'New' estrogen receptor found to be key player in tamoxifen resistance
Washington, D.C. Researchers at Georgetown University Medical Center have discovered a novel way in which breast cancer cells become resistant to tamoxifen, the world's largest-selling breast cancer prevention and treatment drug. They say the findings could provide a way to identify tamoxifen us...
Chronic exposure to estrogen impairs some cognitive functions
University of Illinois researchers report this week that chronic exposure to estradiol, the main estrogen
in the body, diminishes some cognitive functions. Rats exposed to a steady dose of estradiol were impaired on tasks involving working memory and response inhibition, the researchers found.
Improved estrogen reception may sharpen fuzzy memory
GAINESVILLE, Fla. Estrogen
treatments may sharpen mental performance in women with certain medical conditions, but University of Florida researchers suggest that recharging a naturally occurring estrogen
receptor in the brain may also clear cognitive cobwebs.
The discovery suggests that drugs ...
High levels of estrogen associated with breast cancer recurrence
PHILADELPHIA Women whose breast cancer came back after treatment had almost twice as much estrogen
in their blood than did women who remained cancer-free despite treatment with anti-estrogen drugs in a majority of the women according to researchers in a study published in the March issue of Canc...
Changing length of days reverses how estrogen affects aggressiveness in mice
New research shows how simply varying the length of daylight to which mice are exposed to can change how aggressively they react to other mice.
The study found that in the short days of winter, the class of hormones called estrogens acts to increase aggression in males of a particular type of mo...
New path from estrogen to survival in breast cancer cells described
After years of research, scientists at The University of Texas M. D. Anderson Cancer Center are now able to explain, in exquisite molecular detail, how the estrogen
hormone can help keep breast cancer cells alive.
In the Sept. 24 issue of the journal, Nature Cell Biology, they assign roles to a ...
Ultra low-dose estrogen shown safe for post-menopausal women
A study led by researchers at the San Francisco VA Medical Center has shown that extremely low doses of estrogen
had no ill effects on the cognitive abilities or general health of older women over the course of two years.
"This is exciting. It shows that women can take estrogen
High estrogen levels associated with dementia in older men
A prospective population-based study has found that higher estrogen
levels in older men are associated with an increased risk of dementia. By contrast, levels of testosterone were not associated with cognitive decline. The study is in the August issue of Annals of Neurology, a journal published by ...
Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer
A laboratory study has uncovered new details about how estrogen
can activate natural pathways that kill certain breast cancer cells or tumors. The results raise the possibility that estrogen
therapy may overcome resistance to certain breast cancer hormonal therapies. The study appears in the Decemb...
Short stressful events may improve working memory
...presses the transmission of glutamate in the prefrontal cortex of male rodents, which is opposite to the facilitating effect of acute stress, and that estrogen
receptors in female rodents make them more resilient to chronic stress than male rats.
"All these studies should bring new insights into the comple...
Plastics chemical retards growth, function of adult reproductive cells
...mponent of food containers and baby bottles.
The chemical structure of BPA is similar to that of estradiol, a key steroid hormone, and it can bind to estrogen
receptors on the surface of some cells. It is not known whether BPA blocks, or mimics or enhances estrogen's activity on these cells, Flaws said.
Evolution of a contraceptive for sea lamprey
...ndamental insights into the early evolution of the estrogen
receptor, research by a team at the University of ...ers characterized the estrogen-binding site on the estrogen
receptor in the sea lamprey. To accomplish this, ...ructed a 3-D model of the structure of the lamprey estrogen
International collaboration by scientists culminates in novel ion channels database
...update of the GPCR database which has been publicly available since 2005. GPCR pages updated in the current release are melanin-concentrating hormone, estrogen
and P2Y receptors.
Targeting helpers of heat shock proteins could help treat cancer, cardiovascular disease
...eat shock protein 90 gets steroid receptors into shape to use hormones like estrogen
and testosterone could lead to targeted therapies for hormone-driven cancer...rs also have a role in cardiovascular health, including the protective role estrogen
seems to have in women before menopause and the fact that testosterone does...
