All-in-1 nanoparticle: A Swiss Army knife for nanomedicine
...particle, and the effects disappear. The electrical fields of the particles interfere
with one another and so neither behaves as it would on its own. The two hav...eters distance, so the two components' optical and electrical fields do not interfere
with one another. The quantum dot likely would be used for fluorescent imag...
Faster, more cost-effective DNA test for crime scenes, disease diagnosis
...cutting costs. The new method also is more specific, accurately detecting DNA even in the presence of unfavorable PCR products in the samples that may interfere
with quantification results.
UT scientist receives hemophilia research award
...ey can be blocked by using a novel protein that inhibits such responses. This approach may decrease the occurrence of inhibitory antibodies that often interfere
with an otherwise effective treatment for hemophilia."
Smith's hemophilia research also received support through the Center for Clinical and Transl...
New trigger for chronic inflammation in rheumatoid arthritis discovered
...system may be triggered to attack the joints in patients with rheumatoid arthritis. We hope our new findings can be used to develop new therapies that interfere
with tenascin-C activation of the immune system and that these will reduce the painful inflammation that is a hallmark of this condition," added Dr Mi...
MicroRNAs help control HIV life cycle
...A, Calif., June 26, 2009 Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere
with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle...
Evolution of a contraceptive for sea lamprey
... specifically to the lamprey estrogen receptor, but not to estrogen receptors in other animals," said Baker, adding that some of these compounds could interfere
with estrogen action and act as contraceptives in female lamprey, providing a method to control their numbers.
Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
...ormation so they work," says Dr. Ahmed Chadli, biochemist in the MCG Center for Molecular Chaperones/Radiobiology and Cancer Virology. "The goal is to interfere
with their function when they are helping cancer."
Hsp90 is vital to steroid receptors whether they are involved with normal hormonal function or c...
Omega-3 fatty acids appear to impact AMD progression
...edman School of Nutrition Science and Policy at Tufts and Tufts University School of Medicine (TUSM).
The antioxidant supplements did not seem to interfere
with the protective effects of DHA and EPA against progression to advanced stages of AMD. Participants who consumed higher amounts of DHA and EPA appe...
Trans fats hinder multiple steps in blood flow regulation pathways
... in processed foods contain trans fatty acids that interfere
with the regulation of blood flow. A new report re...ummerow reports for the first time that trans fats interfere
with more than one key enzyme in the regulation of... maintenance and growth, Kummerow said, trans fats interfere
with the body's ability to perform certain tasks c...
Plant microbe shares features with drug-resistant pathogen
...l of bacteria to produce or become resistant to antimicrobial compounds."
The findings may also reveal new targets for the development of drugs to interfere
with microbes' ability to form sticky, infection-fostering biofilms, or point the way to closely related non-pathogenic strains that could be useful a...
TRAPping proteins that work together inside living cells
...g in their unique method is made up of a "tetracysteine motif" -- two pairs of the amino acid cysteine separated by two other amino acids that doesn't interfere
with the normal function of the protein of interest. TRAP includes a small "biarsenical" probe, which fluoresces so the team can find the proteins to ...
Slicing chromosomes leads to new insights into cell division
... "By knowing how chromosomes move, we can better understand how these drugs interfere
with those movements and we can design experiments to screen for new drugs,...better handle on what makes these drugs work. There are a lot of drugs that interfere
with mitosis, but only a few are good for cancer therapy."
Understanding plants' overactive immune system will help MU researchers build better crops
... is through effector-triggered immunity (ETI), which relies on the detection of pathogen effector proteins (proteins that are deployed by pathogens to interfere
with the plant immune system). After the detection of a pathogen, specific proteins in the plant, known as resistance proteins, elicit an effective de...
Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics
... Presentation PWB4; Wednesday, June 3, 6:15 6:45 p.m.
MORE QUIET MIRRORS
In physics many subtle phenomena can be studied by allowing waves to interfere
with each other. In an interferometer, light waves travel by two different paths, directed from place to place by strategically places mirrors, and c...
