ICSI or IVF: Babies born from frozen embryos do just as well
Amsterdam, The Netherlands: Analysis of the longest running ICSI programme in the United States has found reassuring evidence that babies born from frozen embryos
fertilised via ICSI (intracytoplasmic sperm injection) do just as well as those born from frozen embryos
fertilised via standard IVF tr...
Female human embryos adjust the balance of X chromosomes before implantation
Amsterdam, The Netherlands: Dutch researchers have found the first evidence that a process of inactivating the X chromosome during embryo development and implantation, which was known to occur in mice but unknown in humans, does, in fact, take place in human female embryos
prior to implantation in...
Red-eyed treefrog embryos actively avoid asphyxiation inside their eggs
Boston University undergraduate Jessica Rogge and associate professor Karen Warkentin, working at the Smithsonian Tropical Research Institute's laboratories in Gamboa, Panama, discovered that frog embryos
at a very early developmental stage actively respond to oxygen levels in the eggas reported i...
Children born from frozen embryos weigh more and do better than those born after fresh transfer
This release is available in Spanish .
Barcelona, Spain: Children born after a frozen, thawed embryo has been replaced in the womb have higher birth weight than those born where fresh embryos
were used, Danish scientists reported to the 24th annual conference of the European Society of H...
Should embryos with a hereditary disorder be transferred if no unaffected embryos are available?
Barcelona, Spain: The numbers of cycles of preimplantation genetic diagnosis or screening are rising steadily in Europe with over 2,700 reported in 2004 (the most recent year for which data are available). Fertility centres are able to screen for a growing number of genetically related conditions,...
Chromosomal problems affect nearly all human embryos
Amsterdam, The Netherlands: For the first time, scientists have shown that chromosomal abnormalities are present in more than 90% of IVF embryos, even those produced by young, fertile couples. Ms Evelyne Vanneste, a PhD student in the Centre for Human Genetics and the University Fertility Center, ...
New test can detect both genetic and chromosomal abnormalities in embryos
Amsterdam, The Netherlands: One-step screening for both genetic and chromosomal abnormalities has come a stage closer as scientists announced that an embryo test they have been developing has successfully screened cells taken from spare embryos
that were known to have cystic fibrosis.
Brain building: Study shows brain growth tied to cell division in mouse embryos
How your brain grows might come down to how your cells divide. In the April 6 issue of the Journal of Cell Biology ( JCB ), Lake and Sokol report that mouse protein Vangl2 controls the asymmetrical cell division and developmental fate of progenitor neurons.
Vangl2 (aka Strabismus in flies) is...
Procedure predicts embryos most likely to result in pregnancy
To address the high rate of multiple births resulting from in-vitro-fertilization (IVF), researchers at Yale School of Medicine and McGill University have developed a procedure that estimates the reproductive potential of individual embryos, possibly leading to a decrease in multiple-infant births ...
Many couples choose to donate surplus embryos for stem cell research
Nearly 50% of couples who were interviewed at least 3 years after undergoing in vitro fertilization (IVF) chose to donate their surplus, stored embryos
for stem cell research, according to a report by the Spanish Stem Cell Bank in an April 26, 2007, advanced online publication of Cell Stem Cell, a ...
Successful transplantation from pig embryos to mice
Millions of diabetics face a lifetime of daily injections to replace the insulin their bodies fail to produce, as well as a host of risks that includes blindness, amputation, kidney failure, and heart disease. For many, particularly those afflicted with juvenile diabetes, transplants of the pancrea...
Forsyth scientists gain greater understanding of how embryos differentiate left from right
Researchers at the Forsyth Institute have discovered a new mechanism responsible for early left/right patterning, the process by which organs locate themselves on the left or right side of the body. The discovery of this novel mechanism, garnered through the study of three different vertebrates (...
Changes to embryos can elicit change in adult fish
In a study illustrating the apparent linkages between the evolutionary development and embryonic development of species, researchers have uncovered the genetic elements that determine the structure and function of a simple biomechanical system, the lower jaw of the cichlid fish. In addition, they'v...