Protein linked to change in tissue that surround and support breast tumors
...GUMC has found that AIB1 acts as a co-activator of growth proteins, such as estrogen
receptor alpha and HER2/neu, which are also often over-expressed in tumor development. "AIB1 and its more active variant potentiate both estrogen
and HER2/Neu at different stages of breast cancer. We knew that AIB1 delta ...
Dual role in breast tissue for a protein involved in leukemia
...fferent in developing breast cancer cells that are estrogen
receptor-positive as compared to estrogen
receptor-negative. When estrogen
receptor levels were overexpressed, loss of Stat5a...
Bisphenol A exposure in pregnant mice permanently changes DNA of offspring
...d subsequent fertility in both mice and humans (HOXA10). Furthermore, these changes in the offspring's uterine DNA resulted in a permanent increase in estrogen
sensitivity. The authors believe that this process causes the overexpression of the HOXA10 gene in adult mice that they found in previous studies.
Lombardi scientist brings 'dream team' breast cancer research effort to GUMC
...f breast cancer cells to preventive and treatment agents. He is recognized by many as the "father" the anti-cancer drug tamoxifen, a drug that blocks estrogen
from fueling some breast cancers. Millions of women around the world continue to be treated with tamoxifen. Jordan's team, led by Dennis Slamon, MD, ...
Lab study shows THC exposure as adolescents linked to negative effects of THC as adults
...chers at Louisiana State University had found that estrogen
or more precisely, having ovaries made adult rat...THC during the equivalent of adolescence, however, estrogen
loses its protective effect. When these rats were ...these results indicate that the effects of THC and estrogen
are different, depending on age, and, even more im...
Hormone-mimics in plastic water bottles -- just the tip of the iceberg?
...o. They then carried out a reproduction test with the New Zealand mud snail to determine the source and potency of the xenoestrogens.
They detected estrogen
contamination in 60% of the samples (12 of the 20 brands) analyzed. Mineral waters in glass bottles were less estrogenic than waters in plastic bottle...
Internationally acclaimed researcher joins UH faculty thanks to $5.5 million grant
... bring an internationally recognized team to study estrogen
action in normal and diseased tissues that will ha...read and expressed. Gustafsson discovered a major estrogen
receptor protein and has worked in a variety of ap...s discovered the existence of a previously unknown estrogen
receptor that plays a pivotal role in the function...
Statin therapy ineffective in breast cancer prevention
...125 or 500 mg/kg in the diet of rats, and it did not alter the incidence of estrogen
receptor-positive mammary cancers or its multiplicity. Similarly, no effect of atorvastatin was observed in an estrogen
receptor-negative model in mice.
By contrast, when these mice were give...
Researchers may have found why women have an edge on salt-sensitive hypertension
...respond but females experienced a significant improvement. When they took out the ovaries, female rats responded more like the males. Dr. Pollock says estrogen
seems to drive the beneficial action of the ETA receptor. Additionally, researchers found stimulation of the ETB receptor increased urine output and s...
National Lung Cancer Partnership and LUNGevity Foundation announce 2009 grant recipients
... fund the scientist's research on visceral pleural invasion and the role of estrogen
in lung cancer tumors, respectively.
Dr. Adusumilli, a general thoracic ...er. Additional research will use new technology to address other ways that estrogen
may affect lung cancer in order to identify future therapies.
"Only by ...
Hormone therapy associated with reduced colorectal cancer risk
... PHILADELPHIA The combination of estrogen
plus progestin, which women stopped taking in drov...men who had never taken these hormones, the use of estrogen
plus progestin was associated with a reduced risk ...ent, was seen among women who had completed use of estrogen
plus progestin five or more years previously.
HWI scientist first in world to unravel structure of key breast cancer target enzyme
...f all three of the enzymes involved in controlling estrogen
levels that can serve as drug targets for estrogen...cent of all breast cancer tumors are estrogen-fed. estrogen
is a female sex hormone and androgens are the male...re was not known, nor the mechanism of androgen to estrogen
conversion, the AIs currently in use have been dev...
BioScience tip sheet, December 2008
...eld and laboratory studies support a mechanism based on endocrine-disrupting chemicals, which interfere with the formation of gonadal steroids such as estrogen
and the development of the reproductive tract.
Of Mice and Men (and Mosquitofish): Antiandrogens and Androgens in the Environment.
