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TRAPping proteins that work together inside living cells

RICHLAND, Wash. -- DNA might be the blueprint for living things, but proteins are the builders. Researchers trying to understand how and which proteins work together have developed a new crosslinking tool that is small and unobtrusive enough to use in live cells. Using the new tool, the scientists...

Peering inside the skull of a mouse to solve meningitis mystery

NEW YORK, Dec. 22, 2008 NYU Langone Medical Center scientists and their collaborators at the Scripps Research Institute in La Jolla, Calif., have discovered an unexpected cause for the fatal seizures seen in mice with viral meningitis, an infection of the central nervous system, according to a st...

New research lights up chronic bacterial infection inside bone

December 22, 2008, Cambridge, UK A new report demonstrates how a sensitive imaging technique gives scientists the upper hand in seeking out bacteria in chronic infections. Listeria monocytogenes is a type of pathogenic bacteria that can cause severe illness and death. Listeria outbreaks rece...

Red-eyed treefrog embryos actively avoid asphyxiation inside their eggs

Boston University undergraduate Jessica Rogge and associate professor Karen Warkentin, working at the Smithsonian Tropical Research Institute's laboratories in Gamboa, Panama, discovered that frog embryos at a very early developmental stage actively respond to oxygen levels in the eggas reported i...

Improving our ability to peek inside molecules

LIVERMORE -- It's not easy to see a single molecule inside a living cell. Nevertheless, researchers at Lawrence Livermore National Laboratory are helping to develop a new technique that will enable them to create detailed high-resolution images, giving scientists an unprecedented look at the at...

Kids: Book features inside scoop on soil

MADISON, WI, JULY 15, 2008 A new book from the Soil Science Society of America (SSSA) digs in the dirt to educate kids about the living world of soil. Soil! Get the Inside Scoop explores how soil is part of our life -- the food we eat, the air we breathe, the water we drink, the houses we live in,...

Scientists discover DNA knot keeps viral genes tightly corked inside shell

A novel twist of DNA may keep viral genes tightly wound within a capsule, waiting for ejection into a host, a high-resolution analysis of its structure has revealed. Using electron microscopy and three-dimensional computer reconstruction, UC San Diego biologists and chemists have produced the m...

A chilling glimpse inside the minds of dangerous criminals

After twenty-five years of investigating, analyzing, and interviewing serial killers, their family members, neighbors, and even surviving victims, criminologist and sociologist Jack Levin has become one of the worlds most respected experts on the motivations and modus operandi of dangerous crimina...

Nanotechnology and the media: The inside story

WASHINGTON--Is media coverage of nanotechnologys potential risks growing" If so, who or what is driving articles in national newspapers and newswiresenvironmental and consumer organizations, scientists, law makers, or industrial and financial groups" How do broadcast journalists decide to cover a...

Glue inside the cell

The acquired immune response is triggered after specific engagement of foreign peptides (antigens) by receptor molecules on white blood cell (lymphocytes). Cellular signaling pathways are responsible for the activation of lymphocytes. Krappmann and co-workers present evidence, that in T cells, whi...

New approach builds better proteins inside a computer

With the aid of more than 70,000 home computer users throughout the world, Howard Hughes Medical Institute (HHMI) researchers have, for the first time, accurately predicted the three-dimensional structure of a small, naturally occurring globular protein using only its amino acid sequence. The acco...

One species' entire genome discovered inside another's

Scientists at the University of Rochester and the J. Craig Venter Institute have discovered a copy of the entire genome of a bacterial parasite residing inside the genome of its host species. The finding, reported in todays Science, suggests that lateral gene transferthe movement of genes betwee...

Study finds blocking angiogenesis signaling from inside cell may lead to serious health problems

Angiogenesis inhibitors that block a tumors development of an independent blood supply have been touted as effective cancer fighters that result in fewer side effects than traditional chemotherapy. However, a new study by researchers at UCLAs Jonsson Cancer Center showed that one method of blockin...

