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Genes in Biological News

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

PHILADELPHIA Nanoparticle delivery of diphtheria toxin-encoding DNA selectively expressed in ovarian cancer cells reduced the burden of ovarian tumors in mice, and researchers expect this therapy could be tested in humans within 18 to 24 months, according to a report in Cancer Research , a journ...

Mystery E. coli genes essential for survival of many species

Scientists have shown that E. coli one of the best known and extensively studied organisms in the world remains an enigma that may hold the key to human diseases, such as cancer. The team, funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and based at the Univers...

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

PITTSBURGH, July 7 The first findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain the...

The tiny difference in the genes of bacteria

It is based on detecting short, repetitive DNA segments in the genome of bacteria. Every single bacterial strain has such characteristic repeats. "With this method we are able to identify bacterial strains as well as clarify their genetic relationships. Furthermore, we can show how new pathogenic ...

The tiny difference in the genes of bacteria

It is based on detecting short, repetitive DNA segments in the genome of bacteria. Every single bacterial strain has such characteristic repeats. "With this method we are able to identify bacterial strains as well as clarify their genetic relationships. Furthermore, we can show how new pathogenic ...

IFAR contributes to study that finds genes that influence the start of menstruation

(Boston, Mass.)Two scientists at the Institute for Aging Research of Hebrew SeniorLife are part of an international team of investigators that has identified genes that influence the start of menstruation, a milestone of female reproductive health that has lifelong influences on overall health. Th...

Immune genes adapt to parasites

Thank parasites for making some of our immune proteins into the inflammatory defenders they are today, according to a population genetics study that will appear in the June 8 issue of the Journal of Experimental Medicine (online May 25). The study, conducted by a team of researchers in Italy, al...

Yeast missing sex genes undergo unexpected sexual reproduction

DURHAM, N.C. An emerging form of the pathogenic yeast Candida is able to complete a full sexual cycle in a test tube, even though it's missing the genes for reproduction. And it may also do so while infecting us, according to Duke University Medical Center researchers. "Sex contributes to t...

Swine flu genes dissimilar to past pandemics

Some genetic markers of influenza infection severity have been identified from past outbreaks. Researchers have failed to find most of these markers, described in the open access journal BMC Microbiology , in samples of the current swine-flu strain. Jonathan Allen and Tom Slezak from Lawrence ...

Tiny differences in our genes help shed light on the big picture of human history

By examining very small differences in people's genes, scientists from Cornell University have developed a new tool for identifying big events in human history and pinpointing the origins of specific gene mutations. This research, published in the May issue of the journal GENETICS ( http://www.g...

Re-awakening old genes to help in the fight against HIV

A new vaginal cream containing a reawakened protein could someday prevent the transmission of HIV. Scientists at the University of Central Florida in Orlando have revived a dormant gene found in humans and coaxed it to produce retrocyclin, a protein that resists HIV. Lead scientist Alexande...

Major international study challenges notions of how genes are controlled in mammals

This release is available in French . Scientists at the Omics Science Center (OSC) of the RIKEN Yokohama Institute in Japan along with researchers from McGill University and other institutions worldwide are challenging current notions of how genes are controlled in mammals. Three years ...

Findings show insulin -- not genes -- linked to obesity

WEST LAFAYETTE, Ind. - Researchers have uncovered new evidence suggesting factors other than genes could cause obesity, finding that genetically identical cells store widely differing amounts of fat depending on subtle variations in how cells process insulin. Learning the precise mechanism resp...

Hopkins scientists ID 10 genes associated with a risk factor for sudden cardiac death

One minute, he's a strapping 40-year-old with an enviable cholesterol level, working out on his treadmill. The next, he's dead. That an abnormality in his heart's electrical system had managed to stay on the Q.T. until it proved lethal is characteristic of sudden cardiac death, which an...

Ten genes identified in connection with sudden cardiac death

ANN ARBOR, Mich.---You're sitting at your desk and suddenly your heart is beating in overdrive or worse, lurching along like a car on fumes. It is a shocking, uncomfortable and frightening sensation. Irregular heart rhythms are a common cause of sudden cardiac death or SCD, a condition that ac...

Cleft lip and palate: Genes more important than thought?

Comparing 500,000 snippets of human DNA put scientists from the University of Bonn on the right track. A genetic variant on chromosome 8 occurs with significantly higher frequency in people with cleft lip and palate than in the control group. The results are to be published in the forthcoming iss...

Magnetic nanoparticles navigate therapeutic genes through the body

Health professionals send genes and healthy cells on their way through the bloodstream so that they can, for example, repair tissue damage to arteries. But do they reach their destination in sufficient quantities? Scientists of the PTB have developed a highly sensitive measuring method with which ...

'It takes a genome: How a clash between our genes and modern life is making us sick'

It's not just the climate that is struggling with what humans have done to the modern world, our genes are feeling the pressure as well, according to Professor Greg Gibson's recently published book. In It Takes a Genome: How a Clash Between Our Genes and Modern Life Is Making Us Sick , Profess...

UCR scientists identify stem-cell genes that help form plant organs

RIVERSIDE, Calif. Plant stem-cells are master cells located at the tip of the stem and are part of a structure called the shoot apical meristem (SAM). Here, the stem cellsall clumped togetherdivide throughout the life of the plant to give rise to other cells, resulting in the formation of above-g...

NC State study finds genes important to sleep

For many animals, sleep is a risk: foraging for food, mingling with mates and guarding against predators just aren't possible while snoozing. How, then, has this seemingly life-threatening behavior remained constant among various species of animals? A new study by scientists at North Caroli...

