Single thawed embryo transfer after PGD does not affect pregnancy rates
Amsterdam, The Netherlands: Transferring just one embryo
at a time to a woman's womb after embryos have undergone preimplantation genetic diagnosis (PGD) and freezing at the blastocyst stage has become a real option after researchers achieved pregnancy rates that were as good as those for blastocy...
Hebrew University scientists reveal mechanism that triggers differentiation of embryo cells
Jerusalem, December 21, 2008 The mechanism whereby embryonic cells stop being flexible and turn into more mature cells that can develop into specific tissues has been discovered by scientists at the Hebrew University of Jerusalem. The discovery has significant consequences towards furthering resea...
Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate
Researchers at the European Molecular Biology Laboratory (EMBL) have generated a digital zebrafish embryo
- the first complete developmental blueprint of a vertebrate. With a newly developed microscope scientists could for the first time track all cells for the first 24 hours in the life of a zebr...
Newly discovered molecular switch helps decide cell type in early embryo development
CINCINNATI Researchers have discovered a central molecular switch in fruit fly embryos that opens new avenues for studying the causes of birth defects and cancer in humans. Writing about their study in the Aug. 12 Developmental Cell, scientists at Cincinnati Children's Hospital Medical Center d...
Decoding effects of toxins on embryo development
Changes in gene expression patterns in zebrafish embryos resulting from exposure to environmental toxins can identify the individual toxins at work, according to research published in the online open access journal Genome Biology. The genetic response of zebrafish to each toxin can be read like ...
In-vitro fertilization improved with 3-D/4-D-guided embryo transfer and new placement target
Beverly Hills, Calif. and Washington DC (ASRM Annual Meeting) - October 15, 2007 - The pregnancy rate for patients undergoing in-vitro fertilization (IVF) is improved when doctors use advanced 3D/4D imaging to guide the placement of embryos to the point where the endometrium is most receptive to i...
Trio of signals converge to induce liver and pancreas cell development in the embryo
PHILADELPHIA - Understanding the molecular signals that guide early cells in the embryo
to develop into different organs provides insight into ways that tissues regenerate and how stem cells can be used for new therapies. With regenerated cells, researchers hope to one day fill the acute shortage ...
Malignant melanoma cells secrete protein required for embryo formation
A Northwestern University research group has discovered that aggressive melanoma cells secrete Nodal, a protein that is critical to proper embryo
An article describing this research was published today in the advanced online issue of the journal Nature Medicine. The researchers ident...
Technique makes it easier to see mouse embryo in all its glory
A fast, high-resolution, 3D mouse embryo
visualization technique developed by collaborators at the University of Texas Health Science Center at San Antonio and the University of Utah will revolutionize the way birth defects and cancer genes are studied in animal models. That's the prediction of the...
NYU biologists map out early stages of embryo formation
A team of genomic researchers headed by biologists at New York University's Center for Comparative Functional Genomics, in collaboration with researchers at Harvard University, the Max Planck Institute, and Cenix Biosciences, has mapped out a preliminary molecular diagram of the early stages of emb...
Scientists discover that three overlapping signals in embryo help get the backbone right
A major step in the development of the vertebrate embryo
- the establishment of a back that morphs into a brain, spinal cord and muscles - turns out to be so important that the body uses at least three signals to make sure it happens properly.
The discovery, reported this month in the journal De...
Clam embryo study shows pollutant mixture adversely affects nerve cell development
A scientist at the Marine Biological
Laboratory (MBL) has published the results of an EPA-funded clam embryo
study that supports her hypothesis that, when combined, the pollutants
bromoform, chloroform, and tetrachloroethylene--a chemical cocktail
known as BCE--can act synergistically to alter a ke...
Protecting cells from their neighbors
...earch professor at CSIC, have identified the mechanism that protects somatic cells against the behaviour of germ cells. When this mechanism fails, the embryo
dies. Made in the fruit fly Drosophila melanogaster , this finding could be universal. This research is published today in the advanced online editio...
Preimplantation genetic diagnosis may pose neurological risks
...erious health risks, the procedure does involve manipulating the developing embryo
and no rigorous long-term studies have been carried out.