Most embryos produced during IVF do not result in live births
Researchers at Yale School of Medicine have found that 85 percent of embryos
transferred during in vitro fertilization fail to become live births, highlighting the need for improving diagnostic techniques to identify viable embryos.
Published in the August issue of Fertility and Sterility, the st...
Scientists succeed in cloning human embryos from eggs matured in the lab
Scientists in Belgium have discovered how to clone human embryos
from eggs that have been matured in the laboratory. Their discovery should make it easier for scientists to create embryonic stem cell lines from cloned embryos
and develop them to provide eggs and sperm for infertile couples, the 21s...
Researchers capture bacterial infection on film
...al-time with living organisms.
The researchers used developing fruit fly embryos
as a model organism, injecting fluorescently tagged bacteria into the embryos
and observing their interaction with the insect's immune system using time-...
Preimplantation genetic diagnosis may pose neurological risks
...in the biopsied and control groups, which is consistent with results found in humans. However, following implantation, successful births from biopsied embryos
were significantly lower than in controls.
Following birth, the authors tracked many physical and behavioral properties; the two groups of mice we...
Playing it safe
... organ and an astonishing one at that. Even at the age of 70, 80 or 85, men have cells that constantly produce new sperm. Therefore, they can conceive embryos
and become fathers at almost any age - assuming they can find a sufficiently young female partner. Based on this, researchers have long assumed that c...
Pitt team finds molecule that regulates heart size by using zebrafish screening model
...Zebrafish are vertebrate animals whose transparent embryos
develop rapidly, are small and easy to handle and,...mbryonic development.
"The transgenic zebrafish embryos
allow us to actually see when a drug or compound i...ecause the cells glow green," Dr. Tsang said. "The embryos
are like biosensors for FGF signaling, showing us ...
Will IVF work for a particular patient? The answer may be found in her blood
...ast three decades, yet success after IVF remains an unpredictable outcome," said Dr. Allen. "Our work will help understand whether the implantation of embryos
is influenced by the constantly changing expression of human genes."
Previous studies in the field of gene-expression have focused on single genes ...
Single thawed embryo transfer after PGD does not affect pregnancy rates
... just one embryo at a time to a woman's womb after embryos
have undergone preimplantation genetic diagnosis (...ates that are comparable to those for non-biopsied embryos
that are frozen as part of conventional fertility ...orders because of concerns about how well biopsied embryos
survive after freezing and thawing. "It was though...
New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis
...d by these women had chromosomal abnormalities, and therefore the resulting embryos
were also chromosomally abnormal. Some of the women had a tendency to produ...could find fertilised eggs free of chromosomal abnormalities, the resulting embryos
were also normal and their transfer to the mother led to pregnancies," said...
Who goes abroad for fertility treatment and why?
... detail at the situation in his own country. 16 out of the 18 Belgian reproductive medicine centres which were licensed to handle oocytes and create embryos
were surveyed on the nationality of foreign patients coming for treatment between 2000 and 2007, as well as on the type of treatment for which they ca...
ESHRE launches international study of polar body screening
...ndependently analysed by Dr. Sjoerd
Repping, from the Academic Medical Centre in Amsterdam, who carried out a randomised trial of PGS
on three-day old embryos
published in 2007. The researchers hope to present the data at ESHRE 2010 in
Rome and to start the RCT with the involvement of at least six centres in...
Beaked, bird-like dinosaur tells story of finger evolution
...e hands of theropod dinosaurs suggest that the outer two fingers were lost during the course of evolution and the inner three remained.
of living birds suggest that birds have lost one finger from the outside and one from the inside of the hand. Unlike all other theropods, the hand of ...
Universitat Autonoma de Barcelona researchers first to clone mice in Spain
... so as to induce embryonic development. The cloned embryos
were later transferred to receptor females.
Th...ntal and Ibez are comparing three groups of cloned embryos
in their research: valproic acid in the first grou...inted to improvements in the development of cloned embryos
using inhibitors. However, scientists must wait un...
Embryology study offers clues to birth defects
...brafish, the forelimb (pectoral fin) is also missing in retinoic acid-deficient embryos, but they were able to rescue fin development by treating such embryos
with a drug that reduces fibroblast growth factor activity, thus supporting the hypothesis that retinoic acid normally reduces this activity.
