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Crystal in Biological News

A crystal ball for brain cancer?

UCLA researchers have uncovered a new way to scan brain tumors and predict which ones will be shrunk by the drug Avastin -- before the patient ever starts treatment. By linking high water movement in tumors to positive drug response, the UCLA team predicted with 70 percent accuracy which patients...

Scripps scientists create first crystal structure of an intermediate particle in virus assembly

The structure, described February 8 in an advance online publication of the journal Nature , provides fresh insights into the elegant dance that viral proteins perform to create the infectious structure that causes all manner of misery and disease, say researchers. While the virus they studied, H...

A crystal clear view of chalk formation

This release is available in German . It has a beautiful, but also an unpleasant side: crystallization determines the shape of precious stones, but also causes the lime scale in washing machines. How this comes about, has been known for a long time - or has it? Scientists at the Max Pla...

Bare bones of crystal growth: Biomolecules enhance metal contents in calcite

Blacksburg, Va. From shells to bones, the skeletons of organisms contain small amounts of impurity elements such as magnesium. Because the levels of these elements provide important clues to past environments, a considerable effort has focused on understanding how to relate impurity contents to t...

Photonic crystal biosensors detect protein-DNA interactions

CHAMPAIGN, Ill. Scientists at the University of Illinois have developed a new class of disposable, microplate-based optical biosensors capable of detecting protein-DNA interactions. Based on the properties of photonic crystals, the biosensors are suitable for the rapid identification of inhibitor...

Liquid crystal phases of tiny DNA molecules point up new scenario for first life on Earth

A team led by the University of Colorado at Boulder and the University of Milan has discovered some unexpected forms of liquid crystals of ultrashort DNA molecules immersed in water, providing a new scenario for a key step in the emergence of life on Earth. CU-Boulder physics Professor Noel Cl...

Researchers develop liquid crystal pharmaceuticals to fight cancer and other diseases

A partnership between Kent State University, Summa Health System and IC-MedTech Inc. has yielded an innovative liquid crystal technology that offers the promise of new drugs which may more effectively manage cancer and other diseases. The American Cancer Society estimates that nearly 1.5 million n...

Scientists find missing evolutionary link using tiny fungus crystal

WEST LAFAYETTE, Ind. - The crystal structure of a molecule from a primitive fungus has served as a time machine to show researchers more about the evolution of life from the simple to the complex. By studying the three-dimensional version of the fungus protein bound to an RNA molecule, scientis...

Enzyme crystal structure reveals 'unexpected' genome repair functions

The study is being published in an advance online version of the journal Molecular Cell. The research looked at XPB helicase from an archaea, a single cell organism similar to bacteria. Helicases are enzymes that unwind or separate the strands of the nucleic acid double helix, an action that is ...

One hit of crystal meth causes birth defects

A single prenatal dose of methamphetamine ?commonly known as speed ?may be enough to cause long-term neurodevelopmental problems in babies, say University of Toronto researchers. In research published in the August issue of Free Radical Biology and Medicine, U of T pharmacy and pharmacology profe...

Jet-propelled imaging for an ultrafast light source

...he structure of a protein or virus has been with x-ray crystallography. The crystal consists of many copies of the protein or virus arranged in regular order. As the crystal rotates in the x-ray beam, x-rays scatter off the atoms and reveal once th...

What scientists know about jewel beetle shimmer

...tle cells form similar to a certain kind of liquid crystal called a 'cholesteric' liquid crystal whose free surface has cone-like structures and th...also forms helices similar to a cholesteric liquid crystal in that its straight cells sit on or are used to f...

Munich researchers discover new target for tailored antibiotics

...ers questioned the results, and for many years the crystal structure of the enzyme that would provide the pro...iversity in Giessen managed to determine the X-ray crystal structure of the enzyme's open state. However, thi...ical environment of the active site cavity. The crystal structure opened the door to a detailed examinatio...

Medical use for waste television screens

...nd is a key element of television sets with liquid crystal display (LCD) technology. When these sets are thro...Chemistry Centre of Excellence and the York Liquid crystal Group, and is published in the journal Green Chem...'s of the research, said: "With 2.5 billion liquid crystal displays already reaching the end of their life, a...

