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LDL in Biological News

Health benefits of physical activity more pronounced in women

...played decreased levels of triglycerides and increased levels of the "good" HDL cholesterol. However, statistically significant decreases in the "bad" ldl cholesterol were only observed in women, with particularly strong effects in menopausal women and African-American women. And total cholesterol levels...

Trans fats hinder multiple steps in blood flow regulation pathways

...ion in the arteries. And trans fats have been found to change the composition of cell membranes, making them more leaky to calcium. Inflammation, high ldl cholesterol and calcified arteries are the signature ingredients of atherosclerosis. Trans fats also were shown to interfere with an enzyme that co...

CFI awards $854,098 to University of Montreal and partners

.... "My research explores a novel hypothesis that high concentrations of ldl particles may be a promoter rather than a consequence of Type 2 diabetes," says Dr. Faraj, adding she will investigate whether decreasing ldl particles by behaviour modification or drug interventions can reduce the ri...

Source of major health benefits in olive oil revealed

...r Fatima Paiva-Martins, who works at the University of Porto. Heart disease is caused partly by reactive oxygen, including free radicals, acting on ldl or "bad" cholesterol and resulting in hardening of the arteries. Red blood cells are particularly susceptible to oxidative damage because they are the...

New approach discovered to lowering triglycerides

...nged, he added, and most experts now see triglycerides as a third important risk factor for atherosclerosis, along with levels of "good" HDL and "bad" ldl cholesterol. Widely prescribed medications are often taken to influence all of these issues, especially when efforts to control them with diet, exe...

For fats, longer may not be better

...intestines, long-chain fats need to be first packaged by the intestinal cells into particles known as chylomicrons (large complexes similar to HDL and ldl particles). Erik Eckhardt and colleagues at the University of Kentucky wondered whether some unwanted LPS particles, routinely shed by the bacteria th...

Apolipoprotein(a): A natural regulator of inflammation

... additional apolipoprotein, apo(a). Numerous clinical studies conducted over the past 40 years have identified Lp(a) as a risk factor independent from ldl for a variety of cardiovascular pathologies. Much of the focus of apo(a) pathogenic activities has centered on its strong resemblance to plasminogen, ...

New study 'pardons' the misunderstood egg

... by 61 percent more than those eating a bagel breakfast of equal calories. In addition, the study found no significant differences between the HDL and ldl cholesterol levels of the egg and bagel eaters.(3) Eggs are an excellent source of choline. A 2008 study concluded that a diet rich in choline and...

New gene variants present opportunities in nutrigenomics

... findings strengthen the association of 19 previously identified genes with ldl and HDL cholesterol and triglycerides. Ordovas collaborated with 60 authors...ultiple variant genes contributing to dyslipidemia, a combination of spiked ldl and triglyceride levels and extremely low HDL-cholesterol signaling cardiov...

New genes present drug targets for managing cholesterol and glucose levels

...leagues had shown that genetic variants that raise ldl cholesterol (low density lipoprotein or so-called ...ct about 40 percent of the population and increase ldl by about 3-6 milligrams per deciliter, a fairly sm...cts roughly 2 percent of individuals but increases ldl by about 15-30 milligrams per deciliter. Finally, ...

The genetic heart of the lipids

...et for statins, commonly used for treating high values of 'bad cholesterol', LDL. The region around NCAN gene has previously been associated with both ldl and triglyceride levels, associated with coronary heart disease. The results are part of an emerging portrait of genes determining lipid levels: a ...

Genes for 9 health indicators

...reviously unknown loci. Five of these associations - HDL with NR1H3 (LXRA), ldl with AR and FADS1/FADS2, glucose with MTNR1B, and insulin with PANK1 - impl...onmental influences and body mass index. Three regions were associated with ldl or insulin when the population was divided into normal or elevated body mas...

Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease

...P to be as important a predictor of future heart problems as high levels of ldl and low levels of HDL cholesterol." The UC Berkeley-led study looked at ... as a preventive measure. For people who have elevated CRP but not elevated ldl cholesterol, our data suggest that vitamin C should be investigated as an a...

Researchers study how pistachios may improve heart health

...ontrol diet, the 20 percent pistachio diet lowered ldl cholesterol -- bad cholesterol -- about 12 percent and the 10 percent energy pistachio diet lowered ldl cholesterol by 9 percent that suggests a 9 to 12 p...nships of total cholesterol to HDL cholesterol and ldl cholesterol to HDL cholesterol may be more powerfu...

