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Engineered in Biological News

Genetically engineered mice yield clues to 'knocking out' cancer

Deleting two genes in mice responsible for repairing DNA strands damaged by oxidation leads to several types of tumors, providing additional evidence that such stress contributes to the development of cancer. That's the conclusion of a recent study* in DNA Repair by researchers at the National I...

Mesothelin engineered on virus-like particles provides treatment clues for pancreatic cancer

New understanding of a protein that spurs the growth of pancreatic cancer could lead to a new vaccine against the deadly disease, said researchers at Baylor College of Medicine in Houston in a report appearing in the current edition of the journal Molecular Cancer Therapeutics. The protein call...

MIT works toward engineered blood vessels

CAMBRIDGE, Mass.-MIT scientists have found a way to induce cells to form parallel tube-like structures that could one day serve as tiny engineered blood vessels. The researchers found that they can control the cells' development by growing them on a surface with nano-scale patterning. A paper o...

Genetically engineered corn may harm stream ecosystems

A new study indicates that a popular type of genetically engineered corn--called Bt corn--may damage the ecology of streams draining Bt corn fields in ways that have not been previously considered by regulators. The study, which was funded by the National Science Foundation, appears in the Oct. 8 ...

Study shows genetically engineered corn could affect aquatic ecosystems

BLOOMINGTON, Ind. -- A study by an Indiana University environmental science professor and several colleagues suggests a widely planted variety of genetically engineered corn has the potential to harm aquatic ecosystems. The study is being published online this week by the journal Proceedings of t...

New study finds genetically engineered crops could play a role in sustainable agriculture

Genetically modified (GM) crops may contribute to increased productivity in sustainable agriculture, according to a groundbreaking study published in the June 8 issue of the journal Science. The study analyzes, for the first time, environmental impact data from field experiments all over the worl...

Adult stem cells from human cord umbilical cord blood successfully engineered to make insulin

In a fundamental discovery that someday may help cure type 1 diabetes by allowing people to grow their own insulin-producing cells for a damaged or defective pancreas, medical researchers here have reported that they have engineered adult stem cells derived from human umbilical cord blood to prod...

Tissue engineered scaffolding allows reproduction of cartilage tissue

A new study examines the use of tissue-engineered scaffolding made of cartilage cells, which have a limited ability to heal naturally, to replace defective cartilage tissue. Cartilage cells are extracted and seeded to the scaffold which is implanted into the body, where new cartilage tissue is grow...

Can engineered immune cells stop AIDS?

Twenty years after its introduction, gene therapy still holds great promise as a way to harness the insidious power of viruses such as human immunodeficiency syndrome (HIV). But scientists have yet to solve a vexing problem: developing an efficient transport system that is capable of delivering the...

Genetically engineered blood protein can be used to split water into oxygen and hydrogen

Scientists have combined two molecules that occur naturally in blood to engineer a molecular complex that uses solar energy to split water into hydrogen and oxygen, says research published today in the Journal of the American Chemical Society. This molecular complex can use energy from the sun t...

New engineered drug may offer prolonged arthritis relief

Researchers at Duke University have devised a new way to significantly prolong the effects of an anti-inflammatory drug, potentially making it useful for providing longer-lasting treatment for osteoarthritis, the most common form of arthritis. The modified drug, which would be injected directly i...

Genetically engineered mosquitoes show resistance to dengue fever virus

Researchers have successfully created a genetically engineered mosquito that shows a high level of resistance against the most prevalent type of dengue fever virus, providing a powerful weapon against a disease that infects 50 million people each year. Anthony James, a UC Irvine vector biologist,...

Genetically engineered animals help in scientific research that may benefit children

The recent use of genetically modified mice and rats in combination with an animal model of obstructive nephropathy, a type of renal disease, has given researchers new insight in the development of kidney disease. This research is published in the September issue of Kidney International. "Chroni...

Insects develop resistance to engineered crops

Genetically modified crops containing two insecticidal proteins in a single plant efficiently kill insects. But when crops engineered with just one of those toxins grow nearby, insects may more rapidly develop resistance to all the insect-killing plants, report Cornell University researchers. A s...

