Express in Biological News

Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target

CLEVELAND: Research out of the Ireland Cancer Center of University Hospitals Case Medical Center has found that the vast majority of triple negative breast cancers express the MUC-1 target. This first-of-its-kind finding, presented today at the San Antonio Breast Cancer Symposium, has paved the w...

Venus Express reboots the search for active volcanoes on Venus

ESAs Venus Express has measured a highly variable quantity of the volcanic gas sulphur dioxide in the atmosphere of Venus. Scientists must now decide whether this is evidence for active volcanoes on Venus, or linked to a hitherto unknown mechanism affecting the upper atmosphere. The search for ...

Mars Express -- 5000 orbits and counting

On 25 December 2003, Europes first Mars orbiter arrived at the Red Planet. Almost four years later, Mars Express continues to rewrite the text books as its instruments send back a stream of images and other data. Today, the spacecraft reached another milestone in its remarkable career by completin...

Scientists discover gene mutation responsible for hereditary neuroendocrine tumor

...thin cells to convert biochemical energy into usable energy. This study will be published in the journal Science , to be released online in Science express on July 23, 2009. Paragangliomas are rare, generally benign tumors that arise from cells called glomus cells, which are located along blood vessel...

Vaccine blocks malaria transmission in lab experiments

...Immunology. For the study, the research team expressed full-length Pfs48/45 in E. coli bacteria to produce the vaccine. Previous attempts to fully express the protein had not been successful. The vaccine was first given to mice in the laboratory. The vaccine was also tested in non-human primates (Olive b...

French Authorities Give Sole Approval to GMAT Exam to Collect Biometric Data to Advance Security

...of the person concerned and therefore presents very little risk for the civil liberties and fundamental rights of the individuals." "We want to express our appreciation to the CNIL for reinforcing, in its decision, our commitment to leadership in protecting personal data and complying with internation...

Hormone clue to root growth

...eir cell production rate and the size of the root meristem, the zone of cell proliferation. Plants in which the cells in the meristem were made to express a mutant version of the growth-repressing protein GAI not degraded by gibberellin showed disrupted cell proliferation. Expressing this mutant form, ga...

Scripps Research scientists observe human neurodegenerative disorder in fruit flies

...disease a few years ago, scientists debated whether problems arose because the mutations interfered with tRNA synthetase's normal function, helping to express genes into proteins, or whether they arose because the mutations interfered with some other unknown function. Schimmel had been studying this type...

Stress puts double whammy on reproductive system, fertility

...cocorticoids, a clear indication that these stress hormones can directly affect the cells that produce RFRP. "Critically, we show that RFRP neurons express the receptors for glucocorticoids, which are released from the adrenal glands in response to stress, and that removal of the adrenal glands prevents t...

Story tips from the Department of Energy's Oak Ridge National Laboratory, June 2009

... cures could one day have a new tool that advances the field to a level previously only imagined. The digital holography technique detailed in OPTICS express allows for high-precision 3D single-shot real-time recording that set new standards in the field. "This technology will give biologists the third dim...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

...olecular Biology have found that certain genetic mutations known to extend the lifespan of the C. elegans roundworm induce 'mortal' somatic cells to express some of the genes that allow the 'immortality' of reproductive germline cells. Their report will appear in the journal Nature and is receiving advan...

New tool isolates RNA within specific cells

...nd research technician Kristin J. Robinson of the UO's institutes of Neuroscience and Molecular Biology manipulated Drosophila so that they would only express UPRT in specific target cells. The group tested the new approach in embryos, larvae and adults using microarray technology to detect cell type-specifi...

Princeton team's analysis of flu virus could lead to better vaccines

...ngreen is a theoretical physicist, Levin is a theoretical ecologist and Ndifon is a graduate student learning theoretical biology. "Our best bet is to express our ideas as clearly as we can and hope someone will find them interesting and do the necessary experiments to verify or disprove them," Wingreen said...

Scientists urge world leaders to respond cooperatively to Pacific Ocean threats

...shing, pollution, habitat destruction and climate change. "This is first time the scientific community has come together in a single voice to express urgency over the environmental crisis facing the Pacific Ocean," said Meg Caldwell, executive director of the Center for Ocean Solutions, who will pre...

