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Diabetic in Biological News

Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment

NEW YORK, Jan. 21, 2009 Researchers from Joslin Diabetes Center, Boston, and ActiveSite Pharmaceuticals, Inc., San Francisco, announced today that they have demonstrated that a specific inhibitor of the protease plasma kallikrein, ASP-440, developed by ActiveSite Pharmaceuticals, may provide a ne...

Researcher tricks immune system in diabetic mice

CHICAGO -- The body's immune system hates strangers. When its security patrol spots a foreign cell, it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the r...

New technique eliminates toxic drugs in islet transplant in diabetic mice

CHICAGO -- The body's immune system hates strangers. When its security patrol spots a foreign cell, it annihilates it. This is the problem when people with type 1 diabetes undergo human islet cell transplantation. The islet cells from a donor pancreas produce robust amounts of insulin for the r...

Blood vessel protein reverses macular degeneration, diabetic retinopathy in mice

SALT LAKE CITY Two major eye diseases and leading causes of blindnessage-related macular degeneration and diabetic retinopathycan be reversed or even prevented by drugs that activate a protein found in blood vessel cells, researchers at the University of Utah School of Medicine and several other i...

Study: diabetic neuropathy costs billions per year in lost work time

DANVILLE, PA. - Workers who have diabetes with neuropathic symptoms such as numbness or tingling in feet or hands lose the equivalent of 1.4 hours a week or $3.65 billion per year in health-related lost productive time, a recent study finds. The 1.4 hours lost was more than twice the amount of ...

Abnormal fat metabolism underlies heart problems in diabetic patients

St. Louis, Aug. 10, 2007 Heart disease hits people with diabetes twice as often as people without diabetes. In those with diabetes, cardiovascular complications occur at an earlier age and often result in premature death, making heart disease the major killer of diabetic people. But why is heart ...

Gene therapy prevents the onset of diabetic symptoms in mice

Acid rain, the environmental consequence of burning fossil fuels, running factories and driving cars, has altered soils and reduced the number of sugar maple trees growing in the Northeast, according to a new study led by Cornell University researchers. The sugar maple is the most economically v...

Trial success for diabetic nerve therapy

A potentially ground-breaking treatment for nerve damage caused by diabetes has shown promising results in preclinical and early patient trials. The University of Manchester team has discovered that injection of a novel therapeutic that works by stimulating a person's genes may prevent nerve dama...

Proteins spur diabetic mice models to grow blood vessels, nerves

University of Utah researchers have taken a potentially powerful new therapy for treating diabetes, peripheral vascular disease, and other illnesses out of the test tube and into animals by demonstrating it restores nerve and blood vessel growth in mice. The research has particularly important im...

Common allergy drug reduces obesity and diabetes in mice

...ere far more abundant in fat tissue from obese and diabetic humans and mice than they were in normal weight fa... out, Shi and colleagues took a group of obese and diabetic mice and, for a period of two months, treated them... both cromolyn and ketotifen fumarate on obese and diabetic non-human primates. Beyond friendly fire ...

Researchers design first model motor nerve system that's insulated and organized like the human body

...f the causes of myelin-related conditions, such as diabetic neuropathy and later, possibly multiple sclerosis ...of new drug therapies for these conditions. MS, diabetic neuropathy, and many conditions that are caused by...e their new model system to explore the origins of diabetic neuropathy. Once the causes of myelin degradation ...

Two dietary oils, two sets of benefits for older women with diabetes

...e time that body fat accumulates toward their middle, so this research shows how dietary oils can complement lifestyle and medication in helping older diabetic women manage their health, she said. The research appears online and is scheduled for later print publication in the American Journal of Clinical ...

Natural compound stops retinopathy

...develop new therapies including eye drops to stop diabetic retinopathy, a disease which affects as many as fi...nter. Diabetic retinopathy is the most common diabetic eye disease and a leading cause of blindness in Am...tissue at the back of the eye. In some people with diabetic retinopathy, blood vessels may swell and leak flui...

