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Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

...flammatory antioxidant compound widely distributed in foods. The results, which appear in the June 2009 issue of Experimental Biology and Medicine , implicate CYP4B1, a form of cytochrome P450 previously found to be associated with resolution of allergic inflammation in another model. The normalization of C...

Team identifies a molecular switch linking infectious disease and depression

...ene deleted were also completely resistant to the depressive-like behavior seen in normal mice exposed to BCG. "This is the first study to directly implicate IDO in depression related to chronic inflammation," Kelley said. The researchers suspect that the metabolites produced when IDO degrades tryptophan...

Plasminogen activator inhibitor type-1 -- a potential link between heart failure and diabetes

...sminogen activator inhibitor type-1 (PAI-1) is profibrotic. The results, which appear in the March 2009 issue of Experimental Biology and Medicine , implicate PAI-1 overexpression, known to accompany insulin resistance and type 2 diabetes, as a factor contributing to the high incidence of heart failure after...

Is there a relationship between sleep-wake rhythm and diabetes?

...e body is high at night and declines in daylight, whereas the insulin level is higher during the day than in the night. Taken together, these new data implicate an association between the sleep-wake rhythm, the so-called circadian rhythm, and fasting glucose levels, which was not known previously. Until now...

AGU journal highlights -- Dec. 31, 2008

...s. No offset in the position of the glacier surface was observed during these events. Instead, modest tsunamis associated with the glacial earthquakes implicate glacier calving as the generator of seismic events, putting to rest the idea that lurching glaciers are responsible for glacial earthquakes at outlet ...

Impaired energy metabolism linked with initiation of plaques in Alzheimer's brain

...e linking impaired energy metabolism, an AD-relevant stress, with BACE1 translation mediated by eIF2? phosphorylation," says Dr. Vassar. "Our findings implicate phosphorylated eIF2? in both the initiation and progression of sporadic AD. Future experiments will determine whether inhibition of eIF2? phosphorylat...

Genes for 9 health indicators

...reviously unknown loci. Five of these associations - HDL with NR1H3 (LXRA), LDL with AR and FADS1/FADS2, glucose with MTNR1B, and insulin with PANK1 - implicate genes with known or postulated roles in metabolism, and are good candidates for further study of the biological role they might play in these conditio...

Yale researchers unravel mystery of brain aneurysms

... disease, providing hope that we may also be able to provide preventive therapy before rupture occurs," Lifton said. For instance, the new findings implicate variations in the gene SOX17, which is known to play a crucial role in the early development and repair of endothelial cells that make up the arterial...

New study points to agriculture in frog sexual abnormalities

...hese two areas of human disturbance, do we see a greater proportion of abnormal animals in one versus another?" Guillette said. Because the results implicate agriculture, future research can narrow the focus to agricultural chemicals, McCoy said. "Because we know what chemicals are used at these agricult...

UC Davis researchers discover how HIV turns food-poisoning into lethal infection

...day bout of diarrhea. Now, UC Davis School of Medicine scientists have discovered how salmonella becomes lethal for AIDS patients. Their findings also implicate a mechanism by which HIV evades the powerful drugs used to treat AIDS. We have found the defect in the immune response that allows Salmonella to cr...

How mammals fuel milk production may have implications for cancer

...is, the researchers said. “Our findings demonstrating a physiological requirement for Akt1 in the control of glucose and lipid metabolism further implicate Akt1 activation as a potential mediator of the Warburg effect and reinforce the importance of efforts to design pharmacologic agents that will inhibit...

'GreeneChip' -- New diagnostic tool that rapidly and accurately identifies multiple pathogens

...a variety of laboratory and clinical settings. The GreeneChip system and its application in an outbreak investigation when other methods failed to implicate a microorganism in a fatal hemorrhagic fever case is described in the January 2007 issue of the CDC’s Emerging Infectious Diseases (online December 6 ...

'Tribbles' protein implicated in common and aggressive form of leukemia

...rwhelming effect when expressed in hematopoietic stem cells, the cell type that gives rise to all elements of the blood." Three lines of evidence implicate Tribbles in AML. First, all mice engineered to express Tribbles-2 (Trib-2) in hematopoietic stem cells developed AML. They also found that Trib-2 inhi...

Altered perception of reward in human cocaine addiction

...d they were engaged in the task) and the objective measures of motivation (how fast and accurately they performed on the task). "These behavioral data implicate a disruption in the ability to perceive inner motivational drives in cocaine addiction," Goldstein said. The fMRI results also revealed that non-...

How blood flow dictates gene expression

..., they had an abnormally high cardiac output, as measured by ultrasound, while the overall structure of their blood vessels was normal. These findings implicate loss of vessel tone as the primary defect in Klf2 knockout mice. Now that Klf2 has been established as an important regulator of blood flow in l...

Carnegie Mellon researchers discover key deficiencies in brains of people with autism

... autism have normal or even superior skills in some areas, while many other types of thinking are disordered. In addition, their findings particularly implicate the lower synchronization between the frontal cortex and other portions of the brain. They have discovered that key portions of the corpus callosum se...

Researchers link two more genes to sudden infant death syndrome

...arate studies, researchers examined caveolin-3 (CAV3) and the cardiac ryanodine receptor (RyR2) and found molecular and functional evidence in both to implicate them as SIDS-susceptibility genes. Researchers examined the tissue of 135 unrelated cases of SIDS -- in infants with an average age of 3 months old --...

New human retrovirus originated in mice

...t increased susceptibility to viral infection may play a role in development of some cancers. However, they emphasized that their findings by no means implicate the virus, dubbed XMRV, in causing prostate cancer. The virus may well have flourished as a result of the failure of the defense mechanism; and other ...

Stowers scientists demonstrate mechanism of vertebral formation

...lar level and how this process is integrated with the overall growth of the embryo," said Dr. Pourquié. "These findings are important because they implicate a novel family of transcription factors -- the Snail proteins -- in the process of embryonic segmentation," said Robb Krumlauf, Ph.D., Scientific Dire...

Forsyth scientists gain greater understanding of how embryos differentiate left from right

...mal localization of serotonin at the 16-cell stage, suggesting that it helps to regulate the early flow of this important neurotransmitter. These data implicate H+-V-ATPase activity in patterning the left right axis of three different vertebrates, reveal mechanisms both upstream and downstream of its activity,...

What can change in the brain? Electrical synapses, research shows

... speech and movement. The thalamic reticular nucleus' role as a sort of switch, starting or stopping the flow of sensory stimuli to the cortex, may implicate it as a major player in the regulation of sleep and wakefulness, the researchers said. The pairs' work sheds important light on electrical synapses...

Complex gene interactions account for autism risk

...utism risk. The Duke team found that the brain mechanism that normally stops or slows nerve impulses contributes to the disease. The team's findings implicate the so-called GABA receptor genes, which are genes that code for key components of "off switches" in the brain's neurons. GABA, or gamma aminobutyric ...

Discovery Promises Simpler Therapy for Sickle Cell Disease

...uted to the physical obstruction of blood vessels by distorted, or "sickled," and rigid red cells, Stamler said. The new findings, for the first time, implicate abnormal vessel dilation by the red cells themselves in oxygen deficiency. That oxygen deficiency, in turn, may result in sickling and, ultimately, th...
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