Recruitment of reproductive features into other cell types may underlie extended lifespan in animals
In the sense that organisms existing today are connected through a chain of life through their parents, grandparents and other ancestors almost a billion years back to the first animals of the pre-Cambrian era, an animal's reproductive cells can be considered to be immortal. These germline cells...
Sex and lifespan linked in worms
A group of scientists who set out to study sex pheromones in a tiny worm found that the same family of pheromones also controls a stage in the worms' life cycle, the long-lived dauer larva.
The findings, published in Nature online on July 23, represent the first time that reproduction and l...
Honeybee researcher to unravel properties governing lifespan with support from Norway
Gro Amdam, associate professor in the School of Life Sciences at Arizona State University, has been awarded two grants totaling the U.S. equivalent of about $1.4 million from the Norwegian Research Council to investigate biochemical factors and social life history properties that can influence agi...
Drug commonly used to treat bipolar disorder dramatically increases lifespan in worms
Nematode worms treated with lithium show a 46 percent increase in lifespan, raising the tantalizing question of whether humans taking the mood affecting drug are also taking an anti-aging medication. Results of the Buck Institute study, led by faculty member Gordon J. Lithgow, PhD, are currently p...
Late motherhood boosts family lifespan
SALT LAKE CITY, May 4, 2009 Women who have babies naturally in their 40s or 50s tend to live longer than other women. Now, a new study shows their brothers also live longer, but the brothers' wives do not, suggesting the same genes prolong lifespan
and female fertility, and may be more important...
M.I.N.D. Institute researchers call for fragile X testing throughout the lifespan
(SACRAMENTO, Calif.) Writing in this week's Journal of the American Medical Association , UC Davis M.I.N.D. Institute researchers urge physicians to test for mutations of the fragile X gene in patients of all ages. That's because, after decades of research, it is clear that mutations in this gen...
Researchers find link between food odors and lifespan in fruit flies
Researchers hoping to learn why organisms tend to live longer if their intake of calories is restricted have made a startling discovery ?in fruit flies, just the smell of food can have a negative effect on longevity.
Scientists have known for decades that restricted dietary intake can increase th...
Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate
By studying a particularly short-lived fish species, researchers have been able to show that a natural compound previously shown to extend lifespan
in non-vertebrate organisms can also do so in at least one vertebrate species. The findings, reported by Alessandro Cellerino of the Scuola Normale Sup...
Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
A UC Riverside-led research team has found that as some populations of an organism evolve a longer lifespan, they do so by increasing only that segment of the lifespan
that contributes to "fitness" ?the relative ability of an individual to contribute offspring to the next generation.
Focusing on ...
MicroRNA gene that regulates lifespan found by Yale scientists
Genes that control the timing of organ formation during development also control timing of aging and death, and provide evidence of a biological timing mechanism for aging, Yale researchers report in the journal Science.
"Although there is a large variation in lifespan
from species to species, t...
New lifespan extension genes found
New genes tied to lifespan
extension in yeast have been identified by researchers from UC Davis and Harvard Medical School.
Drastically reducing calorie intake, or caloric restriction, is known to extend the lifespan
of species including yeast, worms and rodents. Previous research linked a gene c...
Researchers extend mouse lifespan by protecting against free radicals
Scientists at the University of Washington and their colleagues at other research centers have found a way to significantly extend the lifespan
of mice while reducing the impact of the aging process. Their study, which will be published online by the journal Science on May 5, lends more credence to...
Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth
...d to grow at all, while all control tumors increased in size. Administration of nanoparticles to three different ovarian cancer mouse models prolonged lifespan
by nearly four weeks and suppressed tumor growth more effectively, and with minimal non-specific cytotoxicity, than in mice treated with clinically re...
Warmer environment means shorter lives for cold-blooded animals
...ominant factor controlling geographic variation of lifespan
"We were intrigued by the fact that that pearl mussels in Spain have a maximum lifespan
of 29 years, while in Russia, individuals of the s...anted to see whether the geographical variation in lifespan
that we see in all sorts of species has a common p...
