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Marrow in Biological News

Adult bone marrow stem cells injected into skeletal muscle can repair heart tissue

BUFFALO, N.Y. -- University at Buffalo researchers have demonstrated for the first time that injecting adult bone marrow stem cells into skeletal muscle can repair cardiac tissue, reversing heart failure. Using an animal model, the researchers showed that this non-invasive procedure increased...

Multiple route bone marrow stem cell injections show promise to treat spinal cord injury

Tampa, Fla. (Mar. 12, 2009) Researchers from DaVinci Biosciences, Costa Mesa, California, in collaboration with Hospital Luis Vernaza in Ecuador, have determined that injecting a patient's own bone marrow-derived stem cells (autologous BMCs) directly into the spinal column using multiple routes c...

Biomedical researchers create artificial human bone marrow in a test tube

ANN ARBOR, Mich.--- Artificial bone marrow that can continuously make red and white blood cells has been created in a University of Michigan lab. This development could lead to simpler pharmaceutical drug testing, closer study of immune system defects and a continuous supply of blood for trans...

Stowers Institute's Linheng Li Lab expands understanding of bone marrow stem cell niche

The Stowers Institute's Linheng Li Lab has identified the precise location of the bone marrow stem cell niche. The findings were published today in the Advance Online Publication of Nature . The Linheng Li Lab collaborated with several of the Institute's support facilities to develop a new te...

NC State first university in nation to offer canine bone marrow transplants

Dogs suffering from lymphoma will be able to receive the same type of medical treatment as their human counterparts, as North Carolina State University becomes the first university in the nation to offer canine bone marrow transplants in a clinical setting. Dr. Steven Suter, assistant professor...

Healing the heart with bone marrow cells

Researchers at the McEwen Centre for Regenerative Medicine at Toronto General Hospital have discovered the 'SOS' distress signal that mobilizes specific heart repair cells from the bone marrow to the injured heart after a heart attack. While it has long been known that bone marrow cells have the ...

Bone marrow may restore cells lost in vision diseases

University of Florida scientists conducting experiments with mice have found evidence that the body naturally replenishes small amounts of cells in the eye essential for healthy vision. The finding may shatter the belief that a cell layer vital for eyesight called the retinal pigment epithelium, ...

Bone marrow cells can become functional gut lining cells

Researchers report the discovery that cells used in bone marrow transplantation can develop into new cells lining the gut, according to a study by Yale School of Medicine in the Proceedings of the National Academy of Sciences. The study showed that bone marrow derived cells can differentiate into...

Bone marrow stem cells may heal hearts even years after heart attacks

Left ventricular function and exercise capacity increased, while the area of heart muscle damage shrank, in 18 patients given infusions of their own bone marrow stem cells up to eight years after a heart attack, according to a new study in the Nov. 1, 2005, issue of the Journal of the American Coll...

Malfunctioning bone marrow cells sabotage nerve cells in diabetes

Malfunctioning bone marrow cells that produce insulin appear to cause a dangerous nerve condition called neuropathy that disables many people with diabetes, said a research team led by Baylor College of Medicine in Houston. The report from researchers at BCM, Shiga University of Medical Science i...

Stem cells in bone marrow replenish mouse ovaries

Previously unrecognized stem cells found in the bone marrow and blood of mice can "restock" a depleted ovary with new egg cells within weeks, according to new research published in this week's issue of the journal Cell. This finding provides direct evidence to overturn a long-held dogma in reprod...

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

Physicians at Emory University School of Medicine are conducting a clinical trial using stem cells generated within the bone marrow to grow new blood vessels that could improve circulation in patients with blockages in the arteries of their legs -- a condition called peripheral vascular disease (...

Research shows cord blood comparable to matched bone marrow

University of Minnesota researchers report that umbilical cord blood transplants may offer blood cancer patients better outcomes than bone marrow transplants, according to an analysis of outcome data performed at the Center for International Blood and Marrow Transplant Research (CIBMTR), Medical C...

La Jolla Institute discovers novel tumor suppressor

...ome types of lymphoma and leukemia. Myeloproliferative diseases are a group of disorders characterized by an overproduction of blood cells by the bone marrow and include chronic myeloid leukemia. Lymphoma and leukemia are cancers of the blood. "PLC-beta 3 is an enzyme, but the function we found was a co...

