cancer progressi...

Mutation of the COX2 gene can double or treble a woman's risk of ovarian cancer

...e polymorphism could enhance the expression of the COX2 gene, thereby inhibiting apoptosis (programmed cell death) and promoting tumour proliferation, metastasis and angiogenesis (the formation of new blood vessels needed to supply a growing tumour). The reason why the same effect was not observed in cervical c...

Presence of gene mutation helps guide thyroid cancer treatment

...d a trend toward a higher rate of cancer formation in the lymph node due to metastasis (the transfer of tumor cells from one organ or part of the body to another ...ral lymph node along with the diseased thyroid, to avoid the possibility of metastasis following surgery. BRAF V600E testing could also be useful for deciding be...

How cancer spreads by aggregating platelets

..., provide the tumor with the nutrients and oxygen it needs to grow. As a result, locking the podoplanin-CLEC-2 interaction may not only prevent cancer metastasis but also limit the growth of cancer cells, Suzuki-Inuoue says. The researchers also found that podoplanin present within lymphatic vessels which c...

Newly created cancer stem cells could aid breast cancer research

...umors initiated metastasis, which is the main cause of cancer mortality in the clinic. Tan has demonstrated that a critical determinant of eventual metastasis is the identity of the normal cell type that preexists in the breast and becomes the object of mutation and selection, Weinberg says. ...
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