Our brains make their own marijuana: We're all pot heads deep inside

U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines"everybody must get stoned" is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery, published online...

Crammed with charged DNA, pressure rises inside virus

It could be an artist’s depiction of someone’s stomach before and after a rather decadent meal. But it is a 3-D cryoelectron microscope reconstruction of the cross-section of a virus, before and after cramming itself full of its own DNA. The virus, phi29, has a tiny motor that pumps its DNA int...

Researchers wake up viruses inside tumors to image and then destroy cancers

Researchers have found a way to activate Epstein-Barr viruses inside tumors as a way to identify patients whose infection can then be manipulated to destroy their tumors. They say this strategy could offer a novel way of treating many cancers associated with Epstein-Barr, including at least four d...

Microbes start immune response by sneaking inside cells

Immune cells that are the body’s front-line defense don’t necessarily rest quietly until invading bacteria lock onto receptors on their outside skins and rouse them to action, as previously thought. In a new paper, University of Michigan scientists describe their findings that bacteria can barge in...

The molecular post office inside the cell

For most proteins, there is a particular place inside a cell where they carry out their function. But how do they get there? Scientists from the Charité Berlin, the University of Heidelberg, and the Max Planck Institute for Molecular Genetics in Berlin have now been able to visualize the structure...

Schepens scientists are first to discover angiogenesis switch inside blood vessel cells

Scientists at Schepens Eye Research Institute, an affiliate of Harvard Medical School, are the first to discover a switch inside blood vessel cells that controls angiogenesis (new blood vessel growth). The switch, they learned, is turned on and off by the balance between two enzymes (known as PI3K ...

Tiny shock absorbers help bacteria stick around inside the body

Bacteria have hair-like protrusions with a sticky protein on the tip that lets them cling to surfaces. The coiled, bungee cord-like structure of the protrusions helps the bacteria hang on tightly, even under rough fluid flow inside the body, researchers report in the journal PLoS Biology. A grou...

Clues to breast cancer hidden inside stem cells

Stem cells and how to boost them is hot on the research agenda. But stopping them could be critical too, as evidence implicating stem cells in cancer is mounting. In the human breast, up to 20 per cent of all tumours are now suspected to originate in stem cells. Now scientists from the Icelandic...

Common bacteria pirate natural mechanism to get inside cells

Bacteria and viruses utilize a natural mechanism to get inside cells and grow, researchers say. These pathogens gain entry the same way millions of receptors on the cell's surface routinely do after they get activated, says Dr. Yehia Daaka, professor and Distinguished Chair in Oncologic Patholog...

Cellular scale drug delivery from the inside out

Delivering a dose of chemotherapy drugs to specific cancer cells without the risk of side affects to healthy cells may one day be possible thanks to a nanoscale drug delivery system being explored by researchers at the U.S. Department of Energy's Ames Laboratory. Using tiny silica particles call ...

Scientists reveal how disease bacterium survives inside immune system cell

New research on a bacterium that can survive encounters with specific immune system cells has strengthened scientists' belief that these plentiful white blood cells, known as neutrophils, dictate whether our immune system will permit or prevent bacterial infections. A paper describing the research ...

Molecule that usually protects infection-fighting cells may cause plaque deposits inside arteries

A molecule that usually protects the body's infection-fighting cells might also contribute to fatty buildups that coat arteries and lead to heart disease, UT Southwestern Medical Center researchers have found. The molecule, called apoptosis inhibitor of macrophage or AIM, inhibits cell death in m...

Nano-Probes Allow an Inside Look at Cell Nuclei

Nanotechnology may be in its infancy, but biologists may soon use it to watch the inner workings of a living cell like never before. Scientists at the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) and Lawrence Livermore National Laboratory have developed a way to ...

Animal and plant communication at the ESA Annual Meeting

...xcluding birds from experimental plots in a temperate forest in Connecticut and surveying the density of generalist and specialist caterpillar species inside and outside the exclosures. In the exclosures, his team observed a surge in generalist density compared to natural areas. The number of specialists, h...

