Essential

Essential mangrove forest threatened by cryptic ecological degradation

The recent killer tsunami has highlighted once more the importance of coastline protection. In natural conditions, this function is taken up by mangroves, forests thriving at the edge of land and sea that are ecologically and socio-economically important for local people in tropical countries on all continents. Using biology, geography, hydrology, socio-economic interviews, and 18th-century histo...

Scientists identify genetic pathways essential to RNA interference

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the jou...

Scientists identify genetic pathways essential to RNA interference

A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the jou...

Researchers feed tiny pills of RNA to planarians to identify genes essential for regeneration

University of Utah researchers-feeding microscopic pills of RNA to quarter-inch long worms called planarians-have identified many genes essential to understanding a biological mystery that has captivated scientists for hundreds of years: regeneration. In pinpointing the genes, the U School of Medicine researchers have established the planarian as a genetically sound model for human biolog...

An essential regulator of body weight revealed

Scientists are one step closer to unraveling the complex mechanisms in the brain that regulate body weight. Working with mice -- whose appetites are controlled by systems very similar to those in humans -- they have identified a specific type of neuron that is essential for feeding behavior. Without these neurons, adult mice stop eating and undergo rapid weight loss. Remarkably, the rese...

Largest computational biology simulation mimics life’s most essential nanomachine

With preliminary results from a study in Botswana, Harvard School of Public Health researchers have found that people with HIV-1 subtype C in resource-poor settings, who receive antiretroviral (ARV) therapy, can achieve comparable results to those in the developed world. A fully supported health care delivery system and infrastructure help ensure this success, according to data published in Novem...

New mechanism for essential genome-wide gene silencing identified

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes. Estimates are that only about 10 percent of the roughly 25,000 genes in the human genome are activated, or "on," at any given time in a particular cell ?the default setting for most genes is "off," or repressed. Reliable gene...

Groovy protein essential for promoting cancer development

Scientists have determined the detailed structure of an essential piece of the telomerase enzyme, an important contributor to the vast majority of human cancers. Understanding the physical shape of the protein has led to a better understanding of how it acts to immortalize cells ?and should help scientists design broadly effective cancer drugs. Until now, the lack of detailed structural in...