Stem cell research: From molecular physiology to therapeutic applications

...als in China, and is the leading runner in stem cell therapeutics. They have identified a mesenchymal stem cell (MSC) population from human fetal bone marrow and found that these cells could differentiate not only into osteogenic, adipogenic and endothelial lineages, but also hepatocyte-like cells, and neur...

Scientists closer to making implantable bone material, thanks to new research

... form. For example, the researchers have discovered that the 'bone-like' materials that were grown from bone cells from mouse skull and mouse bone marrow stem cells successfully mimicked many of the hallmarks of real bone, which include stiffness. However, they found that the 'bone-like' material grown ...

Children's Hospital Oakland scientists first to discover new source for harvesting stem cells

...highly likely that placental stem cells, like umbilical cord blood and bone marrow stem cells, can be used to cure chronic blood-related disorders such as sic...ople with serious blood- related disorders are not able to receive the bone marrow or cord blood transplant they need because they can't find a match. Dr. ...

Genetically corrected blood cells obtained from skin cells from Fanconi anemia patients

...is observation is particularly important in diseases such as Fanconi anemia, where one of the main problems lies in the lack of blood cell in the bone marrow of those affected. However, according to researchers, this new therapeutic strategy can be applied to many other genetic diseases by differentiating i...

REGiMMUNE presents enhanced efficacy data in preclinical transplantation models

... to provide significant clinical benefits in organ transplantation and bone marrow transplantation. The REGiMMUNE study concluded that the addition of a subt...tional New Drug (IND) for the prevention of acute GvHD associated with bone marrow transplantation later this year. The poster presentation is scheduled du...

Combined stem cell-gene therapy approach cures human genetic disease in vitro

...anemia (FA) genes, the disease often leads to bone marrow failure, leukemia, and other cancers. Even after receiving bone marrow transplants to correct the hematological problems,...ells generated from healthy donors. Since bone marrow failure as a result of the progressive decline in ...

NIH funds work at WPI on regenerating heart tissue and preventing urinary tract infections

...ark. Glenn Gaudette, PhD, assistant professor of biomedical engineering at WPI, will receive $403,000 over two years to advance his work using bone marrow derived stem cells to restore function to damaged hearts. Terri Camesano, PhD, associate professor of chemical engineering at WPI, will receive $218,0...

Tips from the American Journal of Pathology

...r P, Hirrlinger J, Lang K, Zinkernagel M, Odermatt B, Samardzija M, Reichenbach A, Grimm C, Rem C: Cooperative phagocytes: resident microglia and bone marrow immigrants remove dead photoreceptors in retinal lesions. Am J Pathol 2009, 174: 2310-2323 ...

MIT: New tissue scaffold regrows cartilage and bone

...into a joint, the scaffold can stimulate mesenchymal stem cells in the bone marrow to produce new bone and cartilage. The technology is currently limited to s... different ways to treat cartilage injuries, including stimulating the bone marrow to release stem cells by drilling a hole through the cartilage into the bon...

Just in time for spring: Scientists find the cellular on and off switch for allergies and asthma

...in mouse experiments that examined cells from bone marrow and umbilical cord blood that ultimately help crea...mast cells, the developing cells die. Because bone marrow makes both mast cells and these cytokines, the res...rve as the "on switch" for the immune system, bone marrow cells also use them as the "off switch" to stop ma...

Study finds blood cells can be reprogrammed to act as embryonic stem cells

... "Not only has this work identified a new programmable cell type, but the cells are easy to obtain and analyze in many research laboratories and bone marrow transplantation centers around the world," said Grover C. Bagby, MD, Professor of Medicine and Molecular and Medical Genetics at Oregon Health and Sci...

World premiere in stem cell research in Montreal

...erica, nearly 4,000 people wait in vain for a bone marrow transplant due to the lack of compatible donors. It is known that a bone marrow stem cell transplant can reconstitute the recipien...am, these patients will be able to obtain new bone marrow within the next few years. "It could be possible t...