American Chemical Society's weekly PressPac -- May 6, 2009

...lled in vitro or "test tube" testing, simulations of cosmetic effects with computers, and safety information in existing databases. Some manufacturers express concern because EU officials have not yet validated all of the new testing methods and worry that the regulations could stifle development of innovati...

Preclinical work shows how one gene causes severe mental retardation

...city can be restored in Angelman syndrome model mice, our findings suggest that brain cells in Angelman syndrome patients maintain a latent ability to express plasticity. We are now collaborating to find a way to tap into this latent plasticity, as this could offer a treatment, or even a cure, for Angelman s...

EMBL scientists develop first fully automated pipeline for multiprotein complex production

...ase. ACEMBL can produce complexes consisting of different types of components, including protein, RNA and other biomolecules. Currently designed to express proteins in the standard system Escherichium coli, the automated pipeline will in future be adapted for complex production in eukaryotic cells. This w...

Synthetic chemical offers solution for crops facing drought

...ops as soldiers in the blue revolution. Now our goal is to design the best chemical soldiers possible." Study results appear April 30 in Science express and in the May 22 issue of Science magazine. Because of the prior questionable data in the ABA field, Cutler, the research paper's lead author, t...

International team finds key gene that allows plants to survive drought

... profound impacts on the way we farm in both the developing and developed world," says McCourt. The study results will appear April 30 in Science express and in the May 22 issue of Science magazine. Lead author Sean Cutler is a former University of Toronto scientist who is now an assistant professor o...

Scientists shed light on inner workings of human embryonic stem cells

...tem cell," Kosik said. "The way it's done, is that you take the transcription factors that are required for the pluripotent state, and you get them to express themselves in the skin cells; that's how you can restore the embryonic stem cell state. You clone a gene, you put it into what's called a vector, whic...

Toward a systems biology map of iron metabolism

...ML is a powerful, computer-readable format for describing qualitative and quantitative models of biochemical reaction networks. It can also be used to express gene regulatory networks and other phenomena of interest in systems biology. SBML is designed to enable the exchange of biochemical network models bet...

American Chemical Society's Weekly PressPac -- April 22, 2009

...roduction, financing construction costs in the hundreds of millions of dollars, and securing stable markets for bioethanol. Nevertheless, DOE managers express confidence that the emerging bioethanol industry can surmount these problems. ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, April 27, 2009 "Cellu...

MIT: Making waves in the brain

...searchers used a protein called channelrhodopsin-2 (ChR2), which can sensitize neurons to light. "By combining several genetic tricks, we were able to express ChR2 in different classes of neurons, allowing us to manipulate their activity with precise timing via a laser and an optical fiber over the brain," e...

Mouse model provides a new tool for investigators of human developmental disorder

...port published in Disease Models & Mechanisms (DMM), dmm.biologists.org describes how they modify the Fgrfrl1 gene so that it loses function, then express the gene in mice. Fgfrl1 in humans is located on the short arm of chromosome 4 and mice born with the modified Fgfrl1 gene have a variety of physical ...

2009 ASPB Summer Undergraduate Research Fellowship award announcement

...g on my project! Shelley Sianta, Colorado State University Mentor: Patricia Bedinger Analysis of an Emerging Lineage of Wild Tomato I can't express how grateful and excited I am to be a SURF recipient. My project is evaluating a possible diverging lineage of a marginal population of the wild tomat...

Research could lead to new non-antibiotic drugs to counter hospital infections

...is process damages and sometimes even kills their host. Experiments with mice showed that the harm caused when P. aeruginosa becomes activated to express lethal toxins inside the intestinal tract can be mitigated by providing excess phosphate. The research findings could lead to a pharmaceutical prod...

Novel lung cancer vaccine shows promise in fighting early-stage lung cancer

... some melanomas and head and neck cancers. "The principle is that you can possibly teach a patient's immune system to eliminate cancer cells that express certain proteins such as the MAGE-A3 protein," said Dr. Anthony Kim, thoracic surgeon and principal investigator of the study at Rush. "In a trial of...

