Expression in Biological News

Cancer's distinctive pattern of gene expression could aid early screening and prevention

AUGUSTA, Ga. Distinctive patterns of genes turned off or left on in healthy versus cancerous cells could enable early screening for many common cancers and maybe help avoid them, Medical College of Georgia scientists say. Researchers are comparing chemical alterations, called DNA methylatio...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

Scientists have discovered gene expression differences that could lead to better ways to classify, predict outcome, and treat juvenile idiopathic arthritis (JIA). Eventually such findings could enable doctors to target more aggressive treatment to children at risk of more severe arthritis, while t...

GEN highlights increasing use of digital gene expression profiling

New Rochelle, NY, April 3, 2009A novel technique for carrying out gene-expression profiling is set to challenge the market dominance of the current, widely used methodology, reports Genetic Engineering & Biotechnology News ( GEN ). Some scientists believe that digital gene-expression profiling, ...

Krumlauf Lab demonstrates modulation of gene expression by protein coding regions

A research team at the Stowers Institute has discovered how the expression of one of the Hox master control genes is regulated in a specific segment of the developing brain. The findings provide important insight into how and where the brain develops some of its unique and important structures. ...

Social interactions can alter gene expression in the brain, and vice versa

Our DNA determines a lot about who we are and how we play with others, but recent studies of social animals (birds and bees, among others) show that the interaction between genes and behavior is more of a two-way street than most of us realize. This is not a new idea to neuroscience, but one th...

Predicting acute GVHD by gene expression could improve liver stem cell transplant outcomes

Tampa, Fla. (July 21, 2008) Many cell transplants involve the use of stem cells from another human being (known as an allograft), which raises the major concern of the potential for acute graft-versus-host disease (GVHD). GVHD occurs when an immune response is elicited by the grafted cells agains...

Scientists discover small RNAs that regulate gene expression and protect the genome

RNA is best known as a working copy of the DNA sequence of genes. In this role, its a carrier of the genes instructions to the cell, which manufactures proteins according to information in the RNA molecule. But molecular biologists have increasingly realized that many RNA snippets -- so-called...

Powerful integration of lipid metabolic profiling with gene expression analysis

A recently published research article in the Journal of Proteome Research, authored by researchers from the Nestl Reserarch Center, Genomatix Software GmbH, Rosetta Inpharmatics LLC, CXR Biosciences Ltd, the Cancer Research UK Molecular Pharmacology Unit demonstrates the synergisms and enhanced an...

Unique pattern of gene expression can indicate acetaminophen overdose

In a new study, researchers found they could detect toxic levels of acetaminophen in laboratory animals by analyzing gene expression in the blood. This study by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, could be a first step in dev...

Omega fatty acid balance can alter immunity and gene expression

For the past century, changes in the Western diet have altered the consumption of omega-6 fatty acids (w6, found in meat and vegetable oils) compared with omega-3 fatty acids (w3, found in flax and fish oil). Many studies seem to indicate this shift has brought about an increased risk of inflammat...

Exercise helps overweight children reduce anger expression

AUGUSTA, Ga. - Regular exercise seems to reduce anger expression in overweight but otherwise healthy children, researchers said. The first published study on the topic looked at 208 typically sedentary 7- to 11-year-olds who participated in a 10-15 week afterschool aerobic exercise program or m...

Conaway Lab identifies novel mechanism for regulation of gene expression

The Stowers Institute's Conaway Lab has demonstrated that an enzyme called Uch37 is kept in check when it is part of a human chromatin remodeling complex, INO80. The results were published in today's issue of Molecular Cell . Uch37 is a "deubiquitinating enzyme" that can remove protein tags (...

Gene-environment interaction in yeast gene expression

The nature vs. nurture debate is familiar to most people, and modern conclusions usually predict a balance between the two. A new paper published this week in the open-access journal PLoS Biology shows that there is a similar balance between the genes we inherit—nature—and the environment—nurture—...

Tolerance to inhalants may be caused by changes in gene expression

AUSTIN, Texas--Changes in the expression of genes may be the reason why people who abuse inhalants, such as spray paint or glue, quickly develop a tolerance, biologists at The University of Texas at Austin have discovered. The team, led by graduate student Yan Wang, used the fruit fly Drosophi...

Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease typically characterized by the slow but progressive onset of shortness of breath or cough. Most patients live about five years after diagnosis. However, according to a new study being published today in the online journal PLoS ONE, a su...

Gene expression test reveals ER and HER-2 status of breast tumors

Two critical characteristics of breast cancer that are important to treatment can be identified by measuring gene expression in the tumor, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in Lancet Oncology online. Researchers developed and validat...

Clues to gene expression in cystic fibrosis will guide research

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to ...

Mayo Clinic: Gene expression profiling not quite perfected in predicting lung cancer prognosis

While there have been significant advances in the use of gene expression profiling to assess a cancer prognosis, a Mayo Clinic review and analysis of existing lung cancer studies shows that this technology has not yet surpassed the accuracy of conventional methods used to assess survival in lung ca...

Pak1 expression increases tamoxifen resistance in breast cancer patients

A protein that activates estrogen receptors in breast cancer may play a role in resistance to therapeutic effects of anti-estrogen tamoxifen treatment, according to a study in the May 17 Journal of the National Cancer Institute. Pak 1 is a member of a family of proteins involved in many cell ...

Gene expression becomes heterogeneous with age in humans and rats

In a study of the effects of aging on gene expression, researchers have found that variation in gene expression among individuals tends to increase with age. The findings, which impact our understanding of the molecular forces that govern age-related changes, are reported in the May 23rd issue of C...

