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EMBL in Biological News

Luxembourg joins EMBL

Today, the European Molecular Biology Laboratory [EMBL] announces Luxembourg as the new member of its international community. Accepted by EMBL's council and ratified by the parliament of Luxembourg, the Grand-Duchy has officially joined the institute as the 20th member state. "EMBL is a key pl...

Scientists open doors to diagnosis of emphysema

...ntions in patients with inflammatory lung diseases," says Marcus Mall, group leader at the Children's Hospital at the University of Heidelberg. The embl and University researchers hope that the new testing strategy can be extended to other enzymes involved in lung inflammation and that, with a better p...

New e-science service could accelerate cancer research

...d by Prof Carole Goble at The University of Manchester and Rodrigo Lopez at embl EBI. Other contributors include Khalid Belhajjame, Franck Tanoh, Jiten ...f Manchester and Eric Nzuobontane, Hamish McWilliam and Thomas Laurent from embl EBI. The project is been funded by the Biotechnology and Biological Scie...

Sugarcoating fruit fly development

... is called Ogt but since its discovery it has remained elusive why attaching GlcNAc to proteins is important. Researchers in the group of Jrg Mller at embl have now discovered that flies lacking Ogt show dramatic developmental defects. In the absence of Ogt cells do not develop into the appropriate cell t...

EMBL scientists develop first fully automated pipeline for multiprotein complex production

..., now makes the biologist's life easier. In a paper published in the current issue of Nature Methods researchers of the groups of Imre Berger at embl and Michel Steinmetz at the PSI describe ACEMBL, the first fully automated pipeline for the production of multiprotein complexes. Requiring much less ...

New study reveals the protein that makes phosphate chains in yeast

..., but how the same process works in eukaryotes has so far remained elusive. embl scientists now show that in yeast a protein called Vtc4p is responsible for...e a factory," says Klaus Scheffzek, whose group carried out the research at embl in collaboration with the Dpartement de Biochimie at the Universit de Lausa...

Winners announced in the Elsevier Grand Challenge

...nference. First prize winner: Sean I. O'Donoghue, Lars Jensen, Heiki Horn, Evangelos Pafilis, Michael Kuhn, Nigel P. Brown and Reinhard Schneider, embl Germany, for their project "Reflect: Automated Annotation of Scientific Terms" Second prize winner: Vit Novacek, Tudor Groza and Siegfried Handschu...

Digital zebrafish embryo provides the first complete developmental blueprint of a vertebrate

...pens in the first 24 hours and allows you to zoom in on all cellular and even subcellular details," says Jochen Wittbrodt, who has recently moved from embl to the University of Heidelberg and the Karlsruhe Institute of Technology. New insights provided by the digital embryo include: fundamental cell mo...

Pregnant mice block out unwelcome admirers to protect their pups

...bryos have already been implanted into the uterus and loosing them would bear a high cost for the female. Liliana Minichiello and her team at the embl Mouse Biology Unit now discovered the molecular mechanism that underpins this change in sensitivity to male odours. "At day 3 of the pregnancy a ...

Zooming in on genetic shuffling

...ombination can also act to separate the transmission of neighbouring genes, which are normally inherited together. The groups of Lars Steinmetz at embl and Wolfgang Huber at EMBL-EBI have produced the most detailed map to date of recombination events in the yeast genome. "Our map has the highest r...

X chromosome exposed

...eves dosage compensation in flies, but it remains unclear how exactly it accomplishes its function. Now researchers from the lab of Asifa Akhtar at embl and the groups of Nick Luscombe and Paul Bertone at EMBL-EBI have uncovered how one component of the MSL complex, an enzyme called MOF, ensures that t...

Getting wise to the influenza virus' tricks

...al proteins. Researchers of the groups of Stephen Cusack and Darren Hart at embl Grenoble have identified the PB2 domain responsible for binding the tag, pr...de, at the expense of host cell proteins. The atomic resolution image the embl scientists generated of a PB2 domain bound to a cap reveals for the first t...

Europe's most common genetic disease is a liver disorder

...o prevent iron overload. A group of researchers around Matthias Hentze at embl and Martina Muckenthaler and Wolfgang Stremmel at the University of Heidelb...research is a landmark for the joint Molecular Medicine Partnership Unit of embl and the University of Heidelberg. The Unit is dedicated to elucidating the ...

How cells keep in shape

...cognise the dynamic structure of a growing microtubule end is a long-standing puzzle. Researchers in the groups of Thomas Surrey and Damian Brunner at embl and of Marileen Dogetrom at AMOLF have now developed the first method that allows to simultaneously study multiple plus-end tracking molecules, so cal...

Brilliant perspectives

...ty of Hamburg and the Helmholtz Association. In addition, around 25 million Euros for experimental setups are contributed by partner institutions like embl (European Molecular Biology Laboratory), the research centre GKSS (Geesthacht), the Max Planck Society and the Universities of Hamburg and Lbeck. ...

Scientists uncover how hormones achieve their effects

... cells. Scientists in the groups of Michael Knop and Philippe Bastiaens at embl labelled members of the MAP kinase signalling chain with fluorescent molecu... in different parts of the cell. This result is exciting, concludes former embl group leader Philippe Bastiaens, who now is a director at the Max Planck In...

Minimum information standards -- all for 1 and 1 for all

... Three papers published by embl scientists and their collaborators will make it much easier to share and compare information from large-scale proteomics data. The papers are publishe...

