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Fusion in Biological News

Newly discovered gene fusion may lead to improved prostate cancer diagnosis

Researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center have discovered a new gene fusion that is highly expressed in a subset of prostate cancers. The results may lead to more accurate prostate cancer testing and new targets for potential treatments. Experts believe that gene ...

UC Davis bioengineer receives Hartwell Foundation grant to address skull fusion disorder of infants

With support from a foundation that champions cutting-edge medical research, a biomedical engineer at UC Davis will start work this month on developing a new treatment for infants born with disorders that cause the sutures of their skulls to prematurely fuse together. The new approach is based ...

A simple fusion to jump-start evolution

With the aid of a straightforward experiment, researchers have provided some clues to one of biology's most complex questions: how ancient organic molecules came together to form the basis of life. Specifically, this study, appearing online this week in JBC , demonstrated how ancient RNA join...

Several minute intermediate stage in virus-cell fusion discovered; opportunity for drug development

To ignite a life-threatening infection in the body, a virus such as HIV invades body cells by first merging, or fusing, with the cell's outer membrane. Once inside the cell, the invading microbe's genetic material takes over, turning the 'host' cell into a factory to produce more copies of the viru...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

Gene Bridges and Covalys Biosciences AG today announced a collaboration to develop "Copy & Paste" DNA engineering kits to generate SNAP-tag fusion proteins based on Gene Bridges' Red/ET recombination technology. Gene Bridge's Red/ET cloning system does not require restriction enzymes and allows...

Obama administration announces more than $327 million in Recovery Act funding for science research

...several national laboratories and universities for fusion energy research; Expanded funding for integra...at the DOE Joint Genome Institute; $11 million for fusion energy research; $8.8 million for equipment improv...uding $8.8 million for a variety of initiatives in fusion energy research and $5 million for infrastructure ...

Little-known protein found to be key player

... dynamic, and for that to be the case, there has to be a mechanism by which it can grow new pieces and connect those pieces together. That's where the fusion comes in." Daga said the discovery will lay the foundation for a deeper understanding of both basic biological processes and disease. "We hope ...

Indonesia Now Using MegaMatcher Biometric Technology in Integrated Passport Issuance System

...t identification systems (AFIS) for both civil and forensic applications. MegaMatcher includes both fingerprint and face identification engines with a fusion algorithm that allows the two technologies to work together to provide very fast 1:N (1 to many) matching with higher reliability than AFIS or facial ...

DOE-funded research projects win 46 R&D 100 Awards for 2009

...the potential to yield important insights into understanding the process of fusion energy burn. Spectral Sentry - is an advanced technology developed to...ssembling Machine This machine manufactures small and complex laser-driven fusion ignition targets for the world's largest and most energetic laser, the Nati...

GUMC discovery highlights new direction for drug discovery

...iscovered a novel way to block the activity of the fusion protein responsible for Ewing's sarcoma, a rare ca...ccessfully testing a small molecule that keeps the fusion protein from sticking to another protein that is c...is especially surprising since the Ewing's sarcoma fusion protein is extremely flexible, which allows it to ...

Cells use import machinery to export their goods as well

...ee, but we've actually arranged for the streetlight to be focused on exactly where we're interested," Simon says. "We get the vesicles at the point of fusion without the background noise of everything else going on inside the cell." For the first time, Jaiswal was able to observe individual post-Golgi ...

Work of Field Museum scientist addresses question of chance in evolution

... is squeezed out of the box by muscles pulling on a flexible membrane. The next step in diversification was calcified spines around the membrane, then fusion of the spines, then reduction of the fused spinal shield and membrane and invention of a water sac inside the box to provide enough volume to squeeze ...

Scientists develop a new HIV microbicide -- and a way to mass produce it in plants

...hey designed synthetic DNA for producing this molecule and introduced this DNA into plant cells. After regenerating transgenic plants that produce the fusion molecule, they prepared the microbicide from a plant extract made by grinding the leaves. "This study is nothing short of a breakthroughnot only ...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

...ially valuable for monitoring the brilliant bursts of X-rays streaming from fusion targets at the collision point where the multiple laser beams of LLNL's Nat...icosecond oscilloscope or for observing transient events like the miniature fusion reaction that occurs at the National Ignition Facility. Presentation CT...

