People with heart disease still have trouble controlling blood lipid levels
Irvine, Calif., Aug. 7, 2008 Despite some improvements to lower "bad" cholesterol levels, people with cardiovascular diseases still need to do a better job controlling overall blood lipid
levels, according to a UC Irvine Heart Disease Prevention Program study.
Researchers found that 37 percent...
Europe-wide investment in lipid research will help tackle disease, says new report
Leading scientists today called for Europe to invest more funds into the study of lipids the 'fatty' molecules that play a crucial role in the function of human cells and which are implicated in a range of diseases from obesity and diabetes to Alzheimer's.
Common lipids such as cholesterol are...
New genetic variants associated with lipid levels, risk for coronary artery disease
Environmental and genetic factors influence a persons blood fat, or lipid
levels, important risk factors for coronary artery disease (CAD). While there is some understanding of the environmental contribution, the role of genetics has been less defined. Now, in an international collaboration suppor...
Story ideas from the Journal of Lipid Research
Metabolic syndrome, a collection of related abnormalities like hypertension, obesity, insulin resistance, and excess cholesterol, poses a major risk for developing heart disease and diabetes. Individuals with a genetic predisposition to high cholesterol (familial hyperlipidemia or FH) can be espec...
Story ideas from the Journal of Lipid Research
Stories appearing in the Dec. 2007 Journal of Lipid
Research (Vol. 48, No. 12)
Genetic Variants Affect Diet-Associated Cholesterol Metabolism
Crohns Disease Increases Progression of Atherosclerosis
Breaking the Vicious Cycle of Bile Acid Disorders
Genetic Variants Affect Weight-Ass...
Powerful integration of lipid metabolic profiling with gene expression analysis
A recently published research article in the Journal of Proteome Research, authored by researchers from the Nestl Reserarch Center, Genomatix Software GmbH, Rosetta Inpharmatics LLC, CXR Biosciences Ltd, the Cancer Research UK Molecular Pharmacology Unit demonstrates the synergisms and enhanced an...
Story ideas from the Journal of Lipid Research
Articles published in the September 2007 issue of the Journal of Lipid
Research (Vol. 48, No. 9)
Renal transplant recipients genetic makeup does not negatively impact fluvastatin use
New skin-healing chemicals
New anti-inflammatory compound discovered
New designer lipid-like peptide with lipid nanostructures for drug delivery systems
Scientists from Institute of Biophysics and Nanosystems Research (IBN), Austrian Academy of Sciences and of Centre for Biomedical Engineering, Massachusetts Institute of Technology, Cambridge, USA report the study of “Tuning Curvature and Stability of Monoolein Bilayers by Designer Lipid-Like Pept...
Link found between immune system and high plasma lipid levels
Researchers at the University of Chicago have found an unsuspected link between the immune system and high plasma lipid
levels (cholesterol and triglycerides in the blood) in mice. The finding could lead to new ways to reduce the risk of heart disease by lowering elevated lipid
In the A...
Beyond genes: Lipid helps cell wall protein fold into proper shape
A protein that provides a vital passage through a bacterium's outer cell wall will misfold and malfunction if that wall is built of the 'wrong' material, scientists at The University of Texas Medical School at Houston report in a finding that has long-term implications for understanding diseases ca...
Little-known protein found to be key player
"It is fitting that the discovery of a new protein capable of fusing membranes comes 10 years after the demonstration that SNAREs can fuse lipid
bilayers," said Daga, a researcher at the Eugenio Medea Scientific Institute in Conegliano, Italy.
In the new study, Daga's and McNew's research te...
Health benefits of physical activity more pronounced in women
...of exercise than men.
The analysis of this large Atherosclerosis Risk in Communities (ARIC) Study, which appears in the August issue of Journal of lipid
Research , was carried out by Keri Monda and colleagues at North Carolina and Baylor. They found that over a 12 year period, all individuals who incre...
Two dietary oils, two sets of benefits for older women with diabetes
...h must be obtained from food or dietary supplements. Linoleic acid is an omega-6 fatty acid that is important in growth and maintenance of tissues and lipid
metabolism. The American Heart Association recently issued recommendations suggesting that omega-6 fatty acids are among the polyunsaturated fats that...
New nanoparticles could revolutionize therapeutic drug discovery
...et is robust enough for experimental interrogation, has eluded scientists for decades, but is now available."
