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Melanoma in Biological News

Zebrafish provide a model for cancerous melanoma in humans

In a new study published in Disease Models & Mechanisms , scientists use the zebrafish to gain insight into the influence of known cancer genes on the development and progression of melanoma, an aggressive form of human skin cancer with limited treatment options. Inside the cell, signals are d...

New method for detection of phosphoproteins reveals regulator of melanoma invasion

Scientists have developed a new approach for surveying phosphorylation, a process that is regulated by critical cell signaling pathways and regulates several key cellular signaling events. The research, published by Cell Press in the April 10th issue of the journal Molecular Cell , describes the ...

NYU Langone Medical Center researchers find micro RNA plays a key role in melanoma metastasis

NEW YORK CITY (February 5, 2009)Scientists have long wondered how melanoma cells travel from primary tumors on the surface of the skin to the brain, liver and lungs, where they become more aggressive, resistant to therapy, and deadly. Now, scientists from NYU Langone Medical Center have identifi...

Stress may hasten the growth of melanoma tumors

COLUMBUS, Ohio For patients with a particularly aggressive form of skin cancer malignant melanoma stress, including that which comes from simply hearing that diagnosis, might amplify the progression of their disease. But the same new research that infers this also suggests that the use of co...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

Washington, D.C. Researchers at Georgetown University Medical Center have found a gene they say is inactivated in two aggressive cancers malignant melanoma, a form of skin cancer, and glioblastoma multiforme, a lethal brain tumor. They add that because this gene, known as PTPRD, has recently bee...

Variant of vitamin D receptor gene linked to melanoma risk

A new analysis indicates an association between a gene involved in vitamin D metabolism and skin cancer. Published in the November 1, 2008 issue of CANCER , a peer-reviewed journal of the American Cancer Society, the study suggests that individuals with certain variants in a vitamin D-related gen...

New study shows Dermytol produces pronounced decrease in malignant melanoma tumor volume

SAN DIEGO, CA., April 7 . . .A new study presented at the Experimental Biology Annual Meeting shows that a proprietary blend extracted from canola, Dermytol, produces a pronounced reduction of malignant melanoma cell growth. Dermytol, a proprietary compound developed by KGK Synergize Inc., a biot...

Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma

Hoag Memorial Hospital Presbyterian today announced promising data from a clinical study showing patient-specific cancer vaccines derived from patients' own cancer cells and immune cells were well tolerated and resulted in impressive long-term survival rates in patients with metastatic melanoma wh...

Vitiligo skin disorder could yield clues in fight against melanoma

MAYWOOD, Ill. About 1 million Americans suffer a skin disorder called vitiligo, which causes unsightly white patches on the face, hands and other parts of the body. A Loyola University Hospital researcher has won a five-year, $1.7 million federal grant to investigate a new way to treat vitilig...

As rates rise, researchers find better way to identify melanoma

University of Rochester Medical Center researchers found a new protein produced excessively in malignant melanoma, a discovery that is particularly relevant as skin cancer rates climb dramatically among young women. The protein, IMP-3, is not over-expressed in harmless moles but is increased in...

Novel antigen-cloning technique may boost efforts to develop a melanoma vaccine

In recent years, researchers have worked to develop a number of vaccines to help the immune system fight tumors. Cancer vaccines are not intended to prevent cancer; rather, they are used to boost immune responses to preexisting tumors. Unlike traditional chemotherapy, vaccines have relatively low t...

Malignant melanoma cells secrete protein required for embryo formation

A Northwestern University research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical to proper embryo formation. An article describing this research was published today in the advanced online issue of the journal Nature Medicine. The researchers ident...

Researchers discover why melanoma is so malignant

About 60,000 Americans will be diagnosed with melanoma this year, says the American Cancer Society, and 10,000 of those cases will be fatal. If not caught in the early stages, melanoma can be a particularly virulent form of cancer, spreading through the body with an efficiency that few tumors posse...

Protein amplification in melanoma is possible drug target

A newly discovered gene mutation may account for many cases of immune deficiency, in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the July issue of Nature Genetics. The discovery may lead to a new diagnostic t...