Simple drug treatment may prevent nicotine-induced SIDS: Study

...ility to respond to decreases in oxygenknown as hypoxiawhich may result in a higher incidence of SIDS. In the same study on rats, they found that the diabetic medication 'glibenclamide' can reverse the effects of nicotine exposure, increasing the newborn's ability to respond to hypoxia and likely reducing th...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

...ance of the meprin proteases. With colleagues from the National Institutes of Health, she found a linkage between the meprin gene and vulnerability to diabetic nephropathy in Pima Indians in the southwestern United States. "These types of transitional research that provide sound basic understanding of a d...

UCSF discovers new glucose-regulating protein linked with diabetes

...nstrumental in moving proteins between cellular compartments. CHC22 was observed to be associated with the abnormal GLUT4 compartments in muscles from diabetic patients which, for some reason, do not mobilize to the muscle cell surface when stimulated by insulin. Notably, she said, while mice also have an ...

Protective footwear for diabetics at a high-street price

...the Czech Republic to test the DIASHOE prototypes manufactured by Bata. The diabetic volunteers recruited exhibited a range of foot complications, from non-seri...elling medical devices, marketed under the brand name MEDI. "First of all a diabetic customer has to have his or her feet assessed and measured by their diabete...

Society of Interventional Radiology Foundation awards $191,000 in grants

... Dr. Ernest J. Ring Academic Development Grant for his research in "MR-guided Transplantation of Magnetoencapsulated Human Pancreatic Islet Cells in a diabetic Swine Model." This grant, named after the founder of the SIR Foundation, is designed to provide support to junior interventional radiology faculty mem...

American Chemical Society's Weekly PressPac -- May 13, 2009

...hts into the mystery of "high risk platelets" from diabetic donors Journal of Proteome Research Amid ... of a group of abnormal proteins in platelets from diabetic donors. The study could lead to screening tests to... unsafe. However, scientists know little about how diabetic platelets differ from those of healthy people. ...

LSUHSC student awarded top national honor for diabetes research

...ne therapy leads to Ang-(1-7)-mediated restoration of glucose metabolism in diabetic mice." She will present it on Tuesday, April 21, 2009 at 9:00 a.m. in Room ...sly demonstrated that glucose tolerance and fasting blood glucose levels in diabetic mice were improved when the pancreas overproduced Angiotensin-converting en...

Male impotence drugs may deserve a second look in women

...t it does to these internal pudendal arteries. "What we have seen preliminarily is there is big difference in responsiveness in these arteries. The diabetic pudendal arteries are much more sensitive to contraction," Dr. Allahdadi says. They will look at how drugs like Viagra impact that contraction in the ...

Laughter remains good medicine

...ll present their findings entitled Mirthful Laughter, As Adjunct Therapy in diabetic Care, Increases HDL Cholesterol and Attenuates Inflammatory Cytokines and h...d April 18-22, 2009 in New Orleans. The Study A group of 20 high-risk diabetic patients with hypertension and hyperlipidemia were divided into two groups:...

Laughter remains good medicine

...ll present their findings entitled Mirthful Laughter, As Adjunct Therapy in diabetic Care, Increases HDL Cholesterol and Attenuates Inflammatory Cytokines and h...d April 18-22, 2009 in New Orleans. The Study A group of 20 high-risk diabetic patients with hypertension and hyperlipidemia were divided into two groups:...

Gene therapy appears safe to regenerate gum tissue

...oncerns, but certainly this is very important to the field. The two clinical applications to date where it shows potential are periodontal disease and diabetic wounds. Maybe the reason for this is that both diseases result from a compromised or a defective healing environment." The next step for the U-M te...

Novocell awarded seminal stem cell patent

... the first critical step in the creation of a renewable islet source derived from hES cells that is targeted at restoring normal glucose regulation in diabetic patients." "Novocell is a leader in differentiation of stem cells to create functional islet cells of the pancreas, and this broad patent signifi...

New approach discovered to lowering triglycerides

...eir report. "Given its strong safety record, lipoic acid may have therapeutic applications for the treatment or prevention of hypertriglyceridemia and diabetic dyslipidemia in humans." ...

ORNL, Southern Cal set sights on preventing blindness

...ts to provide oxygen to retinal tissue being deprived of oxygen because of restricted blood flow. This condition occurs predominantly in patients with diabetic retinopathy ( http://www.nei.nih.gov/health/diabetic/retinopathy.asp ), which affects an estimated 5.5 million people each year. Elias Greenbaum of...