Ran Huo, Qi Zh...tal and adult development.
They found that there were no differences in embryo
development prior to uterine implantation in the biopsied and control group...
Chromosomal problems affect nearly all human embryos
...e screened genetically in order to select the best embryo
for transfer, do nothing to improve pregnancy and ...s. In PGS, a single cell is removed from the early embryo
for genetic testing, since it is hypothesised that...ate and decrease the spontaneous abortion rate per embryo
"Although PGS is promoted as a way...
New test can detect both genetic and chromosomal abnormalities in embryos
...ome a stage closer as scientists announced that an embryo
test they have been developing has successfully sc...eritance of genetic defects in the preimplantation embryo
without any prior patient or disease specific test...a chunk of DNA from the embryo, then they know the embryo
has inherited the mutation. As karyomapping involv...
New, less invasive genetic test greatly improves pregnancy rates in older women with poor prognosis
...ailed IVF attempts.
"Out of 35 patients who had embryo
transfers after the test, we achieved a pregnancy ...the chromosome content of an egg and its resulting embryo
than other alternatives, such as day-three biopsy,...successful IVF, but also enhance the use of single embryo
transfer, especially in countries where...
ICSI or IVF: Babies born from frozen embryos do just as well
..., between 1993 and 2007.
Ms Neri identified 720 IVF and 1231 ICSI frozen embryo
transfers. The survival rate of the frozen embryos was 74% after IVF and 77...assisted reproduction technology. We found no differences in the ability of embryo
generated by IVF or ICSI to implant, even after undergoing the stress of cr...
Who goes abroad for fertility treatment and why?
...islation, or because by doing so they will receive what they perceive to be better quality treatment. This may mean, for instance, the possibility of embryo
freezing", she said.
In another study, Professor Guido Pennings from the University of Ghent, Ghent, Belgium, looked in more detail at the situatio...
Female human embryos adjust the balance of X chromosomes before implantation
... a process of inactivating the X chromosome during embryo
development and implantation, which was known to o...'s womb during fertility treatment, as well as for embryo
stem cell research.
Males and females have two ...ctivation (or XCI).
In mice, XCI occurs before embryo
implantation when the X chromosome inherited from ...
ESHRE launches international study of polar body screening
...use legislation in their countries restricts the possibility of undertaking embryo
biopsy at a
later stage of development. The data from the study will be ind...is mosaicism confuses the analyses and we don't know what it means for
in the later stages of its development."
24sure, the novel molecular tech...
Stem cell surprise for tissue regeneration
...erturned previous research that identified critical genes for making muscle stem cells. It turns out that the genes that make muscle stem cells in the embryo
are surprisingly not needed in adult muscle stem cells to regenerate muscles after injury. The finding challenges the current course of research into ...
Investigating the development of mechanosensitivity
...few laboratories in the world are specialized in this area."
The researchers in Berlin-Buch were able to show that the sensory neurons in the mouse embryo
have already fully developed their mechanosensitivity competence on embryonic day 13. That corresponds to about the end of the sixth month of pregnanc...
The story of X -- evolution of a sex chromosome
...genome that govern sexual differentiation in many species, including our own," she said.
Not all animals and plants employ genes to determine if an embryo
becomes male or female. Many reptiles, for example, rely on environmental cues such as temperature to specify male or female.
But in life forms tha...
Frogs reveal clues about the effects of alcohol during development
...normal development by inhibiting the production of retinoic acid. Under normal conditions, the levels of retinoic acid made in different areas of the embryo
provide cells with necessary information about their proper location and fate. Researchers now show that alcohol steals away the molecules that make ...
Research links evolution of fins and limbs with that of gills
...nt with the vitamin A derivative retinoic acid in the same way a limb or fin skeleton does: by making a mirror image duplicate of the structure as the embryo
develops. According to the researchers, the genetic circuitry that patterns paired appendages (arms, legs and fins) has a deep evolutionary origin tha...
Molecular fingerprints point the way to earlier cancer diagnosis and more targeted treatment
...and other body components that can affect what and how much they do.
This process called methylation can be a good thing like when it's helping an embryo
develop but when it goes badly, it can cause disease such as cancer. While sarcosine's dumping role seemed to protect from cancer, the Michigan scie...