Engineered pig stem cells bridge the mouse-human gap
... can begin. These iPS cells cannot be tested on humans before thorough safety and efficacy trials in animal models, but the size, physiology and short lifespan
of mice makes them less than ideal for these trials.
Duanqing Pei and colleagues turned to a better pre-clinical model: pigs. These large animals ...
Genes that influence start of menstruation identified for first time
Fellow author John Perry, also from the Peninsula Medical School, added: "Understanding the biological mechanisms behind reproductive lifespan
may also help inform us about associated diseases that affect a lot of women as they get older, including diabetes, heart disease and breast cancer."
Mosquito parasite may help fight dengue fever
...ne forced Scott O'Neill and Elizabeth McGraw to look for a more creative form of defence. Knowing that a parasite, Wolbachia pipientis , shortens the lifespan
of host insects and could restrict dengue fever transmission by killing the insects before they can pass the infection on, O'Neill and his team succes...
UT Southwestern researchers probe kidney damage, protection in lupus
...t blocks CXCR4, the symptoms of lupus significantly diminished; many symptoms of kidney failure were averted; and the mice lived longer. The increased lifespan
was greater when treatment began at an early age.
"This study indicates that drugs acting against CXCR4 might become useful therapies," said Dr. C...
ASBMB Annual Meeting to feature talks on the biochemistry of aging
Regulation of Obesity, Heart Function, and lifespan
by the Nutrient Sensing TOR Pathway
Sean Michael..., there is still concern that any increases in fly lifespan
simply cannot be expected to work in mammals. Kenn...ed a similar response to nutrient restriction, and lifespan
is tightly linked to this response, providing evid...
Better living through chemistry
...Conditions at mud volcanoes show tremendous short-term variation, with eruptions occurring daily to monthly to less frequently. What's more, the total lifespan
of a mud volcano or brine pool is short by geologic standards--on the order of tens of thousands of years, rather than hundreds of thousands or millio...
Living long, living well
...f other questions are the focus of the inaugural conference of the Brandeis lifespan
Initiative on Healthy Aging (LIHA) Friday, April 3, 2009, 8:30 a.m. to 12:3...ive/ . RSVP firstname.lastname@example.org or call 781-736-3302.
"We take a lifespan
approach that emphasizes prevention and intervention as early as possible, ...
Long-term study of orchard ground cover management systems
... Ian A. Merwin and Michael G. Brown (Cornell University) coauthored a study that compared apple root density and distribution, root turnover, and root lifespan
of trees after 10 years under different GMS treatments. The study was published in the journal HortScience .
The experiment involved the use of t...
Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging
...s lifespan, but Hekimi and Van Raamsdonk did not observe this. In fact, they found quite the opposite.
None of their mutant worms showed decreased lifespan
compared to wild-type worms, even though oxidative stress was clearly raised. In fact, one variety actually displayed increased lifespan, the research...
CSHL scientists find a new class of small RNAs and define its function
... undergone "capping," a chemical modification that makes them stable and impervious to degradation. "This quality," Hannon observes, "lengthens their lifespan
in the cell, a clue that suggests these small RNA classes may have significant biological duties."
Curiously, PASRs and non-PASRs may not be initia...
Consumers desire more genetic testing, but not designer babies
... for life altering and threatening medical conditions including mental retardation, blindness, deafness, cancer, heart disease, dwarfism and shortened lifespan
from death by 5 years of age. Consumers, however, are less interested in prenatal genetic testing for traits including tall stature, superior athletic...
Disabling enzyme allows mice to gorge without becoming obese, new study finds
...ent amounts. However, as the mice aged, the disparity in weight gain became clear. By 64 weeks of age - considered the twilight years in a lab mouse's lifespan
- the mice that lacked the AdPLA enzyme averaged only 39.1 grams, a weight more typical of a low-fat diet, while the control mice weighed in at a heft...
