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Learning to fight an adversary that won't stay down

New biomolecular technologies have largely failed to deliver the hoped-for knockout punch breakthrough against the defences of disease-causing bacteria, says a leading Canadian specialist in antibiotic resistance. Techniques such as genomic sequencing and high throughput screening were expected to make the development of new antibiotic compounds easier and more productive. But in most cas...

Bird Brains Show How Trial and Error May Contribute to Learning

The adult male zebra finch knows only one scratchy tune learned in its youth, which it performs repeatedly and intensely when females are listening. But occasionally, the finch might improvise, experimenting with a slower, more sultry variation or emphasizing different notes. Neurobiologists studying the finch now say the improvisation arises from a component of a crucial learning circuit...

Structure-building cell signals also may influence learning and memory

A Burnham Institute study has found that one of the cell's largest families of signaling molecules, called ephrins, which are known to regulate the development of nerve cells, also controls nerve cells' ability to engulf critical chemicals and proteins for learning and memory. These findings, the first to link these molecular semaphores to this important nerve cell function, appear in the May iss...

Building a protein name dictionary from full text: a machine learning term extraction approach

The majority of information in the biological literature resides in full text articles, instead of abstracts. Yet, abstracts remain the focus of many publicly available literature data mining tools. Most literature mining tools rely on pre-existing lexicons of biological names, often extracted from curated gene or protein databases. This is a limitation, because such databases have low coverage o...

Mice brains shrink during winter, impairing some learning and memory

The brains of one species of mouse actually shrink during the winter, causing the mice to have more difficulty with some types of learning, a new study found. This is one of the first studies to show...

More animals join the learning circle

Killer whales and chimpanzees both pass on "traditions" to other members of their group, according to two separate studies of feeding behaviour. The findings add to evidence that cultural learning is widespread among animals. One study involved killerwhales at Marineland in Niagara Falls in Ontario, Canada. An inventive male devised a brand new way to catch birds, and passed the strategy...

Insight into the processes of 'positive' and 'negative' learners

A breakthrough in human stem cell research, producing embryonic-like cells from umbilical cord blood may substantially speed up the development of treatments for life-threatening illnesses, injuries and disabilities. The discovery made during a project undertaken with experts from the University of Texas Medical Branch and the Synthecon Corporation in the United States provides medical researcher...

Learning how SARS spikes its quarry

Researchers have determined the first detailed molecular images of a piece of the spike-shaped protein that the SARS virus uses to grab host cells and initiate the first stages of infection. The structure, which shows how the spike protein grasps its receptor, may help scientists learn new details about how the virus infects cells. The information could also be helpful in identifying potential we...

Researcher says flu responders can learn from 1918 epidemic

A doctoral student's research brings lessons and insight to a looming pandemic While that prospect would terrify the average person, it also intrigues Jim Higgins, a doctoral candidate at Lehigh Unive...

Researchers learn how blood vessel cells cope with their pressure-packed job

UCSD scientists have gained a better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resistant to vascular diseases. UCSD researchers stretched cells in a workout chamber the size of a credit card to gain a better understanding of how repetitive stretching of endothelial cells that line arteries can make them healthy and resista...

Neurons generated in the adult brain learn to respond to novel stimuli

New brain cells that develop in the olfactory system of adult mice appear to play a role in the brain different from that of older neurons. The new olfactory neurons are especially sensitive to novel stimuli, preferentially learning to respond to new odors. This level of flexibility suggests that such newly-generated neurons could be induced to adapt to and integrate into other regions of the b...

Scientists learn to predict protein-stabilizing ability of small molecules

Prostate cancer is the second leading cause of death among American men. It is estimated that one in six males will develop the disease during his lifetime. However, promising new treatment options have been developed to help combat this threatening disease. One of the most innovative of these treatments is robotic-assisted laparoscopic prostatectomy (removal of the prostate...

Picking apart how neurons learn

Johns Hopkins researchers have used mouse mutants to define critical steps involved in learning basic motor skills. The study focuses on the behavior of two proteins and the specific steps they take to control a neuron's ability to learn by adapting to signals from other nerve cells. The findings, published in the March 16 issue of Neuron, pull together a growing body of evidence from the...