Yeast missing sex genes undergo unexpected sexual reproduction

...hey reproduce sexually." Humans, too, have their share of oddly paired chromosomes. "Experts estimate that about 10 to 30 percent of human eggs or fusion products may be aneuploid, with chromosomes from mother and father not paired exactly one to one, but the great majority of those fusions of sperm and...

Story tips From the Department of Energy's Oak Ridge National Laboratory -- May 2009

... Ron Walli, (865) 576-0226; wallira@ornl.gov ] fusion -- Computational confirmation . . . fusion energy took a small step forward with a successful...urbulence in the well-confined edge of plasma in a fusion reactor can penetrate the core and boost its tempe...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

...apart and reattached in new places. This incorrect fusion is thought to create cancer-causing genes, or "oncogenes," that encode so-called fusion proteins. It's the proteins that are the most imme...h a favorable therapeutic outcome in people, while fusion oncogenes involving the MLL gene have been associa...

Protein function and chromatin structure methods featured in Cold Spring Harbor Protocols

...nd tunable method for studying the activity of a protein of interest in cells. The protein is attached to a destabilization domain, and the resulting fusion proteins are unstable and degraded, except in the presence of small ligands. The speed of small-molecule binding makes it an attractive alternative to...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

...owed that the heavy chain of the mAb inserts into a highly conserved pocket in the HA stem, inhibiting the conformational change required for membrane fusion and viral entry into the cell. The scientists further showed that an unprecedented number of different types of bird flu and seasonal influenza vi...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

...owed that the heavy chain of the mAb inserts into a highly conserved pocket in the HA stem, inhibiting the conformational change required for membrane fusion and viral entry into the cell. The scientists further showed that an unprecedented number of different types of bird flu and seasonal influenza vir...

WCC Smart Search & Match to Support U.S. Army's BOSS-U Program

...ssion critical operational support. At the same time, its ability to support multiple third party biometric algorithms and to incorporate customizable fusion algorithms makes it an ideal platform for advanced technology analysis and demonstration as well as test and evaluation." About WCC Foun...

Cell-building discovery could reduce need for some animal research

...structures. Researchers found that the molds helped control the shape of the final microtissue. They also found that they could control the rate of fusion of the cells by aging them for a longer or shorter time before they were harvested. The longer the wait, Morgan found, the slower the process. Rago...

MIT develops new way to fuse cells

...s simple but ingenious sorting method increases the rate of successful cell fusion from around 10 percent to about 50 percent, and allows thousands of cell pairings at once. Though cell fusion techniques have been around for a long time, there are many technical limit...

WCC Smart Search and Match Names Rudie Lion - Product Marketing Manager

...f WCC's US offices. About WCC Smart Search & Match Founded in 1996, WCC Smart Search & Match develops a vendor-neutral multi-modal fusion platform. Its flagship product, ELISE, is search and matching system delivers the best possible identity matching results using multiple biometrics an...

Argonne advancing DOE INCITE scientific research projects

...rojects feature research in: Energy, including advanced systems for fusion energy and nuclear power, and improving combustion to increase efficiency a...s Leadership Computing Facility. "Future breakthroughs will stem from the fusion and knowledge of different fields applying high performance computing and m...

2009 DOE INCITE projects allocated at ORNL

...orations, including the physics of electron transport in the prototype ITER fusion power reactor, the behavior of carbon dioxide sequestered from power plant ...ic problems." Energy assurance projects will also play a prominent role. fusion energy simulations will include teams led by Patrick Diamond of the Univers...

Tracking the molecular pathway to mixed-lineage leukemia

... varying causes of MLL, most cases are caused by a fusion of two genes, the MLL and the AF4 genes. Whe... that the MLL-AF4 protein produced by this genetic fusion causes leukemia, they had not been able to determi...ate, with disastrous consequences. "The MLL-AF4 fusion protein is somehow targeted to a set of genes that...

Breast cancer genome shows evolution, instability of cancer

...enter. "It makes the cell escape normal controls on cell proliferation. Experimentally, some of the rearrangements in the genome that we found produce fusion genes that confer uncontrolled cell growth and prevent tumor cells from dying, allowing them to grow outside their normal tissue environment. These ar...