2000-year-old statue of an athlete sheds light on corrosion and other modern challenges

... perplexing problems. That's the conclusion of a new study on the so-called "biomineralization" of Apoxyomenos appearing in the current issue of ACS' crystal Growth & Design , a bi-monthly journal. Best known as "The Scraper," the statue depicts an athlete scraping sweat and dust from his body with a small ...

Corals stay close to home

... The thought of coral reefs tends to conjure up images of tropical vacations, complete with snorkeling among tropical fish in crystal clear waters. Rapid climate change, and increased pollution, ocean acidification and overfishing threaten to darken this picture considerably. Thes...

Healing wounds with lasers, vehicles that drive themselves, other cutting-edge optics

...ssue in the field, where U.S. soldiers have to maximize precious battery power. Flexible displays are an attractive alternative to existing liquid crystal display (LCD) models because they would be lighter and more durable, consume less power, and could ultimately be rolled up and stuffed in a pocket bet...

American Chemical Society's Weekly PressPac -- May 20, 2009

...ry studies, the researchers coated glass slides with the particles, cooled the slide, and then exposed it to steam. Unlike ordinary glass, it remained crystal clear, opening the door to possible commercial applications, the researchers say. ARTICLE #3 FOR IMMEDIATE RELEASE "Facile Fabrication of Raspbe...

The challenges of avian influenza virus: Mechanism, epidemiology and control

...e conservation and the atomic structure. This provides the basis for identifying structurally and functionally important regions for inhibitor design. crystal structures of some parts of the polymerase complex, PA alone or PA with part of PB1, have been solved. Zihe RAO, Yingfang LIU and colleagues from Inst...

Gene therapy could expand stem cells' promise

...ife. They only last a certain amount of time," Dr. crystal says. "Stem cells are the opposite. Once the futur...ulin levels. "You've totally lost control," Dr. crystal says. "What do you do?" The best chance of circ...em cells prior to actually transplanting them, Dr. crystal says. Theoretically, this is similar to how gene t...

UCSD researchers make first direct observations of biological particles in high-altitude ice clouds

...rtment of Chemistry and Biochemistry at UCSD, sampled water droplet and ice crystal residues at high speeds from an aircraft flying through clouds in the skies...s a wave cloud. The researchers performed in-situ measurements of cloud ice crystal residues and found that half were mineral dust and about a third contained ...

Genetic switch potential key to new class of antibiotics

...When too much preQ1 is present, the enzyme that makes preQ1 is shut off by the riboswitch. In the current study, Wedekind and colleagues solved the crystal structure of a preQ1 riboswitch in complex with its precursor metabolite preQ0. They chose to study the riboswitch from Thermoanaerobacter tengcongens...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

...that the tight interaction between RITS and the methyl marks is a requirement at least as important as the availability of siRNA," Schalch says. A crystal structure provides the answer The team wanted to know the exact points of contact between Chp1 and its target and how these interactions contribute...

Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic

... in horse spleen apoferritin, HSAF, that Eckenhoff and co-workers have shown to bind clinical anesthetics. Researchers noticed a resemblance in the crystal structure of the apoferritin protein to that of the transmembrane region of the superfamily of ligand-gated channels that includes the GABA receptor. ...

Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy

... (NIH) National Institute of General Medical Sciences (NIGMS), which partially supported the work. "In the future, scientists may be able to use these crystal structures to design chemicals that block P-glycoprotein's activity and restore sensitivity to chemotherapeutic agents." Solving the Structure ...

Deep-sea rocks point to early oxygen on Earth

...ssion electron microscopy, the researchers did not find that crystalline structure. "We found that the hematite from this core was made of a single crystal and therefore was not hematite made by ultra violet radiation," said Ohmoto. This could only happen if the deep ocean contained oxygen and the iron...

GEN reports on Madoff scandal's impact on the life sciences

...ies that commented in the GEN article on Madoff and the current economic crisis include the Howard Hughes Medical Institute, Epigenomics, VentureEdge, crystal Cove Capital, Foley Hoag, Bentley University, Ernst & Young, PolyMedix, BioEnterprise, Unigene, and the Colorado Biosciences Association. ...

