A miR boost enables acute leukemia cells to mature
COLUMBUS, Ohio A new study by Ohio State University cancer researchers shows that boosting the level of a molecule called miR-29b in acute myeloid leukemia (AML) cells can reverse gene changes that trap the cells in an immature, fast growing state of development.
The study discovered how the ...
Large DNA stretches, not single genes, shut off as cells mature
Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous studies have implied.
Working with mous...
UT Southwestern researchers create molecule that nudges nerve stem cells to mature
DALLAS June 15, 2008 Inspired by a chance discovery during another experiment, researchers at UT Southwestern Medical Center have created a small molecule that stimulates nerve stem cells to begin maturing into nerve cells in culture.
This finding might someday allow a person's own nerve stem...
Scientists demonstrate feasibility of preventing malaria parasite from becoming sexually mature
Researchers have demonstrated the possibility of preventing the human malaria parasite, Plasmodium falciparum, which is responsible for more than a million malaria deaths a year, from becoming sexually mature.
The discovery could have implications for controlling the spread of drug resistance...
Front-line immune cells mature in four stages, study shows
Researchers here have cracked the site and the stages of development for the last major set of human immune cells.
The researchers found that natural killer (NK) cells, one of the body's front-line defenses against cancer and infections, mature
from progenitor stem cells in four discrete stages....
Biologists rediscover endangered frog population
...ecause the frogs were younger than is typical for breeding. Because of the frogs' young age, only a handful of the eggs were fertile. The one frog to mature
is thriving. The next breeding season is expected to be December 2009 to March 2010.
The goal of the breeding program is to return the mountain yell...
Skin-like tissue developed from human embryonic stem cells
...ce to mimic their growth environment in the oral cavity. Within two weeks, tissues developed that were similar in structure to those constructed using mature
cells derived from newborn skin, which are the current gold standard for tissue fabrication.
"These engineered tissues are remarkably similar to th...
$20 million NIH grant to transform clinical research at UIC
The center also includes researchers at Advocate Health Care and the Jesse Brown VA Medical Center.
"The center will capitalize on mature
conceptual and technological resources at UIC to foster collaboration and innovation," said Theodore Mazzone, professor of medicine and director of th...
Plastics chemical retards growth, function of adult reproductive cells
... annual meeting of the Society for the Study of Reproduction.
A healthy, mature
follicle, called an antral follicle, includes a single egg cell surrounded ..., breast milk, the amniotic fluid of pregnant women and the antral fluid of mature
follicles. A national survey conducted by the federal Centers for Disease C...
Male seahorses like big mates
... seahorse (Hippocampus abdominalis), concentrating on the importance of partner body size in mate selection. A total of 10 female and 16 male sexually mature
seahorses, obtained from a captive breeding facility in Tasmania, took part in the experiment. Individuals of both sexes were presented with potential...
Neural stem cell differentiation factor discovered
...s is exactly what happened upon the addition of EGFL7. In order to verify their findings in vivo, the researchers analyzed mouse brains and identified mature
neurons as a source of EGFL7 in the adult brain. The distribution of these cells in the brain was biologically significant, as EGFL7 was absent from r...
Trio of signals converge to induce liver and pancreas cell development in the embryo
...t have focused on individual molecular signals that induce these tissues to mature
from a common precursor cell population. In a new study, published this wee...simultaneously, converging to direct pancreas and liver progenitor cells to mature
into their final state. They looked at how BMP, TGF-beta, and FGF signaling...
CWRU receives $5 million from Ohio Third Frontier Commission
... for critical limb ischemia.
With further refinement of already established proof of concept, the following programs could mature
into significant opportunities for CSCRM and the region.
Dr. Gerson is partnering with Lentigen, Inc, of Gaithersburg, MD to develop a gene ther...
Pushmi-pullyu of B-cell development discovered
... Although every cell in the body carries the genes necessary to function as an antibody-producing B cell, only a small proportion of stem cells mature
into those important immune-system cells. James Hagman, PhD, Professor of Immunology at National Jewish Health and his colleagues have identified two ...
