Jude in Biological News

ORNL, St. Jude track neurons to predict and prevent disease

Researchers at the Department of Energy's Oak Ridge National Laboratory and St. Jude Children's Research Hospital are looking at how developing nerve cells may hold a key to predicting and preventing diseases like cancer and Alzheimer's and Parkinson's disease. St. Jude scientists have linked m...

St. Jude identifies genomic causes of a certain type of leukemia relapse

Scientists at St. Jude Children's Research Hospital have identified distinctive genetic changes in the cancer cells of children with acute lymphoblastic leukemia (ALL) that cause relapse. The finding offers a pathway to designing treatments for ALL relapse in children and, ultimately, in adults. ...

St. Jude study gives new insights into how cells accessorize their proteins

St. Jude Children's Research Hospital investigators have gained new insight into how the cell's vast array of proteins would instantly be reduced to a confusion of lethally malfunctioning molecules without a system for proteins to "accessorize" in order to regulate their function. Just as eyeg...

St. Jude defines eye cancer gene's role in retinal development

A genetic discovery led by scientists at St. Jude Childrens Research Hospital helps answer a long-standing mystery about the eyes of vertebrates, and may translate into a deeper understanding of how genes coordinate the complex process of eye formation and how a rare pediatric eye cancer progresse...

St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory

Investigators at St. Jude Children's Research Hospital have identified the cell that gives rise to the eye cancer retinoblastoma, disproving a long-standing principle of nerve growth and development. The finding suggests for the first time that it may one day be possible for scientists to induce f...

St. Jude settles century-old debate on origin of mammalian network of lymphatic vessels

Investigators at St. Jude Children's Research Hospital settled a century-old debate on the origin of the mammalian lymphatic vasculaturethe network of vessels and capillaries critical to various essential housekeeping functions in the body. The finding holds the promise for the development of new ...

St. Jude finds factors that accelerate resistance to targeted therapy in lymphoblastic leukemia

Results of a study by investigators at St. Jude Childrens Research Hospital provide strong evidence for why the targeted therapy drug, imatinib, or Gleevec, which has revolutionized the treatment of chronic myelogenous leukemia, (CML) is often unable to prevent relapse of a particularly aggressive...

St. Jude influenza survey uncovers key differences between bird flu and human flu

Scientists at St. Jude Children's Research Hospital have found key features that distinguish influenza viruses found in birds from those that infect humans. The St. Jude team used a mathematical technique to identify specific amino acid building blocks that are statistically more likely to app...

St. Jude study solves mystery of mammalian ears

Protein motor in cochlea hair cells dominates the process of sound amplification in the mammalian ear, while movement of the cilia atop those cells dominates the response in non-mammals A 30-year scientific debate over how specialized cells in the inner ear amplify sound in mammals appears to h...

St. Jude study shows genes play an unexpected role in their own activation

Investigators at St. Jude Children's Research Hospital have discovered how a single molecular “on switch” triggers gene activity that might cause effects ranging from learning and memory capabilities to glucose production in the liver. The “on switch,” a protein called CREB, is a transcription ...

St. Jude announces breakthrough in eye cancer treatment

Scientists at St. Jude Children's Research Hospital have demonstrated in a mouse model a new, locally applied treatment for the eye cancer retinoblastoma that not only greatly reduces the size of the tumor, but does so without causing the side effects common with standard chemotherapy. The treatmen...

St. Jude finds clues to hearing loss from chemotherapy

Children with cancer who suffer hearing loss due to the toxic effects of chemotherapy might one day be able to get their hearing back through pharmacological and gene therapy, thanks to work done with mouse models at St. Jude Children's Research Hospital. Mice with a variety of genetic mutations th...

St. Jude test of bird flu vaccine proves successful

A commercially developed vaccine has successfully protected mice and ferrets against a highly lethal avian influenza virus, according to the investigator who led the study at St. Jude Children's Research Hospital. The vaccine was developed by Vical Incorporated in San Diego, California. This find...

St. Jude projects 90 percent cure rate for ALL

The cure rate for the once almost universally fatal childhood cancer acute lymphoblastic leukemia (ALL) could reach 90 percent in the near future, thanks to improvements in diagnosis and treatment over the past four decades, according to investigators at St. Jude Children's Research Hospital. Almos...

