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Inhibitors in Biological News

New research shows no link between aromatase inhibitors and cardiovascular problems

Berlin, Germany: New evidence has emerged that, contrary to some current fears, aromatase inhibitors (AIs) are not associated with an increased risk of heart problems in women who take them to prevent their breast cancer recurring. In a study presented today (Thursday) at the 6th European Breas...

COX-2 inhibitors significantly reduce risk of cancer

Results from a new, five-year study show that regular use of popular prescription pain relievers may reduce the risk of breast cancer by up to 71 percent and may offer similar benefit in the prevention of prostate, colon and lung cancers. The study findings were released today at the annual meet...

Enzyme inhibitors block replication of SARS virus

The study was conducted by researchers from Scripps Research; the Genomics Research Center, Academia Sinica, Taiwan; and the National Taiwan University. It is being published today in the journal Chemistry and Biology (Vol. 13, No. 3). Chi-Huey Wong is currently the Ernest W. Hahn Chair in Chemis...

Protease inhibitors reach beyond HIV

The immunodeficiency that arises in HIV may be due to excessive programmed cell death of immune CD4 T cells. HIV protease inhibitors (PI) can block programmed cell death in virus-infected T cells in vitro, but have also been shown to induce programmed cell death at higher concentrations. The mechan...

Anthrax inhibitors identified by Burnham team

A collaborative team of scientists led by The Burnham Institute's Maurizio Pellecchia, Ph.D., has identified inhibitors of the anthrax toxin, termed lethal factor ("LF") that could be developed into an emergency treatment for exposure to inhalation anthrax. These findings will be published by the P...

Breast Cancer May Be 'Uniquely Sensitive' To Inhibitors Of PI3K Pathway

"Because up to 75 percent of breast cancer patients have an abnormality in a specific cell signaling pathway, drugs that target different molecules along that pathway may be especially effective for treating the disease, says a researcher from The University of Texas M. D. Anderson Cancer Center." ...

Navigating in the ocean of molecules

...mediately demonstrated how efficiently the program works by discovering new inhibitors of pyruvate kinase. The inhibition of this enzyme is seen as a promising ap...ose biological activity is already known. "In this way, we tracked down new inhibitors for 2-lipoxygenase and the oestrogen receptor alpha," says Steffen Renner, ...

K-State researcher, collaborators study virulence of pandemic H1N1 virus

...tein; the other type includes drugs like Tamiflu that target the neuraminidase protein. He said that this pandemic H1N1 is already resistant to the M2 inhibitors but still is sensitive to Tamiflu. "Some pandemic flu isolates from humans have now shown resistance to the Tamiflu," Richt said. "So the big issue...

UCSF researchers identify new drug target for Kaposi's sarcoma

...oma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family of viruses, which for 20 years has been deem...he first place." Craik, who also led a team that identified HIV protease inhibitors in the late 1980s, said the " Nature Chemical Biology " paper validates thi...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...tion fits into normal development, aging, learning and memory as well as its role in cancer, obesity, depression and other disease. DNA methylation inhibitors already are under study at MCG and other centers for a variety of cancers and blood disorders. Because tumor cells that result from aberrant changes ...

UCLA researchers discover new molecular pathway for targeting cancer, disease

...avioral sciences at the David Geffen School of Medicine at UCLA. "This has great potential in offering other options, because current hedgehog pathway inhibitors have severe side effects which preclude their use in many cancer patients, especially children." Waschek also noted that this discovery may reve...

Flexible neck in cell-receptor DC-SIGN targets more pathogens

...Professor of Chemistry at the U. of I. "Once we begin to understand the molecular design rules that lead to this tight binding, we can begin to design inhibitors to block this interaction." To study the binding behavior of DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integri...

Toxin detection as close as an inkjet printer

...ensor on paper using a FujiFilm Dimatix Materials Printer. The researchers demonstrated the concept on the detection of acetylcholinesterase (AChE) inhibitors such as paraoxon and aflatoxin B1 on paper using a "lateral flow" sensing approach similar to that used in a home pregnancy test strip. The proce...

Possible drug target found for one of the most aggressive breast cancers

...nal Genomic Research Institute (TGen) in Phoenix, Arizona, which initiated an alliance with Van Andel Institute in February. "Since there are many new inhibitors of Met available for clinical trials, we now have a direct route for immediate application of these important findings in the care of patients with th...

Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action

...n of the first Phase I study with FX125L , an orally available small molecule which belongs to a new therapeutic class named Broad Spectrum Chemokine inhibitors ( BSCIs ). The Phase I, single ascending dose study was conducted in the United States. FX125L was well tolerated at all doses studied and no ser...

Protein can help cells or cause cancer, Purdue researcher finds

...rk was funded through a Howard Temin Award from the National Institutes of Health. Liu said the next step in the research is to test different Plk1 inhibitors to see how they affect the phosphorylation process. ...

Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease

...reproduction, securing a constant supply of blood and oxygen and ignoring signals to commit suicide, are all dependent on Hsp90. Experience with Hsp90 inhibitors already under study for cancer shows they tend to migrate to the highly active Hsp90 in tumors. He wants to block Hsp90 in cancer cells by learni...

UC Davis grant zeroes in on novel asthma diagnosis and treatment

...clinical trials on soluble epoxide hydrolase (sEH) inhibitors in asthma, which has recently been demonstrated as...Hammock lab researchers have demonstrated that sEH inhibitors are strongly synergistic with current asthma drugs: cycloxygenase inhibitors and several of the blockers of leukotriene biosynt...

Research uncovers clues to virus-cancer link

...ng in cancer, is a promising strategy for cancer prevention and treatment, since it is much more feasible to block viral infection or develop specific inhibitors of the viral genes than try to inhibit all of the genetic changes within a cancer. ...

Discovery of the cell's water gate may lead to new cancer drugs

...earch can have applications in cancer research and other fields. "The structure of the yeast aquaporin that we have determined can be used to create inhibitors for human aquaporins, and this may in the long term lead to drugs that slow the growth of a cancer tumour", says Karin Lindkvist. ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

...enzymes. Our group will be a leader in the study of these important enzymes," Sobrado said. "If we can learn how it functions, we can perhaps identify inhibitors that can be developed as antibiotics or antifungal agents," he said. "Since humans do not have siderophores, an inhibitor should not be toxic to us." ...

Universitat Autonoma de Barcelona researchers first to clone mice in Spain

... the enzyme histone deacetylase, located at the cell nucleus where the DNA is found. Research carried out until now has shown that histone deacetylase inhibitors seem to contribute to an increase in levels of gene expression, which would favour the reprogramming of the somatic cell nucleus transferred to the oo...

Muscle atrophy through thick but not thin

...ays, because the enzyme is responsible for degrading only some muscle components, whereas others fall victim to other ubiquitin ligases and autophagy. inhibitors that work upstream to block signals that activate ubiquitin ligases and initiate autophagy are a better bet. ...

'Shock and kill' research gives new hope for HIV-1 eradication

...ial means. They write, "This can be achieved using inhibitors of histone deacetylases (HDACs), which are a class...s. Moreover, at non-toxic quantities, class I HDAC inhibitors were able to induce the 'awakening' of a portion o...hat BSO recruited cells non-responsive to the HDAC inhibitors into the responding cell population. An important ...

REGiMMUNE presents enhanced efficacy data in preclinical transplantation models

...tion. The results indicate the potential of RGI-2001 to be a key component of a novel tolerance induction regimen, avoiding the use of calcineurin inhibitors that are not only associated with high toxicity but suppress Treg activity. The finding suggests the possibility to develop a pharmacological approach...

A longer lasting tumor blocker

...fter treatment was stopped. Kubota and his team compared the efficacy of inhibitors against M-CSF and VEGF in mice with a certain kind of bone tumor. Three wee...d suppressed in the absence of drug. Another distinction between the two inhibitors was the type of vessel growth that was blocked. Blocking VEGF prevented dan...

Details of bacterial 'injection' system revealed

... engine to drive injection. These are important steps toward developing a detailed understanding of how the injection machine works, and to developing inhibitors that can prevent bacterial infections. Although STEM was built more than 25 years ago, it remains a state-of-the-art tool for accurately determinin...

