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Immune in Biological News

Scientists link immune system's natural killer cells to infant liver disease

CINCINNATI Scientists have linked an overactive response by one of the immune system's key weapons against infection natural killer, or NK, cells to the onset of biliary atresia in infants, a disease where blocked bile ducts can cause severe liver damage and death. Researchers at Cincinnati ...

The right messenger for a healthy immune response

Researchers from the Molecular Immunology group at the Helmholtz Centre for Infection Research (HZI) in Braunschweig, Germany have now shown that Beta-Interferon also plays a crucial role during an immune response: without Beta-Interferon immune cells are unable to show "wanted posters" of pathoge...

Fate in fly sensory organ precursor cells could explain human immune disorder

HOUSTON (June 21, 2009) Notch signaling helps determine the fate of a number of different cell types in a variety of organisms, including humans. In an article that appears in the current issue of Nature Cell Biology , researchers at Baylor College of Medicine report that a new finding about th...

NIH funds $9.5 million for research on HIV and the human innate immune system

CLEVELAND Studying how the mouth wards off diseases will have implications for understanding overall how people stay healthy. The Case Western Reserve University School of Dental Medicine will use a five-year, $9.5 million grant from the National Institutes of Health's National Institute for Dent...

Scientists discover new genetic immune disorder in children

Your immune system plays an important function in your healthit protects you against viruses, bacteria, and other toxins that can cause disease. In autoinflammatory diseases, however, the immune system goes awry, causing unprovoked and dangerous inflammation. Now, researchers from the National Ins...

Understanding plants' overactive immune system will help MU researchers build better crops

COLUMBIA, Mo. A plant's immune system protects the plant from harmful pathogens. If the system overreacts to pathogens, it can stunt plant growth and reduce seed production. Now, University of Missouri researchers have identified important suppressors that negatively regulate the responses of the...

Strong immune response to new siRNA drugs in development may cause toxic side effects

New Rochelle, NY, May 20, 2009Small synthetic fragments of genetic material called small interfering RNA (siRNA) can block production of abnormal proteins; however, these exciting new drug candidates can also induce a strong immune response, causing toxic side effects. Understanding how siRNA stim...

Genetic study confirms the immune system's role in narcolepsy

Scientists funded by the National Institutes of Health have identified a gene associated with narcolepsy, a disorder that causes disabling daytime sleepiness, sleep attacks, irresistible bouts of sleep that can strike at any time, and disturbed sleep at night. The gene has a known role in the immu...

Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer

DENVER, CO and AUCKLAND, NZ (April 21, 2009) MIS416, a novel microparticle-based immune response modifier, demonstrated the ability to significantly reduce the number and size of metastatic tumors in preclinical mouse models of lung and breast cancers, Innate Therapeutics (formerly Virionyx Corpo...

Device protects transplanted pancreatic cells from the immune system

LA JOLLA, Calif., April 9, 2009Scientists at Burnham Institute for Medical Research (Burnham) and the University of California San Diego (UC San Diego) School of Medicine have demonstrated in mice that transplanted pancreatic precursor cells are protected from the immune system when encapsulated i...

New evidence explains poor infant immune response to certain vaccines, says MU researcher

COLUMBIA, Mo. For years, researchers and physicians have known that infants' immune systems do not respond well to certain vaccines, thus the need for additional boosters as children develop. Now, in a new study from the University of Missouri, one researcher has found an explanation for that poo...

Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer

Washington, DC - New research suggests that monoclonal antibody therapy of cancer can be improved to be much more powerful than it is today, says a researcher at Georgetown University Medical Center's Lombardi Comprehensive Cancer Center in the March 21 issue of the Lancet . "We believe that a...

A paradigm shift in immune response regulation

Over the past decade various pieces of the puzzle how signal transmission controls immunity have been coming together. Now, in Cell an international team reports a paradigm shift in the regulation of immune response. Their results show that interaction with a linear ubiquitin chain is crucial fo...