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...ul of missteps, according to new findings from St. jude Children's Research Hospital. The research appears...give rise to this cancer. James Downing, M.D., St. jude scientific director and the paper's senior author,..., researchers analyzed leukemia cells from 111 St. jude AML patients representing the seven most common su...

Scientists track impact of DNA damage in the developing brain

... and emotion, according to new research led by St. jude Children's Research Hospital scientists. The wo...king. Peter J. McKinnon, Ph.D., a member of St. jude Genetics and Tumor Cell Biology, said the work pro...s cre recombinase, in just the nervous system. St. jude researchers then developed a mouse that carried an...

Breakthrough in the treatment of bacterial meningitis

... open new doors and pave the way for new discoveries." The research, carried out in collaboration with the Department of Infectious Diseases at St. jude Children's Research Hospital in Memphis Tennessee, also involved students from the University who have been regular and willing volunteers in the rese...

Eye cells believed to be retinal stem cells are misidentified

...e retinal stem cells are, in fact, normal adult cells, investigators at St. jude Children's Research Hospital have found. If retinal stem cells could be obt...oceedings of the National Academy of Sciences . Dyer is a member of the St. jude Department of Developmental Neurobiology. In studies reported in 2000, s...

Gene therapy corrects sickle cell disease in laboratory study

...ive gene into mouse blood cells, scientists at St. jude Children's Research Hospital have alleviated sickl...-globin, but another form called gamma-globin. St. jude researchers had found that treating patients with ... Persons, M.D., Ph.D., assistant member in the St. jude Department of Hematology. He and his colleagues...

Reprogrammable cell type depends on a single gene to keep its identity

... Scientists at St. jude Children's Research Hospital have discovered that ... said Guillermo Oliver, Ph.D., a member of the St. jude Department of Genetics and Tumor Cell Biology. Dif...ess," said Oliver, the paper's senior author. "St. jude researchers showed that lymphatic endothelial cell...

New insight into the controls on a go-to enzyme

... Scientists at St. jude Children's Research Hospital have gained new insig...them," said Douglas Green, Ph.D., chair of the St. jude Department of Immunology. Calpains are triggere... function." To obtain that overall picture, St. jude researchers used the analytical technique of X-ray...

Biophysical Society announces winners of 2008 Student Travel Awards

...Calcium-dependent Current Conducted by Cav2.1 and Cav2.2 Channels: Implications for Asynchronous Neurotransmitter Release. John C. Fisher, St. jude Children's Research Hospital, How PUMA Attacks its Prey: Understanding the Molecular Basis of PUMA-Induced Cell Death. Eric W. Frey, Miami Unive...

UTSA and University in Mexico to collaborate in science research

...sented at the event by Harriett Romo, director of the UTSA Mexico Center; Julius Gribou, UTSA interim provost and vice president for academic affairs; jude Valdez, UTSA vice president for community services; and George Perry, dean of the UTSA College of Sciences. "It's a way for our students to learn m...

Phase 2 of Singapore's Biomedical Sciences Initiative gains momentum for clinical research

....) New Council Members BMS IAC also welcomed three new members at this 12th meeting. They are Professor William Evans, Director and CEO, St jude Childrens Research Hospital; Dr Anthony Pawson, Director of Research, Samuel Lunenfeld Research Institute of Mount Sinai Hospital; and Professor Rolf ...

Venous origin of the mammalian lymphatic vasculature

... In the October 1 issue of G&D, Dr. Guillermo Oliver (St. jude Childrens Research Hospital) and colleagues present new evidence to resolve a century-old debate over the origin of the mammalian lymphatic vasculatur...

Cells re-energize to come back from the brink of death

...pairing the damage, is giving investigators at St. jude Children's Research Hospital insights into a key s...hem to survive and become cancerous. The St. jude study also suggests that a drug that disrupts a ca...ction, said Douglas Green, Ph.D., chair of the St. jude Immunology department and the study’s senior autho...

Peramivir protects mice from lethal H5N1 infection

...N1, according to results of mouse studies conducted by investigators at St. jude Children's Research Hospital. Peramivir, an antiviral drug, blocks the ...particles and their spread from one infected cell to another. The St. jude team studied different approaches to treating infected mice according to du...

