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Cystic in Biological News

Two-pronged model could help foil tough cystic fibrosis infections

Hanover, NH--Dartmouth Medical School researchers have devised a novel approach for thwarting the relentless bacterial infections that thrive in the lungs of people with cystic fibrosis (CF), unlocking new possibilities against a tenacious and toxic hallmark of the common genetic disease. Combi...

Nanoemulsion potent against superbugs that kill cystic fibrosis patients

ANN ARBOR, Mich. University of Michigan scientists report highly encouraging evidence that a super-fine oil-and-water emulsion, already shown to kill many other microbes, may be able to quell the ravaging, often drug-resistant infections that cause nearly all cystic fibrosis deaths. Cystic fi...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

Researchers at National Jewish Health have identified a simple gene-based blood test that more accurately and quickly measures cystic fibrosis patients' response to therapy than current tests. The test, a measure of inflammatory gene expression, could improve patient care and help clear a backlog ...

New approach to treating cystic fibrosis lung infection shows promise

Toronto, ON (September 22, 2008) Researchers at the University of Calgary have found a new method of fighting severe lung infections in people with cystic fibrosis (CF). These findings are published in Proceedings of the National Academy of Science USA, this week. Communities of bacteria gr...

PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet

SOUTH PLAINFIELD, NJ August 20, 2008 New phase 2 data published today in The Lancet show that the investigational oral drug PTC124 demonstrates activity in nonsense-mutation cystic fibrosis (CF). The data show that treatment with PTC124 results in statistically significant improvements in the...

Computer simulations point to key molecular basis of cystic fibrosis

Researchers from the University of North Carolina at Chapel Hill have identified a key molecular mechanism that may account for the development of cystic fibrosis, which about 1 in 3000 children are born with in the US every year. The findings, published February 29 in the open-access journal PLo...

Study uncovers clues to cystic fibrosis gene dysfunction and gastrointestinal disease

PROVIDENCE, R.I. A new study by researchers at Hasbro Childrens Hospital, the pediatric division of Rhode Island Hospital, and Mount Sinai Hospital, New York, offers new insight into the role that the cystic fibrosis gene plays in the development of gastrointestinal disease. The cystic fibrosi...

CU-Boulder technology used to identify unexpected bacteria in cystic fibrosis patients

Molecular technology developed by a University of Colorado at Boulder professor to probe extreme life forms in undersea hydrothermal vents has been used to identify unexpected bacteria strains in the lung fluid of Denver children suffering from cystic fibrosis, findings that may lead to more effec...

Galapagos and Cystic Fibrosis Foundation Therapeutics announce drug discovery collaboration

Mechelen, Belgium and Bethesda, Maryland, USA; 29 November 2007 Galapagos NV (Euronext & LSE: GLPG) and Cystic Fibrosis Foundation Therapeutics, Inc. (CFFT), the non-profit affiliate of the Cystic Fibrosis Foundation, announced today a new collaboration aimed at discovering new treatments for cys...

Penn study on lung-infecting bacterial enzyme suggests new approach to cystic fibrosis treatment

Researchers at the University of Pennsylvania School of Medicine have discovered that an enzyme produced by lung-infecting bacteria further shuts down a protein that is defective in cystic fibrosis patients. The disruption to this protein that conveys ions from lung cells to airways causes thick mu...

Key found to kill cystic fibrosis superbug

Researchers from the Schulich School of Medicine & Dentistry at The University of Western Ontario , working with a group from Edinburgh, have discovered a way to kill the cystic fibrosis superbug, Burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Departm...

Clues to gene expression in cystic fibrosis will guide research

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to ...

Discovery could aid fight against cystic fibrosis infection

Harvard Medical School researchers have discovered one way that a hardy disease-causing bacteria could be surviving in the lungs of chronically infected cystic fibrosis (CF) patients. "This work is important because pathogenic bacteria such as Pseudomonas aeruginosa (PA) use protein secretion s...

Study reveals how cells destroy faulty proteins in cystic fibrosis

The cellular system that degrades faulty proteins created by the cystic fibrosis gene has been identified by University of North Carolina at Chapel Hill scientists. Turning off the degradation system allows some proteins to regain their proper shape, offering a new avenue for treatments aimed at cu...

