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Compounds in Biological News

2 new compounds show promise for eliminating breast cancer tumors

Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors. Associate Professor James Turkson's compounds disrupt the formation and spread of breast cancer tumors in tests on mice. The compounds, S3I-201 and S3I-M2001, break up...

Two new compounds show promise for eliminating breast cancer tumors

Two new compounds created by a University of Central Florida professor show early promise for destroying breast cancer tumors. Associate Professor James Turkson's compounds disrupt the formation and spread of breast cancer tumors in tests on mice. The compounds, S3I-201 and S3I-M2001, break up...

Scripps research scientists identify compounds for stem-cell production from adult cells

In the study, the scientists screened known drugs and identified small molecules that could replace conventional reprogramming genes, which can have dangerous side effects. This new process offers a new way to generate stem cells from fibroblasts, a general cell type that is abundant and easily ac...

3-substituted indolones as novel therapeutic compounds for neurodegenerative conditions

Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), disrupt the quality of life for patients, put a tremendous burden on family caregivers, and cost society billions of dollars annually. The most consistent risk factor for develop...

New $11 million center to speed production of new compounds for drug discovery

Scientists from three Chicago-area universities have joined forces to develop new ways of building state-of-the-art chemical libraries that will help identify new compounds for future drug development and basic biomedical research. Scientists from the University of Chicago, Northwestern Univers...

Discovery of natural compounds that could slow blood vessel growth

Using computer models and live cell experiments, biomedical engineers at the Johns Hopkins University School of Medicine have discovered more than 100 human protein fragments that can slow or stop the growth of cells that make up new blood vessels. Reporting online last week in the Proceeding...

Duke team finds compounds that prevent nerve damage

DURHAM, N.C. Duke University Medical Center scientists have made a significant finding that could lead to better drugs for several degenerative diseases including Huntington's disease and Alzheimer's disease. Compounds that block the activity of a specific enzyme prevented brain injury and greatl...

New study shows compounds from soy affect brain and reproductive development

Two hormone-like compounds linked to the consumption of soy-based foods can cause irreversible changes in the structure of the brain, resulting in early-onset puberty and symptoms of advanced menopause in research animals, according to a new study by researchers at North Carolina State University...

Natural compounds in cocoa tied to blood flow improvements for adults with type 2 diabetes

McLEAN, VA (May 26, 2008) Scientists have found that consuming cocoa flavanols naturally occurring compounds in cocoa may offer a benefit to those affected by type-2 diabetes. Consuming a cocoa flavanol-rich beverage daily may have the potential to positively impact the blood vessel dysfunct...

Green tea compounds beat OSA-related brain deficits

Chemicals found in green tea may be able to stave off the cognitive deficits that occur with obstructive sleep apnea (OSA), according to a new study published in the second issue for May of the American Thoracic Societys American Journal of Respiratory and Critical Care Medicine. Researchers ex...

UD's Bobev receives NSF Early Career Award for research on novel compounds of rare Earth metals

Svilen Bobev, assistant professor of chemistry and biochemistry, has received the National Science Foundation's prestigious Faculty Early Career Development Award. The highly competitive funding award, designed to support the integrated research and educational activities of faculty early in th...

Naturally-occurring apple compounds reduce risk of pancreatic cancer

Eating flavonol-rich foods like apples may help reduce the risk of pancreatic cancer, says a team of international researchers. Quercetin, which is found naturally in apples and onions, has been identified as one of the most beneficial flavonols in preventing and reducing the risk of pancreatic c...

New microsensor measures volatile organic compounds in water and air on-site

Researchers at the Georgia Institute of Technology have developed a miniature sensor that uses polymer membranes deposited on a tiny silicon disk to measure pollutants present in aqueous or gaseous environments. An array of these sensors with different surface coatings could be used during field-t...

