Rethinking the genetic theory of inheritance
Embargoed Until January 18, 2009 at 18:00 Greenwich Mean Time / 13:00 Eastern Standard Time (TORONTO): Scientists at the Centre for Addiction and Mental Health (CAMH) have detected evidence that DNA may not be the only carrier of heritable information; a secondary molecular mechanism called epigen...
Political participation is partially rooted in genetic inheritance
The decision to vote is partly genetic, according to a new study published in the American Political Science Review. The research, by James H. Fowler and Christopher T. Dawes, of the University of California, San Diego and Laura A. Baker, of the University of Southern California, is the first to ...
Scientists clarify a mechanism of epigenetic inheritance
Although letters representing the three billion pairs of molecules that form the rungs of the helical DNA ladder are routinely called the human genetic code, the DNA they comprise transmits traits across generations in a variety of ways, not all of which depend on the sequence of letters in the co...
Two central mysteries in genome inheritance solved at UCSD
The dance of the chromosomes during cell division, first described in the late 1800s and familiar to all high-school students from movies shown in biology classes, has long fascinated biologists. However, the molecular nature of a key component of cell division, the "chromosome-spindle" connection...
Key mechanism in genetic inheritance during cell division identified
A key mechanism in the passing of genetic material from a parent cell to daughter cells appears to have been identified by a team of Berkeley researchers. Their study may explain how a complex of proteins, called kinetochores, can recognize and stay attached to microtubules, hollow fibers in the wa...
Plants defy Mendel's inheritance laws, may prompt textbook changes
Contrary to inheritance
laws the scientific world has accepted for more than 100 years, some plants revert to normal traits carried by their grandparents, bypassing genetic abnormalities carried by both parents.
These mutant parent plants apparently have hidden templates containing genetic inform...
Scientists discover gene mutation responsible for hereditary neuroendocrine tumor
...oviding strong evidence that hSDH5 is the PGL2 gene. The seven individuals who inherited the mutation from their mothers are unaffected, suggesting an inheritance
pattern that is specific to the parent of origin.
The researchers also discovered that, as in yeast, the inactivation of hSDH5 dramatically impaire...
New test can detect both genetic and chromosomal abnormalities in embryos
...told a news briefing: "Karyomapping is a universal method for analysing the inheritance
of genetic defects in the preimplantation embryo without any prior patient ... development, which often delays patient treatment. For the first time, the inheritance
of both single gene defects and chromosomal abnormalities can be detected s...
Further gene mutations linked to autism risk
... Pieces in the complex autism inheritance
puzzle are emerging in the latest study from a research team including geneticists from the University of Pennsylvania School of Medicine and The Chil...
First comprehensive guidelines for managing medullary thyroid carcinoma published in Thyroid journal
...t University of Massachusetts Medical School, in Worcester. "This form of thyroid cancer is especially important because of its high mortality, strong inheritance
patterns, and associations with other serious glandular disorders. These evidence-based guidelines will become a benchmark for patient management and ...
100 reasons to change the way we think about genetics
...lists over 100 well-documented cases of epigenetic inheritance
between generations of organisms, and suggests that non-DNA inheritance
happens much more often than scientists previously...e suspected for years that some kind of epigenetic inheritance
occurs at the cellular level. The different kinds ...
For cancer cells, genetics alone is poor indicator for drug response
... to do with genetics.
"Genetics are permanently heritable, while these protein levels are temporarily heritable," says Sorger. "But this temporary inheritance
can make all the difference in the world when it comes to the effectiveness of certain medications."
These findings are published April 12 online i...
Redefining what it means to be a prion
...on proteins in yeast and have further clarified the role prions play in the inheritance
of both beneficial and detrimental traits.
"The big debate in the field ...ay researchers view prions, from biological anomalies to mediators of trait inheritance
and adaptations to fluctuating environments.
work shifts the way researche...
Why didn't Darwin discover Mendel's laws?
