ExcellGene and Khner achieved milestone in development of novel 250 Liter mammalian cell culture bioreactors
May 12, 2009 / b3c newswire / - ExcellGene SA, Monthey and Adolf Kühner AG, Birsfelden announce today that they achieved an important milestone in the development of a revolutionary cell culture technology for scale up and manufacturing from suspension cultured mammalian
As part of a...
Atomic structure of the mammalian 'fatty acid factory' determined Mammalian
fatty acid synthase is one of the most complex molecular synthetic machines in human cells. It is also a promising target for the development of anti-cancer and anti-obesity drugs and the treatment of metabolic disorders. Now researchers at ETH Zurich have determined the atomic structure...
Adult stem cells activated in mammalian brain
Irvine, Calif., July 24, 2008 Adult stem cells originate in a different part of the brain than is commonly believed, and with proper stimulation they can produce new brain cells to replace those lost to disease or injury, a study by UC Irvine scientists has shown.
Evidence strongly shows that ...
A mammalian clock protein responds directly to light
We all know that light effects the growth and development of plants, but what effect does light have on humans and animals? A new paper by Nathalie Hoang et al., published in PLoS Biology this week, explores this question by examining cryptochromes in flies, mice, and humans. In plants, cryptoch...
First high-res 3D structures of mammalian HSP90 protein solved
Dr. Dan Gewirth, Hauptman-Woodward senior research scientist, has just solved the structure of the first mammalian
GRP94 protein implicated in immune diseases such as sepsis, AIDS and certain cancers. His work is being published today in a cover article in a top scientific journal - Molecular Cel...
St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels
Investigators at St. Jude Children's Research Hospital settled a century-old debate on the origin of the mammalian
lymphatic vasculaturethe network of vessels and capillaries critical to various essential housekeeping functions in the body. The finding holds the promise for the development of new ...
Venous origin of the mammalian lymphatic vasculature
In the October 1 issue of G&D, Dr. Guillermo Oliver (St. Jude Childrens Research Hospital) and colleagues present new evidence to resolve a century-old debate over the origin of the mammalian
lymphatic vasculature. Understanding the development of the lymphatic vasculature is integral to understa...
St. Jude study solves mystery of mammalian ears
Protein motor in cochlea hair cells dominates the process of sound amplification in the mammalian
ear, while movement of the cilia atop those cells dominates the response in non-mammals
A 30-year scientific debate over how specialized cells in the inner ear amplify sound in mammals appears to h...
Common algae helps illustrate mammalian brain electrical circuitry
Mice whose brain cells respond to a flash of light are providing insight into the complexities of the sense of smell and may ultimately yield a better understanding of how the human brain works.
Investigators at Duke University Medical Center and the Howard Hughes Medical Institute have engineere...
Chimpanzees found to use tools to hunt mammalian prey
Reporting findings that help shape our understanding of how tool use has evolved among primates, researchers have discovered evidence that chimpanzees, at least under some conditions, are capable of habitually fashioning and using tools to hunt mammalian
prey. The work, reported by Jill Pruetz of I...
First major study of mammalian 'disorderly' proteins
Investigators at St. Jude Children's Research Hospital turned up the heat on "disorderly" proteins and confirmed that most of these unruly molecules perform critical functions in the cell. The St. Jude team completed the first large-scale collection, investigation and classification of these so-cal...
Non-coding RNAs help silence the mammalian transcription
Dr. Shirley Tilghman and colleagues (Princeton University) lend new insight into the mechanism of genomic imprinting, demonstrating a necessary role for a non-coding RNA transcript in the silencing of an imprinted gene cluster in mice.
Imprinting, or the differential expression of a gene based up...
Sexual reproduction delays aging in a mammalian species
Past research on aging and the life histories of diverse species has shown that sexual reproduction is biologically costly for individuals and tends to decrease lifespan rather than increase it. But a new study by Philip Dammann and Hynek Burda from the University of Duisburg-Essen shows that, in a...
Marsupial genome reveals insights into mammalian evolution
The genetic code of marsupials has now been documented for the first time. An international team led by Kathy Belov from the University of Sydney's Faculty of Veterinary Science published an analysis of the marsupial genome in the open access journal PLoS Biology. The paper details the evolution o...
