New trigger for chronic inflammation in rheumatoid arthritis discovered
A signal molecule made by the human body that triggers the immune system into action may be important in rheumatoid arthritis, according to new research published today in Nature Medicine . The authors of the study, from Imperial College London, say that if scientists could block this signal, it ...
Key protein regulating inflammation may prove relevant to controlling sepsis
Scientists at Singapore's Institute of Molecular and Cell Biology (IMCB), under the Agency for Science, Technology and Research (A*STAR), have identified the protein, WIP1, as the molecular "brake" that curbs severe inflammation
in the body.
The findings may prove relevant to developing m...
Vitamin D deficiency related to increased inflammation in healthy women
COLUMBIA, Mo. According to a recent study in the Archives of Internal Medicine, 75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri ...
Jefferson scientists discover a key protein regulator of inflammation and cell death
(PHILADELPHIA) Reporting in the journal Nature , researchers led by Emad Alnemri, Ph.D., professor of Biochemistry and Molecular Biology in the Kimmel Cancer Center at Jefferson, discovered a key protein component involved in inflammation.
The protein, AIM2 (absent in melanoma 2), is involved...
Vitamin C lowers levels of inflammation biomarker considered predictor of heart disease
Berkeley -- A new study led by researchers at the University of California, Berkeley, adds to the evidence that vitamin C supplements can lower concentrations of C-reactive protein (CRP), a central biomarker of inflammation
that has been shown to be a powerful predictor of heart disease and diabet...
Failure to bridle inflammation spurs atherosclerosis
When a person develops a sore or a boil, it erupts, drawing to it immune system cells that fight the infection. Then it resolves and flattens into the skin, often leaving behind a mark or a scar.
A similar scenario plays out in the blood vessels. However, when there is a defect in the resolutio...
Apolipoprotein(a): A natural regulator of inflammation
In a study to be published in the January 09 issue of Experimental Biology and Medicine , Hoover-Plow and co-workers in seeking to define a role of apo(a) in leukocyte recruitment have identified a novel activity of apo(a) apolipoprotein that may function as a natural and cell specific suppressor...
Vitamin E shows possible promise in easing chronic inflammation
With up to half of a person's body mass consisting of skeletal muscle, chronic inflammation
of those muscles which include those found in the limbs can result in significant physical impairment.
According to University of Illinois kinesiology and community health professor Kimberly Huey, past...
LIAI launches new division to look at novel approaches to heart disease and inflammation
SAN DIEGO (September 30, 2008) While cholesterol-lowering drugs and new technologies have significantly advanced the nation's battle against heart disease, it continues to rank as the No. 1 killer of U.S. men and women. But if researchers at the La Jolla Institute for Allergy & Immunology (LIAI)...
Brain inflammation may be friend, not foe, for Alzheimer's patients Inflammation
in the brain may not be so bad after all when it comes to Alzheimer’s disease.
In the June 1 issue of the Journal of Clinical Investigation, a team of scientists from the University of Rochester Medical Center shows that a key inflammatory regulator, a known villain when it comes t...
Antibody signal may redirect inflammation to fuel cancer
As evidence mounts that the body's normally protective inflammation
response can drive some precancerous tissues to become fully malignant, UCSF scientists report discovering an apparent trigger to this potentially deadly process.
Typically, the "innate" immune system's Pac-Man-like white blood ...
Researchers create mouse lacking key inflammation gene
In a paper published yesterday in The Proceedings of the National Academy of Science (PNAS), researchers from Boston University School of Dental Medicine generated a mouse model exhibiting reduced inflammation.
The Boston University researchers found that the transcription factor LITAF (Lipopol...
Bare metal stents deliver gene therapy to heart vessels with less inflammation in animal studies
Improved materials may allow stents, tiny metal scaffolds inserted into blood vessels, to better deliver beneficial genes to patients with heart disease, by reducing the risk of inflammation
that often negates initial benefits. The new technique, using a compound that binds in an extremely thin lay...
Scientists pinpoint inflammation gene
Discovery has implications for wide range of diseases
A team of international researchers has discovered that a specific gene on chromosome 15 regulates inflammation, a finding with implications for a wide range of disorders, including cancer, cardiovascular disease, diabetes, obesity, Alzheimer...