Caltech researchers explore how cells reconcile mixed messages in decisions about growth
...e implications for our understanding of how cancer develops, as well as for how best to grow tissues in a laboratory.
In normal epithelial tissues, mature
cells that are in contact with one another tend not to divide, explains Anand Asthagiri, assistant professor of chemical engineering at Caltech, and t...
The downside of microtubule stability
...plex, Tanabe and Takei discovered. Dynamic microtubules help construct the Golgi complex in two ways: they capture the vesicles that combine to form a mature
Golgi complex; and they provide a track along which these vesicles can travel to their rendezvous point near the nucleus. By breaking up the Golgi app...
Universitat Autonoma de Barcelona researchers first to clone mice in Spain
...hree female brown-coloured mice and were born respectively on 12 May, 3 June and 10 June. By means of nuclear transfer techniques, scientist collected mature
oocytes, removed their chromosomes and substituted them for the nucleus of an adult somatic cell. The cloning of mice is part of a research being carr...
Dioxins in food chain linked to breastfeeding ills
... dioxin altered the induction of milk-producing genes, which occurs around the ninth day of pregnancy, and decreased the number of ductal branches and mature
lobules in the mammary tissue.
The timing of dioxin exposure also seemed to be significant, the study noted. For example, when exposure occurs ver...
Stem cell protein offers a new cancer target
...ted let-7 from maturing, making the cell more immature and stem-like. Since these qualities also make a cell more cancerous, and because low levels of mature
let-7 have been associated with breast and lung cancer, the discovery suggested that LIN28 might be oncogenic.
Now, publishing Advance Online in N...
Temporary infidelity may contribute to the stability of ancient relationships
...st--when partner switching can occur."
Ants in the genus Acromyrmex cultivate a single fungal species in their nests: Leucoagaricus gonglyophorus. mature
ant colonies contain one fungal clone--a single genotype, which uses several strategies to make sure that other fungi do not invade.
Sweden to host 1.3 billion Euro research center
...mmented: "Thanks to the dedication of hundreds of scientists and engineers from across the whole of Europe, ESS is now fully developed as a viable and mature
project that could and should move rapidly to the construction phase."
He added: "Although final agreements on the funding of ESS have still to be...
Did the North Atlantic fisheries collapse due to fisheries-induced evolution?
...lation genetics and lead author.
In addition to the molecular results, the study also demonstrates that the length and age at which the fish become mature
have decreased. So-called "probabilistic maturation reaction norms" show that the length at which there is a 50% probability of becoming mature, has, ...
Getting to the root of science in a nutty way
...watch as these roots grow and see how they respond to various conditions over time."
A pecan tree spends its first five or six years growing into a mature
tree capable of producing nuts. Spring is typically a period of growth for the trees, but it is not currently known whether first-year roots grow much...
One size does not fit all
...f MS, following an immune system attack on myelin, oligodendrocyte progenitor cells or stem cells in the CNS are recruited to the lesion. These cells mature
and produce new myelin to repair the damage.
"Statins, which are known to modify the immune system response and have a wide array of effects on ot...
American Chemical Society's Weekly PressPac -- May 13, 2009
...ehyde dehydrogenase the same protein known to protect human blood from radiation damage.
ARTICLE #3 FOR IMMEDIATE RELEASE
"Proteomic Analysis of mature
Soybean Seeds from the Chernobyl Area Suggest Plant Adaptation to the Contaminated Environment"
DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/st...
Focus on the formation of bones, teeth and shells
...he TU/e researchers demonstrated a second role for the organic layer: it directed quite precisely the direction in which the mineral could grow into a mature
biomineral. In the near future they hope to show that the mechanism they have discovered also applies to the formation of other crystalline biomineral...
Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy
...stem cells are theoretically capable of differentiation to all cells of the mature
human body (and are hence defined as "pluripotent"). This ability, along wi...cancers and in early stage embryos, but it is almost completely absent from mature
The survivin gene is especially highly expressed in und...