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

...hey can transduce non-proliferating cellular targets. These vectors can be engineered to target specific tissues. In the August issue of Cold Spring Harbor Pro...irology_dpt ) present a method for targeting hematopoietic stem cells using engineered viral vectors. The article, "Hematopoietic Stem Cell Targeting with Surface...

La Jolla Institute discovers novel tumor suppressor

...derstand the PLC-beta 3 enzyme's possible role as a signaling pathway in asthma and other allergic diseases, so we began working with mice genetically engineered not to have that enzyme," he said. "We noticed that these mice developed a strange phenotype myeloproliferation and a variety of tumors including lym...

Antibody targeting of glioblastoma shows promise in preclinical tests, say Lombardi researchers

... Washington, DC Cancer researchers at Georgetown University's Lombardi Comprehensive Cancer Center have successfully tested a small, engineered antibody they say shuts down growth of human glioblastoma tumors in cell and animal studies. Glioblastoma is the deadliest of brain cancers; there is ...

EPA grant to University of Chicago for research on food allergy triggers

...ad to improved methods to assess whether pesticides produced in genetically engineered plants can trigger food allergies, which impact more than 11 million Americ...lp predict the potential for people to develop allergies to new genetically engineered foods. With better understanding of how foods trigger allergic responses, s...

Skin-like tissue developed from human embryonic stem cells

...skin, which are the current gold standard for tissue fabrication. "These engineered tissues are remarkably similar to their human counterparts and can be used ...m cell biology that are related to their clinical use. We can now use these engineered tissues as 'tissue surrogates' to begin to predict how stable and safe hESC...

Promising new treatment for Alzheimer's suggested based on Hebrew University research

...searchers used synthetic tails of the normal and the K proteins, as well as engineered human BChE produced in the milk of transgenic goats at a U.S. company, Phar...ty to Alzheimer's could be substantially improved by treating them with the engineered normal protein that is produced in the milk of the transgenic goats. ...

New technique can fast-track better ionic liquids for biomass pre-treatments

...uate the deconstruction of lignocellulosics in biomass of different chemical compositions, and also to assist in determining the impact of genetically engineered feedstocks," Simmons says. "By utilizing this technique, the development and selection of pre-treatment conditions for the selective solubilization ...

UTSA infectious disease researchers advancing vaccine against Valley fever

...infection of humans, commonly called Valley Fever, which is caused by the Coccidioides fungus. For the first time, the researchers have genetically engineered a live, attenuated vaccine that successfully protects mice against Valley Fever, known in scientific circles as coccidioidomycosis. A live, attenua...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

...-based discoveries into novel approaches for the treatment of major diseases. Working at Genentech, Inc. in the early 1980s, he developed genetically engineered human insulin, the first therapeutic derived from gene cloning. In 1987, Ullrich and collaborators discovered that the neu/HER2 gene is amplified and ...

Ecological Society of America announces 2009 award recipients

...owlife," draws from science, art and literature to explain plant movements. Flanagan's other activities involve educating the public about genetically engineered plants and the importance of pollinator conservation. Sustainability Science Award: B.L. Turner and coauthors The recipients of the Sustainabil...

Singapore nanotechnology combats fatal brain infections

...ple, the nanoparticles cause damage to bacteria cell walls and prevent further bacterial growth." The IBN research team has demonstrated that these engineered peptide nanoparticles have high antimicrobial activity and are highly effective in killing microbes. Additionally, the peptide nanoparticles are m...

Dolphins get a lift from delta wing technology

... lift and drag coefficients that the team calculated for each flipper at different inclination angles, they found that the flippers behave like modern engineered aerofoils. Defining the flippers' shapes as triangular, swept pointed or swept rounded, the team used computer simulations of the fluid flows around t...

RSA Designated as the Leader in One-Time Password Market by Frost & Sullivan

...D(R) is the market-leading two-factor authentication system used by more than 40 million people across more than 30,000 organizations worldwide and is engineered to prevent unauthorized access to corporate applications and resources. RSA SecurID technology is comprised of a broad range of hardware and software ...