Scientists discover basic defect in cystic fibrosis airway glands

Scientists at Stanford University have determined that the buildup of sticky mucus found in cystic fibrosis is caused by a loss in the epithelial cell's ability to secrete fluid. This research appears as the "Paper of the Week" in the March 17 issue of the Journal of Biological Chemistry, an Ameri...

Test helps in fight against lung infections and for treating other life-threatening infections

...tment for serious lung infections in patients with cystic Fibrosis (CF), a population recognized as having a...atory Medicine and Dr. Neil Brown, Director, Adult cystic Fibrosis Clinic conducted the clinical research fr... The clinical research involved 14 patients with cystic fibrosis at the University of Alberta hospital CF ...

ISU researchers find possible treatment for spinal muscular atrophy

...r mutation in SMN1. Singh believes this technology could also work treating other diseases. "We know that Parkinson's disease, Alzheimer's disease, cystic fibrosis, multiple sclerosis and cancer all come from genes that are aberrantly spliced," he said. "If this is a model disease, meaning we succeed i...

Brain malformations significantly associated with preterm birth, Wake Forest research shows

...ent resulting in the absence of a major portion of the brain, skull, and scalp (57.7 percent); multicystic encephalomalacia, the formation of multiple cystic cavities of various sizes in the cerebral cortex (50.5 percent); and hydranencephaly, a rare condition in which the brain's cerebral hemispheres are a...

New test can detect both genetic and chromosomal abnormalities in embryos

...s taken from spare embryos that were known to have cystic fibrosis. They told a news briefing at the 25t...s caused by a specific gene mutation, in this case cystic fibrosis, but that it was also capable of detectin... embryos that have already been diagnosed with the cystic fibrosis gene mutation using conventional preimpla...

Single thawed embryo transfer after PGD does not affect pregnancy rates

...ues offered single embryo transfer together with freezing of surplus blastocysts to couples seeking PGD for single inherited genetic disorders such as cystic fibrosis. All the embryos were biopsied for the purposes of PGD on the third day after fertilisation, which is the time that they start to divide. Hea...

CSHL scientists harness logic of 'Sudoku' math puzzle to vastly enhance genome-sequencing capability

...has collected DNA from thousands of members of orthodox Jewish communities. The organization's aim is to prevent genetic diseases such as Tay-Sachs or cystic fibrosis that occur frequently within specific ethnic populations. The team's new method will now allow the many thousands of DNA samples gathered by ...

American Society for Microbiology honors Melissa B. Miller

...nizes outstanding laboratory research in clinical microbiology or antimicrobial agents. Dr. Miller has contributed significantly to the fields of cystic fibrosis microbiology and detection and epidemiology of MRSA, and is known for her research on the development and application of molecular assays for...

'Disordered' amino acids may really be there to provide wiggle room for signaling protein

.... NHERF1 is representative of a large class of proteins with an array of biological roles, including signaling pathways implicated in diseases such as cystic fibrosis and breast cancer. "Here we have a molecule that serves an important role in how cells function and survive, but it contains these puzzlin...

Simulated gene therapy

...nism to replace these specific genes, swapping out the bad for the good. If doctors could safely do this, they could treat or even cure diseases like cystic fibrosis, certain types of cancer, sickle cell anemia, and a number of rare genetic disorders. Safety is a primary concern when working with gene t...

Cystic fibrosis testing -- next steps

...Chantilly, VA Three reports describing advances in cystic fibrosis genetic testing appear in the May 2009 is...ue of The Journal of Molecular Diagnostics . cystic fibrosis is a hereditary disease that affects mucu...hildren born in the United States is affected with cystic fibrosis. ...

Sugar on bacteria surface serves as base for a web of resistance

... COLUMBUS, Ohio The bacteria responsible for chronic infections in cystic fibrosis patients use one of the sugars on the germs' surface to start buil...nfection with these bacteria is what causes the death of most patients with cystic fibrosis, a genetic disease characterized in part by excess mucus in the lu...

No hiding place for infecting bacteria

...ry difficult to treat. P. aeruginosa biofilms cause disease in burns, wounds, contact lens infections and are particularly prevalent in the lungs of cystic fibrosis patients. "We specifically targeted the F-actin protein with a negatively charged peptide, and the DNA with the enzyme DNase, which both ...

