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Almost 7 million pregnant in sub-Saharan Africa infected with hookworms; at risk of anaemia

A study published today in the open-access journal PLoS Neglected Tropical Diseases reveals that between a quarter and a third of pregnant women in sub-Saharan Africa, or almost 7 million, are infected with hookworms and at increased risk of developing anaemia. Hookworms are parasitic worms whi...

Herpes drug inhibits HIV in patients infected with both viruses

This release is available in French . Researchers at the U.S. National Institutes of Health (NIH), McGill University and other institutions have discovered how a simple antiviral drug developed decades ago suppresses HIV in patients who are also infected with herpes. Their study was publi...

Anti-herpes treatment reduces HIV levels in women infected with both viruses

Experts call for HSV control measures, including vaccine, to rank high on international HIV prevention and research agenda as exciting trial findings are published Treating women who are infected with both the HSV-2 and HIV viruses with anti-herpes treatment can reduce the amount of HIV in the bl...

Higher risk for cervical cancer seen among women infected with multiple HPV types

Although doctors have known that the cervical tissue at the opening to the womb can harbor multiple HPV types, this study is the first to document that the risk for developing cervical cancer, the second most common form of cancer in women worldwide, is higher in females infected with multiple HPV ...

Treating populations infected with HIV and latent TB could speed the emergence of drug-resistant TB

In 2005, 46 regional Ministers of Health in Africa declared that a dramatic rise in tuberculosis (TB) cases was cause for emergency. In some African countries, annual TB case notifications have increased as much as four-fold over the past 15 years. The main culprit? The emergence of HIV. When indiv...

Viral protein helps infected T cells stick to uninfected cells

New research shows that a protein made by a cancer virus causes infected immune cells to cling to other immune cells, enabling the virus to spread. The virus, the human T lymphotropic virus type 1 (HTLV-1), is transmitted mainly when infected cells known as T lymphocytes, or T cells, touch uninf...

Mosquitoes are more attracted to individuals infected with malaria

Malaria remains a devastating problem in Africa and understanding the factors affecting its transmission remains a crucial part of the effort to combat the disease. A new study published in the premier open access journal PLoS Biology conducted in Western Kenya by Jacob Koella and colleagues now re...

Rats infected as newborns grew up vulnerable to memory problems during an immune challenge

Underscoring the value of good prenatal care, new research suggests that early infection may create a cognitive vulnerability that appears later during stress on the immune system. Researchers at the University of Colorado at Boulder have reported that rats who experienced a one-time infection as n...

First human gets new antibody aimed at hepatitis C virus

...s for Disease Control and Prevention, 3.2 million Americans are chronically infected with HCV and some 10,000 die annually of the disease. Globally, as many as...eatment; however, in nearly all cases the patient's new liver is eventually infected by HCV because the virus remains in the patient's bloodstream during surger...

Pinhead-size worms + robot = new antibiotics

...test would involve screening of potential new antibiotics in living animals infected with bacteria to see the effects on the entire body of the animal. Th...test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threate...

Pitt researchers find promising candidate protein for cancer prevention vaccines

... a childhood viral infection, when inflammatory responses are strong. Cells infected with chicken pox virus, for example, look very much like tumor cells becaus...st protein, which ultimately gets shown to the immune system as a marker of infected cells that must be destroyed. "Because cyclin B1 is a 'self' protein, th...

K-State researcher, collaborators study virulence of pandemic H1N1 virus

... is done by creating diagnostics that detect antibodies produced by animals infected with the virus. "We do this work to protect the pig industry in case the...w is if these Tamiflu-resistant strains take over, we have no drug to treat infected patients. And because we don't have a vaccine yet in the United States, thi...

Stress signals link pre-existing sickness with susceptibility to bacterial infection

...d energy regulation, and in this case, the association between energy regulation and susceptibility to infection. Like humans, Dictyostelium can be infected by Legionella and quickly responds by producing a host of metabolism-associated proteins. Another similarity between humans and Dictyostelium is ...

Nanodiamonds deliver insulin for wound healing

... bound firmly to the tiny carbon-based nanodiamonds, is released when it encounters basic pH levels, similar to those commonly observed in bacterially infected wounds. These basic pH levels are significantly greater than the physiological pH level of 7.4. The results of the study were published online July...

