Continuous glucose monitoring technology -- special issue of Diabetes Technology and Therapeutics
New Rochelle, NY, May 29, 2009Continuous Glucose
Monitoring (CGM) devices represent a critical step toward achieving automated glucose
measurement, offering people with diabetes a promising new tool for maintaining optimal glucose
control. A comprehensive review of this rapidly changing field, fea...
New evidence of how high glucose damages blood vessels could lead to new treatments
AUGUSTA, Ga. New evidence of how the elevated glucose
levels that occur in diabetes damage blood vessels may lead to novel strategies for blocking the destruction, Medical College of Georgia researchers say.
They found a decreased ability of blood vessels to relax resulted from increased acti...
New genes present drug targets for managing cholesterol and glucose levels
ANN ARBOR, Mich.---Scientists have identified 12 new genes that are somewhat strange bedfellows: Some link gallstones and blood cholesterol levels, others link melatonin and sleep patterns to small increases in glucose
levels and larger jumps in the risk of diabetes.
While these associations a...
JDRF-funded clinical trial demonstrates continuous glucose monitoring improves blood sugar control
NEW YORK, September 8, 2008 Patients with type 1 diabetes who used continuous glucose
monitoring (CGM) devices to help manage their disease experienced significant improvements in blood sugar control, according to initial results of a major multicenter clinical trial funded by the Juvenile Diabet...
UCLA researchers clarify function of glucose transport molecule
Researchers at the David Geffen School of Medicine at UCLA have solved the structure of a class of proteins known as sodium glucose
co-transporters (SGLTs), which pump glucose
into cells. These transport proteins are used in the treatment of chronic diarrhea via oral rehydration therapy, saving th...
Genetic breakthrough explains dangerously high blood glucose levels
This release is available in French .
Canadian, French and British researchers have identified a DNA sequence that controls the variability of blood glucose
levels in people. This is a potentially significant discovery because high blood glucose
levels in otherwise healthy people often ar...
Nano-tetherball biosensor precisely detects glucose
WEST LAFAYETTE, Ind. - Researchers have created a precise biosensor for detecting blood glucose
and potentially many other biological molecules by using hollow structures called single-wall carbon nanotubes anchored to gold-coated "nanocubes."
The device resembles a tiny cube-shaped tetherball....
U of M researchers invent 'flashy' new process to turn soy oil, glucose into hydrogen
Anyone who's overheated vegetable oil or sweet syrup knows that neither oil nor sugar evaporates--oil smokes and turns brown, sugar turns black, and both leave a nasty film of carbon on the cookware. Now, a University of Minnesota team has invented a "reactive flash volatilization process" that hea...
Jefferson scientists find high glucose before surgery raises risk of dangerous complications
Patients who have high blood sugar before undergoing surgery run an increased risk of developing blood clots, deep vein thrombosis and even pulmonary embolism after surgery.
Boris Mraovic, M.D., assistant professor of anesthesiology in the Artificial Pancreas Center at Jefferson Medical College o...
New mechanism explains glucose effect on wakefulness
One of the body's basic survival mechanisms is the neural machinery that triggers the hungry brain to the alertness needed for seeking food. That same machinery swings the other way after a hearty meal, as exemplified by the long and honored custom of the siesta. However, scientists have understood...
Software might revolutionize glucose monitoring in critically ill patients
Researchers have developed a new computerized system to easilymonitor the levels of glucose
in the blood of patients in intensivecare.
A study published today in the open access journal BMC MedicalInformatics and Decision Making reports that GRIP, a computersoftware that assists in the monitoring...
Scientists at Galileo Pharmaceuticals confirm inflammatory response linked to glucose levels
A team of scientists has discovered three molecules –?from a search of 58,000 compounds –?that appear to inhibit a key perpetrator of Alzheimer's disease.
Each of the three molecules protects the protein called "tau," which becomes hopelessly tangled in the brains of patients with Alzheimer's. Th...
Mouse with designer liver has enhanced glucose tolerance, insulin response
A collaborative effort led by The Burnham Institute's Gen-Sheng Feng has created a mouse with improved glucose
tolerance and insulin activity in the liver, and generated new findings about insulin-signaling in the liver that could prove useful in understanding the pathogenesis of type 2 diabetes. T...