Adults who eat eggs for breakfast lose 65 percent more weight

...t loss studies. The researchers also found that blood lipids were not impacted during the two month study. They found that blood levels of HDL and ldl cholesterol, as well as triglycerides, did not vary compared to baseline cholesterol blood levels in subjects who ate either the bagel or egg breakfas...

Quest for better treatment for effects of menopause

...icial, has a neutral effect on the cardiovascular system, given that it does not modifiy other cardiovascular risk markers, nor the characteristics of ldl (bad cholesterol) particles. As regards combined hormonal therapy, Ruiz del Agua points to two main conclusions: it reduces one of the cardiovascu...

Chocolate bar shown to lower cholesterol

... the bars, was published in this months Journal of Nutrition. Erdman attributes the drop in cholesterol numbers (total cholesterol by 2 percent and ldl or bad cholesterol by 5.3 percent) to the plant sterols that have been added to the bar and the drop in blood pressure to the flavanols found in dark ...

Macadamia nuts can be included in heart healthy diet

... The standard American diet had 13 percent saturated fat, 11 percent monosaturated fat and 5 percent saturated fat. "We found that the reduction in ldl or bad cholesterol we observed was greater than would be predicted by just the healthy fats in the nuts alone," says Griel. "This indicates that there...

LDL particle measurement by NMR recognized by ADA, ACC

...sus statement today that states the measurement of ldl particle number by nuclear magnetic resonance (NMR... the April issue of Diabetes Care, reinforces that ldl cholesterol may not be the best way to quantify a ...isk factors that often cluster together. ApoB and ldl particle concentration appear to be more closely a...

Women's health-related scientific findings presented by University of Pittsburgh researchers

...han 37 weeks gestation. Concentrations of total cholesterol, triglycerides, ldl and HDL also were collected an average of 7.4 years postpartum and compared...rmal gestation births, said Dr. Catov, adding that results were similar for ldl and HDL cholesterol, even after adjustment for race, age, smoking and body ...

Cigarette after Valentine snuggle deadlier for some

...ol. Unlike low-density lipoproteins (LDL), which build up plaque on artery walls and predispose a person to heart attacks or strokes, HDL helps filter ldl out of the blood and chips away at the plaque lining artery walls. When CETP has a common defect, it makes the protein controlling HDL work on ove...

Study locates cholesterol genes; finds surprises about good, bad cholesterol

...ead the medical community to rethink the role of HDL (good cholesterol) and ldl (bad cholesterol) in heart disease, said Goncalo Abecasis, associate profes...ics. "Nearly all of the gene regions that we found to be involved in higher ldl levels were also involved in coronary artery disease risk. This is a remark...

New genetic variants associated with lipid levels, risk for coronary artery disease

...ple with a certain trait, such as higher levels of ldl cholesterol, tend to have one version of the varia...dentify variations in 18 genes that influence HDL, ldl and/or triglyceride levels. This list of lipid-ass...nes, two were associated with HDL levels, one with ldl levels, three with triglyceride levels and one wit...

Scientists associate 6 new genetic variants with heart disease risk factor

... "good" cholesterols, respectively." The levels of ldl and HDL cholesterol in the blood have been shown t... of 18 SNPs reproducibly associated with levels of ldl cholesterol, HDL cholesterol, or triglycerides. Tw...ed out to be entirely new: two are associated with ldl cholesterol, one with HDL cholesterol, and five wi...

Story ideas from the Journal of Lipid Research

...eagues wondered whether such a protective effect would extend to mice with excess cholesterol levels. They mimicked FH in mice by knocking out the ldl receptor, causing a cholesterol buildup. When fed a high-fat Western diet, these mice develop obesity and diabetes in adulthood. However, when the res...

University of Alberta researchers report breakthrough in lowering bad cholesterol, fatty acid levels

...es report they successfully decreased the level of ldl (low-density lipids) the so-called bad cholestero...ening. Drugs called statins are used to lower ldl levels in patients, but do not treat obesity. What...gs noteworthy is their discovery of how to inhibit ldl and triglycerides, which are another form of fat i...

Oatmeal's health claims strongly reaffirmed, science shows

... benefits that extend beyond total cholesterol and ldl cholesterol reduction, Anderson said. Recent stu...ssure, Type 2 diabetes, and weight gain Reduce ldl cholesterol during weight-loss Provide favorable changes in the physical characteristics of ldl cholesterol particles, making them less susceptibl...