Study reveals genomics of inflammation from severe injury
Could improve prediction of patient outcomes, lead to tailored treatmentsWhen it comes to inflammation, too much of a good thing can be deadly. In some severely injured patients, this normal healing process can develop into a lethal, whole-body response, including bloodstream infection (sepsis) and...
New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
A key obstacle to early detection of type 1 diabetes - as well as to rapid assessment of the effectiveness of therapeutic intervention - has been the lack of direct, non-invasive technologies to visualize inflammation
in the pancreas, an early manifestation of disease. Instead, clinicians have had ...
Ibruprofen and other commonly used painkillers for treating inflammation may increase the risk of heart attack
When it comes to the deadly skin cancer melanoma, studying functional tissue rather than cell lines may better provide insight into the disease's development, according to new research from a Howard Hughes Medical Institute predoctoral fellow at Stanford University School of Medicine.
VCU study shows hormone-like molecule kills cells that cause inflammation in allergic disease
Virginia Commonwealth University immunologists studying mast cells, known to play a central role in asthma and allergic disease, have identified a hormone-like molecule that can kill these cells by programming them to die in studies with mice.
The findings move researchers another step closer to...
Navigating in the ocean of molecules
...earcher at the Max Planck Institute and now an employee of the Novartis pharmaceutical concern. 5-lipoxygenase is a target protein in the treatment of inflammation
and bladder cancer, while the oestrogen receptor alpha is an important starting point in the treatment of breast cancer.
"Scaffold Hunter is a key ...
NIH stimulus funding supports Emory biomedical scientists
...aluates risk factors connected with heart disease in women such as: depression and history of trauma and biological changes in the heart and brain and inflammation
in response to stress.
Pediatric heart development:
Children's hearts respond differently to medications and surgery than adults' hearts, and more ...
Neuropathic pain: The sea provides a new hope of relief
...is that this new compound could be a candidate.
Recent research suggests inflammation
in the nervous system is a major causative factor for this condition. inflammation
activates supporting cells, such as microglia and astrocytes, that surround...
Scientists open doors to diagnosis of emphysema
...pplying this test to samples of lung cells from a mouse model of acute lung inflammation
showed that MMP12 activity in macrophages was indeed increased.
Althoug... the new testing strategy can be extended to other enzymes involved in lung inflammation
and that, with a better picture of the processes underlying these diseases,...
Scientists uncork a potential secret of red wine's health benefits
...rvivors of sepsis develop a very low quality of life due to the damage that inflammation
causes to several internal organs. The ultimate goal of our study was to i...from inflammation. They found that resveratrol used a one-two punch to stop inflammation
in the mice by preventing the body from creating two different molecules kn...
Nanodiamonds deliver insulin for wound healing
...elerates wound healing by acting as a growth hormone. It encourages skin cells to proliferate and divide, restores blood flow to the wound, suppresses inflammation
and fights infection. Earlier investigations have confirmed an increase in alkalinity of wound tissue, due to bacterial colonization, to levels as hig...
Placenta-derived stem cells may help sufferers of lung diseases
...membrane-derived cells as a therapeutic tool for disorders characterized by inflammation
and fibrosis is supported in previous studies," says Dr. Ornella Parolini, ...do confer benefits for bleomycin-induced lung injury. While the severity of inflammation
did not show an overall reduction, there was a marked reduction in neutroph...
Discovery to aid in future treatments of third-world parasites
...years) and dwell within blood vessels, where they produce eggs that become the focus of intense, chronic inflammatory responses. In severe cases, this inflammation
is associated with life-threatening liver disease.
No vaccine is currently available to prevent schistosomiasis. Options for treating the disease ...
Common allergy drug reduces obesity and diabetes in mice
...abolic and immune systemsin this case, controlling inflammation
in fat tissue. Fat tissue from obese and insulin-r...rbage" into the tissue. This can result in chronic inflammation
that causes asthma and certain allergies.
As S...elson, an endocrinologist. "It's possible that the inflammation
caused by macrophages results in insulin resistanc...