Plant biologists discover gene that switches on 'essence of male'
...ring plants, unlike animals require not one, but two sperm cells for successful fertilisation. One sperm cell to join with the egg cell to produce the embryo
and the other to join with the central cell to produce the nutrient-rich endosperm tissue inside the seed. A mystery in this 'double fertilisation' p...
Engineering bouncing babies, 1 at a time
...cally studying how the uterus contracts before the embryo
implants itself onto the uterine wall," he says. T...hese contractions play a vital role in keeping the embryo
in the uterus, and knowledge of its mechanics can ...r fertilization, this same peristalsis propels the embryo
to its implantation site in the uterine wall. It's...
Tuning in on cellular communication in the fruit fly
...er wing formation.
Many links along the BMP pathway within a cell are well-characterized, but how the pathway works from one cell to another as the embryo
develops is less clear. In the current study, Duffy's team focused on a protein called Kekkon5 (Kek5), which extends through the cell membrane, much l...
Director of Berman Institute comments on FDA Approval of first human embryonic stem cell trial
...nly, or even primarily, because what is at issue is an embryonic stem cell-based intervention. Although deep-seated disagreements about the ethics of embryo
research surround the interest in this study, we need to focus as well on this being the first human trial of its kind. Any "first in human beings" m...
How chromosomes meet in the dark -- Switch that turns on X chromosome matchmaking
... chromosomes in female cells at a crucial stage of embryo
development. Their discovery could also provide ne... rule are X-linked genes in female mammals. During embryo
development, in a step necessary to survival, one ...out colocalization of the X chromosomes and making embryo
The researchers believe...
Recipe for capturing authentic embryonic stem cells may apply to any mammal, study suggests
...ission. Chimeras are produced when embryonic stem cells are inserted into a developing blastocyst and those stem cells go on to contribute to a normal embryo
with cells of two origins, Ying explained. Because those embryonic stem cells can contribute to the germ line, any genetic alterations they carry such...
Patient-derived induced stem cells retain disease traits
... The resulting induced pluripotent stem cells, known as iPS cells, harness the blank-slate developmental potential of embryonic stem cells without the embryo
and have been heralded as a powerful potential way to study development and disease.
Just one year later, the new work is fulfilling that promise. ...
Snails and humans use same genes to tell right from left
... lab, even though he had never before worked with snails.
Snail handedness becomes obvious very early in the embryo, Patel said. When the four-cell embryo
divides to become eight cells, the new cells blossom from their predecessors in a clockwise spiral, in which case the snail ultimately forms a right-h...
Attitudes towards assisted reproduction and preimplantation genetic diagnosis
...for the purpose of selecting a healthy, compatible embryo
that may help cure a sibling suffering some geneti...e recently, the selection of a healthy, compatible embryo
that can help cure a brother or sister of a geneti...ery country)
so any couple can detect whether an embryo
carries a gene predisposing it to suffer some grav...
Study of placenta unexpectedly leads to cancer gene
... in 50 percent of all cancers.
Until now, the SENP2 gene's role in early embryo
development was not known. As a result of making the connection between SEN...een investigating how cellular signaling triggered by gene mutations affect embryo
development in mice. The goal is to better understand the genetic causes an...
Bacterial biofilms as fossil makers
...nd Elizabeth Raff found that the invasion of dying embryo
cells by bacteria -- and the subsequent formation of densely packed bacterial biofilms inside the embryo
cells -- can completely replace embryo
cell structure, generating a faithful replica of t...
Chicks to give scientists clearer picture of fetal development
...ing at how genes relate to development in both time and space; letting us know when and where genes make an impact."
"These early stages of a chick embryo
are essential in the development of the nervous system, heart and limbs and by understanding what happens we can also understand why things may go wro...
Female embryonic sexual development driven by universal factor
...l the difference. Unless it had a Y chromosome, an embryo
developed ovaries and became female, more or less ... which is expressed in many organs and tissues, an embryo
will not survive.
Yao and Liu knew that other p...ing the ovaries, the researchers developed a mouse embryo
in which the beta-catenin gene could be shut off a...