Disease threat may change how frogs mate

...-up of populations, and indicates that wild frog populations that have been infected with this virus may be choosing mates differently to those in healthy populations. As Ranavirus is typically associated with heavy death tolls in infected populations, there are often few frogs left alive to mate. This frequently ...

Researchers capture bacterial infection on film

...hat allows them to make a movie of bacteria infecting their living host. Whilst most studies of bacterial infection are done after the death of the infected organism, this system developed by scientists at the University of Bath and University of Exeter is the first to follow the progress of infection in r...

In vitro antibody production enables HIV infection detection in window period -- key to safer blood

...ion of potentially infectious blood units which were missed by regular HIV serology. Interestingly, the ratio of missed infections among the total HIV infected blood donors was higher among the younger (high-school) donors versus adult donors. The research team, Dr. Jasper Mumo, immunologist from the Depar...

Parasitic worms make sex worthwhile

... the snail, causing infertility. Ducks that live on the lakes scavenge for food at the lakes' periphery, where the water is shallow. The ducks consume infected snails, but are not, as far as the scientists can tell, adversely affected by the worms. Inside the ducks' enteric tracts, the worms reach adulthood a...

New lab test offers better prediction of HIV microbicide safety

... to pass through to the lower chamber, leaving the T cells uninfected. "But when we applied nonoxynol-9, the virus went right through the barrier and infected the T cells," says Dr. Herold. This result was no surprise, since nonoxynol-9 is a detergent, a class of chemicals known to be disruptive to cells. W...

Data published in the New England Journal of Medicine support use of raxibacumab (ABthrax) for the treatment of inhalation anthrax

...rgets anthrax toxins after they are released by the bacteria into the blood and tissues. In an inhalation anthrax attack, people may not know they are infected with anthrax until the toxins already are circulating in their blood, and it may be too late for antibiotics alone to be effective. "We are very p...

UTSA infectious disease researchers advancing vaccine against Valley fever

... In approximately 40% of human Valley Fever cases, respiratory problems set in one to three weeks after inhalation. Although less than one percent of infected individuals experience severe symptoms, such as chronic-progressive pneumonia or meningitis, the incidence of reported primary pulmonary infection cas...

Singapore nanotechnology combats fatal brain infections

...'s peptide nanoparticles, on the other hand, contain a membrane-penetrating component that enables them to pass through the blood brain barrier to the infected areas of the brain that require treatment. The ability of IBN's peptide nanoparticles to traverse the blood brain barrier offers a superior alternativ...

MicroRNAs help control HIV life cycle

...rgeting miR29, we can force HIV into a more active state and improve our ability to eliminate it." Rana's team looked at miR29 expression levels in infected and uninfected cells and found that miR29 expression was enhanced by HIV-1 infection. Blocking the activity of miR29 with interfering RNA resulted in ...

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

...erican Journal of Pathology . More than 50% of the world's population is infected with Helicobacter pylori , which causes chronic inflammation of the stomac...sive drugs, such as proton-pump inhibitors, for a long-term use in patients infected with Helicobacter pylori ." In future studies, Dr. Wang and colleagues pl...

U of M study finds new insight on therapy for a devastating parasitic disease

...ant new insight into how a commonly prescribed drug may work to treat those infected by a parasitic flatworm. The Schistosomasis parasite infe...eas worldwide and is endemic in more than 70 countries, where people become infected simply by bathing, drinking, or cooking water contaminated with the flatwor...

Study shows Chronix technology using serum DNA can identify early presence of disease

...es in serum DNA before clinical symptoms appeared in animals experimentally infected with BSE (mad cow disease). "These new results add to the growing body ...ify distinctive DNA signatures indicating the presence of BSE in all of the infected animals well before clinical symptoms appeared." These new findings foll...

Tips from the journals of the American Society for Microbiology

...c antimicrobial peptide L5 out of antibacterial proteins from Sarcophaga peregrina and found it to be an effective prophylactic treatment of MRSA in infected mice. In this study mice were administered intra-abdominal implantation as well as normal injections of L5 and observed for its ability to prevent de...

