Lymph

Source of molecular triggers in cutaneous T cell lymphoma identified

In a study published in the journal Blood, Yale scientists identify the molecular triggers that stimulate Cutaneous T Cell Lymphoma (CTCL) cells to clonally expand into large populations of malignant lymphocytes. CTCL is the most common adult malignancy of T lymphocytes, the white blood cells of the immune system. Finding CTCL triggering factors has been a major goal of Richard L. Edelson...

Imaging Lymph Nodes with Nanoparticles

Accurate staging of cancers is one of the most important parts of thework up of patients for both prediction of prognosis and determinationof the most appropriate treatment. And an essential part of this workup is assessing wh...

Potential Cure for Lymphoma in HIV patients

Stem cell transplants have become thestandard of care for patients with relapsed lymphoma, but not forpatients who suffer from both this disease and HIV. A new study showingthat this treatment is a viable option for select patients withHIV-associated lymphoma will be published in the January 15, 2005,issue of Blood, the official journal of the American Society ofHematology.Because of the i...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

The genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma. This finding, from investigators at St. Jude Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB). B-cell lymphoma is a cancer in which the antibody-producing cells (B lymphocytes) multiply uncontrollably and crowd out other blo...

New Treatment Rivals Chemotherapy For Lymphoma, Study Finds

A new form of treatment for lymphoma that takes a fraction of the ti...

Reversal of role for a viral protein associated with the development of lymphoma

Important messages require accurate transmission. Big genes are especially challenging because they combine many coding segments (exons) that lie between long stretches of non-coding elements (introns). During processing, introns are snipped out and exons pasted together to form a template for proteins called messenger RNA (mRNA). Mistakes in RNA processing can reduce the expression of a function...

Tadpole soon to help in the fight against cancer and lymphedema

Lymph circulates in our bodies through a complex network of lymphatic vessels, of which little is known. This network is, however, of major importance for the support of the immune system and the fluid in our body. Researchers from the Flanders Interuniversity Institute for Biotechnology (VIB) connected with the Catholic University of Leuven, are the first to indicate that this network can be stu...

Combination therapy improves AIDS-related lymphoma outcome

Combining aggressive HIV therapy and chemotherapy significantly improves the survival rates of HIV-positive men and women treated for lymphoma, according to a new study. ), a peer-reviewed journal of the American Cancer Society, t...

Malaria parasites develop in lymph nodes

In the first quantitative, real-time imaging study of the travels of the malaria parasite Plasmodium through mammalian tissue, researchers at the Pasteur Institute in Paris found the parasites developing in an unexpected place: the lymph nodes. The parasites' presence in the lymph nodes almost certainly has implications for the mammalian immune response, said Robert Ménard, a Howard Hughes...

Antibiotic treats lymphoma of the eye

The common antibiotic doxycycline effectively treats a type of lymphoma associated with chlamydia infection, according to a study in the October 4 issue of the Ocular adnexal lymphoma of the MALT-type (OAL) is a kind of cancer of the eyelids and related tissues. It is not often fatal, but its symptoms can compromise a patient's quality of...

Interaction between lymph and liver cells may affect immune response

A new study on the ability of liver cells to interact with T cells (lymph cells that play a role in regulating the immune response) found that such interactions do occur and demonstrated the mechanism by which they may take place. The results may help explain the altered immune responses that occur with aging and other conditions and may be useful in developing therapies for viral hepatitis and a...

How T lymphocytes attack

Our immune system finds it difficult to eliminate tumours effectively. Deciphering the strategies it implements may increase the immune system's effect on tumour cells and thus improve the clinical perspectives for anticancer immune therapy. At the Institut Curie, INSERM and CNRS researchers have used two-photon microscopy to demonstrate, for the first time in vivo and real-time, how T lymphocy...

Finnish scientists discovered a new approach to treat virus-induced lymphomas

Kaposi’s sarcoma herpesvirus (KSHV) is a human tumor virus and an etiological agent for Kaposi’s sarcoma and primary effusion lymphoma (PEL). PELs are aggressive lymphomas with reported median survival time shorter than six months after diagnosis. Researchers at the University of Helsinki have discovered that activation of the p53 pathway offers a novel effective treatment modality for KSHV-infec...

Risk of lymphoma increases with hepatitis C virus infection

People infected with the hepatitis C virus (HCV) are at an increased risk of developing certain lymphomas (cancers of the lymphatic system), according to a study published in the May 8, 2007, issue of the Journal of the American Medical Association. Researchers from the National Cancer Institute (NCI), part of the National Institutes of Health, and Baylor College of Medicine, found that HCV infe...

Migration alert -- How tumor cells home in on the lymphatic system

Scientists know that tumor cells spread via the lymphatic system, but they don’t understand the details of how this deadly migratio...