Tiny samples could yield big predictive markers for pancreatic cancer

...ging techniques, such as magnetic resonance imaging (MRI), are used more often in clinical medicine, doctors are finding many more small, fluid-filled cystic lesions of the pancreas. "Many of these cysts are completely benign and have little or no risk of becoming cancerous. However, a subset of pancre...

Gene therapy demonstrates benefit in patients with rheumatoid arthritis

... and led by an investigator at Beth Israel Deaconess Medical Center (BIDMC). Originally conceived as a means of treating genetic diseases, such as cystic fibrosis and hemophilia, gene therapy involves implanting a normal gene to compensate for a defective gene in the patient. The first clinical trial to...

Research elucidates way lungs fight bacteria and prevent infection

...ssive inflammation, interfering with breathing and damaging the airways. cystic fibrosis is one disease where this work might have particular import, Dr. Chun says. People with cystic fibrosis possess an abnormal gene that causes normal mucus to become thick ...

Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding

...protein folding, and its role in Alzheimer's disease, Huntington's disease, cystic fibrosis and other life-threatening diseases. Additionally, an Honorary 200...ted with approximately 20 diseases, including Alzheimer's, Huntington's and cystic fibrosis. Targeting the activity of the chaperones to correct misfolded pro...

Swiss Institute of Bioinformatics celebrates 10th birthday by presenting major gifts to human health

...ring and often early death. Man's knowledge of proteins such as insulin and haemoglobins is crucial to combating diseases such as cancer, Alzheimer's, cystic fibrosis and haemophilia. Professor Bairoch said, "The general public would understand some of the entries in our protein encyclopaedia. Insulin, f...

Leader of Human Genome Project honored with the Inamori Ethics Prize

...s laboratory is dedicated to researching both rare and common diseases and has discovered a number of important genes, including those responsible for cystic fibrosis, neurofibromatosis, Huntington's disease, adult onset diabetes and Hutchinson-Gilford progeria syndrome, a dramatic form of premature aging. ...

Rattlesnake-type poisons used by superbug bacteria to beat our defenses

...the major cause of death and serious disability in cystic fibrosis patients which is the most common lethal... affects about 8,000 people," says Dr Welch. In cystic fibrosis the gene defect means that people are ver...tic treatment can usually control the infection in cystic fibrosis sufferers but eventually the strain becom...

Gaining a better understanding of kidney diseases

... This press release is available in German . cystic kidney disease, renal fibrosis, or renal cell carcinoma: Many diseases of the excretory organs are characterized by overproduction or on the contrary...

American Chemical Society's Weekly PressPac -- Aug. 27, 2008

... ARTICLE #5 EMBARGOED FOR 9 A.M., EASTERN TIME, Sept. 1, 2008 Helping cystic fibrosis patients breathe easier Chemical & Engineering News Research...ve of new drugs that could dramatically improve the health of patients with cystic fibrosis (CF), which remains difficult to treat with today's drugs, accordi...

Researchers discover cell's 'quality control' mechanism

...ough has significant implications for the development of new treatments for cystic fibrosis (CF) and some other hereditary diseases, the researchers say. Thei... It's the degradation of the protein, not the mutation itself, which causes cystic fibrosis. We're hoping this discovery will open up new avenues of research ...

Consortium develops new method enabling routine targeted gene modification

...ld also stimulate additional research into the potential application of ZFNs for gene therapy of single-gene disorders, such as sickle cell anemia and cystic fibrosis." Joung's lab has already begun to explore ways to further simplify the OPEN method so that it can be performed more quickly and for a larger...

Consortium develops new method to manipulate genetic material

...ld also stimulate additional research into the potential application of ZFNs for gene therapy of single-gene disorders, such as sickle cell anemia and cystic fibrosis." ...

RNA emerges from DNA's shadow

...esulting from mutations that cause genes to be incompletely read, including cystic fibrosis and muscular dystrophy. A drug based on the molecule is now enteri... generally available. Results so far indicate dramatic improvements in both cystic fibrosis and muscular dystrophy sufferers, although it is only suitable for...
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