Using a polymer - styrene maleic acid lipid
particles (SMALPs), the researchers solubilised a pair of membrane proteins. They found that not only did the proteins maintain their folded structure...
Trans fats hinder multiple steps in blood flow regulation pathways
...lities, such as the lower melting point of margarine that makes it creamy at room temperature.
Kummerow, 94, has spent nearly six decades studying lipid
biochemistry, and is a long-time advocate for a ban on trans fats in food.
While the body can use trans fats as a source of energy for maintenance ...
Fatty foods -- not empty stomach -- fire up hunger hormone
...m ingested dietary fats. In a departure from an earlier model that was upheld for nearly a decade, Tschp says, it appears that the ghrelin system is a lipid
sensor in the stomach that informs the brain when calories are availablegiving the green light to other calorie-consuming processes such as growing.
American Chemical Society's weekly PressPac -- May 27, 2009
...ientists describe development of a first-of-its-kind microcapsule made from lipid
oils and nanoparticles 1/50,000th the width of a human hair. Although actin...E RELEASE
"Dry Hybrid Lipid-Silica Microcapsules Engineered from Submicron lipid
Droplets and Nanoparticles as a Novel Delivery System for Poorly Soluble Dr...
MicroRNAs grease the cell's circadian clockwork
... role of a microRNA called miR-122, which is highly abundant in liver. It has caught considerable attention for its role in regulating cholesterol and lipid
metabolism and in aiding the replication of hepatitis C virus" explains David Gatfield, one of Professor Schibler's collaborators.
Performance of ...
Nanotechnology holds promise for STD drug delivery
...nd are unable to provide sustained release. In the current work, the researchers demonstrated that PLGA nanoparticles were safer than the best current lipid
Gene interference therapy is moving rapidly from basic research to application. The PLGA packaging these researchers chose is already a...
Researchers discover link between schizophrenia and diabetes
...tion Effectiveness Schizophrenia Trial showed the prevalence rate of metabolic syndrome, a group of risk factors that include abdominal obesity, high lipid
and cholesterol blood levels and insulin resistance, is more than 50 percent in women and about 37 percent in men with schizophrenia.
"Many people ...
Difference in fat storage may explain lower rate of liver disease in African-Americans
Scientists aren't sure why the location of fat storage matters.
"This seems to argue that there is a fundamental difference in the lipid
metabolism between African-Americans and Hispanics or Caucasians, and this difference is maintained even when insulin resistance is present," Dr. Brow...
UC Davis bench-to-bedside research: Promising treatment in clinical trials
...ys of treatment. The AR9281 enzyme inhibitor will be studied for safety, tolerability, reduction of blood pressure and various measures of glucose and lipid
metabolism. Results are expected the first quarter of 2010.
The winding, twisting path that took Hammock from his lab, to collaborative research wi...
Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
...ry fiber, mostly from fruits and vegetables, lowers blood glucose levels and leads to decreased insulin levels in the blood, as well as lowering blood lipid
concentrations in patients with type 2 diabetes, the most prevalent type of diabetes.
For the current study, 13 patients with type 2 diabetes ate ...
Lipid droplets lead a Spartin existence
...expected role for Spartin in regulating the cell's lipid
Cells transport excess fats into lipid
droplets (LDs), where they are kept until needed a...r Paul Bieniasz points to precedents of defects in lipid
turnover triggering neuronal disorders, such as mu...
Synthesizing the most natural of all skin creams
...ater. Its outstanding properties come from the addition of just 10% each of lipid
molecules and dead skin cells (corneocytes), so the exact composition of th...water content.
But equally important is how the mixture arranges itself. lipid
molecules are shaped something like lollipops, with a round end that prefer...
Scripps research scientists 'watch' as individual alpha-synuclein proteins change shape
...ing here directly is that the shape can actively change," Deniz says. "It starts off in an unfolded state, and as we increase the concentration of the lipid
mimics, the protein reacts to what is in effect a different binding partner, even though it is the same small molecule at different concentrations. It...
Scripps research team identifies key molecules that inhibit viral production
...gested that these core-core or core-other protein interactions can modulate various functions including signaling, apoptosis or programmed cell death, lipid
metabolism, and gene transcription.