NIH Researchers Discover How Insulin Allows Entry of Glucose Into Cells
Researchers from the National Institutes of Health have discovered the critical sequence of events by which insulin stimulates the entry of glucose
into fat cells.
The study, appearing in the May 9 Journal of Cell Biology, was conducted by researchers from the National Institute of Child Health ...
Common allergy drug reduces obesity and diabetes in mice
...trictly metabolic condition in which cells grow increasingly deaf to insulin signals and thus lose their ability to metabolize glucose. In both cases, glucose
mounts in the blood, at times to fatal levels.
But it is becoming increasingly clear that we should also think of type 2 diabetes in the context o...
Two dietary oils, two sets of benefits for older women with diabetes
...ams per deciliter; the women's average blood sugar levels ranged from 129 to 148 after 16 weeks of safflower oil supplementation.
"Lowering fasting glucose
is important for these women. The overall effect in just 16 weeks wasn't bringing them back to normal, but safflower oil still improved it significant...
The battle for CRTC2: How obesity increases the risk for diabetes
...verly activated in obese people, triggers aberrant glucose
production in the liver, an important step on the ...n healthy people, a "fasting switch" only flips on glucose
production when blood glucose
levels run low during fasting. "The existence of a...
Omega-3 fatty acids appear to impact AMD progression
...SM. "Our previous research suggests a low-GI diet may prevent AMD from progressing to the advanced stage. We hypothesize that the rapid rise of blood glucose
initiated by high-GI foods results in cellular damage that retinal cells cannot handle, thus damaging eye tissues."
dGI is a scale used to determin...
From the glass to the brain in 6 minutes
...l. "Our study provides evidence for alternative energy utilization upon alcohol ingestion, i.e. the brain uses an alcohol breakdown product instead of glucose
for energy demands," explains Dr. Armin Biller of the working group for cerebral metabolism at the Department of Neuroradiology at Heidelberg Universi...
USC researchers present diabetes findings at American Diabetes Association Scientific Sessions
...earch that determined the portal vein connecting the pancreas and liver has glucose
sensors that alert the body to low blood sugar, Donovan will talk about dif...current Hypoglycemia; Peripheral vs. Central Sensors Importance of Rate of glucose
Richard Watanabe, Ph.D., associate professor of pre...
UF makes gene therapy advance in severe genetic disorder
...g as two to three hours without needing additional glucose
to supplement its diet. But several weeks later th...ter the therapy, the dog was completely weaned off glucose
"We have never had to use any glucose
supplementation since we weaned her off," Mah said...
UCSF discovers new glucose-regulating protein linked with diabetes
...rotein in human muscles to the process that clears glucose
out of the bloodstream, shedding light on what goe...
"Much has been learned from mouse models about glucose
metabolism that is relevant to human diabetes, but...
In humans, muscles play a key role in clearing glucose
from the bloodstream, Brodsky explained. In normal...
Study shows CGM devices also benefit people with type 1 diabetes
...ar goals can further benefit from using continuous glucose
monitoring (CGM) devices, according to results of ...at with intensive insulin therapy, excellent blood glucose
control was obtained, but at the expense of a cons...sed CGM devices or one using standard finger-stick glucose
testing for 26 weeks.
"The research suggests ...
Are you okay to kiss?
Biomarkers, like the ones used by Prof. Rosenberg's new invention, are the basis of popular diagnostic kits today, like home pregnancy tests or glucose
monitors used by diabetics. Checking the sweetness of one's breath may seem frivolous, but millions worry about it on a continual basis. Prof. Rosenbe...
Blood testing, mosquito style
...e for diabetics who need to take regular samples of their own blood to keep glucose
levels in check. The common method of drawing blood from fingertips and using glucose
testing strips and metres can be painful, inconvenient and time-consuming. ...
University of Texas at Austin engineer elected to American Academy of Arts and Sciences
.... These patents formed the basis of the continuous glucose
monitor for diabetes management known as FreeStyle... developed a technology of coulometrically testing glucose
levels using blood samples so small that they coul...fering from diabetes are required to measure their glucose
levels several times daily. The technology, the co...
LSUHSC student awarded top national honor for diabetes research
...therapy leads to Ang-(1-7)-mediated restoration of glucose
metabolism in diabetic mice." She will present it ...er. The research team previously demonstrated that glucose
tolerance and fasting blood glucose
levels in diabetic mice were improved when the pan...