Engineered skin offers clues to melanoma development

When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine. Though mult...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

...tors and the protein that binds to it, the growth factor pleiotrophin (PTN), are both also over-expressed in other difficult-to-treat cancers, such as melanoma and pancreatic tumors. "We have found that PTN drives metastasis of those cancers, suggesting that antibody treatment may be additionally useful in th...

Skin cancer study uncovers new tumor suppressor gene

... The NIH analysis found that one-quarter of human melanoma tumors had changes, or mutations, in genes that co...ut that one of the most often mutated MMP genes in melanoma is not an oncogene at all. In its study, the team ...anoma. Consequently, in the estimated 6 percent of melanoma patients whose tumors harbor a mutated MMP-8 gene ...

Beach vacations may increase future skin cancer risk in children

...risk factor for malignant melanoma, the most dangerous form of skin cancer. melanoma rates have been rising dramatically over recent decades. More than 62,000 Americans are diagnosed with melanoma each year and more than 8,000 die. The study was conducted among childr...

TGen Clinical Research Services at Scottsdale Healthcare and Mayo Clinic study new cancer drug

...tivity of TH-302 in patients with advanced solid tumors. After evidence of tumor activity was observed in the Phase 1 trial in patients with advanced melanoma both non-small cell lung cancer and small cell lung cancer the study was expanded to further investigate TH-302 anti-tumor activity in these tumors....

Implants mimic infection to rally immune system against tumors

...under the skin can reprogram the mammalian immune system to attack tumors. The research -- which ridded 90 percent of mice of an aggressive form of melanoma that would usually kill the rodents within 25 days -- represents the most effective demonstration to date of a cancer vaccine. Harvard's David J. M...

Jefferson scientists discover a key protein regulator of inflammation and cell death

...lecular Biology in the Kimmel Cancer Center at Jefferson, discovered a key protein component involved in inflammation. The protein, AIM2 (absent in melanoma 2), is involved in the detection and reaction to dangerous cytoplasmic DNA that is produced by infection with viral or microbial pathogens, or by tiss...

Meyskens honored with AACR-Prevent Cancer Foundation award

...ars of detailed laboratory work, he proposed a new conceptual framework for melanoma etiology, prevention, and treatment. Most recently, he has provided a major, new insight into the non-UVR causation of melanoma with suggestions for potential preventive strategies. Meyskens has publi...

Children's National researchers develop novel anti-tumor vaccine

... WASHINGTON, DCA novel anti-tumor vaccine for neuroblastoma and melanoma developed by scientists and clinicians at Children's National Medical Center in collaboration with investigators from the University of Iowa is show...

More than skin deep: There's no such thing as a 'safe' suntan, researchers warn

... published in the October issue of Pigment Cell & melanoma Research , the official journal of The Internation...Pigment Cell Societies (IFPCS) and the Society for melanoma Research. The authors of the three review paper...by young women, are linked to an increased risk of melanoma (the most dangerous form of skin cancer), and do n...

Fish cancer gene linked to pigment pattern that attracts mates

...adly to male fish, it also has one perk: The black melanoma splotches arise from attractive natural markings t...onal Academy of Sciences this week shows that the melanoma gene can be conserved in swordtail fish because of...ce a lot of offspring, he noted. The swordtail melanoma has been studied since the 1920s, and scientists p...

The genetics of the white horse unraveled

...int of view since the mutation also predisposes for development of melanoma. About 75% of Grey horses older than 15 years of age have a benign form of melanoma that in some cases develops into a malignant melanoma. Thus, the study reported today has also given new insight in a molecular pathway that may lead ...

New oral angiogenesis inhibitor offers potential nontoxic therapy for a wide range of cancers

...ncreased half-life, selectively accumulated in tumor tissue, blocked angiogenesis, and significantly inhibited primary tumor growth in mouse models of melanoma and lung cancer, with no apparent side effects when used at effective doses. Subsequent tests suggest that Lodamin retains TNP-470's unusually broad s...

Synthetic compound promotes death of lung-cancer cells, tumors

...ac mimic alone, without having to add TNFa. The researchers also found that the Smac mimic alone was effective against some types of breast cancer and melanoma cells in culture. The apparent ability of a Smac mimetic, as a single agent, to induce cell death in nearly one-quarter of lung-cancer cell lines t...