Identification of genetic variants affecting age at menopause could help improve fertility treatment
...reen women who have problems getting pregnant to see if they have one or more of these variants which might relate to their sub-fertility, and perhaps interfere
with the relevant physiological pathways in order to delay their total infertility", said Ms Stolk.
New lead on malaria treatment
...ompounds, fumarranol, because it interacts with human MetAP2 and is less toxic to mice.
The team first tested whether fumarranol can stick to and interfere
with PfMetAP2 by treating mouse cells containing PfMetAP2 with different amounts of fumarranol and fumagillin and comparing them to untreated cells. I...
Association for Molecular Pathology joins ACLU to challenge gene patents
... access gene sequence data to develop the tests needed to make molecular medicine a reality," said Dr. Nowak.
The lawsuit charges that gene patents interfere
with the free flow of information and knowledge (among researchers, doctors, patients) in violation of the First Amendment, and that patents on human ...
Small molecules might block mutant protein production in Huntington's disease
... DALLAS May 3, 2009 Molecules that selectively interfere
with protein production can stop human cells from making the abnormal molec...so designed short lengths of RNA called small interfering RNA, or siRNA, to interfere
with CAG repeats.
In cells from Huntington's patients, the PNAs, LNAs an...
Nanotechnology holds promise for STD drug delivery
...neering & Applied Science . "We wanted to develop a new strategy of delivering siRNAs with a FDA-approved material."
As their name suggests, siRNAs interfere
and knock out the function of genes in higher organism as well as in microbes that may cause STDs. The researchers designed siRNAs to target a gene ex...
Cystic fibrosis testing -- next steps
...l and Hantash et al identify mutations that may lead to false screening results, either due to a large deletion in CFTR or because of mutations that interfere
with laboratory screening methods.
Wayne Grody, of the UCLA School of Medicine, Los Angeles, CA, who is not affiliated with these studies, states...
Laughing hyenas, wailing levees, the sound of cheese and blaring bagpipes
To improve the specificity of this targeting, Lindner grafts long arm-like molecules to the outside of the bubbles. These arms, which do not interfere
with the DNA attached to surface, are designed to recognize and bind to molecules on the outside of specific cells in the body, allowing the bubbles t...
NIH funds development of resistance-breaking insecticides to reduce malaria transmission
...entomologists, and biologists in the United States with malaria mosquito control experts in Kenya. The focus was to develop insecticides that strongly interfere
with acetylcholinesterase (AChE), a key enzyme in the mosquito brain, while leaving the related human enzyme untouched. The promising new idea was tha...
UGA licenses invention that kills food-borne pathogens in minutes
...tly, Doyle said, the wash has no effects on smell, taste or appearance of the foods that are treated, even delicate produce. "The new product doesn't interfere
with the shelf-life of sensitive foods," he said.
Like the original FIT Fruit and Vegetable Wash now used at home by consumers and by food service ...
Mollusks taste memories to build shells
... for a few days, resulting in an on/off pattern that produces a series of bands.
The most interesting patterns, however, are waves of activity that interfere
to produce zigzags, diamonds, chevrons, arrowheads and a host of other shapes. These come about when a pigment inhibits future secretion at that site ...
UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs
...aduate student Heather Workman, lead author of the study. "We now need to refine our understanding of this disruption process in order to find ways to interfere
with it. There currently are no drugs that target Muc4, and this research will help change that."
Carraway is now preparing to test metastasizing b...
UW-Madison study reveals new options for people with PKU
...ns we eat in everyday foods. While small amounts of phenylalanine are essential for PKU patients, excess amounts stay in their bodies indefinitely and interfere
with brain function. Those who go off-diet often suffer from concentration problems and depression. Some even sustain permanent brain damage. The GMP ...
Cancer Genomics Browser gives cancer researchers a powerful new tool
...er of copies of a gene. Moreover, microarrays and high-throughput methods for measuring proteins make it possible to see how these genomic alterations interfere
with the cell's normal workings.