ASBMB Annual Meeting to feature talks on the biochemistry of aging
...substrates in mice. Insulin-like signaling regulates the storage and usage of nutrients, a process best exemplified by insulin's role in keeping blood glucose
levels from getting too low or high; therefore proper insulin-like signaling is absolutely critical for growth and development. Interestingly, though,...
Findings show insulin -- not genes -- linked to obesity
... the pancreas after meals to trigger the uptake of glucose
from the blood into the liver, muscle or fat cells...ing pathway." The pathway enables cells to take up glucose
from the blood.
"Only one small variation at th... on cell membranes, signaling the cells to take up glucose
from the blood. Cells that are said to be resistan...
SIRT1 takes down tumors
...span. Whether SIRT1 slows aging in mammals isn't certain, but it's beneficial in other ways. The protein tunes up metabolism, reducing blood levels of glucose
and insulin, and might forestall neurodegenerative illnesses such as Alzheimer's disease and ALS. Given its pro-life credentials, you might expect SIR...
Vitamin D deficiency related to increased inflammation in healthy women
...g milk and orange juice."
In future studies, Peterson will determine the effectiveness of Vitamin D in reducing disease symptoms and reducing blood glucose
levels in diabetics. The study, "Serum tumor necrosis factor-alpha concentrations are negatively correlated with serum 25(OH) D concentrations in heal...
Novocell awarded seminal stem cell patent
...of endoderm represents the first critical step in the creation of a renewable islet source derived from hES cells that is targeted at restoring normal glucose
regulation in diabetic patients."
"Novocell is a leader in differentiation of stem cells to create functional islet cells of the pancreas, and th...
New approach discovered to lowering triglycerides
...europathic complications of diabetes.
"Lipoic acid is known to influence glucose
uptake, and bring down blood glucose
by increasing its transport into skeletal muscle," Moreau said. "Less has b...
Researchers discover link between schizophrenia and diabetes
...r known risk factors, 16 percent had either diabetes or an abnormal rate of glucose
metabolism, says Dr. Brian Kirkpatrick, vice chair of the MCG Department of...celona in Spain and the University of Maryland administered a two-hour oral glucose
test to patients who had not yet been placed on anti-psychotic medication. ...
UC Davis bench-to-bedside research: Promising treatment in clinical trials
... will enroll a total of 150 patients with impaired glucose
tolerance, mild obesity and mild to moderate hyper...eduction of blood pressure and various measures of glucose
and lipid metabolism. Results are expected the fir...sh proof of concept that s-EH inhibition modulates glucose
metabolism or blood pressure in patients with impa...
HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
... and directly affected the ATP levels in these cells. A significant decrease in ATP production was also observed which may account for the decrease in glucose
stimulated insulin secretion upon nelfinavir treatment. This study appears in the April 2009 issue of Experimental Biology and Medicine . Although in...
Diabetics on high-fiber diets might need extra calcium, report UT Southwestern researchers
"We already know that fiber helps improve your cholesterol and glucose
control and improves your bowel regularity. Our new findings suggest that d...gh intake of dietary fiber, mostly from fruits and vegetables, lowers blood glucose
levels and leads to decreased insulin levels in the blood, as well as lower...
Symposium to look at genetic basis of exercise
...(a measure of aerobic fitness), blood pressure and glucose
and insulin metabolism.
The researchers compare...etermining an individual's insulin sensitivity and glucose
disposal ability in response to exercise. This gen...f this gene improved their insulin sensitivity and glucose
disposal ability with exercise while people with a...
Gladstone scientists reveal key enzyme in fat absorption
...hen fed a high-fat diet that is similar to that eaten by many Americans, the mice do not get fat and do not develop other symptoms of obesity, such as glucose
intolerance, hypercholesterolemia, and fatty livers. The mice eat the same number of calories as other mice, and the calories are fully absorbed. Resu...
Simple test helps predict heart attack risk
... crucial. Primary preventionsuch as initiating lifestyle changes and medical intervention directed at modifying risk factors (smoking cessation, blood glucose
and blood pressure control, lowering cholesterol and exercise)can be started to improve one's health before costlier and more intensive interventions ...