New aerosol observing technique turns gray skies to blue

...thod we have to retrieve accurate and detailed aerosol properties over land surfaces," said Michael Mishchenko, Glory's project scientist. RSP uses crystal prisms to effectively filter out the bright glare from Earth's surface, functioning somewhat like polarized sunglasses by only allowing light waves or...

AGU journal highlights -- March 12, 2009

... Expanding on past research that demonstrated that crystal lattice orientations in the analog postperovskite ...erovskite to analog postperovskite itself yields a crystal lattice structure different from postperovskite de...downwelling material that underwent these observed crystal lattice transformations. Title: Transformatio...

Scientists identify human monoclonal antibodies effective against bird and seasonal flu viruses

... 10 mAb that bind to the stem of H5 type HA, the influenza protein responsible for viral entry into the host cell. The scientists determined the X-ray crystal structure of the mAb bound to the H5N1 HA, which showed that the heavy chain of the mAb inserts into a highly conserved pocket in the HA stem, inhibit...

Scientists identify human monoclonal antibodies effective against bird, seasonal flu viruses

... 10 mAb that bind to the stem of H5 type HA, the influenza protein responsible for viral entry into the host cell. The scientists determined the X-ray crystal structure of the mAb bound to the H5N1 HA, which showed that the heavy chain of the mAb inserts into a highly conserved pocket in the HA stem, inhibit...

The Burnham Buzz, February 2009

...ISC). The Fas-FADD DISC is a receptor platform, which once assembled, initiates the induction of programmed cell death. Dr. Riedl determined the X-ray crystal structure of the DISC to 2.7 Angstroms resolution and found that protein-protein interactions between Fas and FADD mechanistically control DISC format...

University of Miami engineer designs stretchable electronics with a twist

...otential uses for the new design include electronic devices for eye cameras, smart surgical gloves, body parts, airplane wings, back planes for liquid crystal displays and biomedical devises. "Our design is of great interest because the requirements for complex shapes that can function during stretching,...

Researchers first to 'see' reactive oxygen species in vital enzyme

...n animals, plants, fungi, and in some types of bacteria a process known as oxygen activation. Although scientists have determined more than 1,200 crystal structures of flavoproteins, they've been blind to exactly what oxygen activation looks like within these enzymes. Specifically, researchers have been...

Heavy pyridine crystallizes differently

...searchers led by Roland Boese at the University of DuisburgEssen have discovered that deuterated pyridine crystallizes at about -85 C with a different crystal structure than that usually adopted by pyridine. In parallel, British researchers working with Simon Parsons determined that non-deuterated pyridine a...

Burnham researchers discover 'on switch' for cell death signaling mechanism

... mechanistically control DISC formation. The X-ray crystal structure of the Fas-FADD death domain complex rev...tion. Another interesting point is that this X-ray crystal structure uncovered a general mechanism for recept...ectly characterized prior to this study. The X-ray crystal structure now provides detailed information about ...

Tufts University Prof. Maria Flytzani-Stephanopoulos named as AAAS Fellow

...hich oxide structure binds gold stronger. The researchers synthesize single crystal oxides at the nanoscale with specific shapes (rods, cubes, polyhedra) and crystal faces; dope these with various metals and study them as catalysts for alcoh...

Elsevier announces winners of 3rd Annual Scopus Young Indian Scientist Award

...ure were used in providing statistical data on applicants to the selection panel. Recipients received a certificate of recognition, a cash prize and a crystal trophy. Over 200 Indian scientists and researchers under the age of 40 submitted their work for consideration in eleven disciplines included - Agr...

Moving new technologies from the lab to the marketplace

...ations. They include heat ray shielding laminated glass or film, plasma display grade filters, heat-retaining and heat-accumulating fibers, and liquid crystal display devices. Zafar Iqbal, research professor of chemistry, received support to develop technology that applies the principles and materials o...

New insight into the controls on a go-to enzyme

...t crystallize a protein to be studied. Then, they direct X-rays through the crystal and deduce the protein structure from the diffraction pattern of those X-ra...n Green's laboratory, performed X-ray structural analysis on such a protein crystal that consisted of a critical part of the calpastatin molecule attached to c...
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