MSU discoveries upend traditional thinking about how plants make certain compounds

EAST LANSING, Mich. Michigan State University plant scientists have identified two new genes and two new enzymes in tomato plants; those findings led them to discover that the plants were making monoterpenes, compounds that help give tomato leaves their distinctive smell, in a way that flies in t...

Grape-seed extract kills laboratory leukemia cells, proving value of natural compounds

PHILADELPHIA An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky. They found that within 24 hours, 76 percent of leukemia cells had died after being exposed to the extract. The investigators, who report t...

Pharmaceutical compounds found in nation's fresh water

According to a study in the May/June 2007 issue of the journal Ground Water, pharmaceuticals are being found in septic tanks and, consequentially, ground water due to incomplete human metabolism and excretion into the waste stream or by disposal of unused medications in the toilet or down the sink....

Harvard scientists identify compounds that stimulate stem cell growth in the brain

Scientists at Harvard University have identified key compounds that stimulate stem cell growth in the brain, which may one day lead to restored function for people affected by Parkinson's disease, strokes, multiple sclerosis, and a wide range of neurological disorders. These findings, which appear ...

Legume compounds may help cancer treatment

The ARC Centre of Excellence for Integrative Legume Research (CILR) has lodged a complete patent application for compounds to treat cancer. CILR researchers screened legumes (plants which obtain useable nitrogen from soil bacteria in their roots) for biological activity and they identified a num...

Marijuana-like compounds suppress the immune response

A group of Japanese scientists has discovered that cannabinoids can cause some white blood cells to lose their ability to migrate to the sites of infection and inflammation. These findings, which appear in the May 5 issue of the Journal of Biological Chemistry, could have potential use in the deve...

Phenolic compounds may explain Mediterranean diet benefits

Phenolic compounds in olive oil, which have antioxidant, anti-inflammatory and anti-clotting properties, may explain cardiovascular health benefits associated with the so-called Mediterranean Diet, according to a new study in the Nov. 15, 2005, issue of the Journal of the American College of Cardio...

Seaweed yields new compounds with pharmaceutical potential

Researchers have discovered 10 new molecular structures with pharmaceutical potential in a species of red seaweed that lives in the shallow coral reef along the coastline of Fiji in the south Pacific Ocean. Some of these natural compounds showed the potential to kill cancer cells, bacteria and th...

Metal-containing compounds show promise as HIV weapon

A molecule consisting of two "cages" of metallic atoms bound to carbon has shown great promise in preliminary tests of becoming a new weapon in the anti-HIV arsenal, researchers at UT Southwestern Medical Center report. The molecule - called metallacarborane - and its variants appear to fight HIV p...

Novel compounds show promise as safer, more potent insecticides

Research teams at Nihon Nohyaku Co., Ltd., Bayer CropScience and DuPont have developed two new classes of broad-spectrum insecticides that show promise as a safer and more effective way to fight pest insects that damage food crops. The insecticides, which represent the first synthetic compounds des...

Scientists discover the body's marijuana-like compounds are crucial for stress-induced pain relief

new study shows, for the first time, that the release of the body's own marijuana-like compounds is crucial to stress-induced analgesia ?the body's way of initially shielding pain after a serious injury. The work, led by scientists at the University of Georgia and the University of California, I...

Researchers discover chemical compounds that affect plant growth

A team of biologists from the University of California, Riverside has used chemical genomics to identify novel compounds that affect the ability of plants to alter their direction of growth in response to gravity, a phenomenon known as gravitropism. The researchers screened a library of 10,000 sm...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

Two compounds that zero in on cancer cells spreading throughout the body, while ignoring primary tumor cells, could someday give doctors a whole new weapon in the fight against tough-to-treat metastatic disease, according to Weill Medical College of Cornell University researchers. The compounds, ...

The hepatitis healing power of blueberry leaves

...o disease, a dietary supplement might help slow or stop disease progression. So they screened nearly 300 different agricultural products for potential compounds that suppress HCV replication and uncovered a strong candidate in the leaves of rabbit-eye blueberry (native to the southeastern US). They purified...

