EST

Association of herpesvirus with lung disorder questioned

Contrary to the results of a recent U.S. study, investigators in Japan found no association between a herpesvirus infection and a potentially life-threatening form of high blood pressure, as reported in the March 1 issue of The Journal of Infectious Diseases, now available online. The researchers reported that they were not able to detect human herpesvirus 8 (HHV-8), also known as the Kap...

University of Manchester makes made-to-measure skin and bones a reality using inkjet printers

Made-to-measure skin and bones, which couldbe used to treat burn victims or patients who have suffered severedisfigurements, may soon be a reality using inkjets which can printhuman cells.Scientists at The University of Manchester have developed thebreakthrough technology which will allow tailor-made tissues and bonesto be grown, simply by inputting their dimensions into a computer....

Emory Study Tests Bone Marrow Stem Cells to Improve Circulation in Legs

Physicians at Emory University School ofMedicine are conducting a clinical trial using stem cells generatedwithin the bone marrow to grow new blood vessels that could improvecirculation in patients with blockages in the arteries of their legs --a condition called (PVD). Individuals with PVD...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

Research on adult stem cells found in the skin hints at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes ?dubbed pangenes ?can both govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecular control of these genes has implications for therapies that involve t...

Research advances quest for HIV-1 vaccine

Scientists have uncovered new information that may help guide design of vaccines for HIV-1, the virus that causes AIDS. A new detailed structural analysis of the complex formed by an anti-HIV antibody called 4E10 and its specific target provides insight into why this particular antibody is so broadly effective, a rare characteristic for HIV discovered thus far. The research is published in the Fe...

Another Look Finds Promising Proteomics Test is Not Biologically Plausible

In a new study, researchers present a “cautionary tale?about what may go wrong when using the fledgling science of proteomics to devise a diagnostic test for cancer. In the February 16 issue of the Journal of the National Cancer Institute, researchers from The University of Texas M. D. Anderson Cancer Center detail why an experimental test intended to identify early ovarian cancer from a...

Ecological destruction fuels emerging diseases

The destruction of habitat by human activity and the extinction of species around the world is more than a looming environmental catastrophe, warns a Canadian zoologist. This ecological damage also endangers human health by turning parasites into "evolutionary land mines." Dr. Daniel (Dan) Brooks, a parasitologist at the University of Toronto, says the decline of global biodiversity is li...

Ancient olfaction protein is shared by many bugs, offering new pest control target

In the battle against insect pests, new research indicates that it may all come down to the sense of smell. A group of Rockefeller University scientists who had previously identified a key gene essential for the sense of smell in fruit flies now shows that this gene's function appears to be evolutionarily conserved across very different insect species. Research by Leslie Vosshall's laborat...

Bound for destruction: Ubiquitination protects against improper Notch signaling

The is an important molecular signaling mechanism whose existence has beenknown, or at least hinted at, for nearly a century since theidentification of a mutant strain of Drosophila fruit flies with“notched?wings in Thomas Hunt Morgan’s lab in 1910. Later studiesrevealed that the Notch gene encodes a receptor protein tha...

Novel Therapy Tested in Mice Could Chase Away Cat Allergies

A molecule designed to block cat allergies successfully prevented allergic reactions in laboratory mice, as well as in human cells in a test tube, University of California, Los Angeles (UCLA) researchers report in the April issue of Nature Medicine, available online now. In the future, the investigators say, these promising results could lead to a new therapy not only for human cat allergies, but...

Essential mangrove forest threatened by cryptic ecological degradation

The recent killer tsunami has highlighted once more the importance of coastline protection. In natural conditions, this function is taken up by mangroves, forests thriving at the edge of land and sea that are ecologically and socio-economically important for local people in tropical countries on all continents. Using biology, geography, hydrology, socio-economic interviews, and 18th-century histo...

New research questions basic tenet of neuron function

New findings by researchers at UT Southwestern Medical Center challenge one of the established views of how nerve cells communicate with one another. Every time we move, feel emotions, think or remember, the nerve cells, or neurons, in our body transmit messages to one another via chemical signals called neurotransmitters. Within neurons are tiny organelles called synaptic vesicles that s...

Study: Soap And Water Work Best In Ridding Hands Of Disease Viruses

The largest, most comprehensive study ever done comparing the effectiveness of hand hygiene products shows that nothing works better in getting rid of disease-causing viruses than simply washing one’s hands with good old-fashioned soap and water. Among the viruses soapy hand washing flushes down the drain is the one that causes the common cold. Other removable viruses cause hepatitis A, ac...

Scientists develop new color-coded test for protein folding

Every protein--from albumin to testosterone --is folded into a unique, three-dimensional shape that allows it to function properly. Now Stanford University scientists have developed a simple test that instantly changes color when a protein molecule attached to a gold nanoparticle folds or unfolds. The new technique, which works on the sa...