Andrew K. Hot...
Birth control has long-term effect on hormone exposure
...fect of post-menopausal dietary soy consumption on estrogen
metabolism in cynomolgus monkeys, Latanya M. Scott...th control earlier in life had a reduced amount of estrogen
excreted in their urine. The research was done in ...eing affected, they do know that both the level of estrogen
in the blood and the amount of...
Clue to genetic cause of fatal birth defect
...lity, but they survive.
The UIC researchers had previously discovered this novel enzyme and were focused on its role in converting the weak hormone estrogen
into the more potent estradiol in the ovaries and its possible role in breast cancer.
Recent research has shown that the HSD17b7 enzyme has an add...
6 environmental research studies reveal critical health risks from plastic
...ng chemicals" that can block the production of the male sex hormone testosterone (phthalates used in PVC plastic), mimic the action of the sex hormone estrogen
(bisphenol A or BPA used in polycarbonate plastic), and interfere with thyroid hormone (brominated flame retardants or PBDEs used in many types of pla...
Breast cancer cells recycle to escape death by hormonal therapy
... and can be tolerated by patients only for relatively short periods. Antiestrogen therapy is more specific, targeting breast cancer cells that express estrogen
In the laboratory, 20-25 percent of breast cancer cells died when Dr. Schoenlein and colleagues gave antiestrogen continuously over tim...
The dietary supplement genistein can undermine breast cancer treatment
...stein, a soy isoflavone that mimics the effects of estrogen
in the body, can negate the effectiveness of aroma...verting precursor molecules to estradiol, the main estrogen
in the body.
About two-thirds of all cases of breast cancer diagnosed in the U.S. are estrogen
Breast cancer treatment resistance linked to signaling pathway
...ed subsets of patients with high Src activation who expressed low levels of estrogen
receptor, progesterone receptor and HER2, also known as triple negative breast cancer, as well as subsets expressing the estrogen
or progesterone receptors.
These patient sets had lower overall surviva...
Is that song sexy or just so-so?
...s than the "non-breeding" ones. But the effects of estrogen
were not identical in every region. "If every node... the presence of estrogen, then we'd conclude that estrogen
acts as an on-off switch," Maney says. "But what w...th estrogen, and some goes down. We are seeing how estrogen
changes the big picture as the brain processes soc...
Expert urges FDA to take action to reduce BPA exposure
...Journal of the American Medical Association ( JAMA ), researchers report a significant relationship between urine concentrations of the environmental estrogen
bisphenol A (BPA) and cardiovascular disease, type 2 diabetes and liver-enzyme abnormalities. In an accompanying editorial, Frederick vom Saal, a Univ...
Gap junction protein vital to successful pregnancy, researchers find
... detail the mechanism by which the steroid hormone estrogen
spurs cell differentiation and blood-vessel growth...lyzing genes that are activated in the presence of estrogen
in uterine cells. They found that Cx43 was promine...als is to identify the genes that are regulated by estrogen
and progesterone precisely at the time when the em...
Bisphenol A linked to metabolic syndrome in human tissue
...ubcutaneous and visceral (around the organs).
Tissue was immediately taken to the laboratory and incubated with different concentrations of BPA or estrogen
for six hours to observe how the varied amounts of BPA affected adiponectin levels. The effects of BPA were then compared to those of estradiol, a nat...
Growth factor predicts poor outcome in breast cancer
...that the effect of IGF was independent of whether the tumor was affected by estrogen
"This is very important," said Lee. "Once patients are resistan...th a drug called exemestane (Aromasin or an aromatase inhibitor that blocks estrogen
production) in postmenopausal women. One group of women take the combinatio...
Songbirds may hold key to advances in treatment of brain degeneration
...lth (NIH) for "Synaptic Aromatase: A Novel Form of estrogen
Delivery." The $1.8 million grant extends a five-y...testes, adipose tissue and neurons. These modes of estrogen
delivery underlie many, but not all, of the multip... in females.
"All songbirds make high levels of estrogen
in their brains," says Saldanha. "The parts of the...
Fish with temperature-dependent sex determination face global warming
...ial for female sex differentiation in fish and reptiles, more work needs to be done into the molecular mechanism linking environmental temperature and estrogen