For some young fish, early gene expression is a clear harbinger of fated lifestyle

As juveniles, individuals of many fish species face a developmental choice that will profoundly affect their future: whether to adopt a sedentary or migratory lifestyle. Sedentary (or "residential") individuals remain in the region of their birth, while their migratory compatriots set forth on l...

Swiss researchers develop all-in-one remote control gene expression tool

In an article appearing online today in the journal Nature Methods, researchers at the EPFL (Ecole Polytechnique Fédérale de Lausanne) unveil a powerful new tool that will facilitate genetic research and open up new avenues for the clinical treatment of genetic disease. The researchers have comb...

Gene expression profile helps predict chemotherapy response in ovarian cancer patients

A newly identified gene expression profile could help predict how patients with advanced ovarian cancer will respond to chemotherapy treatment. Described in a study in the November 1, 2005 issue of The Journal of Clinical Oncology (JCO), the new findings further establish an important role for micr...

Gene Expression in the Aging Brain

No matter how healthy a life one leads, no person has managed to live much longer than a century. Even though the advances of the modern age may have extended the average human life span, it is clear there are genetic limits to longevity. One prominent theory of aging lays the blame on the accumula...

Researchers at UGA provide first look at protein expression in Chagas disease-causing parasites

Covering ship hulls with artificial shark skin could help ships sailing smoothly. The growth of marine organisms such as barnacles on ship hulls is a major cause of increased energy costs in the naval industry. Shark skin offers a structural design that prevents this so called 'bio-fouling'. Ralp...

Divergent life history shapes gene expression in brains of salmon

Scientists working with salmon have found that gene expression in the brain can differ significantly among members of a species with different life histories. Their study indicates that roughly 15 percent of Atlantic salmon genes show differential expression in males who migrate from their freshwat...

Confirmation of human protein interaction data by human expression data

As the brain develops, neurons reach out helter-skelter forming new connections, only a small number of which take hold. How the brain chooses which connections to keep and which to prune back appears to be governed by which branches have the most electrical activity—a finding that could help to ex...

Random gene expression may drive HIV into hiding

Random fluctuations in gene expression can influence the fates of cells infected with human immunodeficiency virus (HIV) far more than previously thought, according to new research from Howard Hughes Medical Institute (HHMI) researchers at the University of California, Berkeley. By combining experi...

Multiple-drug resistant gene expression pattern predicts treatment outcome for pediatric leukemia

A new study is providing scientists with a better understanding of why some pediatric acute lymphoblastic leukemia (ALL) patients fail to respond to treatment even when existing clinical predictive criteria point towards a positive treatment outcome. The research, published in the April issue of Ca...

Agilent Technologies releases probe sequence, annotation information for all its commercial gene expression microarrays

Agilent Technologies Inc. (NYSE: A) today announced that it has for the first time released the chip design, probe sequence and annotation information for all of its microarrays. The release of this information is expected to improve cross-laboratory experimental research and cross-platform data co...

Study: 'homemade' gene expression technology unreliable

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says. Otherwise, scientists using DNA microarrays, also known as gene chips...

Expression Project for Oncology (expO) completes first phase of standardized gene expression analyses

The International Genomics Consortium’s (IGC) Expression Project for Oncology (expO) has released clinically annotated gene expression profiles for 60 tumor specimens, completing the initial phase of the nation’s first and eventually largest public database dedicated to standardized gene expression...

Towards precise classification of cancers based on robust gene functional expression profiles

Chemists say they have identified a gene that appears to play a key role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disease that affects about one million people in the U.S. and is on the rise worldwide. They described their findings, which they s...

Applied Biosystems Introduces Advanced Gene Expression Service Provider Program

Applied Biosystems (NYSE:ABI), an Applera Corporation business, today announced the introduction of the Applied Biosystems Advanced Gene Expression Service Provider Program, a new program for service providers who are interested in accessing Applied Biosystems comprehensive solution for gene expres...

Carnegie Mellon scientists develop tool that uses MRI to visualize gene expression in living animals

In a first, Carnegie Mellon University scientists have "programmed" cells to make their own contrast agents, enabling unprecedented high-resolution, deep-tissue imaging of gene expression. The results, appearing in the April issue of Nature Medicine, hold considerable promise for conducting preclin...

Alcohol's effects on gene expression in the central nervous system

Alcohol's primary target is the central nervous system (CNS), where it influences neurotransmission to produce intoxication. Scientists can now use microarray technology to study brain function gene by gene. Symposium proceedings published in the February issue of Alcoholism: Clinical & Experim...

Study Demonstrates Gene Expression Microarrays are Comparable and Reproducible

For everyone doing or reading a paper about microarray-based experiments, reproductibility, especially inter-lab, is the #1 concern. Can I trust these results? If I redo the same experiment in one month, will I be able to compare both? The NIH recently demonstrated that microarrays experiments pe...

Mary had a lot of lambs: Researchers identify way to accelerate sheep breeding

...Breeding out of season is a complex trait," Mateescu said, "so there are a lot of genes controlling it." Mateescu observed the phenotype the physical expression of the gene in the researchers' flock during a postdoctoral fellowship at Cornell. "In this case, we're talking about a receptor gene for melatoni...

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

...iral vectors. Use of the "Sleeping Beauty Transposon System for Stable Gene expression in Mouse Embryonic Stem Cells" from Catherine Krull and colleagues at the U...krull.htm ) provides a method for stable integration and reliable long-term expression of a transgene. Sleeping Beauty transposon-based transfection is a two-comp...

La Jolla Institute discovers novel tumor suppressor

...d young adults. "Some Burkitt's lymphoma cells have very little PLC-beta 3 expression and have very high levels of STAT5 activity, which is similar to our findin...oid leukemia -- indicating that these diseases also use this mechanism (low expression of PLC-beta 3 and high STAT5 activity)." Dr. Kawakami added that much w...