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Interference in Biological News

RNA interference therapy heals growth deficiency disorder in a live animal

A team of Vanderbilt researchers have demonstrated for the first time that a new type of gene therapy, called RNA interference, can heal a genetic disorder in a live animal. The study, which was published online Nov. 15 by the journal Endocrinology, shows that RNA interference can rescue a strain...

Cocaine high caused by interference in neuronal receiving stations

Researchers have found evidence for a fundamental molecular mechanism underlying the hyperactive high of cocaine. In studies with rats, they have traced the effect to interactions between two types of receiving stations in neurons for nerve signals from their neighbors. The researchers' studies in ...

RNA interference stops colon cancer spread in mice

Using one of the newest and most powerful tools of biomedical science, University of Texas Medical Branch at Galveston (UTMB) researchers have scored a dramatic success in the battle against colorectal cancer. The scientists were the first to use what are known as "small interfering RNAs" to bloc...

Used in a new way, RNA interference permanently silences key breast cancer gene

In laboratory mouse experiments, researchers at The University of Texas M. D. Anderson Cancer Center have developed a way to use RNA interference (RNAi) so that it permanently hampers breast cancer development. The technique permanently silences activated STAT3, a crucial gene found in some human b...

Silence the gene, save the cell: RNA interference as promising therapy for ALS

Scientists at the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland have used RNA interference in transgenic mice to silence a mutated gene that causes inherited cases of amytrophic lateral sclerosis (ALS), substantially delaying both the onset and the progression rate of the fatal mot...

AGU journal highlights -- Aug. 6, 2009

... in the amount of solar energy reaching the Earth can affect society, the environment, and the economy. A growing body of evidence supports that human interference has affected the amount of solar radiation that is able to penetrate the atmospherein general, aerosol pollutants have been shown to scatter or absorb...

Parasites ready to jump

...s also detectable when multiple copies of a mobile element were present in the cell but not yet incorporated into the genome. The phenomenon of RNA interference first came to light only a short time ago, but has already become a well established field of study. Thanks to more recent findings, the known reperto...

UTMB study identifies women at risk of gaining excessive weight with injectable birth control

...note that possible mechanisms include glucocorticoid-like activity, how the body breaks down simple carbohydrates such as glucose, and DMPA-associated interference with insulin action. Previous findings seem to argue against the theory that weight gain could be due to the drug's perceived effects on increased cal...

A genetic basis for schizophrenia

..., particularly the dentate gyrus, which is considered the gateway to the hippocampus. In this study, the authors decreased Disc1 expression using RNA interference in the developing mouse hippocampus. The loss of Disc1 resulted in hindered migration of dentate gyrus granule cells to their proper location in the ...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

...an. Longevity-associated mutations have been shown to lead to enhanced immune response including increased control of gene expression through RNA interference (RNAi) in somatic cells. Since it is known that RNAi is among the mechanisms underlying germline cells' enhanced resistance to pathogens and other s...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

... travel by two different paths, directed from place to place by strategically places mirrors, and converge at a detector, where they produce a striped interference pattern. The pattern can be read out to learn details of the journey taken by the waves. Interferometry is used in many endeavors, such as navigation,...

Princeton team's analysis of flu virus could lead to better vaccines

...lti-stage interactive process -- known as antibody interference -- to advantage, the scientists believe it may be ... of Sciences . "We have proposed that antibody interference plays a major role in determining the effectivenes...ics, suggested that a phenomenon known as antibody interference was at play. It arises when a virus prompts the cr...

UCLA scientists discover ultrasonic communication among frogs

...d calls that are audible to humans. "Our hypothesis is that these frogs have shifted to use higher frequencies in their communication to avoid the interference of sound produced by rushing water in the lower-frequency range," Arch said. "However, high-frequency sounds do not transmit as far. By producing some...

Coral 'can't escape the heat'

...he effects of global warming, corals will not be able to avoid the acidification of the oceans, which is a simple and direct consequence of humanity's interference in the atmosphere. About 40 per cent of the CO2 we release dissolves into the oceans, turning them more acidic." Analysis of corals taken from the ...