Last chance for media to register for ECCO 14 -- the European Cancer Conference

...r survival Couples more likely to divorce if one partner is diagnosed with certain types of cancer New type of drug shows promise in tackling melanoma in innovative way. . . . and much more. Press Office opening times: Sunday 23 September: 09.00 19.00 Monday 24 Wednesday 26 September: 08....

Sun exposure early in life linked to specific skin cancer gene mutation

...). The results indicate that different subtypes of melanoma are associated with different risk factors "The findings suggest that melanoma subtypes have different causes. This is important ...ion in melanomas. Researchers interviewed 214 melanoma patients in North Carolina about their risk factor...

Rising skin cancer rates are more likely to affect wealthy people, says 12-year review

... skin cancers - basal cell carcinoma, squamous cell carcinoma and malignant melanoma - accounted for 27 per cent of all male cancers and 26 per cent of all fema...en were, however, 30 per cent more likely than men to suffer from malignant melanoma - the least common, but most serious skin cancer - which averages 186 cases...

Researchers publish first marsupial genome sequence

... of the sun's ultraviolet rays. Having the sequence of the opossum genome will give researchers the ability to learn more about the molecular basis of melanoma and its progression, as well as explore development of new therapies and preventive treatments. The opossum genome sequence also provides resear...

Dealing deadly cancers a knockout punch

...splatin, a standard chemotherapy agent, in a mouse melanoma model that included both cultured cells and live a...ective than cisplatin or reovirus alone at killing melanoma cancer cells in a mouse model. The investigators ...re expected to begin in 2007, including a Phase II melanoma trial and a Phase I/II ovarian cancer trial. ...

Researchers from the University of Navarra analyze new kinds of cancer-fighting antibodies

... Five cancer-fighting agents being tested The first cancer-fighting agent of this kind, anti-CTLA-4, began to be tested in patients in 1999. In melanoma treatment, between 15 and 20% of clinical objectives have been reached (reduction or disappearance of the tumor), which the researchers see as a posit...

'Guardian of the genome' protein found to underlie skin tanning

...t light from the sun, it deters the development of melanoma skin cancer, the fastest-increasing form of cancer... of melanoma. "The number one risk factor for melanoma is an inability to tan; people who tan easily or h... author, David E. Fisher, MD, PhD, director of the melanoma Program at Dana-Farber and a professor in pediatri...

Study calculates patient time costs associated with cancer care

...21.1 and 20.8 days) and shortest for patients with melanoma (2.2 days), prostate cancer (3.8 days) and breast ...h medical care varied, ranging from 17.8 hours for melanoma to 351.3 hours for gastric cancer and 368.1 hours ... found that net patient time costs were lowest for melanoma ($271) and prostate cancer ($842) and highest for ...

A genetic 'gang of 4' drives spread of breast cancer

...h as the bone and brain. Finally, they will explore whether the LMS genes play a corresponding role in metastasis of other cancers -- such as sarcoma, melanoma and colon cancer -- to the lung, said Massagué....

Molecular differences between early and advanced melanomas could provide new drug targets

...sts introduced the gene for Akt into radial growth melanoma cells, the cells expressed nearly eight times as m... tumors and lead to unregulated cell growth. When melanoma cells overexpressing Akt were introduced into immu...rs. The scientists also found that the Akt-induced melanoma cells produced more of the enzyme NOX4, one of the...

UCSF brain tumor vaccine trial shows promising results

...apy and radiation therapy. Vitespen has been granted fast-track and orphan drug designations from the Food and Drug Administration for both metastatic melanoma (skin cancer) and renal cell carcinoma (kidney cancer). Reviewing the presentation at AANS, Henry Brem, MD, director of neurosurgery at the John...

Researchers urge monitoring of bone health during chemotherapy

...process of bone turnover. The resulting loss of bone density created a favorable environment for bone tumor growth. When the researchers injected melanoma or breast cancer cells into mice, those getting G-CSF developed a two-fold increase in tumor burden, a measure of the size and severity of tumors, com...
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