WCC Smart Search and Match Names Rudie Lion - Product Marketing Manager

...C's US offices. About WCC Smart Search & Match Founded in 1996, WCC Smart Search & Match develops a vendor-neutral multi-modal fusion platform. Its flagship product, ELISE, is search and matching system delivers the best possible identity matching results using multiple biometrics an...

Studies on imaging and tracking transplanted cells

...m to evaluate via noninvasive monitoring the effectiveness of transplanted cells to engraft and repopulate the recipient liver. Using double or triple fusion lentiviral vectors in a mouse model transplanted with immortalized fetal hepatocytes, the researchers for the first time imaged in vivo human hepatic ...

Bangladesh Voter Registration Project Now Using MegaMatcher Biometric Technology to Detect and Prevent Duplicate Registrations

...tionality for the solution to this problem." The Dohatec Biometrics fusion Server(C) system uses MegaMatcher Client to generate templates from face an...egaMatcher includes both fingerprint and face identification engines with a fusion algorithm that allows the two technologies to work together to provide very...

The physics of star-forming clouds and the urban environment

...ttp://meetings.aps.org/Meeting/DFD08/Event/91470 . TURBULENT MIXING IN fusion IMPLOSIONS The phenomenon known as Rayleigh-Taylor instability occurs whe...erface between fluids of different density, such as in inertial confinement fusion implosions. In San Antonio, David Youngs (Aldermaston, UK) will show that 3...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... what the cell does to regulate this mitochondrial fusion gene and we explain why this gene is decreased in ...s? One of the hypotheses is that mitochondrial fusion is crucial for the correct function of these organelles and when the gene that regulates this fusion is decreased, the function of mitochondria is also...

Oak Ridge supercomputer is the world's fastest for science

... burnsimportant for fuel-efficient, low-emission engines. Computer models have helped physicists use radio waves to heat and control ionized fuel in a fusion reactor. Similarly, engineers have designed materials to recover energy escaping from vehicle tailpipes. Simulation insights have enabled biologists t...

Tick-borne encephalitis virus reveals its access code

... fusing their membrane with that of the endosome. fusion is triggered by the endosome's acidic environment. Low pH prompts the aptly named fusion protein, on the virus's outer membrane, to change ...hly conserved histidine residues in the flavivirus fusion protein. The chemical properties of histidines mak...

BIO-key(R) International To Exhibit at Oracle OpenWorld

...tate-of-the-art identification technology in Oracle's Security, Risk Management & Compliance Pavilion. BIO-key will be demonstrating ID Director for fusion Middleware(TM) along with a variety of deployed solutions including retail, government, financial and healthcare applications. By implementing ID Dire...

CSC Identity Labs Headquarters Relocates to West Virginia

...eviously served as CSC's executive program manager for the DoD's Biometrics fusion Center. He joined CSC in 2004 after serving 22 years as a special agent wit...fighter and our country," said Hooks. "During CSC's tenure at the Biometric fusion Center, our identity management support has helped the DoD become the major...

Leading scientist named new chair of Cell Biology at Yale

...ered a complex of vesicle membrane proteins which he implicated in membrane fusion and formulated the highly influential "SNARE hypothesis." This hypothesis p...o appropriate membranes and then unleash the biochemical changes leading to fusion of vesicles with those membranes and the delivery of the vesicles' cargo to...

Estrogen helps drive distinct, aggressive form of prostate cancer

...disease caused by a chromosomal translocation, which in turn results in the fusion of two genes. "Fifty percent of prostate cancers harbor a common recurr...erian Hospital/Weill Cornell Medical Center. "Interfering with this gene fusion -- or its downstream molecular pathways -- will be crucial in the search fo...

Scientists announce top 10 new species, issue SOS

...ns and others. The Web site www.PlanetBob.asu.edu and the video Planet Bob represent new ways to present taxonomy and biodiversity, in a creative fusion between academia and popular technology, says Wheeler, who also is ASU vice president and dean of the College of Liberal Arts and Sciences. The Intern...
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