Cyto

Cytoplasm affects the number of vertebrae in carp-goldfish clones

The March 2005 issue of Biology of Reproduction contains a report of some intriguing findings in cloned offspring created when nuclei from one genus of fish were transplanted to enucleated eggs of another genus of fish. The seven offspring, cloned from nuclei of common carp and egg cytoplasm of goldfish, were virtually identical to the nuclear donor species, Cyprinus carpio, in appearance...

A Jekyll and Hyde of cytokines: IL-25 both promotes and limits inflammatory diseases

The same signal responsible for promoting the type of immune responses that cause asthma and allergy can also limit the type of inflammation associated with debilitating diseases like inflammatory bowel disease, arthritis and multiple sclerosis, according to researchers from the University of Pennsylvania School of Veterinary Medicine. The researchers discovered how IL-25, a signaling protein kn...

Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection

Attaching a recently discovered cytokine to neural stem cells derived from bone marrow, researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute have developed a tool to track and kill malignant brain tumor cells and provide long-term protection against their return. Results of an animal study are published in the March 1, 2006 issue of Cancer Research, and the re...

Innovative method for creating a human cytomegalovirus vaccine outlined

Each year, about 40,000 children are born infected with human cytomegalovirus, or CMV, and about 8,000 of these children suffer permanent disabilities due to the virus ?almost one an hour. These disabilities can include hearing loss, vision loss, mental disability, a lack of coordination, and seizures. According to the Centers for Disease Control and Prevention, CMV is as common a cause of seriou...

LIAI scientists make important finding on cytomegalovirus transmission

Researchers at the La Jolla Institute for Allergy & Immunology have shown that cytomegalovirus (CMV) in the salivary glands can be reduced ?and in some cases eliminated ?through the use of antibodies to enhance the disease-fighting power of the immune system. The research team’s findings, based on controlled laboratory studies of mice, may also have implications for other chronic virus infec...

Cytomegalovirus exacerbates atherosclerosis through an autoimmune mechanism

Atherosclerosis is the main cause of morbidity and mortality worldwide. Classic risk factors including smoking, diabetes, hypertension and high cholesterol levels are known...