Highly adaptable genome in gut bacterium key to intestinal health

A bacterium that lives in the human gut adaptively shifts more than a quarter of its genes into high gear when its host's diet changes from sugar to complex carbohydrates. This adaptive mechanism not only allows the bacterial species to survive rapidly changing nutrient conditions but also helps maintain the functions and stability of the gut's highly complex microbial society, according...

Studies reveal methods viruses use to sidestep immune system

A series of studies by researchers at UT Southwestern Medical Center sheds light on the mechanisms used by viruses to thwart a host's immune defenses and may aid in the development of more effective drugs to fight hepatitis C and West Nile viruses, as well as the flu and the common cold. In a study to appear in a March issue of the Journal of Virology and currently available online, UT So...

Scientists discover unique microbe in California's largest lake

Scientists at the University of Oregon havediscovered a form of blue-green algae that lives independently inCalifornia's Salton Sea, using near-infrared light for photosynthesis,according to an article published in this week's online edition of theProceedings of the National Academy of Sciences (PNAS)."This new strain of Acaryochloris is unique because it is able to liveon its own," says UO...

New studies suggest airborne SARS transmission is possible

Two new studies present evidence that the virus causing severe acute respiratory syndrome (SARS) may spread through the air, not just through direct contact with contaminated water droplets as previous research had shown. SARS coronavirus was detected in the air in a patient's room during the 2003 outbreak in Toronto, according to a new study published in The Journal of Infectious Diseases...

Ice core 'dipstick' indicates West Antarctic ice has thinned less than believed

Rising sea levels 20,000 years ago, as the last ice age was beginning to wane, often are attributed in part to melting in West Antarctica. But in a new study led by University of Washington researchers, an ice core of 1,000 meters was used as a sort of dipstick to show that a key section of the West Antarctic Ice Sheet probably never contained as much ice as scientists originally thought...

New Breast Cancer Test Could Save Lives

A team of researchers at the University of Bristol is developing a revolutionary new test to detect breast cancer at an early stage. If successful, this test will be effective for women of all ages; given that breast cancer is the largest killer of women between the ages of 35-55 in Europe, the test could have a dramatic effect on the number of deaths from this disease. The test, which ut...

Estrogen-like Component of Plastic Stimulates Growth of Certain Prostate Cancer Cells

An estrogen-like chemicalcommonly used to synthesize plastic food containers has been shown toencourage the growth of a specific category of prostate cancer cell,potentially affecting the treatment efficacy for a subset of prostatecancers.According to a study published in the January 1 issue of CancerResearch, such prostate cancer cells proved to be vulnerable toexposure to the chemical BP...

UCSD discovery may help extend life of natural pesticide

A team led by biologists at the University of California, San Diego has discovered a molecule in roundworms that makes them susceptible to Bacillus thuringiensis toxin, or Bt toxin--a pesticide produced by bacteria and widely used by organic farmers and in genetically engineered crops to ward off insect pests. Their findings should facilitate the design and use of Bt toxins to prevent ins...

Falling ants glide back to trunk to avoid dangers of forest floor

An amazing variety of arboreal animals have learned to glide through the forest, from flying squirrels to flying lizards and frogs, and even ?frightening as it sounds ?snakes. Gliding ants ?the only wingless insects known to actively...

World's largest rainforest drying experiment completes first phase

Scientists with The Woods Hole Research Center are analyzing the surprising results of the first phase of a drydown experiment occurring in the Amazonian rainforest. From January 2000 to July 2004, rainfall was excluded from a one-hectare (2.2 acre) plot in the middle of the Tapajós National Forest, in Brazil. A total of 6 feet of rainfall was diverted with six thousand 2' by 6' clear plas...

Rush Physicians Using Gene Therapy For Heart Patients With Moderate To Severe Chest Pains Who Do Not Benefit From Other Treatments

Individuals with moderate to severe chest pains (angina) who have not found relief from medication may benefit from a new gene therapy approach being used by cardiologists at Rush University Medical Center to grow new blood vessels in the heart. The phase II clinical research study uses vascular endothelial growth factor-2 (VEGF-2) in the form of a solution containing a DNA plasmid that i...

New Insights Into HIV Immunity Suggest Alternative Approach to Vaccines

New insights by Duke University Medical Center researchers as to how HIV evades the human immune system may offer a new approach for developing HIV vaccines. The findings suggest some HIV vaccines may have failed because they induce a class of antibodies that a patient's own immune system is programmed to destroy. The Duke team discovered that certain broadly protective antibodies, which...

Scientists discuss improved biopesticides for locust control in West Africa

Two Virginia Tech scientists contributed by invitation to an international scientific meeting called by Abdoulaye Wade, president of Senegal, to identify strategies for the control of the ongoing locust outbreak in West Africa. Last year, locusts stripped fields of crops and trees of foliage across several countries, causing severe income and food supply loss. Larry Vaughan, associate pro...