Targeting children effective use of limited supplies of flu vaccine and could help control flu spread

...These measures include the use of antiviral treatment, social distancing (for example, closing schools and stopping public transport) and quarantining infected individuals. Pharmaceutical companies have also stepped up production of vaccines effective against this particular strain of the virus. However, i...

Scientists tackle the mystery of white-nose syndrome in bats

...its distinctive white fungus growing on the muzzles and other body parts of infected bats. More than a half million bats have died in the last three years due t...m bat to bat. Other evidence suggests that humans transport the fungus from infected sites to clean sites on clothing and equipment. The purpose of the meeti...

'Shock and kill' research gives new hope for HIV-1 eradication

...oke out' the virus in order to render the latently infected cells targetable by the immune system or artificia...awakening' of a portion of cells within a latently infected cell population. The researchers then repeated the... cell population. An important result was that the infected cells' 'awakening' was followed by cell death, whe...

Scientists unravel the mystery of white-nose syndrome

...its distinctive white fungus growing on the muzzles and other body parts of infected bats. More than a half million bats have died in the last three years due t...m bat to bat. Other evidence suggests that humans transport the fungus from infected sites to clean sites on clothing and equipment. The purpose of the meeti...

Newly discovered reactions from an old drug may lead to new antibiotics

...of cases is on the rise. There are an estimated 500,000 cases per year in the United States alone. Between 15,000 to 20,000 people die each year while infected with this superbug. Treponema denticola is one of leading causes of gum disease and costs individuals thousands of dollars in dental care each year....

American Chemical Society's weekly PressPac -- May 27, 2009

...a report for the first time that poultry carcasses infected with another threat the "bird flu" virus can rem...oncern. Hundreds of millions of chickens and ducks infected with the virus have died or been culled from flock...is an appropriate method for disposal of carcasses infected with avian influenza," says the study, noting that...

A quicker, cheaper SARS virus detector -- one easily customizable for other targets

...e the antibody/target protein pair. The protein the prototype system detects is the SARS (severe acute respiratory syndrome) virus n-protein, which infected more than 8,000 people in 2002-2003, killing nearly 10 percent of them. Commercial systems using enzyme-linked immunosorbent assay (ELISA) now ex...

Jeepers creepers: Climate change threatens endangered honeycreepers

...otozoan parasite, and avian pox is a viral infection that typically causes tumor-like swellings on exposed skin of the feet, legs, beak and eyelids of infected birds. Malaria often results in appetite and weight loss, anemia, and massive enlargement of birds' liver and spleen. ...

Protective footwear for diabetics at a high-street price

...h as nerve damage and problems with the blood supply to their feet. Both conditions can lead to slow-healing wounds and foot ulcers which, if they get infected and become gangrenous, can lead to amputation. According to the International Diabetes Federation, most cases of foot ulcers and amputations can be...

American Chemical Society's Weekly PressPac -- May 20, 2009

... At HP outbreak sites, M. immunogenum is known to colonize metalworking fluids, used to cool the cutting tools that grind metals. Workers inhale the infected particles as they spray into the air from drills and other cutting tools. HP's symptoms include fever, cough, shortness of breath and chills. The s...

Yeast missing sex genes undergo unexpected sexual reproduction

...ction found in other species. "The unrecognized sex cycle could mean we need to develop new treatments to combat what is really happening in humans infected by yeast," said co-author Jennifer Reedy M.D. Ph.D. With co-author Anna Floyd, Heitman and Reedy explored the question further in a study appearin...

The challenges of avian influenza virus: Mechanism, epidemiology and control

...of influenza viruses, including seasonal influenza in addition to the H5N1 virus. In 2005, even the natural reservoir host, migratory birds were found infected with an outbreak of more than 6000 dead birds involved. Therefore in this special topic, we invite scientists from Hong Kong and mainland China to rev...

TB -- hiding in plain sight

... A group led by Dr. Susanna Grundstrom Brighenti at the Karolinska Institutet in Stockholm, Sweden therefore examined the immune response in patients infected with tuberculosis. This is the first study describing the immunoregulatory mechanism associated with the development of clinical disease at the site o...
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