MicroRNAs have shaped the evolution of the majority of mammalian genes
RNA continues to shed its reputation as DNA's faithful sidekick. Now, researchers in the lab of Whitehead Institute Member David Bartel have found that a class of small RNAs called microRNAs influence the evolution of genes far more widely than previous research had indicated.
"MicroRNAs are affe...
Climate-caused biodiversity booms and busts in ancient plants and mammals
...ppeared on the scene.
But then, as temperatures declined again, the number of mammal genera dropped to a low of 84, with the complete loss of many mammalian
groups that previously were well represented. Lower temperatures and a dryer climate continued to influence mammal and plant evolution as savanna habi...
Parasites ready to jump
...can become unstable or cancers can develop. We now want to find out whether mammalian
cells possess this newly discovered defence mechanism and to elucidate prec...l now test whether the mechanism we have found in Drosophila also exists in mammalian
cells. We would also like to know how the mechanism is targeted specificall...
Stem cell research: From molecular physiology to therapeutic applications
...erlying these different cellular processes and to discover new ways to improve cloning efficiency, which will provide a powerful tool for the study of mammalian
reprogramming and ultimately offer important opportunities for regenerative medicine. Professor Zhou has helped to build the National Stem Cell Bank i...
After dinosaurs, mammals rise but their genomes get smaller
...ence initially dropped into genomes by viruses. IU School of Informatics (Bloomington) bioinformaticians Mina Rho and Haixu Tang oversaw the survey of mammalian
and non-mammalian genomes.
Transposable elements often lose their functionality soon after insertion but nevertheless are disturbingly common. In ...
LincRNAs serve as genetic air-traffic controllers
...work together with lincRNAs to target specific regions of the genome."
Standard "textbook" genes encode RNAs that are translated into proteins, and mammalian
genomes contain about 20,000 such protein-coding genes. Some genes, however, encode functional RNAs that are never translated into proteins. These inc...
International collaboration by scientists culminates in novel ion channels database
...ted (LGIC) ion channels.
This represents a major addition to its existing mammalian
receptor database, which is freely available at http://www.iuphar-db.org/ ...ajor online reference resource and first-port-of-call for information about mammalian
drug targets for students and scientists throughout the world, attracting a...
Test detects molecular marker of aging in humans
...tanding of cellular aging. They found that as cells and tissues age, the expression of a key protein, called p16INK4a, dramatically increases in most mammalian
organs. Because p16INK4a is a tumor suppressor protein, cancer researchers are interested in its role in cellular aging and cancer prevention.
New method separates cancer cells from normal cells
...hey could design channels of different geometries -- some a series of connected triangles -- through which cells can move in a single direction. (Live mammalian
melanoma, breast cancer and normal cells were studied.)
To create the channels, the researchers patterned cell-adhesive and cell-repellant chemical...
Nutricia launches Nutra Neocate, weaning product designed for cows milk protein allergy
...Guy's and St Thomas', London.
Standard weaning foods available potentially contain allergens such as milk, wheat and gluten. The use of unmodified mammalian
milk or unmodified soy or rice milk, is not recommended for infants as these milks are not adequately nutritious.2 In addition, soy can also present c...
Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
...at similar mutations in the corresponding pathways also dramatically extend mammalian
Longevity-associated mutations have been shown to lead to enh... across species, the activity of these genes may play a role in controlling mammalian
lifespan," says Ruvkun, senior author of the Nature paper. "Understandin...
InVitria Sponsors ESACT 2009 in Dublin, Ireland
...duced a new product called ZAP-CHO , a performance enhancing cell culture media supplement designed to improve cell growth and antibody production in mammalian
“ZAP-CHO improves CHO product development in chemically defined media that are completely free of animal components,” said...
Caltech scientists reveal how neuronal activity is timed in brain's memory-making circuits
In addition, Siapas notes, it's unlikely that this behavior is found only in rat brains; after all, theta oscillations are ubiquitous in mammalian
brains. "I would expect the traveling-wave nature of theta oscillations to be a general finding, applicable to humans as well," he says.
And while i...
Sugarcoating fruit fly development
... how the sugar tag affects the function of Polyhomeotic.