A low dose of caffeine when pregnant may damage the heart of offspring for a lifetime
...ine (just two cups of coffee) ingested during pregnancy may be enough to affect fetal heart development and then reduce heart function over the entire lifespan
of the child. In addition, the researchers also found that this relatively minimal amount of exposure may lead to higher body fat among males, when co...
Key to 'curing' obesity may lie in worms that destroy their own fat: McGill researchers
...f Human Genetics and the McGill and Genome Quebec Innovation Centre. "It will be exciting to see whether this pathway that controls energy storage and lifespan
in worms plays a similar role in humans. The implications for patients with obesity and diabetes might be quite far-reaching."
Unique transatlantic tie-up to understand the aging process
...ether research groups from both countries. The call for proposals from researchers is now open.
Prof Doug Kell, Chief Executive of BBSRC, said: "As lifespan
increases we need to work to ensure that health-span increases as well. This is an issue that affects every person, in Britain, America or elsewhere, ...
Feed a cold, feed a fever: Research shows calorie cut makes it harder to fight flu
...s so your body is ready for any additional stress, including fighting a virus."
Calorically restricted diets in general have been shown to increase lifespan
in everything from yeast to primates, according to Gardner. But the model used in Gardner's research can be extended to more vulnerable groups includ...
Old flies can become young moms
... Female flies can turn back the biological clock and extend their lifespan
at the same time, University of Southern California biologists report.
Their study, published online this month in Molecular Genetics and Genomics...
Social interactions can alter gene expression in the brain, and vice versa
...t differed in their behavior. Robinson had found that social information altered expression of the same gene over a much shorter timescale within the lifespan
of a honey bee also changing its behavior.
"An appreciation of the idea that differences in gene expression can occur over vastly different time ...
Rhode Island Hospital simulation center examines benefits and applications of medical simulation
...niversity, the region's first simulation center opened in 2002. Since then, the center's staff have served as leaders in simulation-based training for lifespan
and its affiliates, the Alpert Medical School, other health care providers in the community, and at national and international venues.
Purple tomatoes: The richness of antioxidants against tumors
...a significant increase of lifespan". The last group has reported an average lifespan
of 182 days in comparison to the 142 recorded for mice fed standard diet.
...alth benefits from diet supplementation with modified food. Although mice's lifespan
has significantly increased once fed on purple tomatoes we still don't know...
Fried purple tomatoes
...The fruit are an intense purple colour.
The scientists tested whether these elevated levels actually had an effect on health. In a pilot test, the lifespan
of cancer-susceptible mice was significantly extended when their diet was supplemented with the purple tomatoes compared to supplementation with norma...
Deprived of a sense of smell, worms live longer
"Emerging evidence suggests that core metabolic pathways that modulate lifespan
in worms also modulate lifespan
in vertebrates such as mice and perhaps humans," Kornfeld says. "Sensory pa...
Study: Elderly Women can increase strength but still risk falls
...se performance that's so closely associated with falls," says LaRoche. It seems that the key to muscle power in the elderly is to maintain it over the lifespan
rather than try to develop it later in life, he says.
Acknowledging that the type or frequency (six sets, three times per week) of his training pr...
Fitness in a changing world
...e Eda low allele in freshwater.
An experimental test by Barrett et al. has shown surprisingly unexpected results in fitness of the fish. The fish's lifespan
is approximately a year. Over the course of a year, researchers sampled a controlled population of stickleback. They found that early in life, fish wi...
Researchers note differences between people and animals on calorie restriction
...ie restriction. In the majority of the animal models of longevity, extended lifespan
involves pathways related to a growth factor called IGF-1 (insulin-like gro...Because calorie restriction is linked to extraordinary increases in maximal lifespan
in rats and mice, Fontana and colleagues at Washington University, includin...
ACS PressPac -- Sept. 17, 2008
...cal & Engineering News
Researchers are reporting progress toward a wave of new drugs and vaccines that could significantly improve the health and lifespan
of millions infected with or at risk for HIV, the virus that causes AIDS, according to an article ( http://pubs.acs.org/cen/coverstory/86/8638cover.ht...