LPS in Biological News

For fats, longer may not be better

...versity of Kentucky wondered whether some unwanted lps particles, routinely shed by the bacteria that inh... oleic acid they observed significant secretion of lps together with the chylomicron particles, a phenome...t butyric acid, promoted significant absorption of lps into the blood and lymph nodes and subsequent expr...

Researchers create new class of fluorescent dyes to detect reactive oxygen species in vivo

...ced, or the control saline solution. Samples treated with hydro-Cy3 and lps showed fluorescence intensity almost four times greater than explants treat...o-Cy3 and saline. Once more, adding TEMPOL to the sample with hydro-Cy3 and lps decreased the fluorescence to a level comparable to the control saline expl...

Researchers identify new weapon to fight deadly bacterial sepsis

...mp blood normally and allowed mice injected with otherwise lethal levels of lps to survive. Other experiments conducted in cell cultures traced the specific biochemical pathways by which lps triggers an inflammatory cycle that damages the cells of the heart. By bloc...

Pest control research leads to pain control discovery

...nd enzyme inhibitors (a previously undescribed soluble epoxide hydrolase inhibitor or sEHIs) in lipopolysaccharide (LPS)-challenged mice. "We used lps as an inflammatory agent, which is a component of some bacterial cell walls," said, co-author Steven Jinks. His laboratory examined the effects of the...

A step forward in the fight against bacterial infections

... of the bacterial cell wall is LPS. The binding of lps with its specific receptor in our immune system &#...the process of inflammation following contact with lps is a profuse production of type 1 interferons. The...searchers administered 10 times the lethal dose of lps to the mutant mice, without deadly consequences. T...

Scripps research scientists solve structure of a critical innate immune system protein

... the innate immune system works something like this. Certain cells have the ability to recognize foreign molecules such as components of membrane like lps or other protein molecules unique to microorganisms . The presence of these pathogen-specific molecules activates the immune system, which responds wi...

Protein prevents detrimental immune effects of bacterial sepsis

...ct by analyzing the effects of the bacterial toxin lps on normal and annexin 1 knockout mice. Annexin 1 w...ne was activated as early as 1.5 and 6 hours after lps administration, with levels returning to normal by...ombinant annexin 1 in the first 24 hours following lps treatment, survival increased to 60%. These res...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

...immune response. Because it spurs an immune response without live bacteria, lps helps to reveal how the immune system works on its own, without the complic...e effects. The team found that E. coli-infected pups later injected with lps had significantly lower concentrations of cytokines called interleukins tha...

Scientists solve structure of key protein in innate immune response

...r membrane of certain bacteria. Once CD14 binds to lps or another ligand, it presents the molecule to oth...pose that this pocket is the main binding site for lps because previous biochemical studies demonstrate t...id residues comprising the pocket are critical for lps binding. Most, if not all, of the CD14 ligands com...

Dysentery uses 'sword and shield' to cause infection

...oteins into human cells. This causes the cells to become inflamed, resulting in symptoms of dysentery, such as bloody diarrhoea. At the same time, the lps chains on the surface of the bacteria are shortened. This allows the needles to inject proteins, while protecting the bacteria from being destroyed by...