Marine microbes creating green waves in industry

...mes which will reduce waste and increase productivity in the manufacture of drugs and agrochemicals. The enzymes they seek have the ability to convert compounds that would have previously been waste products in the manufacturing process, into the desired product, therefore increasing the efficiency of the proc...

Navigating in the ocean of molecules

... biological activity in the ocean of all potential compounds is not an easy task. "Organic synthesis cannot ... in Dortmund. Chemists cannot cook up all possible compounds to test them. Therefore, the researchers have deve...advantage lies in the fact that chemically similar compounds are very likely to display similar biological acti...

Carbon nanoparticles toxic to adult fruit flies but benign to young

...of carbon nanoparticles in the environment, said David Rand, professor of biology, who specializes in fruit fly evolution. "The point is these same compounds that were not toxic to the (fruit fly) larvae were toxic to the adults in some cases, so there may be analogies to other toxic effects from fine parti...

AGU journal highlights -- Aug. 6, 2009

...one production and longevity. For example, bromine compounds can turn into active forms that can efficiently de...l tropopause layer (TTL). To better understand how compounds are transported through the TTL, Gettelman et al. ...hemical reactions important to several short-lived compounds that pass through this region. Their model is one-...

Hormone levels contribute to stress resilience

...are important in understanding why and how soldiers may differ in their ability to tolerate stress and also raise the possibility that, in the future, compounds like DHEA might be used to protect military personnel from the negative impact of operational stress." Clearly, additional research is still needed ...

Neuropathic pain: The sea provides a new hope of relief

...nd the nerve cells. These activated cells release compounds called cytokines that can excite nerves carrying p...a key role in a research study searching for novel compounds that have potential for use in pain relief. Dr Wen...s of the condition in rats. They found that the compounds significantly reduced pain-related activities in i...

UCSF researchers identify new drug target for Kaposi's sarcoma

...ign to identify and create a potential drug to target that protease interface. Using high-throughput screening, the team screened a library of 182 compounds that it had specifically and rationally designed to mimic the protease interface. The work identified six molecules that inhibited the Kaposi's sarcom...

New supercomputer to reel in answers to some of Earth's problems

...ir clean-up skills. Green plastics: Industrial chemists can turn propane gas into plastics and generate only water as a byproduct with the help of compounds called catalysts. Chinook is helping scientists develop a new catalytic material based on small clusters of platinum atoms that does this at least 40 ...

Airway cells use 'tasting' mechanism to detect and clear harmful substances

...lain why injured lungs are susceptible to further damage. The study, published online July 23 in Science Express, shows that receptors for bitter compounds that are found in taste buds on the tongue also are found in hair-like protrusions on airway cells. In addition, the scientists showed that, unlike ta...

SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center

...sfully identifying, developing and advancing novel compounds into clinical evaluation. SRI's Center for Cancer ...nder-represented areas to advance the discovery of compounds active against novel molecular and genetic cancer ...molecular descriptors that are derived from active compounds within the target family and from the structure of...

IOS Press announces launch of Journal of Berry Research

...and metabolomics, plant physiology, plant pathology and plant development, as well as results dealing with the chemistry and biochemistry of bioactive compounds contained in such fruits and their possible role in human health. Contributions detailing possible pharmacological, medical or therapeutic use or diet...

Healing power of aloe vera proves beneficial for teeth and gums, too

...e cases more effective, than the commercial brands at controlling cavity-causing organisms. Aloe latex contains anthraquinones, which are chemical compounds that are used in healing and arresting pain because they are anti-inflammatory in nature. But, because aloe vera tooth gel tends to be less harsh on t...

Munich researchers discover new target for tailored antibiotics

...oprene building blocks, thereby killing pathogens in a very targeted way. Since the enzyme and the associated reaction do not appear in mammals, these compounds should have few or no side effects in humans." ...
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