Nanotechnology holds promise for STD drug delivery

...orted May 4 as an advance online publication of Nature Materials . "RNA interference is a promising approach for prevention and treatment of human disease," sai...GA nanoparticles were safer than the best current lipid vehicles. Gene interference therapy is moving rapidly from basic research to application. The PLGA pack...

Satellites show how Earth moved during Italy quake

...sitions. The InSAR technique merges data acquired before and after the earthquake to generate 'interferogram' images that appear as rainbow-coloured interference patterns. A complete set of coloured bands, called 'fringes', represents ground movement relative to the spacecraft of half a wavelength, which is 2.8...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

..., death. Children who have a parent with Huntington's disease have a 50 percent chance of inheriting the disease themselves. Zamore studies how RNA interference can be used to silence genes selectively. In the 1990s, he and other scientists learned they could shut down the production of specific proteins by in...

Making a point: Picoscale stability in a room-temperature AFM

...onds, magnetic forces and other atomic-scale interactions. While extremely sensitive to atomic-scale features, AFMs also are extremely sensitive to interference from acoustic noise, temperature shifts and vibration, among other factors. This makes it difficult or impossible either to hold the probe in one plac...

200,000 rice mutants available worldwide for scientific investigation

...za sativa genome was sequenced in 2002 and researchers have come a long way since. Advances in technologies such as high-throughput sequencing and RNA interference gene silencing methods should help to accelerate the process of identifying the functions of the remaining genes in the rice genome." He added: "The a...

200,000 rice mutants available worldwide for scientific investigation

...za sativa genome was sequenced in 2002 and researchers have come a long way since. Advances in technologies such as high-throughput sequencing and RNA interference gene silencing methods should help to accelerate the process of identifying the functions of the remaining genes in the rice genome." He added: "The a...

Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols

...d, except in the presence of small ligands. The speed of small-molecule binding makes it an attractive alternative to studying gene function using RNA interference (RNAi). The method is freely accessible on the website for Cold Spring Harbor Protocols ( http://www.cshprotocols.org/cgi/content/full/2009/3/pdb.pr...

Lower increases in global temps could lead to greater impacts than previously thought, study finds

...States has ratified, calls for "stabilization of greenhouse gas concentrations in the atmosphere at a level that would prevent dangerous anthropogenic interference with the climate system." That level is not defined by the Convention nor has it been clearly defined in subsequent negotiations by parties to the Con...

Marine scientists to assess environment before offshore drilling begins in US arctic waters

...line for the Chukchi Sea's seabed, or benthos. Information from the work will be used to help identify areas of ecological importance, to minimize interference of drilling with areas of rich natural resources and native subsistence harvesting activities. The data collected by the scientific team will also be ...

Cold Spring Harbor Protocols features stem cell differentiation, plant RNAi methods

...second featured article for February comes from S.P. Dinesh-Kumar and colleagues at Yale University ( http://plantfunctionalgenomics.yale.edu/ ). RNA interference (RNAi) has become an effective tool for the down-regulation of genes in plants. The most effective means of accomplishing this gene silencing is thro...

Apolipoprotein(a): A natural regulator of inflammation

... its important role in clot lysis, plasmin is required for leukocyte recruitment in inflammation. While several in vitro studies have demonstrated the interference of apo(a) in plasminogen leukocyte recruitment, evidence for this in vivo has been lacking. In vivo investigation of Lp(a) function has been impeded...

New edition of laboratory manual includes cutting-edge techniques to study gene regulation

... a new transcription factor. In addition to chromatin-based techniques such as chromatin immunoprecipitation (ChIP), the new edition incorporates RNA interference (RNAi), mass spectrometry, and bioinformatic and experimental methods that exploit genome sequencing information to examine gene regulation on a more ...

CSHL researchers map changing epigenetic modifications that enable transposons to run amok

...f complicated steps masterminded by small molecules of RNA, called small interfering RNA (siRNA). They perform this feat in a phenomenon known as RNA interference (RNAi). The discovery that modifications of heterochromatin -- densely packed, genetically "inactive" regions of DNA -- are targeted by RNAi was made ...

Researchers solve piece of large-scale gene silencing mystery

... fight RNA To determine the pathway regulating nucleolar dominance, Pikaard's team exploited a naturally occurring cellular mechanism known as RNA interference (RNAi). Pikaard likens RNAi to a "search and destroy mission." Fragments of RNA known as small interfering RNAs (siRNAs) prevent specific genes f...