Scientists identify key gene that protects against leukemia

...ed evidence that could lead to a protocol for bone marrow transplants that could boost the chance of a cure ...portant ramifications for patients undergoing bone marrow transplants, for leukemia, lymphoma, multiple myel...n cancers. "Currently, patients undergoing bone marrow transplants may not be getting enough of the quies...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

...followed by additional chemotherapy cycles or bone marrow transplantation. Yet only a quarter of patients a...st treated with radiation to destroy existing bone marrow cells. The altered stem cells then took over the "host" bone marrow and promoted the development of leukemia. To track...

Amniotic fluid may provide new source of stem cells for future therapies

...of pregnancy. Amniotic fluid (AF) cells that had markers similar to bone marrow stem cells (termed AFKL cells) were then isolated for use in experiments, a...-term ability of the transplanted cells to produce new blood cells. Bone marrow samples from the transplanted mice were also taken and injected in a second...

Lancet study supports new, highly effective treatment for blood disorder

...am infections because of the spleen's role as a filtering organ of the immune system. Promacta works by stimulating the production of cells in bone marrow that form platelet cells in the blood. Past studies have shown that the drug boosts platelet counts in both ITP and normal subjects. Ongoing and fu...

'Seeing' stem cells helps in fight against peripheral arterial disease

...dicine. Transplanting stem cells derived from bone marrow (not embryonic stem cells), accompanied by necessa...t stem cells extracted from a healthy donor's bone marrow and inject the cells into the patients' legs where...earchers took rabbit stem cellsseparated from bone marrow in the laband injected them into the animal's hind...

A new way to assemble cells into 3-D microtissues

...stems that communicate via growth factors. Artificial tissues are presently used in medicine for a range of applications such as skin grafts, bone marrow transplants, or blood substitutes, as well as in basic medical and biological research. Tissue engineers try to improve upon or repair natural tissues...

Stem cell breakthrough gives new hope to sufferers of muscle-wasting diseases

...he research team, which is based at UNSW and formerly from Sydney's Westmead Children's Hospital, adapted a technique currently being trialled in bone marrow transplantation. Adult stem cells are given a gene that makes them resistant to chemotherapy, which is used to clean out damaged cells and allow the n...

From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine

...Center describe how they were able to use a "scaffolding" material extracted from the groin area of mice on which stem cells from blood, fat, and bone marrow grew. This advance clears two major hurdles to bioengineered replacement organs, namely a matrix on which stem cells can form a 3-dimensional organ an...

Researchers identify a cell type that limits stroke damage

...nism that slows this harmful effect of immune cells in the brain, but no one had yet been able to demonstrate it. Treg cells, produced in the bone marrow and other organs of the immune system, migrate to the brain during the first few days after a stroke. They limit the extent of secondary damage by blo...

2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research

...sity of Michigan: for Radical Improvements of Bone marrow Transplant Safety Bone marrow transplantation is frequently used to treat cancer...ly leukemias and lymphomas. When successful, bone marrow transplants literally offer a new lease on life fo...

Texas Medical Center researchers win collaborative grants

...pond to mycobacterium tuberculosis, which causes the disease. When the system goes awry, immune cells cannot effectively digest bacteria nor will bone marrow make blood or more immune cells, and the mice become anemic and die of infection. The researchers suspect similar processes take place in humans and ...

Research shows cell's inactive state is critical for effectiveness of cancer treatment

...tain a cell's quiescence, a state that allows bone marrow cells to escape the lethal effects of standard can...etic stem cells (HSCs) immature cells in the bone marrow that have the capacity to differentiate into all t...role in determining the sensitivity of normal bone marrow cells to chemotherapy and radiation. They have now...

New research lights up chronic bacterial infection inside bone

...und that small persistent patches of Listeria took up residence inside bone marrow in the mice. This is significant because it is thought that the bone marrow can act as a reservoir to the brain and spinal cord, potentially causing li...

UC Davis researchers exploring gene therapy to fight AIDS

...ch German doctors cured a man of AIDS using a bone marrow transplant comes as no surprise to Gerhard Bauer, ...also had leukemia, which is best treated by a bone marrow transplant. Thinking they might be able to cure th...n of both diseases, the physicians gave him a bone marrow transplant from a person with natural immunity to ...
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