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Deficiency in Biological News

Tryptophan deficiency may underlie quinine side effects

Researchers have found that the anti-malarial drug quinine can block a cell's ability to take up the essential amino acid tryptophan, a discovery that may explain many of the adverse side-effects associated with quinine. Once confirmed, these findings would suggest that dietary tryptophan suppleme...

Is vitamin D deficiency linked to Alzheimer's disease and vascular dementia?

Amsterdam, The Netherlands, May 26, 2009 There are several risk factors for the development of Alzheimer's disease and vascular dementia. Based on an increasing number of studies linking these risk factors with Vitamin D deficiency, an article in the current issue of the Journal of Alzheimer's D...

Vitamin D deficiency related to increased inflammation in healthy women

COLUMBIA, Mo. According to a recent study in the Archives of Internal Medicine, 75 percent of Americans do not get enough Vitamin D. Researchers have found that the deficiency may negatively impact immune function and cardiovascular health and increase cancer risk. Now, a University of Missouri ...

Lamin A/C deficiency is 'unnerving'

Mutations in the nuclear intermediate filament lamin A/C (LMNA) gene are associated with Emery-Dreifuss muscular dystrophy, but cause the disease by unknown mechanisms. Mjat et al. show that one mechanism involves the disruption of neuromuscular junctions. The study will appear online on Monda...

Vitamin D deficiency in infants and nursing mothers carries long-term disease risks

New Rochelle, NY, December 16, 2008Once believed to be important only for bone health, vitamin D is now seen as having a critical function in maintaining the immune system throughout life. The newly recognized disease risks associated with vitamin D deficiency are clearly documented in a report in...

RNA interference therapy heals growth deficiency disorder in a live animal

A team of Vanderbilt researchers have demonstrated for the first time that a new type of gene therapy, called RNA interference, can heal a genetic disorder in a live animal. The study, which was published online Nov. 15 by the journal Endocrinology, shows that RNA interference can rescue a strain...

Worldwide mission to solve iron deficiency

A University of Adelaide researcher will lead an Australian project to help address the world's biggest nutritional deficiency lack of iron. Dr Alex Johnson has been awarded nearly $300,000 to work with the Bill Gates-funded HarvestPlus Challenge Program to increase iron content in rice and ot...

Bloodless worm sheds light on human blood, iron deficiency

Using a lowly bloodless worm, University of Maryland researchers have discovered an important clue to how iron carried in human blood is absorbed and transported into the body. The finding could lead to developing new ways to reduce iron deficiency, the worlds number one nutritional disorder. Wit...

A genetic cause for iron deficiency

The discovery of a gene for a rare form of inherited iron deficiency may provide clues to iron deficiency in the general population particularly iron deficiency that doesnt respond to iron supplements - and suggests a new treatment approach. The finding was published online by the journal Nature ...

Vitamin D deficiency widespread during pregnancy

Even regular use of prenatal multivitamin supplements is not adequate to prevent vitamin D insufficiency, University of Pittsburgh researchers report in the current issue of the Journal of Nutrition, the publication of the American Society for Nutrition. A condition linked to rickets and other musc...

Selenium-protein deficiency raises prostate cancer risk

Selenium, an essential dietary mineral that can act as an antioxidant when incorporated into proteins, has been shown in many studies to reduce the incidence of cancers -- notably lung, colorectal and prostate. "The problem is, nobody seems to know how the mechanism works, and that's not trivial,...

Gene for immune deficiency syndromes found

A newly discovered gene mutation may account for many cases of immune deficiency, in particular two syndromes known as immunoglobulin A (IgA) deficiency and Common Variable Immunodeficiency (CVID), report researchers in the July issue of Nature Genetics. The discovery may lead to a new diagnostic t...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

Researchers at Duke University Medical Center have demonstrated for the first time what happens inside a cell when it is deprived of the essential nutrient iron. Iron is found abundantly in red meats, shellfish dried fruits, whole grains, spinach, seeds and other foods. Their study in yeast cells d...

Got zinc? New zinc research suggests novel therapeutic targets

... the Food Science and Human Nutrition Department at the University of Florida. "Age-related declines in immune function have also been related to zinc deficiency in the elderly." Scientists administered either a zinc supplement or a placebo to healthy volunteers to assess the effects of zinc on T cell activa...