Contribution of cholesterol transporter to vascular disease

...O reports. The study reveals a link between native ldl (nLDL) and the vascular endothelial growth factor ...plays a central role in blood vessel formation. ldl is responsible for transporting cholesterol from t...nd colleagues found that when nLDL is bound to the ldl receptor, it can activate VEGFR1 and accelerate mi...

'Knocking out' cell receptor may help block fat deposits in tissues, prevent weight gain

...dition and the November 2007 print issue of the Journal of Clinical Investigation, the findings about a specific cell receptor, known as the adipocyte ldl receptor-related protein 1 (LRP1), provide important clues about the underlying biological mechanisms that control fat transport in the body. Using...

More on mate tea: lower cholesterol and an international agreement

...ate (mah tā) tea drinkers had experienced a significant increase in the activity of an enzyme that promotes HDL (good) cholesterol while lowering ldl (bad) cholesterol, University of Illinois scientist Elvira de Mejia headed for Argentina where mate tea has been grown and taken medicinally for centu...

Corazonas Foods and Brandeis University partner to create cholesterol-reducing snacks

...getable oils, plant sterol levels are usually too low to effectively combat ldl cholesterol. The Brandeis technology makes natural plant sterols biologica...rcent, enabling them to effectively block cholesterol absorption and reduce ldl levels. A variety of scientific studies have shown that plant sterols, ...

Eating competence may lower risk of heart disease

...ion was already at high risk due to high levels of ldl the bad cholesterol and elevated total cholester...ng competent were five times more likely to have a ldl greater than the cutoff prescribed by the American...ing people with dietary information to lower their ldl or triglyceride levels, it might be more prudent t...

Mechanism for the in-vivo transport of siRNA

...cid molecules are already firmly bonded to HDL and ldl before being administered. Stoffels team also disc...A-fatty acid molecule is bonded to HDL or LDL: all ldl compounds trigger responses in the liver, but HDL ...ing indicated that the uptake proceeds via HDL and ldl receptors. The researchers proved this assumption ...

Dominant cholesterol-metabolism ideas challenged by new research

...holesterol metabolism is an area of intense inquiry because high levels of ldl cholesterol or total cholesterol put about half of all Americans at signif...e Tangier patients and the knock-out mice experience a serious build-up of ldl in the tissues, we know that ABCA1 plays an important role in the choleste...

Hawaiian treasure, macadamia nuts good for the heart

... cholesterol, low-density lipoprotein cholesterol and triglyceride levels compared with the standard American diet. "We observed a reduction in ldl similar to that seen with other tree nuts like walnuts and almonds," says Griel. Individual calorie levels were used for each participant so that...

Pistachios lower cholesterol, provide antioxidants

...r cardiovascular disease by significantly reducing ldl cholesterol levels and the higher dose significant... decreased the ratios of total cholesterol to HDL, ldl to HDL and non-HDL to HDL and apolipoprotein B, wh...s looked at the effects of these diets on oxidized ldl and on antioxidants in the blood. "We were ...

A cherry on top: Tart cherries may alter heart/diabetes factors

...ll look at whether tart cherries have an impact on the storage of fat in fat tissue and in muscle, and on the production of specific blood lipids like ldl and HDL. In addition, they will characterize cherries chemically, to assess the levels of phytochemicals in whole cherries, cherry juice and dry cherr...

Magic Beans -- Anti-obesity soya could help prevent diabetes

...hose getting 10% of their energy from black soya had gained half as much weight as those in the control group. Total blood cholesterol fell by 25% and ldl (so-called ‘bad? cholesterol fell by 60% in the rats in the 10% group. David Bender, sub-dean at the Royal Free and University College Medical Sc...

New study finds chocolate chip cookies lower cholesterol

...ion Cookies daily showed a ten percent decrease in ldl cholesterol as well as shifting the ldl particles toward a less atherogenic pattern. N...ut not always. Recent studies reveal small, dense ldl particles have been linked to increased formation ...

Ghengis Khan wonder berry could conquer heart disease

... the red berries. Antioxidants in the berries inhibit so-called 'bad' ldl cholesterol oxidisation, which could provide a new weapon to fight cardiovascular disease. When ldl cholesterol is oxidized, it sticks to the lining of blood vessels. Consumin...
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