... Mendel solved the logic of inheritance
in his monastery garden with no more technology th... variation is the last place where clean Mendelian inheritance
can be seen," says Howard. "Darwin boxed himself in, unable to see the laws of inheritance
in continuous variation, unable to see the real im...
Mixed population provides insights into human genetic makeup
...npoint genes that influence the shape of the human face and head, Shriver began with an online database of genes linked to disease -- Online Mendelian inheritance
of Man. If the symptoms of the disease involved the face or skull the gene implicated in the disease became a candidate for those facial traits.
Biologists solve mystery of black wolves
...wolves of Yellowstone represent an unparalleled population for studying the inheritance
of traits," Wayne said. "In Yellowstone, we have followed very precisely the inheritance
of coat color throughout the entire wolf population and document that coat ...
Eating eggs when pregnant affects breast cancer in offspring
... A stunning discovery based on epigenetics (the inheritance
of propensities acquired in the womb) reveals that consuming cholinea nutrient found in eggs and other foodsduring pregnancy may significantly affect ...
Study identifies genetic variants giving rise to differences in metabolism
...individuals and compared it to their genetic inheritance.
The results suggest that most individuals carry one or more risk alleles in their genetic inheritance
that may determine a certain medical phenotype, the response to a given drug treatment, or the reaction to a nutritional intervention or environmental...
CSHL scientists discover a new way in which epigenetic information is inherited
... offspring in fruit flies.
A new mechanism of inheritance
In a paper to be published on Nov 27th in Sci...ting a silencing response against transposons.
via small RNAs
Hannon likens this protection t...ns to be seen whether this mechanism of epigenetic inheritance
is found in organisms besides fruit flies. "Small ...
Kidney function discovery sheds light on genetic complexity of disease
...ed to high blood pressure, kidney stones, deafness and problems in the brain.
"Iminoglycinuria was observed to occur in families and the pattern of inheritance
suggested that the cause might be due to an inherited abnormality of a specific pump on the surface of kidney cells," Professor Rasko explains.
Important new hair-loss gene discovered
The results reveal that more than one gene is involved in the development of male hair-loss. These results also throw interesting light on the inheritance
of baldness in that hitherto the only known risk gene for the androgen receptor lay on the X-chromosome, and was thus inherited from the mother which...
Egalitarian revolution in the Pleistocene?
...en more surprisingly, under certain conditions (which include some cultural inheritance
of social networks) a single alliance comprising all members of the group c...uld increase father-son social bonds or an increase in fidelity of cultural inheritance
of social networks. Interestingly, the fact that mother-daughter social bon...
New research suggests diabetes transmitted from parents to children
...nal of Lipid Research suggests an unusual form of inheritance
may have a role in the rising rate of diabetes, es...re just starting to understand additional kinds of inheritance
like metabolic programming, which occurs when an i...g but earlier research has shown that this kind of inheritance
is at work in humans. For example, there is an inc...
Large reservoir of mitochondrial DNA mutations identified in humans
...rial DNA mutations in the general population, for example, have depended on identification of clinically affected patients and subsequent retracing of inheritance
on the maternal side of the family. This approach fails to detect the gradual accumulation of mutations in some members of the population, including t...
Can you be born a couch potato?
...a at Charlotte kinesiologist J. Timothy Lightfoot announced that they had found six specific chromosomal locations that significantly correlate to the inheritance
of a trait of high physical activity in mice, indicating that at least six genetic locations were affecting activity. Now, in a study forthcoming in T...
Charcot-marie-tooth disease research funding
...ase or CMT.
CMT is the most common inherited neuromuscular disease, affecting as many as one in every 2,500 individuals. CMT usually shows dominant inheritance
and symptoms generally appear during adolescence or young adulthood. It is characterized by degeneration of long motor and sensory axons, which result...
New gene discovered for new form of intellectual disability
... this mutation was found on the autosome (The 22 pairs of non-sex chromosomes, that make up the 46 chromosomes in the human body). Autosomal-recessive inheritance
(where both mother and father carry a gene mutation on one chromosome, but both maternal and paternal copies must be passed on to the offspring to cau...