New origin found for a critical immune response

DURHAM, N.C. An immune system response that is critical to the first stages of fighting off viruses and harmful bacteria comes from an entirely different direction than most scientists had thought, according to a finding by researchers at the Duke University Medical Center. "This finding will...

HIV adapts to 'escape' immune response

BIRMINGHAM, Ala. The human immunodeficiency virus (HIV) adapts so well to the body's defense system that any successful AIDS vaccine must keep pace with the ever-changing immunological profile of the virus, according to researchers at the University of Alabama at Birmingham (UAB) and the Universi...

Frog's immune system is key in fight against killer virus

Scientists from Queen Mary, University of London have discovered how changes to a frog's immune system may be the key to beating a viral infection which is devastating frog populations across the UK. Communities of common frogs (Rana temporaria) are being struck down by a foreign virus which i...

Molecule that suppresses immune response under study in type 1 diabetes

AUGUSTA, Ga. - The idea is to teach the immune system of children at high risk for type 1 diabetes not to attack the insulin-producing cells of the pancreas. "We want to create a no-go zone," said Dr. Andrew Mellor, immunologist who directs the Medical College of Georgia Immunotherapy Center. T...

Brain structure assists in immune response, according to Penn vet study

PHILADELPHIA - For the first time, a team of researchers at the University of Pennsylvania School of Veterinary Medicine have imaged in real time the body's immune response to a parasitic infection in the brain. The findings provide unexpected insights into how immune cells are regulated in the...

DNA component can stimulate and suppress the immune response

AUGUSTA, Ga. A component of DNA that can both stimulate and suppress the immune system, depending on the dosage, may hold hope for treating cancer and infection, Medical College of Georgia researchers say. Low levels of CpG increase inflammation, part of the body's way of eliminating invaders...

Implants mimic infection to rally immune system against tumors

CAMBRIDGE, Mass., Jan. 22, 2009 -- Bioengineers at Harvard University have shown that small plastic disks impregnated with tumor-specific antigens and implanted under the skin can reprogram the mammalian immune system to attack tumors. The research -- which ridded 90 percent of mice of an aggre...

Researchers engineer pancreatic cell transplants to evade immune response

In a finding that could significantly influence the way type 1 diabetes is treated, researchers at Albert Einstein College of Medicine of Yeshiva University have developed a technique for transplanting insulin-producing pancreatic cells that causes only a minimal immune response in recipients. ...

TGen, Scottsdale Healthcare, Mayo Clinic study new drug to stimulate immune system of cancer victims

SCOTTSDALE, Ariz. Dec. 19, 2008 The Translational Genomics Research Institute (TGen), Scottsdale Healthcare and Mayo Clinic are testing a new drug that could help cancer patients by stimulating the immune system. Clinical trials of the drug VTX-2337 are being conducted at TGen Clinical Resear...

High blood sugar's impact on immune system holds clues to improving islet cell transplants

AUGUSTA, Ga. A biological tit for tat may hold clues to improving the success of islet cell transplants intended to cure type 1 diabetes, according to a Medical College of Georgia scientist. In type 1, the immune system attacks insulin-producing cells causing high blood glucose levels that ma...

Scientists film inner workings of the immune system

Forget what's number one at the box office this week. The most exciting new film features the intricate workings of the body, filmed by scientists using ground-breaking technology. For the first time in Australia, scientists at Sydney's Centenary Institute have filmed an immune cell becoming i...

New type of vaccines deliver stronger and faster immune response

A new vaccine principle is being developed by scientists at the University of Copenhagen which if it works to its full expected potential could help to save millions of lives and revolutionise current vaccine technology. The 'InVacc' platform, as it is known, represents an advance on the origina...

Researcher tricks immune system in diabetic mice

CHICAGO -- The body's immune system hates strangers. When its security patrol spots a foreign cell, it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the r...

Proteomics study yields clues as to how tuberculosis might be thwarting the immune system

BERKELEY, CA -- A link between the immune system and the self-cleaning system by which biological cells rid themselves of obsolete or toxic parts may one day yield new weapons in the fight against tuberculosis and other deadly infectious diseases. Scientists with the U.S. Department of Energy's (D...