UC Davis researchers identify a protein that may help breast cancer spread, beat cancer drugs

...nducted two experiments. They started by comparing breast cancer cells that express Muc4 with those for which Muc4 production is blocked. The researchers then ...eriment with breast cancer cells and epithelial cells that do not naturally express Muc4 but were engineered to do so. Both sets of cells avoided cell death an...

Skin cancer study uncovers new tumor suppressor gene

...ormance of drugs designed to treat cancer by blocking MMP enzymes. Because members of the MMP gene family were thought to be oncogenes and many tumors express high levels of MMP enzymes, researchers have spent decades pursuing MMPs as promising targets for cancer therapies. However, when MMP inhibitors were ...

UK researcher identifies just 8 patterns as the cause of all humor

...ur has massively accelerated humankind's ability to order and manipulate multiple units for multiple uses. Put like that, there are few better ways to express human ingenuity and adaptability." This publication is one of several within a series regarding Clarke's Pattern Recognition Theory Of Humour, whic...

New deep-sea coral discovered on NOAA-supported mission

...f coral had never been recorded in Hawaii before, according a Smithsonian Institution coral expert they consulted. Finding new species was not an express purpose of the research mission, but Dunbar and Christopher Kelley, a scientist with the University of Hawaii, both collected specimens that looked un...

AGU journal highlights -- March 12, 2009

...rn hemispheres and tropical cyclones and hurricanes on Earth. First detected by the Pioneer Venus Orbiter near the northern pole and recently by Venus express orbiter around the southern pole, an S-shaped feature in the center of the vortices on Venus is also known to occur in Earth's tropical cyclones. Usin...

A new way to assemble cells into 3-D microtissues

...o react with other cells in a controlled way by coating the cell surfaces with DNA (not where DNA is normally found!). First they induced the cells to express artificial sugars bearing special chemical groups. Lengths of synthetic DNA, introduced into the cell-growth medium, were equipped to recognize these ...

New deep-sea coral discovered on NOAA-supported mission

...f coral had never been recorded in Hawaii before, according a Smithsonian Institution coral expert they consulted. Finding new species was not an express purpose of the research mission, but Dunbar and Christopher Kelley, a scientist with the University of Hawaii, both collected specimens that looked un...

Mountain on Mars may answer big question

...ey'd eventually find clay sediment deposited there billions of years ago, before the mountain was even a molehill. The European Space Agency's Mars express spacecraft has in recent years found abundant evidence of clay on Mars. This supports a previous theory that where Olympus Mons now stands, a layer of...

From stem cells to new organs: Stanford and NYU scientists cross threshold in regenerative medicine

...in the animal's body. In addition to engineering the stem cells to form a specific organ around the extracted tissue, they also could be engineered to express specific proteins which allows for even greater potential uses of this technology. "Myth has its lures, but so does modern science. The notion of u...

Gene to reduce wheat yield losses

...of these genes has had limited durability in the field because the pathogen has mutated to overcome them. In the paper to be published in Science express tomorrow, the international team of scientists report finding a novel type of gene in wild wheat that is absent in modern pasta and bread wheat variet...

Tailor-made recombinant proteins in mammals

...ere we wanted the chemical modification to occur." Bertozzi calls that six-residue sequence the aldehyde tag. "You just sit back and allow the cell to express the protein. When it does, the FGE system is already in place to convert the cysteine to formylglycine" the nonstandard amino acid bears the aldehyde...

Molecule that suppresses immune response under study in type 1 diabetes

...their dendritic cells that hurts IDO expression. Dendritic cells, which can express IDO, show antigens to the T-cells. A Journal of Immunology paper last ...two-step treatment: prompting inflammation, which causes dendritic cells to express IDO, at the same time they give antigens to the insulin-producing cells. "T...

February 2009 Geology and GSA Today media highlights

...l" (northwest) direction, accounting for the asymmetry. Such a layer likely corresponds to widespread and ancient clay deposits discovered by the Mars express mission, and may constitute a favored environment for extant thermophilic ("heat-loving") organisms on Mars. Mantle weakening and strain localiz...