Learning to love bacteria: Stanford scientist highlights bugs' benefits

Bacteria are bad. Mothers and doctors, not to mention the cleaning product industry, repeatedly warn of their dangers. But a Stanford University School of Medicine microbiologist is raising the intriguing idea that persistent bacterial and viral infections have benefits. Stanley Falkow, PhD, the Robert W. and Vivian K. Cahill Professor in Cancer Research, is publishing his thoughts on this...

Learning and memory stimulated by gut hormone

Researchers at Yale School of Medicine have found evidence that a hormone produced in the stomach directly stimulates the higher brain functions of spatial learning and memory development, and further suggests that we may learn best on an empty stomach. Published in the February 19 online issue of Nature Neuroscience by investigators at Yale and other institutes, the study showed that the...

How the brain learns to become addicted

Researchers have identified a key signaling molecule in the brain that appears to trigger the brain to "learn" a craving for cocaine. Their finding could offer an important target for drugs to treat addiction by short-circuiting that adaptive process. In an article in the February 16, 2006, issue of Neuron, Antonello Bonci and colleagues established that a short protein, or peptide, called...

Losing sleep undoes the rejuvenating effects new learning has on the brain

As the pace of life quickens and it becomes harder to balance home and work, many people meet their obligations by getting less sleep. But sleep deprivation impairs spatial learning -- including remembering how to get to a new destination. And now scientists are beginning to understand how that happens: Learning spatial tasks increases the production of new cells in an area of the brain in...

Paleontologists learn how not to become a fossil

The best way to avoid becoming a fossil is to be small and live in deep, tropical waters. So say four paleontologists who have published a detailed, global study of clam preservation. Their work is intended to enhance evolutionary studies by determining what's missing from the fossil record and why. "Everyone talks about how imperfect the fossil record is, but not many people do anything a...

Poison dart frog mimics gain when birds learn to stay away

Studying neotropical poison dart frogs, biologists at the University of Texas at Austin uncovered a new way that the frog species can evolve to look similar, and it hinges on the way predators learn to avoid the toxic, brightly colored amphibians. In the Mar. 8 issue of Nature, Catherine Darst and Molly Cummings show that a harmless, colorful frog living in the Amazonian rainforest gets p...

How low can you go? Ants learn to limbo

Have you ever tried to do the limbo? For ants it's a way of life! Scientists at the University of Zurich have discovered that ants are able to learn how to visually judge the height of horizontal barriers so that they can successfully crawl under it without slowing down. Tobias Seidl will be presenting his latest research findings at the Annual Meeting for the Society for Experimental Biology on...

Cultural transmission in bats: When listening for dinner, bats learn from their neighbors

In an exciting study that provides new understanding of how animals learn--and learn from each other--researchers have demonstrated that bats that use frog acoustic cues to find quality prey can rapidly learn these cues by observing other bats. While numerous examples are known of instances where predators can use so-called "social learning" to learn new visual and olfactory cues associated with...

Immune system police learn early and sometimes badly

Regulatory T cells, which function like immune system police, learn early in life what to protect, and that may include viruses, bacteria and tumors, researchers have shown. Using genetically manipulated mice and technology that enables a snapshot of the repertoire of antigen receptors that determine what cells recognize, Medical College of Georgia researchers followed T cells as they spe...

Mice learn tasks that may help treat human psychiatric disorders

Mice that couldn't be dissuaded from the object of their attention by a piece of sweet, crunchy cereal may help researchers find new treatments and cures for human disorders like autism and Parkinson's disease. For the first time, a psychiatric test for monitoring many human mental abnormalities has been adapted for use in mice, according to researchers at Purdue University, University of...

Learning the language of DNA

An international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), is a step closer to the next generation of treatments to combat disease, after publishing a comprehensive analysis of the human and mouse transcriptomes. A senior member of the consortium and IMB researcher Professor David Hume said transcriptome descri...