DNA repair proteins monitored at double-strand break

... Investigators at St. jude Children's Research Hospital had a molecule’s eye ...e developed specifically for this project, the St. jude researchers could determine when repair proteins a...uman cells," said Michael Kastan, M.D., Ph.D., St. jude Cancer Center director. "Our approach solved that ...

NIAID expands capability for influenza research and surveillance

...ew awards build upon an ongoing program led by St. jude Children’s Research Hospital in Memphis, TN, initi...d Surveillance awards are provided below. St. jude Children’s Research Hospital, Memphis (principal i...sceptible to flu virus infection. In addition, St. jude will expand its animal surveillance to more than a...

Major gene study uncovers secrets of leukemia

... Investigators at St. jude Children's Research Hospital have discovered previ...ood cells the body needs to survive. The St. jude team used microarrays, postage-stamp-sized chips t...f detail that was previously unattainable. The St. jude group used this approach to analyze leukemia sampl...

Protein sensor for fatty acid buildup in mitochondria

...ese fatty acids, according to investigators at St. jude Children's Research Hospital. This breakdown of fa...hat excess fatty acids will accumulate. The St. jude discovery explains how the fatty acid-sensing enzy...ids—a process called beta-oxidation. The St. jude team demonstrated that PanK2 does its job of respo...

Chemical switch triggers critical cell activities

...vital functions, according to investigators at St. jude Children's Research Hospital. A report on this wor...ced online publication issue of Nature. The St. jude discovery explains how a simple chemical link betw...renda Schulman, Ph.D., associate member of the St. jude Structural Biology and Genetics and Tumor Cell Bio...

Leukemic cells find safe haven in bone marrow

...ct of that drug, according to investigators at St. jude Children's Research Hospital. The researchers s...id Dario Campana, M.D., Ph.D., a member of the St. jude Oncology and Pathology departments. Campana ...eed asparagine," added James R. Downing, M.D., St. jude scientific director and chair of the Pathology dep...

Viral protein is an effective preventative against infection

...llaboration between Rockefeller University and St. jude Children’s Hospital could change all that. In t...eller’s Vincent A. Fischetti and colleagues at St. jude show that middle ear infections in mice can be pre...ated ?Fischetti sent McCullers, a physician at St. jude Children’s Hospital Department of Infectious Disea...

2,000 influenza virus genomes now completed and publicly accessible

...n a marked increase in the number of scientists worldwide depositing influenza genome sequence data into the public domain including scientists at St. jude Children’s Research Hospital and the Centers for Disease Control and Prevention." ...

Solution to bacterial mystery promises new drugs

... these bacteria, according to investigators at St. jude Children's Research Hospital. The finding is signi...ording to Charles Rock, Ph.D., a member of the St. jude Department of Infectious Diseases and senior autho... over more than two decades. Now, however, the St. jude team reports that the gram-positive pathogens use ...

New way of tracking muscle damage from radiation

...diation therapy, according to investigators at St. jude Children's Research Hospital. The researchers ... Matthew Krasin, M.D., associate member of the St. jude Department of Radiological Sciences. The St. jude study showed that changes in images taken of muscl...

First major study of mammalian 'disorderly' proteins

... Investigators at St. jude Children's Research Hospital turned up the heat on...es perform critical functions in the cell. The St. jude team completed the first large-scale collection, i...rd Kriwacki, Ph.D., an associate member of the St. jude Department of Structural Biology. Moreover, he sai...

Key gene controlling kidney development found

...ts of the organ, according to investigators at St. jude Children's Research Hospital. Differentiation is t...ood as urine and direct it to the bladder. The St. jude team showed that Six2 works by preventing some of ... said Guillermo Oliver, Ph.D., a member of the St. jude Genetics and Tumor Cell Biology Department. Oliver...

Cell wall of pneumonia bacteria can cause brain and heart damage

... Investigators at St. jude Children's Research Hospital have discovered in mo...cording to Elaine Tuomanen, M.D., chair of the St. jude Department of Infectious Diseases. S. pneumoniae i...rrounding the brain and spinal cord). The St. jude team found that pieces of cell wall from S. pneumo...