Researchers shed light on shrinking of chromosomes

...hromosomes. Using powerful microscopes, researchers led by Jan Ellenberg at embl looked at living mammalian cells to find out how and when chromosomes short...omes and acts as a back-up mechanism to rescue separation defects.” The embl researchers found that an enzyme called Aurora kinase is crucially involved...

Researchers identify gene involved in dog size

...public databases: Dog Genome Resources ( http://www.ncbi.nlm.nih.gov/genome/guide/dog ) at NIH's National Center for Biotechnology Information (NCBI); embl Bank ( www.ebi.ac.uk/index.html ) at the European Molecular Biology Laboratory's Nucleotide Sequence Database; UCSC Genome Browser ( http://www.genome...

Putting an old drug to a new use

...ollaborators from the University of Heidelberg and embl now found out that nifedipine, a substance commonl...nces its excretion into the urine," says Weiss, an embl alumnus who now heads a lab at the Department for ...e used on patients," says Martina Muckenthaler, an embl alumna who is now at the University of Heidelberg....

A first glimpse of the influenza replication machine

...n Hart, whose team participated in the research at embl Grenoble. "But no one could get enough protein to ...he virus is replicated. Cell microscopy studies at embl Heidelberg revealed that the human nuclear transpo...ase and importin interact, Stephen Cusack, head of embl Grenoble, and collaborators at the UVHCI, used the...

How nature tinkers with the cellular clock

...ing the right phase of the cycle. Comparing cell cycle genes that are conserved between humans, yeasts and thale cress, Peer Bork and colleagues at embl and DTU found that while many genes in each organism are expressed only at specific times of the cell cycle, it is not the same genes that are tempora...

A switch between life and death

... The breakthrough came as Barry Thompson from Stephen Cohen's group at embl looked at a recently discovered signaling pathway called "Hippo." "Hippo acts as a switch between cell division and death," says Barry Thompson, "I...

New potential drug target in tuberculosis

... because of the activity of key molecules," says Matthias Wilmanns, Head of embl Hamburg. "We are investigating the functions of tuberculosis proteins and d...s of the molecule. Using the high-energy synchrotron radiation beamlines at embl Hamburg, on the campus of the German Electron Synchrotron Radiation Facilit...

The giant protein titin helps build muscles

...ng the steps by which they are formed," says Matthias Wilmanns, Head of the embl Hamburg Outstation. "That probably starts when proteins link up to each oth...as been difficult." Wilmanns' lab and the team of Mathias Gautel, an embl alumnus and now at King's College, have thought that a molecule called titi...

Waking a sleeping virus

... contains the codes for about 100 genes," says Christoph Müller, head of an embl research lab in Grenoble. "Less than 10 genes are sufficient for the virus ...ap of the protein's structure. Using the unique technology "platforms" that embl and the IVMS have set up in partnership with the neighbouring institutes, t...

The closest look ever at the cell's machines

...rk, new computational techniques were developed at embl that gave new insights into the dynamic nature of ... few molecules. Patrick Aloy and Rob Russell at embl used sophisticated computer techniques to reveal t...hways." The collaboration between Cellzome and embl has been very successful, she says, producing fund...

Many needles, many haystacks

...these motifs were already known was a sign we were on the right trail; we then did follow-up experiments in collaboration with Luis Serrano's group at embl to test some of the others." One prediction, for example, suggested that a linear motif would bind to the fly protein translin. The scientists veri...

A new link between stem cells and tumors

...t what to become," says Cayetano Gonz�lez, whose group began the project at embl and has continued the work as they moved to the IRBB-PCB. "The current stud...the right place depends on the activity of specific genes in the stem cell. embl PhD student Emmanuel Caussinus from Gonz�lez's group created neuroblasts in...

The earliest animals had human-like genes

...rent picture than we've seen from the quickly-evolving species that have been studied so far." Raible is member of both Arendt's group and a second embl lab, that of Peer Bork, whose specialty is analyzing genomes by computer. "Human genes are typically more complex than those of flies," explains Bork....

Hunt for human genes involved in cell division under way

...ncludes 10 other institutes throughout Europe, the embl scientists will silence all human genes, one-by-on...library for this project," says Dr. Jan Ellenberg, embl Group Leader and co-initiator of the MitoCheck pro...are targeted specifically against each human gene. embl chose Ambion as a supplier of the siRNA library be...

Public collections of DNA and RNA sequence reach 100 gigabases

...se Collaboration [INSDC, http://www.insdc.org ] - embl Bank [Hinxton, UK], GenBank [Bethesda, USA] and th... the nucleotide sequence databases. From the first embl Data Library entry made available in 1982 to today... to the launch of two databases: the first was the embl Data Library, based at the European Molecular Biol...

Gene Bridges And Covalys To Develop Restriction-Enzyme-Free SNAP-tag Gene Fusion Kits

...rly useful for the rapid generation of targeting vectors, modification of BACs and E. coli chromosomes, as well as viral engineering. Gene Bridges, an embl spin-off, is headquartered in Dresden, Germany and maintains a commercial centre is in Heidelberg. For more information, visit: www.genebridges.com ...

The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life

...odern science," says Ernst Stelzer, whose group at embl developed SPIM. "Molecular biology has graduated u...n Raditsch, Deputy Managing Director of EMBLEM. embl Director-General Prof. Fotis Kafatos and embl Group Leader Dr. Ernst Stelzer met with the Member...
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