Computation to unravel how genes are regulated and shed light on how cells become different
...ough changes in their expression is fundamental to development of organisms, along with their structure and function during their lifetime, as well as inheritance
of adaptations to environmental factors.
Team finds an economical way to boost the vitamin A content of maize
...luence production of the precursors of vitamin A. They also used association mapping, which involves studying variation in selected genes and tracking inheritance
patterns to see which form of a gene coincides with the highest provitamin A content. Polymerase chain reaction (PCR) allowed them to amplify and sequ...
Mom's obesity during conception phase may set the stage for offspring's obesity risk
...ght. Studies also show that greater body-weight at birth and weight gain early in life increases the risk of becoming overweight or obese as an adult. inheritance
studies show that a child's body mass index (BMI) correlates more closely with the mother's BMI than with it's father's, suggesting that an interactio...
Simple reason helps males evolve more quickly
... and director of UFs Graduate Program in Genetics and Genomics. The mode of inheritance
in males involves simpler genetic architecture that does not include as man...numbers of offspring.
Relationships between gene expression and modes of inheritance
have been addressed before, but this study analyzed an extremely large data...
From GM farm animals to embryonic stem cell research
...wers, Tomorrows Questions gives us a chance to examine the latest findings on how genomics - which embraces a whole range of biological processes from inheritance
to development and beyond - is impacting on peoples lives.
The work of the ESRC Genomics Network spans the whole field - covering areas as diverse...
Surprise in the organic orchard -- a healthier worm in the apple
...concentrations" explains the leader of the research team.
"This means of inheritance
offers the quickest possible way for the insects to evolve resistance" says...ng for the future in response to this alarming result. In parallel with the inheritance
studies, several new isolates of the codling moth granulovirus have been sc...
The importance of gene regulation for common human disease
...stablished cell cultures from participants from four populations as well as, for some samples, information from families, which can help to understand inheritance
of genetic variation. The team used these resources to study gene activity in the cell cultures and tie that to DNA sequence variation
We have gen...
Exploring the dark matter of the genome
...Karpen notes that one intensively studied and puzzling problem in chromosome biology will benefit enormously from the new findings: epigenetics -- the inheritance
of traits and genetic information as controlled by proteins associated with the chromosomes, rather than by DNA sequence. Starting in the 1920s, epige...
Latent memory of cells comes to life
...f these changes can be that a latent capacity that was dormant comes to life, or, conversely, that a previously active capacity shuts down.
In the practical experiment molecular biologists used a mutant of a yeast cell which was bi-stable, in that it could become eit...
Researchers identify gene involved in dog size
...rector of the NHGRI Division of Intramural Research. “Discoveries like this illustrate the exciting promise of genomics research for understanding the inheritance
of a wide range of traits, including those that have an impact on health and disease.?
The branch of the canine family tree that includes domestic...
Analysis of rhesus monkey genome uncovers genetic differences with humans, chimps
...ue populations, and developed a set of 'single nucleotide polymorphisms' or SNPs (single base DNA differences) that can be used for future analysis of inheritance
of biomedically important traits in rhesus. The rhesus genomic DNA samples used for these studies were contributed by the California NPRC, Oregon NPR...
Scripps research study reveals structural dynamics of single prion molecules
Intriguingly, certain prions and amyloids can play beneficial roles. The subject of the new study, Sup35, enables protein-based inheritance
in yeast. When this prion protein misfolds, it converts into self-perpetuating amyloid fibrils, thus altering its function in an inheritable manner. T...
Fruit fly gene research may shed light on human disease processes
...gnal the fly to be female, and one X chromosome means it will be male."
A chromosome is a single DNA molecule that may contain different units of inheritance
called genes, along with proteins that help to activate these genes under certain conditions.
Even though it is the presence or absence of the h...