Stem cell infusion and hyperbaric oxygen treatment improve islet function in diabetes

...he chronic injury that attack the endothelial progenitor cells and the islet cells. "Overall, our results show that a close follow-up with intensive diabetic management alone could not be the only cause of the positive, progressive and consistent outcomes we obtained in this trial over one year of follow-up...

Decreasing insulin resistance prevents obesity-related cardiovascular damage

...ery Institute. "That is the point where you need to be intervening." If he's right, PTP1B becomes a drug target for obese people who may not yet be diabetic but already have trouble with blood glucose control. "We have shown cardiovascular function is improved by knocking out this gene. The question is ...

Molecule that suppresses immune response under study in type 1 diabetes

...n the not too distant future where you can identify an individual at risk, such as a 5-year-old child who has a 90 percent chance of becoming a type 1 diabetic within 10 years," he said. "Once you know that information the onus is on medicine to do something about reducing that risk." A three-year, $646,00...

Researchers may have found why women have an edge on salt-sensitive hypertension

...g that occurs in some patients taking powerful new ETA antagonists, which are in use for pulmonary hypertension and under study for conditions such as diabetic nephropathy and uncontrolled hypertension. These antagonists block the action of ETA receptors which are believed to raise blood pressure and help res...

American Chemical Society's weekly PressPac -- Jan. 14, 2009

... from individuals with and without Type 2 diabetes for protein biomarkers of diabetes. They identified 65 proteins that appeared twice as often in the diabetic samples than the non-diabetic samples. These newly identified proteins could lead to new, noninvasive tests for diabetes screening, detection, and mon...

JDRF-funded researchers discover proteins regulating human beta cell replication

...when injected into human islets by viral delivery methods, triggered the beta cells to replicate. These transduced islets were then transplanted into diabetic mice for six weeks. The transplanted islet cells with cdk6 and cyclin D performed better than control (non-modified) human islets as measured by bloo...

Is there a relationship between sleep-wake rhythm and diabetes?

...IC Consortium (MAGIC = Meta-Analyses of Glucose and Insulin-related traits Consortium) combined the data from 13 case-control studies with over 18,000 diabetic and 64,000 non-diabetic study participants and was able to identify a variant of the MTNR1B gene which is associated with both elevated fasting glucos...

Human beta cells can be easily induced to replicate, according to study in Diabetes

.... Untreated human islets did not replicate. "After we transplanted some of these engineered human beta cells under the outer layer of a kidney in a diabetic mouse, we saw that replication continued and blood sugar levels normalized," explained Dr. Fiaschi-Taesch. "When we took out the kidney that contained...

Researchers engineer pancreatic cell transplants to evade immune response

... that were harvested from mice. When injected into diabetic mice, these foreign cells can restore normal gluco...esponsible for making immunosuppressive proteins. diabetic mice that received these engineered foreign beta c... to three months. In contrast, a control group of diabetic mice that received the regular foreign beta cells ...

Caltech scientists develop 'barcode chip' for cheap, fast blood tests

...e IBBC also will potentially allow doctors to assess their patients' responses to drugs and to monitor how those responses evolve with time, much as a diabetic patient might use a blood glucose test to monitor insulin delivery. The barcode chip is now being tested in human clinical trials on patients with ...

Researchers at IRB Barcelona produce more data on key genes in diabetes

... by means of oxidative phosphorylation. Now, for the first time, a study has shown that another gene, called Mitofusin 2 (Mfn2), which is decreased in diabetic patients, is also controlled by PGC1-beta. This information is highly relevant because until now it was considered that PGC1-beta controlled the produ...

NC State finds new nanomaterial could be breakthrough for implantable medical devices

...hers have long sought to develop medical devices that could be implanted into patients for a variety of purposes, such as monitoring glucose levels in diabetic patients. However, existing materials present significant problems. For example, devices need to be made of a material that prevents the body's protei...

Bayhill Therapeutics and the Juvenile Diabetes Research Foundation announce research collaboration

...fe. Tight control of blood glucose is critical to both the long- and short-term health of patients. Short-term effects of poor glucose control include diabetic ketoacidosis, which is a condition that can lead to coma. Long-term effects include elevated glucose levels, blindness, kidney disease, heart disease,...
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