The core protein is particularly important in the assembly of the hepatitis C nucleocapsid, an essential step ...
New potential therapeutic target discovered for genetic disorder -- Barth syndrome
...The debilitating disorder is caused by a mutation in the genetic coding of tafazzin, an enzyme of the cardiolipin pathway. Cardiolipin is an essential lipid
in the inner membrane of mitochondria responsible for normal cell structure and energy production. BTHS patients exhibit defects in cardiolipin metabo...
Cutting-edge amfAR grants fight HIV/AIDS in the lab and on the phone
...e which cell proteins help ensure that constituent parts of the virus come together in an appropriate fashion. He is particularly interested in a cell lipid
called PIP2 that binds to the viral protein Gag, a core protein that defines the physical structure of the virus. If, as he suspects, PIP2 is critical...
Einstein scientists receive $10 million NIH grant
... with age of two essential immune functions (antigen processing and presentation, and T helper cell activation and tolerance), and to abnormalities in lipid
"These studies will involve the cooperation of all four of us on the Einstein faculty who have jointly received this NIH grant," says ...
High-fat diets inflame fat tissue around blood vessels, contribute to heart disease
... "However, many patients who consume high fat diets do not exhibit abnormal lipid
profiles but still develop atherosclerosis nonetheless.
"These new fin...'t a problem because their weight and cholesterol levels are under control. lipid
profiles don't hold all the answers.
"Bad dietary habits can lead to a n...
Artificial cells, simple model for complex structure
... is possible using large polymeric molecules and a lipid
Keating uses lipids to create vesicles, tiny cell-sized bubbles of lipid
membrane in an aqueous solution of two large polym...of PEG, a small amount of dextran, water and dried lipid
Compounds could be new class of cancer drugs
...o study this important enzyme," Brown said.
There are two related "isoforms" of PLD: PLD1 and PLD2. Both PLD enzymes produce phosphatidic acid, a key lipid
metabolic and signaling molecule. But whether the two PLDs have different roles is an open question, one that the new isoform-selective inhibitors can...
Phytoplankton cell membranes challenge fundamentals of biochemistry
...the desert. How are they doing it? These creative plankton build a membrane lipid
called SQDG, a molecule based on sulfur rather than phosphorus. Van Mooy ex... the ocean. Of his future research working out the dynamics of the membrane lipid
substitutions Van Mooy says, "You could think of it like a tool. Something ...
In India: A search for more effective tuberculosis drugs
...in the way Mycobacterium tuberculosis builds the lipid
layer that coats its surface. Unlike other organis...ne. Some scientists have suggested that these long lipid
molecules contribute to the bacteria's ability to ...aped enzymes involved in the assembly line that is lipid
use and degradation. These enzymes are required du...
Inflammation worsens danger due to atherosclerosis
...olesterol diets, smoking, and diabetes. People with atherosclerotic plaques often show no symptoms for decades.
Atherosclerotic plaques consist of lipid
cores covered by collagen fiber caps. These plaques can suddenly rupture, resulting in blood clots that completely block blood flow and lead to heart...
World breakthrough in treating premature babies
The findings were published today in the Journal of the American Medical Association ( JAMA ).
Researchers found that a major lipid
in the brain the omega-3 fatty acid known as Docosahexaenoic acid (DHA) is not developed sufficiently in babies born before 33 weeks' gestation, lea...
Nearly a century later, new findings support Warburg theory of cancer
...roup of mouse brain tumors, specifically a complex lipid
known as cardiolipin (CL). They reported their findings in the December edition of the Journal of lipid
Abnormalities in cardiolipin can imp...ce. Bioinformatic models were used to compare the lipid
characteristics of the normal and the tumor mitoch...
New scientific knowledge on juvenile diabetes
...erstand the development of type 1 diabetes. They discovered disturbances in lipid
and amino acid metabolism in children who later progressed to type 1 diabet...te physiological response to the early metabolic disturbances. The observed lipid
changes were not attributable to HLA-associated genetic risk.
Scientists fool bacteria into killing themselves to survive
...urnal's Web site.
The researchers show that a synthetic "hole punching" antimicrobial depends on the presence of phosphoethanolamine, a cone-shaped lipid
found in high concentrations within Gram-negative bacterial membranes. Although PE lipids are commandeered to kill the bacteria, without the lipids th...