When evolution is not so slow and gradual
...ngs. In the environment where predators were present, females produced more embryos
each reproductive cycle. This makes sense because where predators abound, o...econd chance to reproduce. In less dangerous waters, females produced fewer embryos
each time, thus expending fewer resources on reproduction.
Finally, the ...
Study may aid efforts to prevent uncontrolled cell division in cancer
...ty, the time required to complete cell division remains the same during embryogenesis, even as cells get smaller."
During their early development, embryos
are progressively partitioned into smaller and smaller cells by successive rounds of cell division. The division of one cell into two is accomplished ...
Exhibition showcases the 'art of science'
...nceton University campus on May 8.
First prize went to Celeste Nelson, assistant professor chemical engineering, for baby squid, an image of squid embryos
taken using bright field microscopy. Second prize went to Pat Watson, Mike Gaevski, Joe Palmer, and Conrad Sylvestre of Princeton's Micro/Nanofabricat...
Scaling the wall of deafness
...normal hearing, as well, says Prof. Avraham. The work in fish suggests that microRNA mutations may also cause abnormal development of the inner ear in embryos
and deafness in newborns.
MicroRNAs are tiny pieces of RNA, the chemical building blocks that carries genetic information between DNA, to becoming ...
Frogs reveal clues about the effects of alcohol during development
...rstanding early vertebrate development since these embryos
are large, easy to work with and very responsive t...ded for correct positioning of cells in developing embryos
and by preventing its normal production, alcohol k...ase or RALDH2, increased sensitivity of developing embryos
to low doses of alcohol. Conversely, more of the ...
Two innovative University of Texas at Austin biologists become HHMI Early Career Scientists
...s interest in this field began as an undergraduate when he manipulated frog embryos
and watched them develop in a dish of pond water. He later found that activating a single gene in the embryos
triggers a series of shape-shifting events that curl a flat sheet of cells ...
Hormone-mimics in plastic water bottles -- just the tip of the iceberg?
...hese chemicals are potent in vivo and result in an increased development of embryos
in the New Zealand mud snail. These findings, which show for the first time...d glass water bottles, the researchers found more than double the number of embryos
in plastic bottles compared with glass bottles. Taken together, these resul...
Gene exchange common among sex-manipulating bacteria
...ected animals so that more females are produced in the population. Mechanically speaking, the bacteria convert genetic males into females or kill male embryos
that are then eaten by their sisters or make females lay unfertilized eggs that all become females. However, what happens most commonly is that the ma...
Engineering bouncing babies, 1 at a time
...es of a successful IVF implantation, women can opt for three or more viable embryos
to be implanted in the womb during one cycle. Many, emotionally and financi...ion or after IVF procedures, to model how and when artificially inseminated embryos
should be implanted in the uterus.
Mount Sinai Hospital researcher makes stem cell breakthrough
...nd Regeneration. "This new method of generating stem cells does not require embryos
as starting points and could be used to generate cells from many adult tiss.... In 2005, he created Canada's first embryonic stem cell lines from donated embryos
no longer required for reproduction by couples undergoing fertility treatme...
Researchers piggyback to safer reprogrammed stem cells
...amming process. Once the Piggybac Klf4 is removed, they report, iPS cells can go on to create normal mice when introduced into newly developing mouse embryos
and can give rise to the offspring of these mice by contributing to their reproductive cells. This is the most stringent test of the normality of iPS ...
Researchers generate functional neurons from somatic cells
...from adult somatic cells and can differentiate into most other cell types. A potential new source of motor neurons that does not require human eggs or embryos
could be an enormous boon to research into conditions such as amyotrophic lateral sclerosis (ALS) and spinal cord injury and could open the door to ev...
Toxicology program features wide range of human health and environment topical sessions
...city. For example, recent studies have shown that microRNAs have important roles during embryonic development and disruption of microRNA synthesis in embryos
can have dramatic consequences. MicroRNAs also are involved in several human studies and appear to regulate cellular responses to a variety of physiol...