How many genes does it take to learn? Lessons from sea slugs

Scientists analyzing the genomics of a marine snail have gotten an unprecedented look at brain mechanisms, discovering that the neural processes in even a simple sea creature are far from sluggish. At any given time within just a single brain cell of sea slug known as Aplysia, more than 10,000 genes are active, according to scientists writing in Friday's (Dec. 29, 2006) edition of the jo...

Pheromone from mother's milk may rapidly promote learning in newborn mammals

By studying the ability of newborn rabbit pups to learn the significance of new odors, researchers have found that a mammary pheromone secreted in mother's milk may act as a chemical booster that facilitates the ability of pups to quickly associate environmental odors with the opportunity to nurse. The findings, which deepen our understanding of pheromone function and how learning occurs...

Learning during sleep?

If I can't remember this morning where I put my car keys last night, it's due to my memory failing me again. Scientists at the Max Planck Institute for Medical Research in Heidelberg have been investigating how memories might be consolidated. Their new study offers the hitherto strongest proof that new information is transferred between the hippocampus, the short term memory area, and the cerebra...

Researchers identify neurons that assign value during learning

By using an experimental trick to activate certain sets of neurons and effectively substitute activation of these cells for positive or negative experiences, researchers have been able to identify neurons in the fruit fly Drosophila that are responsible for assigning value to stimuli during so-called associative learning. The findings, which advance our understanding of how, at the cellular level...

Household transmission of SARS: Lessons learned

In the 2003 outbreak of severe acute respiratory syndrome (SARS) in Toronto, Ontario, about 20% of cases resulted from household transmission (spread of the infection within a household). Wilson-Clark and colleagues studied the characteristics of these household transmissions and report on risk factors that contributed to the spread of infection. Primary risk factors for transmission fall...

Drug treatment improves learning in mice with Down syndrome symptoms, Stanford/Packard study shows

A once-a-day, short-term treatment with a drug compound substantially improved learning and memory in mice with Down syndrome symptoms, say researchers at the Stanford University School of Medicine and Lucile Packard Children’s Hospital. What’s more, the gains lasted for months after the treatment was discontinued. The researchers are now considering a clinical trial to test whether the compound...

Experience affects new neuron survival in adult brain; study sheds light on learning, memory

Experience in the early development of new neurons in specific brain regions affects their survival and activity in the adult brain, new research shows. How these new neurons store information about these experiences may explain how they can affect learning and memory in adults. A team of researchers headed by Fred Gage, PhD, of the Salk Institute, found that experience enhances the surv...

Using brain scans, researchers find evidence for a two-stage model of human perceptual learning

Using advanced brain imaging techniques, researchers at Georgetown University Medical Center have watched how humans use both lower and higher brain processes to learn novel tasks, an advance they say may help speed up the teaching of new skills as well as offer strategies to retrain people with perceptual deficits due to autism. , the research team...

Scientists learn the origin of rogue B cells

Doctors have long wondered why, in some people, the immune system turns against parts of the body it is designed to protect, leading to autoimmune disease. Now, researchers at the National Institutes of Health's (NIH) National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), in collaboration with the Oklahoma Medical Research Foundation, have provided some new clues into one...

Researchers learn what sparks plant growth

A secret long held by plants has been revealed by Howard Hughes Medical Institute researchers. The new discovery, which builds on more than a decade of painstaking surveillance of cellular communication between different types of plant tissues, shows clearly for the first time how plants "decide" to grow. The research, conducted by Sigal Savaldi-Goldstein and Howard Hughes Medical Institut...

Mechanism of nicotine's learning effects explored

While nicotine is highly addictive, researchers have also shown the drug to enhance learning and memory—a property that has launched efforts to develop nicotine-like drugs to treat cognitive deficits in Alzheimer’s and Parkinson’s diseases, schizophrenia, and attention-deficit/hyperactivity disorder. A key problem in designing such drugs has been that little was known about the detailed me...

'Smart' mice teach scientists about learning process, brain disorders

, reveal a new mechanism of learni...

Math that powers spam filters used to understand how brain learns to move our muscles

The engineers, from Johns Hopkins, MIT and Northwestern, exploited the fact that all...