New drug may reduce heart attack damage
...th Wales (UNSW) have shown.
The drug, known as Dz13, specifically targets and neutralises the master regulator c-Jun gene, which is responsible for inflammation
and muscle death in the aftermath of a heart attack, trials in preclinical models have found.
The drug also reduces incidental cell and tissue dea...
Newly discovered gene fusion may lead to improved prostate cancer diagnosis
...of care, yet it is not accurate enough to predict prostate cancer, because many men may have an elevated PSA level, but have benign conditions such as inflammation
of the prostate."
It is important to distinguish harmful cancer from non-lethal diseases, such as benign prostatic hyperplasia, or enlarged prostat...
Stop and smell the flowers -- the scent really can soothe stress
...the new study, Akio Nakamura and colleagues note that people have inhaled the scent of certain plants since ancient times to help reduce stress, fight inflammation
and depression, and induce sleep. Aromatherapy, the use of fragrant plant oils to improve mood and health, has become a popular form of alternative me...
Early-life experience linked to chronic diseases later in life: UBC research
... National Academy of Sciences , shows that among subjects with low early-life socioeconomic circumstances, there was evidence that genes involved with inflammation
were selectively "switched-on" at some point. Researchers believe this is because the cells of low-SES individuals were not effectively responding to ...
LSUHSC's Bazan awarded ARRA grant to preserve vision
...azan's research project explores the mechanisms of inflammation
and repair during corneal wound healing. Sustained corneal inflammation
may lead to destruction and corneal ulceration, but inflammation
is a component of the corneal wound healing proces...
Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging
...) that is a promoter of cell division. Hence, IGF is required for normal embryonic and postnatal growth. But IGF also is associated with tumor growth, inflammation
and cardiovascular disease in adults. By deleting PAPPA, the researchers were able to control the availability of IGF in tissues and dampen its many i...
New lab test offers better prediction of HIV microbicide safety
...ng the epithelial barrier.
"Our findings strongly suggest that microbicides can increase the risk of HIV infection through a mechanism other that inflammation
namely, by disrupting the protective epithelial cell barrier," says Dr. Herold. "If confirmed by further study, this assay should be used early on to...
Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients
... were differentially expressed between IPF patients who had accelerated disease and those who were stable."
There was no evidence that infection or inflammation
was the cause of disease acceleration, he noted. Instead, there were indications that the cells of the alveolar epithelium, which is the tissue that c...
Natural compound stops retinopathy
The discovery of the compound's function in inflammation
and blood vessel formation related to eye disease ...lindness.
Oklahoma researchers found that this inflammation
and leakage is caused by an imbalance of two syste...nt in research models stopped the leakage, blocked inflammation
and kept unwanted blood vessels from growing. Rese...
Gene expression findings a step toward better classification and treatment of juvenile arthritis
... a diagnosis of JIA is imprecise and based largely on the presence of joint inflammation
persisting for at least six weeks, for which no other cause can be determin...affecting five or more joints), systemic arthritis (with fever and rash and inflammation
throughout the body) and enthesitis-related arthritis (affecting the juncti...
Ovarian transplantation: First baby is born after a new technique
...ir ovaries frozen. In addition to the first patient, treated for sickle cell anaemia, the second patient had been treated for periarteritis nodosa, an inflammation
of medium-sized arteries, which become swollen and damaged from attack by rogue immune cells.
"She suffered menopause for eight and a half yea...
Tummy troubles -- gastrin key in bacterial-induced stomach cancer
...d's population is infected with Helicobacter pylori , which causes chronic inflammation
of the stomach lining and is strongly linked to the development of gastric ...es induced by Helicobacter infection, and modulated by gastrin, that link inflammation
and cancer. In addition, they plan to study the role of other non- Helicoba...
NIH expands Human Microbiome Project; funds sequencing centers and disease projects
...r from ulcerative colitis, a type of inflammatory bowel disease that causes inflammation
and sores in the lining of the rectum and colon, are treated with surgical ... patient with bowel movements. For unknown reasons, some, patients develop inflammation
of the pouch, necessitating further surgery. This research will determine ...