New hope for advances in treating malaria

...arum is unable to grow and therefore it dies. The inhibitors developed at Leeds bind to the DHODH enzyme in the...ntrating our studies on it we can develop chemical inhibitors that have a negative impact on the parasite withou...search is to develop a larger collection of potent inhibitors and to see how these chemicals work alongside comm...

Newly discovered epidermal growth factor receptor active in human pancreatic cancers

...pancreatic cancers cannot be a one-size-fits-all target for treatment. Earlier studies in other laboratories and clinical trials already had tried EGF inhibitors as a treatment for pancreatic cancer and concluded that they did not work. When Dr. Pandey's collaborators allowed them to re-examine their samples, t...

Male impotence drugs may deserve a second look in women

...al in the 40 percent of women who report sexual dysfunction, researchers say. In one of the first studies of the effect of phosphodiesterase Type 5 inhibitors - Viagra, Levitra and Cialis - on the pudendal arteries that supply the penis, vagina and clitoris the blood needed to produce a satisfying sexual exp...

NIH funds development of resistance-breaking insecticides to reduce malaria transmission

...red out how to inhibit target site-resistant mosquito AChE and demonstrated this effect in vitro," said Carlier. "The challenge now is to modify these inhibitors so that they can make their way into the mosquito's brain and thus exert the desired insecticidal action." The new insecticides should also be les...

Corrosion-inhibiting coatings containing 'good' bacteria

...is estimated that corrosion costs the UK around 3-4% of GDP. Existing anti-corrosion treatments are costly, ineffective and often include biocides and inhibitors that are toxic to aquatic life. The corrosion-preventing bacteria occur naturally in the environment. Incorporating its spores into the coating di...

Skin cancer study uncovers new tumor suppressor gene

...y tumors express high levels of MMP enzymes, researchers have spent decades pursuing MMPs as promising targets for cancer therapies. However, when MMP inhibitors were tested in people with a wide range of cancers, the drugs failed to slow -- and in some cases even sped up -- tumor growth. Now, it turns out t...

New high-throughput screening technique makes probing puzzling proteins possible

...he molecules these proteins interact with, and for inhibitors that might block, the proteins' activity. Already,...e Biotechnology , has allowed the team to identify inhibitors for two enzymes thought to play significant roles ...gh-throughput screening system. Once effective inhibitors have been identified through the new technique, re...

UC Davis bench-to-bedside research: Promising treatment in clinical trials

... but no one else was. When we finally found potent inhibitors for the enzyme that worked in whole animals, we ha...timize the potency and drug properties of the s-EH inhibitors to the stage where we could present a convincing p...ock said. "The chemistry developed around the s-EH inhibitors allows us to make powerful but inexpensive drugs t...

New drug agent knocks out multiple enzymes in cancer pathway

...ompound that would inhibit multiple enzymes in the tumor cell survival pathway, rather than just one, an approach analogous to the use of multi-kinase inhibitors in cancer therapy. Andrew Wang, of Academia Sinica, Taipei, and Illinois chemist Rong Cao began by producing crystallographic structures of the tar...

HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection

... Researchers at the Tulane University School of Medicine, New Orleans, Louisiana have discovered that the HIV-1 protease inhibitors (PIs), such as nelfinavir included in highly active antiretroviral therapy (HAART) regimen for the treatment of HIV-1 patients, induce deleterious eff...

Alzheimer's disease therapeutic prevents long-term damage from TBI in pre-clinical studies

...meant they were incapable of producing amyloid. They also treated "normal" mice with the experimental agent DAPT, one of the first gamma secretase inhibitors developed and the model upon which some Alzheimer's disease drugs now in clinical testing are based. As a result, amyloid peptide production was subst...

The genetics of fear: Study suggests specific genetic variations contribute to anxiety disorders

...yme COMT. Serotonin is a brain chemical involved in mood regulation. The serotonin transporter, which is the target of selective serotonin reuptake inhibitors (SSRI) used to treat anxiety and depression, harbors a common polymorphism in its gene. This polymorphism can come in two different versions that diff...

Scripps research team identifies key molecules that inhibit viral production

...o develop therapeutic strategies against HCV have concentrated on designing inhibitors that target several of the 10 HCV proteins that comprise the virus, includi...ng these protein-protein interactions with the specific goal of identifying inhibitors of the core dimerization, which would block virus production. "People h...
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