"Our findings were very surprising. GlcNAc has been found on so many different proteins in mammalian
cells that we expected many processes to go wrong in a fly lacking Ogt. Instead we see a very specific effect on development in fruit flies that is li...
Scientists find formula to uncover our planet's past and help predict its future
..., the researchers from California and Lancaster were able to successfully recreate measurements in a study on a vole-mustelid community.
Many small mammalian
species have cyclic population dynamics, periodically oscillating between large and small communities, a behavioral phenomenon which has puzzled ecolo...
The challenges of avian influenza virus: Mechanism, epidemiology and control
...my of Agricultural Sciences, discusses the situation of animal infection and the control in China.
As we know more and more species, especially some mammalian
species such as cats and tigers, are found victims or carriers of H5N1, the expansion of the host range and interspecies transmission of H5N1 virus is...
InVitria to Unveil Powerful Cell Culture Media Component ZAP-CHO
...the sharing of advances and discoveries in the biopharmaceutical sector.
ZAP-CHO, a new product from InVitria , enhances performance of mammalian
cell culture including improved cell growth and antibody production. It achieves these performance advantages in chemically defined media that are com...
ExcellGene SA first company to offer contract manufacturing in 250 Liter OrbShake bioreactor
...d short timelines as it offers optimal growth and production conditions for mammalian
cell lines. In combination with the cost, quality and time advantage of dis...ops innovative technologies for the production of recombinant proteins from mammalian
cells in bioreactors. As a service company, ExcellGene generates entire ups...
The evolutionary foundation of genomic imprinting in lower vertebrates
...e Science, Zhejiang University, has shown that, as mammalian
Igf2 CpG island, goldfish Igf2 CpG island has a pa...for maternal nutrients between mother and fetus in mammalian
species. However, how genomeic imprinting was orig...the methylation status of the teleost homologue of mammalian
imprinting gene Igf2 during gametogenesis. Their r...
Penn State entomologists seek fungus to blunt mosquitoes' sense of smell
...ct batches of mosquitoes with a variety of fungi known to infect insects. They will expose the mosquitoes and an uninfected control group to potential mammalian
blood meal -- an animal in an adjacent cage. Those mosquitoes that approach the warm-blooded food source will be separated out from those that are uni...
Neuroscientists discover long-term potentiation in the olfactory bulb
...plain how we store information about specific places, names and events. While laboratories around the world have found LTP in nearly every part of the mammalian
brain there was one glaring exception: the part of the brain that first processes the sense of smell, the olfactory bulb.
Gao, a fourth-year gradu...
K-State researcher finds 1918 flu resulted in current lineage of H1N1 swine influenza viruses
...e University researcher has found that the virus causing the pandemic was able to infect and replicate in pigs, but did not kill them, unlike in other mammalian
hosts like monkeys, mice and ferrets where the infection has been lethal.
Juergen A. Richt, Regents Distinguished Professor of Diagnostic Medicine ...
Genome projects launched for three extreme-environment animals
.... It has several adaptations for alpine-cold tolerance and most specifically for anti-hypoxia and running, making it a key model animal to investigate mammalian
The launch of these sequencing projects not only fills taxonomic gaps for completing an extensive and detailed complete genom...
American Chemical Society's Weekly PressPac -- April 22, 2009
... other types of dangerous pathogens, the researchers say. - MTS
ARTICLE #2 FOR IMMEDIATE RELEASE
"Targeted Capture of Pathogenic Bacteria Using a mammalian
Cell Receptor Coupled with Dielectrophoresis on a Biochip"
DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.org/stoken/presspac/presspac/full/10.1021/a...
Gladstone scientists identify key factors in heart cell creation
...combination of three genes could do the trick. This is the first time any combination of factors has been found to activate cardiac differentiation in mammalian
cells or tissues.
"The heart has very little regenerative capacity after it has been damaged," said Dr. Bruneau. "With heart disease the leading c...
DNA blueprint for healthier and more efficient cows
...ries researcher Dr Ross Tellam said the bovine genome has about 14,000 genes which are common to all mammals and these constitute the 'engine room' of mammalian
"The team found that cows share about 80 per cent of their genes with humans, also providing us with a better understanding of the human...