"The Cancer Genomics Browser is fantastic in that it helps users display many different dimensions of clinical and...
DNA repair mechanisms relocate in response to stress
...nd resulted in a new level of understanding of the cell's response to genetic damage. The finding could lead to new targets for anti-cancer drugs that interfere
with DNA repair, says Paul Doetsch, PhD, professor of biochemistry, radiation oncology, and hematology and oncology at Emory University School of Medi...
Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
...y forcing tumor related receptors to shut down pro-growth signals, Weiner says.
"For years it has been presumed that the ability of antibodies to interfere
with malignant cell-related signaling is the dominant mechanism of anticancer activity, but we have also known that the normal job of an antibody is t...
Dancing 'adatoms' help chemists understand how water molecules split
...nergy's Pacific Northwest National Laboratory, who reported the team's results in March 6 issue of the Physical Review Letters . "This mobility might interfere
with some reactions and help others."
Bustling Bright Spots
While exploring titanium dioxide as a way to split water into its hydrogen and oxy...
Low levels of vitamin B12 may increase risk for neural tube defects
...r investigator in the Division of Epidemiology, Statistics, and Prevention Research. He added it is advisable for women with digestive disorders that interfere
with the absorption of foods to consult a physician before getting pregnant, to make sure they are receiving adequate amounts of B12.
Dr. Mills exp...
Einstein scientists receive $10 million NIH grant
... autophagy becomes less efficient with age, allowing protein and other cellular components to gradually accumulate inside cells and, almost certainly, interfere
with normal cell function.
The Einstein consortium is led by Ana Maria Cuervo, M.D., Ph.D., associate professor of developmental & molecular biolo...
Special issue of BMC Microbiology spotlights standardized language for describing microbes
... the animal pathogen Escherichia coli strains.
Many plant pathogens that draw their nutrition from living tissue have evolved sophisticated ways to interfere
with programmed cell death, an in-built suicide mechanism that kills infected plant tissue so the pathogen can no longer feed on it. One of the articl...
Capillary mats labor-saving, economical alternative to hand watering
...-up and maintenance than the capillary mats", but added that sprinklers are not a true alternative to hand-watering in a retail situation because they interfere
with customer traffic and retail workers.
LSUSHC researchers find potential new target for hypertension treatment
...s system where a network of brain stem cells adjust vascular resistance and heart rate. Action of a hypertensive hormone Angiotensin II is known to interfere
with that process.
First, the researchers demonstrated that chronically hypertensive mice showed dramatically decreased baroreceptor reflex sensiti...
New generation of orthopedic, dental and cardiovascular prostheses
... of cells on an implant is not ideal. For example, when using cardiovascular stents, it is important to limit the growth of certain cells in order not interfere
with blood flow. Also, in some cases, cells can form an undesirable capsule around dental implants causing them to fall. The scientists demonstrated t...
Rewrite the textbooks: Transcription is bidirectional
... itself is also likely to play an important role in regulation of gene expression. Transcribing one stretch of DNA might either help or in other cases interfere
with the transcription of a gene close by. Moreover, transcripts without a current purpose can serve as 'raw material for evolution' and acquire new f...
New infant feeding and obesity research adds insight to ongoing issue
...ternal factors include maternal health status, maternal care-giving, motherchild interactions or other health-related behaviors of the mother that may interfere
with determining the association of infant feeding and health outcomes and the strength of any possible associations. Additionally, he added that his...
Mutant host cell protein sequesters critical HIV-1 element
...oplasm, suggesting that it may serve some function in the cytoplasmic stage of the HIV-1 life cycle.
The ability of the Sam68 cytoplasmic mutant to interfere
with Nef correlated with its ability to induce stress granules in the cytoplasm. Stress granules regulate gene expression at the translational level i...
Biologists learn structure, mechanism of powerful 'molecular motor' in virus
Because herpes and other viruses contain similar DNA packaging motors, such findings could someday help scientists design drugs that would interfere
with the function of these motors and mitigate the result of some viral infections. The findings also could have other future applications, such as de...