2 genes influence social behavior, visual-spatial performance in people with Williams syndrome

SALT LAKE CITYUnraveling the genetics of social behavior and cognitive abilities, researchers at the University of Utah and the Salk Institute for Biological Studies have traced the role of two genes,GTF2I and GTF2IRD, in a rare genetic disorder known as Williams Syndrome. Their results, publi...

Scientists uncover new class of non-protein coding genes in mammals with key functions

A research team at the Broad Institute of Harvard and MIT and Beth Israel Deaconess Medical Center has uncovered a vast new class of previously unrecognized mammalian genes that do not encode proteins, but instead function as long RNA molecules. Their findings, presented in the February 1st advanc...

Missing genes link to psoriasis

Genetics experts at The University of Nottingham have been involved in a scientific breakthrough which is helping to explain why some people may be more likely to suffer from the chronic skin condition, psoriasis. The research, which has just been published in the journal Nature Genetics , sho...

U-M researchers discover new genes that fuse in cancer

ANN ARBOR, Mich. Using new technologies that make it easier to sequence the human genome, researchers at the University of Michigan Comprehensive Cancer Center have identified a series of genes that become fused when their chromosomes trade places with each other. These recurrent gene fusions are...

Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect

The international GIANT (Genetic Investigation of Anthropometric Parameters) consortium works on the discovery of obesity genes. So far, the scientists have analyzed two million DNA variations in 15 genome-wide association studies with a total of more than 32,000 participants. The hereby identifie...

Snails and humans use same genes to tell right from left

Berkeley -- Biologists have tracked down genes that control the handedness of snail shells, and they turn out to be similar to the genes used by humans to set up the left and right sides of the body. The finding, reported online in advance of publication in Nature by University of California,...

New genes present drug targets for managing cholesterol and glucose levels

ANN ARBOR, Mich.---Scientists have identified 12 new genes that are somewhat strange bedfellows: Some link gallstones and blood cholesterol levels, others link melatonin and sleep patterns to small increases in glucose levels and larger jumps in the risk of diabetes. While these associations a...

From genes to farmers' fields

Delhi, India "Waterproof" versions of popular varieties of rice, which can withstand 2 weeks of complete submergence, have passed tests in farmers' fields with flying colors. Several of these varieties are now close to official release by national and state seed certification agencies in Banglade...

Researchers at IRB Barcelona produce more data on key genes in diabetes

One of the most reliable indicators to predict that a person will develop type 2 diabetes is the presence of insulin resistance. Insulin is produced in the pancreas and is the hormone responsible for ensuring that glucose reaches several tissues and organs in the body, such as muscles. Insulin res...

Human genes sing different tunes in different tissues

CAMBRIDGE, Mass. -- Scientists have long known that it's possible for one gene to produce slightly different forms of the same protein by skipping or including certain sequences from the messenger RNA. Now, an MIT team has shown that this phenomenon, known as alternative splicing, is both far more...

Researchers continue to find genes for type 1 diabetes

Genetics researchers have identified two novel gene locations that raise the risk of type 1 diabetes. As they continue to reveal pieces of the complicated genetic puzzle for this disease, the researchers expect to improve predictive tests and devise preventive strategies. "As we add to our know...

Scientist plans to test for blood pressure genes affected by age

A geneticist at The University of Texas Health Science Center at Houston plans to scan the genomes of about 4,000 people in the hopes of finding out why blood pressure often increases as young adults age. The two-year study by principal investigator Myriam Fornage, Ph.D., is funded with a new $...

Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells

PHILADELPHIA A research team, led by investigators at the Department of Surgery at Jefferson Medical College of Thomas Jefferson University and the Kimmel Cancer Center at Jefferson, has achieved a substantial "kill" of pancreatic cancer cells by using nanoparticles to successfully deliver a dead...

Scientists identify the genes that cause blindness produced by corneal edema

This press release is available in French and Spanish . Scientists of the University of Granada (Spain) and the San Cecilio Teaching Hospital (Granada) have determined for the first time the causes for the blindness produced by corneal oedema and have identified the genes which cause it...

Biologists identify genes controlling rhythmic plant growth

A team of biologists from UC San Diego, the Salk Institute for Biological Studies and Oregon State University has identified the genes that enable plants to undergo bursts of rhythmic growth at night and allow them to compete when their leaves are shaded by other plants. The researchers report ...

'Biological clock' genes control plant growth

CORVALLIS, Ore. More than 125 years ago Charles Darwin first reported that most plants grow in a spurt during the night, not the day and this week, scientists are reporting the discovery of the genes that control this phenomenon. These rhythmic growth spurts, and the ability of plants to move...

New genes found for inflammatory bowel disease in children

Researchers have discovered two new genes that increase the risk of developing inflammatory bowel disease (IBD) in childhood. While further study is needed to identify the specific disease-causing mutations in these new genes, the researchers say the genes are particularly strong candidates to ...

Study shows more genes are controlled by biological clocks

The tick-tock of your biological clock may have just gotten a little louder. Researchers at the University of Georgia report that the number of genes under control of in living things than suspected only a few years ago. The biological clock in a much-studied model organism is dramatically hig...

Obesity genes revealed

A study of 228 women has revealed genetic variants responsible for body shape. Based on work in the fruit fly Drosophila melanogaster, research published today in the open access journal BMC Genetics identifies natural variation in the human LAMA5 gene as a key determinant of weight. As the p...

Various species' genes evolve to minimize protein production errors

CAMBRIDGE, Mass. -- Scientists at Harvard University and the University of Texas at Austin have found that genetic evolution is strongly shaped by genes' efforts to prevent or tolerate errors in protein production. Their study also suggests that the cost of errors in protein production may lie ...
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