Fear of hypoglycemia a barrier to exercise for type 1 diabetics

... type 1 diabetes answered questionnaires to assess their barriers to physical activity. The biggest fear was hypoglycaemia and other barriers included interference with work schedule, loss of control over diabetes and low levels of fitness. When questioned further, only 52 of the participants demonstrated app...

Acoustical Meeting, Nov. 10-14, 2008 in Miami, Florida

...ic pitch categories for the Mandarin listeners. In contrast, the English listeners could perform the musical pitch pattern identification task without interference from any pre-existing pitch categories. However, in the pitch discrimination task -- where listeners do not compare the input to stored categories bu...

UC Davis researchers discover a key to aggressive breast cancer

... the normal tissues. The researchers next conducted a series of laboratory experiments using human breast cancer cell lines and a technique called RNA interference that allows for selective depletion of cellular proteins. Interestingly, they found the same results in the human breast cancers that they found in...

8 National Medals of Science awardees to be honored at gala, then the White House

... standards for digital cellular telephony utilize the Viterbi algorithm for interference suppression, as do most digital satellite communications systems. Viterb...co-founded QualComm with Irwin Jacobs. He created the Viterbi Algorithm for interference suppression and efficient decoding of a digital transmission sequence, used...

Modest CO2 cutbacks may be too little, too late for coral reefs

...onvention on Climate Change (UNFCCC) greenhouse gases in the atmosphere need to be stabilized at levels low enough to "prevent dangerous anthropogenic interference with the climate system." But scientists have come to realize that an even more acute danger than climate change is lurking in the world's oceansone t...

Fires regenerate African grassland

...selected an area measuring 500 by 500 metres in Etosha National Park because it has one dominant grass species and because it was possible to rule out interference such as grazing and other human influences. Etosha National Park in the north of Namibia is the second largest nature reserve in Africa, measuring 20,...

Researchers identify cancer-causing gene in many colon cancers

...beta-catenin and are involved in the proliferation of colon cancer cells, the research team ran three screening tests. In the first two, they used RNA interference to shut down more than a thousand genes one by one and recorded the instances where beta-catenin activity decreased and the cells stopped growing. Th...

MGH researcher Gary Ruvkun named a co-recipient of the Lasker Award

...t the microRNAs of both lin-4 and let-7 are released from their precursor hairpin RNA molecules by the enzyme Dicer, which is also critical to the RNA interference process that Mello and Fire had discovered and for which they received the 2006 Nobel Prize. It now appears that the human genome contains between...

N.Y. research team discovers how antidepressants and cocaine interact with brain cell targets

...ansporter. Therefore, the researchers conclude that anti-cocaine therapy will be more complicated, because interfering with cocaine binding also means interference with the binding of natural messengers. "This finding might steer anti-cocaine therapy in a completely new direction," says Dr. Weinstein. Mol...

Birdsong not just for the birds

...itoring at Brandenburg's Parsteiner Weiher, is characterised by what researchers call 'robust recognition', i.e. a high degree of reliability. Despite interference from rain, wind and amphibians the programme recognised, with a 92% detection accuracy, the song of a species of bird which is still found on the shor...

Class of antibiotics can enhance gene-silencing tool

...antibiotics known as fluoroquinolones can make RNA interference more effective in the laboratory and reduce potent...idered safe." The most powerful enhancer of RNA interference was enoxacin, which has been used to treat gonorrh...tic ciprofloxacin. The antibiotics' effect on RNA interference appears to be chemically separate from their bacte...

Zooming in on genetic shuffling

...n, with events concentrated at so-called hotspots, some of which favoured either crossovers or non-crossovers. The researchers also found evidence for interference between crossovers and non-crossovers - a phenomenon previously only known to occur between crossovers - that makes it unlikely for two recombination ...
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(Date:9/18/2014)... roaches of the fish world, are the ideal animal ... shape. They,ve moved from the ocean into tens of ... each time changing their skeleton to adapt to the ... populations of sticklebacks now have turned up one of ... a simple change in that gene,s regulation in a ...
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