Researchers design first model motor nerve system that's insulated and organized like the human body

...our nerves, can be debilitating and even deadly. Adequate treatments do not yet exist. Researchers at the UCF have identified this to be a result of a deficiency in model research systems. James Hickman, a bioengineer at UCF and the lead researcher on this project explained: "The nodes of Ranvier act like p...

Probiotics help gastric-bypass patients lose weight more quickly, Stanford study shows

... suggests that the use of a dietary supplement after Roux-en-Y gastric bypass surgery can help obese patients to more quickly lose weight and to avoid deficiency of a critical B vitamin. In a study published in the July issue of the Journal of Gastrointestinal Surgery , John Morton, MD, associate professor ...

Versartis presents positive preclinical data on 2 product candidates at ENDO 09

... for patients with metabolic diseases, today presented data for its long-acting product candidates, VRS-317 (hGH-rPEG) for treatment of growth hormone deficiency and for VRS-826 (IL-1ra-rPEG) for treatment of type 1 and type 2 diabetes, at the Endocrine Society's Annual Meeting in Washington, DC. Versartis, t...

Breakthrough made in assessing marine phytoplankton health

...ation and other changes, the researchers said. It will also be a key to determining which areas of the ocean are limited in their productivity by iron deficiency as this study just showed the Indian Ocean was. "Until now we've really struggled to make this technology work and give us the information we need...

Low levels of vitamin D linked to common vaginal infection in pregnant women

...in turn may help the immune system prevent and control bacterial infection. However, only about one in four Americans gets enough vitamin D. Vitamin D deficiency may be more common in African-Americans because dark pigmentation limits the amount of vitamin D that can be made in the skin through casual exposure ...

Vitamin D expert receives Linus Pauling Prize for Health Research

...h sunblock use was leading to increasing vitamin D deficiency with serious implications for cancer and other di...estigation that has now demonstrated how vitamin D deficiency increases the risk of cancer, autoimmune diseases,...ent work, Holick has shown links between vitamin D deficiency and the development of preeclampsia in pregnancy. ...

Vitamin D levels linked to asthma severity

...y synthesized in the body rather than consumed. Because about 90 percent of circulating vitamin D is produced by the body in response to sun exposure, deficiency is often related to behavioral issues rather than an inadequate dietary intake. Increased time spent indoors, increased use of sunscreen and sun-prote...

Vitamin D may exacerbate autoimmune disease

... deficiency in vitamin D has been widely regarded as contributing to autoimmune disease... in patients with autoimmune disease, leading to a current consensus that a deficiency of the secosteroid may contribute to the autoimmune disease process. Howev...

Potential new HIV drug may help patients not responding to treatment

...when the viral load is high, the disease progresses and it depletes the patient's immune system. This eventually leads to the onset of Acquired Immune deficiency Syndrome (AIDS), where the patient cannot fight infections which would be innocuous in healthy individuals. Currently, the 'gold standard' treatme...

Genetic irregularities linked to higher risk of COPD among smokers

...en to be associated with COPD a deficit of the protein A1AT, which has also been linked to the development of lung cancer. "But we know that A1AT deficiency appears in only 1-2 percent of people with COPD, so we were pretty sure that there had to be other genetic variants at work, as well," says Goldstein....

Malaria immunity trigger found for multiple mosquito species

...ule involved in regulating several potent anti-Plasmodium defense genes that attack the parasite in the mosquito gut. Rel 2 is activated by the immune deficiency pathway (Imd) which, in turn, is negatively regulated by the caspar gene; when caspar is silenced the Rel 2 is activated. The researchers found that s...

New potential therapeutic target discovered for genetic disorder -- Barth syndrome

...earch has established a causal role of cardiolipin deficiency in the pathogenesis of Barth syndrome and identifi...esearchers documented that tafazzin or cardiolipin deficiency in Drosophila disrupts the final stage of spermato...l, the study showed that this trait of cardiolipin deficiency can be genetically suppressed by inactivating calc...

Researchers uncover 'obesity gene' involved in weight gain response to high-fat diet

...more PKC beta in their fat tissue than did mice eating a regular diet. "So we now know this gene is induced by a high-fat diet in fat cells, and a deficiency of this gene leads to resistance to fat-induced obesity and related insulin resistance and liver damage," said Kamal Mehta, senior author of the study...