Research explores interactions between nanomaterials, biological systems

... understanding of the nano-bio interface to identify the potential risks of engineered nanomaterials and to explore design methods that will lead to safer and mor...relatively little is known about the intracellular activity and function of engineered nanomaterials, an area of study particularly important for the development ...

TRAPping proteins that work together inside living cells

...new if this tail -- also known as the C-terminus of the alpha subunit -- touches anything else in the core of the RNA polymerase complex. The team engineered a tag in the C-terminus and cultured bacteria with the tagged RNA polymerase. After adding TRAP to the cells and giving it time to find the C-terminus...

American Chemical Society weekly presspac -- June 10, 2009

...emissions using a single molecule. Their specially engineered molecule combines two light-emitting materials, on...se food poisoning, but which have been genetically engineered to be harmless. Instead of causing disease, the n...or the microbes. The researchers demonstrated that engineered bacteria containing a test protein could successfu...

Advance in understanding cellulose synthesis

...crotubulesthat provide the scaffolding that allow diverse plant cell shapes to be created as the cell wall pushes outward. In that study, the group engineered plants to produce a fluorescent version of cellulose synthase, the enzyme that creates cellulose fibers. They also included a fluorescent version of t...

Jefferson receives $1.7 million grant to study stem cells in intervertebral discs of the spine

...t Jefferson, as well as Dr. Ernestina Schipani, an expert in molecular genetics at Harvard University. The investigators plan to develop a genetically engineered mouse model that lacks selected proteins of the notch signaling pathway in the intervertebral disc. This model will provide important mechanistic insi...

American Chemical Society's weekly PressPac -- May 27, 2009

...n the new microcapsule version absorbed almost twice as much of the drug. ARTICLE #4 FOR IMMEDIATE RELEASE "Dry Hybrid Lipid-Silica Microcapsules engineered from Submicron Lipid Droplets and Nanoparticles as a Novel Delivery System for Poorly Soluble Drugs" DOWNLOAD FULL TEXT ARTICLE: http://pubs.acs.o...

A quicker, cheaper SARS virus detector -- one easily customizable for other targets

...It is also potentially considerably cheaper than alternatives. "We believe," the authors write, "that nanowire bisensor devices functionalized with engineered proteins can have important applications ranging from disease diagnosis to homeland security." Additionally, the system can be useful in basis res...

Boston University biomedical engineers teach bacteria to count

...fundamental application is as a safety mechanism," said Collins. "If you've engineered an organism to be released into the environment as a biosensor, or you've engineered an organism to go into your body to deliver a therapeutic, in many cases yo...

Swine flu experts gather at New York Academy of Sciences May 28

...s to develop improved methods of prevention and control. Keynote speaker Edwin D. Kilbourne, M.D., emeritus professor, developed the first genetically engineered vaccine of any kind more than 30 years ago. He is an internationally recognized research scientist who has made significant contributions to the study...

Scientists work to plug microorganisms into the energy grid

...problem, there are companies ready to move forward. Andreas Schirmer from the company LS9 in South San Francisco describes a unique strategy. LS9 has engineered a proprietary microbe to produce UltraClean diesel in a one-step process. They have discovered a way to exploit the pathway that microbes use to make...

Novel vaccine approach offers hope in fight against HIV

... to bind to SIV and block it from infecting cells. Once proven to work against SIV in the laboratory, DNA representing SIV-specific immunoadhesins was engineered into a carrier virus designed to deliver the DNA to monkeys. The researchers chose adeno-associated virus (AAV) as the carrier virus because it is a v...

UC Riverside geneticist receives highest honor from Botanical Society of America

... flow, the movement of genes from one organism to another. His research has involved the study of the possibility of escape of genes from genetically engineered crops into their wild relatives as well as the potential consequences of that escape. His work has shown that crops can mate with their wild rela...

Cholesterol-busting bug with a taste for waste

...a. "We are trying to work out exactly how Gordonia cholesterolivorans metabolises cholesterol so that we can identify and construct metabolically engineered strains that are more rapid and effective in breaking down cholesterol." ...
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