Scientists open doors to diagnosis of emphysema

... to emphysema. "We developed a tool which, for the first time, allows us to study MMP12 activity in specific cells, as if we were actually looking inside the lungs," says Carsten Schultz, whose group carried out the research at EMBL. The researchers designed a special fluorescent probe that essential...

August 2009 Geology and GSA Today media highlights

...one, revealing a change in the age of the sediment inside and outside the ring of cenotes, with the youngest sediment deposited inside the ring between about 6 and 2.3 million years ago...a terrain of near uniform strontium isotope ratios inside the cenote ring that will offer new possibilities ...

UC San Diego engineer provides insights to decades-old DNA squabble

...ciated with proteins in this complex aggregate we call chromatin," he added. "Undoubtedly, DNA codes for nearly all the proteins and RNAs manufactured inside our cells but how, when, and which genes are turned on and off is almost completely determined by the structure, dynamics, and chemical properties of ...

Parasites ready to jump

...th the fruitfly Drosophila melanogaster have now uncovered a new type of cellular defence that acts against DNA sequences present in high copy numbers inside the cell, even if they have not integrated into the genome. Small molecules of RNA (a class of nucleic acid closely related to the genetic material DN...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

...a nanoparticle, to the actual tumor site (peritoneum) with a basis for selective activity in the cancer cells (how the toxin genes were regulated once inside the cells). "A real plus of a cancer therapy like this is not just the functionality of the nanoparticle construct molecule, but the ability to de...

Jet-propelled imaging for an ultrafast light source

...ain the protein or virus in an aqueous environment inside the vacuum?" Shot from a microcannon The ...ir nozzle, liquid flows through a narrow capillary inside the tube through which the gas flows; the liquid i...ly molecules like proteins and viruses. DNA or RNA inside a virus is often packed differently in each virus,...

Naming evolution's winners and losers

...ig mysteries about biodiversity," Alfaro said. "Why these evolutionary losers are still around is a very hard thing to explain. They have been drawing inside straights for hundreds of millions of years. It's a real mystery to biologists how there can be any tuataras, given their low rate of speciation. They...

Stress signals link pre-existing sickness with susceptibility to bacterial infection

...heir own needs and survival requirements. By manipulating AMPK levels, scientists were able to directly influence the ability of bacteria to replicate inside of the single-celled organism, Dictyostelium . Striking similarities that exist between simple organisms like Dictyostelium and humans allow sci...

Warmer environment means shorter lives for cold-blooded animals

...ture. "You can think of an animal as a beaker in which chemical reactions are taking place," said Salinas. "The same rules that apply to a liquid inside a beaker should apply to animals. Chemists have a relationship for how an increase in temperature will speed up reaction rates, so the MTE borrows tha...

121 breeding tigers estimated to be found in Nepal

...009 in the Terai Arc Landscape (TAL) of Nepal both inside and outside the protected areas of Nepal. [TAL enc...rvey employed two methods - Camera Trapping method inside the protected areas and Habitat Occupancy survey both inside and outside the protected areas." According to ...

Results of national assessment of first responder location systems to be announced Aug. 3

...ue teammates who become lost, disabled, or trapped inside a building. Coupled with physiological monitoring ...r over-exhaustion and becoming lost or disoriented inside buildings as two of the top three leading causes o...ting people in three dimensions to within one foot inside buildings--this level of accuracy is necessary to ...

DOE-funded research projects win 46 R&D 100 Awards for 2009

...ge will make one of the world's most powerful electron microscopes even better by enabling atomic-scale imaging in 3-D. It holds and positions samples inside electron microscopes with unprecedented stability, position-control accuracy and range of motion. (Jointly with Attocube Systems, FEI Company and the ...

Parasitic worms make sex worthwhile

...phery, where the water is shallow. The ducks consume infected snails, but are not, as far as the scientists can tell, adversely affected by the worms. inside the ducks' enteric tracts, the worms reach adulthood and mate. The worms' eggs are excreted in the ducks' spoor, which often lands in the lake and sin...
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