Protein 'tubules' free avian flu virus from immune recognition

A protein found in the virulent avian influenza virus strain called H5N1 forms tiny tubules in which it "hides" the pieces of double-stranded RNA formed during viral infection, which otherwise would prompt an antiviral immune response from infected cells, said Baylor College of Medicine researcher...

Lung airway cells activate vitamin D and increase immune response

Vitamin D is essential to good health but needs to be activated to function properly in the human body. Until recently, this activation was thought to happen primarily in the kidneys, but a new University of Iowa study finds that the activation step can also occur in lung airway cells. The stud...

A double-barreled immune cell approach for neuroblastoma

Adding an artificial tumor-specific receptor to immune system cells called T-lymphocytes that target a particular virus extended and improved the cells' ability to fight a form of childhood cancer called neuroblastoma, said researchers form Baylor College of Medicine and Texas Children's Hospital...

Mercury pollution causes immune damage to harbor seals

Methylmercury (MeHg), the predominant form of mercury found in the blood of marine mammals and fish-eating communities, could be more damaging to seals than has previously been thought. Research published in BioMed Central's open access journal Environmental Health shows that MeHg harms T-lympho...

Seemingly suicidal stunt is normal rite of passage for immune cells

St. Louis, Oct.20, 2008 Researchers have shown that self-induced breaks in the DNA of immune cells known as lymphocytes activate genes that cause the cells to travel from where they're made to where they help the body fight invaders. Scientists have known for two decades or more that lymphocy...

Scripps research team sheds light on immune system suppression

The work was reported in the October 16 issue of the journal Cell Host & Microbe . The study described the suppression of this immune response in mice infected with lymphocytic choriomeningitis virus, pointing to potential new avenues for the development of drug treatments for immunosuppressiv...

Response to immune protein determines pathology of multiple sclerosis

New research may help reveal why different parts of the brain can come under attack in patients with multiple sclerosis (MS). According to a new study in mice with an MS-like disease, the brain's response to a protein produced by invading T cells dictates whether it's the spinal cord or cerebellum...

Genetic finding implicates innate immune system in major cause of blindness

Scientists have identified one of the genes implicated in age-related macular degeneration, the most common cause of blindness in developed countries. The research, published online today in the Lancet , adds to the growing understanding of the genetics of age-related macular degeneration (AMD...

Entertainment Software Association Foundation awards grant to FAS for immune attack

WASHINGTON DC The Federation of American Scientists (FAS) will reach new levels with Immune Attack TM the first biologically accurate immunology video game through a generous grant awarded by the ESA Foundation (ESAF). This bold and fun game is available for download at http://fas.org/immuneatt...

Fly studies reveal immune cell responses to tumor and tissue damage

September 17, 2008, Cambridge, UK Knee scrapes and tumor growth might have more in common than you think. The idea that tumor growth triggers the same immune response as a cut or wound was once a highly controversial notion. However, increasing evidence supports the idea that the same ce...

Individuals vary their immune response according to age, sex and the costs

Is it always good to respond maximally when pathogens or disease strike, or should individuals vary their immune response to balance immediate and future costs? This is the question evolutionary physiologists Oliver Love, Katrina Salvante, James Dale, and Tony Williams asked when they examined how...

CMV infections affect more than just patients with compromised immune systems, researchers find

An infection due to a virus called cytomegalovirus (CMV), which most commonly affects people with compromised immune systems, can also affect hospital intensive-care patients who have no immune-system problems, University of Washington researchers have found. CMV infection is also associated with ...

Imiquimod, an immune response modifier, is dependent on the OGF-OGFr signaling pathway

Researchers at The Pennsylvania State University College of Medicine, Hershey, Pennsylvania have discovered that the efficacy of imiquimod, a clinically important immune response modifier with potent antiviral and antitumor activity, is dependent on the Opioid Growth Factor (OGF)-OGF receptor (OGF...
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