Stanford scientists turn adult skin cells into muscle and vice versa
...e Baxter Laboratory in Genetic Pharmacology at Stanford. "We show here that mature
cells can be directly reprogrammed to generate those necessary cells, provi...ctively transforming the cell from one type to the other.
cells will likely complement the use of embryonic stem cells in regeneratin...
UC Riverside professor receives top scientific honor
Raikhel has deciphered in great molecular detail a chemical chain reaction and genes which prompts disease-spreading mosquitoes to produce and mature
their eggs. Manipulation of this process may be key to controlling the mosquito populations responsible for the spread of disease.
His laboratory ...
Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies
...oduction of inflammatory cytokines and chemokines. PGN632 also induced an increase in the expression of cell-surface molecules that are indicative of mature
dendritic cells and that assist in antigen presentation functions, as well as in stimulating T-cell proliferation.
Dr. Xianming Huang, assistant pr...
Fossils suggest earlier land-water transition of tetrapod
... suited to weight-bearing, terrestrial locomotion than the juvenile morphology. It is possible that Ichthyostega came out of the water only as a fully mature
In contrast, in Acanthostega "there is less change from the juvenile to the adult. Although Acanthostega appears to be aquatically adapted t...
New insights into progressive hearing loss
...rupting this process.
"No one has seen a disease-causing mutation in the mature
sequence of a microRNA," says Dr Moreno-Pelayo. "This is the first microRNA... in the mouse gene. All three sit in a vital region of seven letters in the mature
sequence of miR96" says Dr Angeles Menca, the Spanish team member who found...
Device protects transplanted pancreatic cells from the immune system
...e team of scientists showed that after transplantation, the precursor cells mature
into functional beta cells that are glucose-responsive and control blood su...anted into immunodeficient mice to study the viability and function of both mature
beta cells and precursor cells inside the device. Itkin-Ansari's team found...
Scientists identify key gene that protects against leukemia
...n which engraftment of the HSCs occurred in the mice, the scientists noted a progressive expansion of the myeloid lineage, which constitutes a type of mature
white blood cell that fights infection. This expansion led by 6 to 12 months post-transplantation to the development of a myeloproliferative disease, ...
UIC biologists use DNA to study migration of threatened whale sharks
...ermen for meat and fins used in soup.
Little is known about the shark's biology, perhaps because they have been studied primarily near shore, while mature
animals may breed and give birth out in the open ocean. Nor is much known about neonatal or juvenile sharks, including where they grow to maturity, or...
Gutsy germs succumb to baby broccoli
...t H. pylori was reported in 2002 by Fahey and colleagues at Johns Hopkins. "Broccoli sprouts have a much higher concentration of sulforaphane than mature
heads," Fahey explains, adding that further investigation is needed to affirm the results of this clinical trial and move the research forward. The st...
New evidence explains poor infant immune response to certain vaccines, says MU researcher
... that the immune systems of newborns might require some time after birth to mature
to a point where the benefits of vaccines can be fully realized.
Habib Z...y the foreign microbes. When an antigen from a vaccine enters a body with a mature
immune system, Th-1 cells respond and, after destroying the invader, the Th...
Changes in gene may stunt lung development in children
... of mice with poor lung function to one with more efficient airways and lungs two times the size. As with people, the lungs of mice fully form as they mature
to adulthood. The better-functioning strain maintained higher levels of SOD3 levels in these mice were four times higher at the final stage of lung d...
The egg makes sure that sperm don't get too old
...ient who needs a stem cell transplantation. As soon as the cell has divided a few times, it is possible to harvest stem cells that are then allowed to mature
to the cell type that the recipient needs.
"The genetic stability of the transplanted cells has been a serious concern up until now, and it was fea...
Human adult testes cells can become embryonic-like
...rrently being explored, says Dym. The use of embryonic stem cells is controversial because it necessitates destruction of an embryo, and pushing fully mature
cells, such as skin cells, back into a stem-like state requires use of cancer genes, and has therefore been viewed as potentially risky for human trea...