UCLA launches $20 million stem cell institute to investigate HIV, cancer and neurological disorders

Experts in bioengineering, imaging, molecular genetics, immunology, ethics, hematology/oncology and cellular biology to collaborate on Proposition 71 research Drawing together experts from fields as diverse as engineering to molecular biology, UCLA officials announced March 16 the formation of the Institute for Stem Cell Biology and Medicine to conduct embryonic and adult stem cell resear...

Live fast, die young true for forests too

Trees in the world¹s most productive forests -- forests that add the most new growth each year -- also tend to die young, according to a U.S. Geological Survey (USGS) study published in a recent issue of the journal Ecology Letters. This discovery could help scientists predict how forests will respond to ongoing and future environmental changes. "One implication of this fast turnover rate...

Insight into natural cholesterol control suggests novel cholesterol-lowering therapy

New work reported in the March issue of Cell Metabolism has provided insight into a key mechanism by which cells limit cholesterol synthesis. The finding suggests a novel approach to the development of cholesterol-lowering drugs that may boost the effect of statins, one of the most prescribed cholesterol inhibitors, according to researchers at the University of Texas Southwestern Medical Center.<...

No relief for Pacific Northwest drought

It does not appear there will be any major relief this spring or summer from the unusually dry weather that has recently hit the Pacific Northwest, according to new projections of drought severity and fire risk that are based on "general circulation" models that forecast global climate. The analysis, which was developed by researchers at the U.S.D.A. Forest Service and Oregon State Univers...

Transgenic plants remove more selenium from polluted soil than wild plants, new tests show

In the first field trial of plants genetically tweaked to absorb more contaminants, researchers found that the transgenic plants handily beat out their wild-type counterparts. The results raised hopes that the plants might become a viable alternative for cleaning up polluted soil. The new research findings, published Feb. 1 in the journal Environmental Science and Technology, show that th...

Light therapy may combat fungal infections, new evidence suggests

A newly discovered mechanism by which an infectious fungus perceives light also plays an important role in its virulence, according to Howard Hughes Medical Institute investigators at Duke University Medical Center. The findings suggest that changes in light following fungal invasion of the human body may be an important and previously overlooked cue that sparks infection, the researchers said.</...

Promising new West Nile therapy cures disease in mice

West Nile virus alarmed Americans when it made its first U.S. appearance in New York City in 1999. It has since spread from coast to coast, sickened more than 16,000 Americans and killed more than 600. As the virus spread, medical investigators hastened research to develop an effective vaccine or therapy. None currently exist, but a newly published paper by researchers at Washington University in...

Strongest proof yet found for prion hypothesis

UTMB scientists offer strongest evidence yet that infectious misformed proteins cause mad cow disease and other mysterious brain disorders Researchers at the University of Texas Medical Branch at Galveston (UTMB) have produced the strongest proof yet that the mysterious and devastating brain diseases known as "transmissible spongiform encephalopathies" (TSEs) are transmitted by an infecti...

Harmful chemicals may reprogram gene response to estrogen

New research shows that exposure to harmful chemicals and drugs during critical developmental periods early in life may actually "reprogram" the way certain genes respond to the female hormone estrogen. This genetic reprogramming may determine whether people with a genetic predisposition for a disease actually develop the disease. The new research shows that when rats with a genetic predis...

Canadian youth 4th highest in international obesity study

Canadian youth rank fourth-highest on the obesity scale in a new international study of adolescents from 34 countries, says co-author Dr. Ian Janssen, a professor in Queen's University's School of Physical & Health Education and Department of Community Health & Epidemiology. And sedentary behaviour ?like watching television ?was strongly correlated with being overweight, he adds.</...

New Estimates For The Causes Of Child Deaths Worldwide

The most accurate estimates of the causes of child deaths to date, published in the March 26, 2005 of THE LANCET, reveal that worldwide more than 70% of the 10.6 million child deaths that occur annually are attributable to six causes: pneumonia (19%), diarrhoea (18%), malaria (8%), neonatal sepsis or pneumonia (10%), preterm delivery (10%), and asphyxia at birth (8%). Robert Black (Johns H...

Test for early detection of prostate cancer shows promise

In the first clinical study of a new blood protein associated with prostate cancer, researchers have found that the marker, called EPCA or early prostate cancer antigen, can successfully detect prostate cancer in its earliest stages. At the same time, the marker successfully avoids the problem of false positive results that plagues prostate-specific antigen (PSA) testing. Study results ap...

Shift of weather patterns necessitates rethinking of reforestation methods

Forest landowners can greatly increase the survival rate of pine tree seedlings by changing when and how they plant, according to research conducted here. "Some landowners have had to replant two, three or even four years in a row beca...