Genetic study shows direct link between vitamin D and MS susceptibility 'gene'

...s journal PLoS Genetics , suggests that vitamin D deficiency during pregnancy and the early years may increase ...less sunshine. This supports a direct link between deficiency in vitamin D, which is produced in the body throug...fessor Ebers and colleagues believe that vitamin D deficiency in mothers or even in a previous generation may le...

What we don’t know still hurts us, environmental researchers warn

...id, given its strengths in researching coupled human and natural systems. The lack of long-term ecosystem monitoring and data collection is another deficiency the world scientific and policy communities must address, Dietz and colleagues wrote. Research tends to be underwritten for maybe three years, but dat...

New drug holds out promise of normal diet for sufferers of devastating PKU genetic disease

...tolerate anything more than a low-protein diet. PKU is described by scientists as an autosomal recessive genetic disease that is characterized by a deficiency in an enzyme called phenylalanine hydroxylase (PAH). Without PAH, the body cannot metabolize the amino acid phenylalanine. It then builds up in th...

Joslin research finds nearly three-quarters of youths with diabetes insufficient in vitamin D

...middle-aged and older. At the same time, vitamin D deficiency in infants and children is associated with bone de..., the paper adds. For these reasons, vitamin D deficiency or insufficiency poses an increased risk for child... In addition, there has been a rise in vitamin D deficiency among children in general, mostly among those livi...

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

...to begin tamoxifen therapy. This data confirms that women with an inherited deficiency in the CYP2D6 gene, which is important for the metabolism of tamoxifen, hav...e drug is less effective in postmenopausal breast cancer patients who had a deficiency in the CYP2D6 gene, which is key for activating tamoxifen and many other dr...

Lack of vitamin D causes weight gain and stunts growth in girls

... and the University of Southern California conducted their study, vitamin D deficiency was found to cause higher body mass and shorter stature in girls at the pea...tamin D). They also assessed body fat and height to determine how vitamin D deficiency could affect young women's health. "The high prevalence of vitamin D in...

UC Davis researchers exploring gene therapy to fight AIDS

...ss, and gene therapy offers real hope as a cure for AIDS." Last month, German doctors reported that they had cured a 42-year-old of acquired immune deficiency syndrome, or AIDS. The patient, an American living in Berlin, also had leukemia, which is best treated by a bone marrow transplant. Thinking they migh...

Claudin 11 stops the leaks in neuronal myelin sheaths

...ion, Devaux and Gow compared electrical recordings from the optic nerve of wild-type and claudin 11 knockout mice. They found that although claudin 11 deficiency caused no gross defects in the appearance of the myelin sheath, it slowed electrical signalsat least in neurons with small-diameter axons. Using a ...

Master gene plays key role in blood sugar levels

...p of this storage form of sugar can cause the liver to fail. "It's one of the few examples of a metabolic genetic disease that can be created by a deficiency in a coactivator," O'Malley said. He actually identified the first coactivator SRC-1. His work with another called SRC-3 has led to better underst...

December 2008 highlights from Biology of Reproduction

... indicators of regulatory complexity. In a paper on p. 1038, Park et al. report genetic background effects on the phenotype produced by Dax1 (Nrob1) deficiency in mice. Intriguing work from several laboratories has demonstrated that the severity of the Dax1 -deficiency phenotype is greatest on a C57BL/6J bac...

UC Davis researchers discover Achilles' heel in pancreatic cancer

... UC Davis Cancer Center researchers have discovered a metabolic deficiency in pancreatic cancer cells that can be used to slow the progress of the deadliest of all cancers. Published in the October issue of the Internatio...

Mitochondria could be a target for therapeutic strategy for Alzheimer's disease patients

...te generation of mitochondrial ROS. Furthermore, CypD-deficient neurons protect against Aβ- and oxidative stress-induced cell death. Importantly, deficiency of CycD greatly improved the learning, memory, and synaptic function of an Alzheimer's disease mouse model and alleviated Aβ-mediated reduction o...

Lung airway cells activate vitamin D and increase immune response

...to contributing to calcium absorption and bone health, vitamin D is increasingly recognized for its beneficial effects on the immune system. Vitamin D deficiency has been recently linked to increased risk of some infections, autoimmune diseases such as multiple sclerosis and type 1 diabetes, and some cancers. ...
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