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Combination in Biological News

Galiximab in combination with rituximab in patients with previously untreated follicular lymphoma

Lugano, Switzerland June 7, 2008 The Cancer and Leukemia Group B (CALGB) today announced data from a phase II clinical trial showing that 70 percent of patients with previously untreated follicular lymphoma responded to treatment with galiximab, an investigational anti-CD80 monoclonal antibody, ...

Old stain in a new combination

New combinations of agents based on the oldest synthetic malaria drug, the methylene blue stain, can curb the spread of malaria parasites and make a significant contribution to the long-term eradication called for by the international "Roll Back Malaria Initiative." In a study on 160 children with...

Chemo combination improves survival in asbestos-related cancer

People with mesothelioma ?a form of cancer associated with asbestos exposure ?have a higher survival rate when treated with a combination of two cancer drugs, a large multicenter study finds. Mesothelioma, a rare but aggressive form of cancer that occurs in the lining of the lungs, heart and abdo...

Study shows combination of immune substances to be safe

New research has shown that the immune-stimulating hormone known as interleukin-12 (IL-12) can safely be administered with interferon, another immune-system protein, as an experimental therapy for some cancers. Normally, interferon is used alone to stimulate the immune system to attack certain c...

Wake Forest scientists find new combination vaccine effective against plague

Plague, a bacterium that ravaged Europe in the Middle Ages and is today one of the most feared potential agents of bio-terrorism, may have met its match, according to Wake Forest University School of Medicine scientists. Steven B. Mizel, Ph.D., principal investigator, told the American Gastroente...

The hepatitis healing power of blueberry leaves

...es at the University of Miyazaki and elsewhere in Japan on a search for better treatment options. Currently, there is no vaccine for HCV, and though a combination drug regimen can clear HCV infection, this treatment is only about 60% effective on average and poses risks of severe side effects. Kataoka and col...

Advances in lung cancer research announced at conference

...atients with advanced solid tumors. In one, they are treated with TH-302 in combination with other chemotherapy agents. In the other, they are treated only with TH...ved stable disease or better." In the study of those treated with TH-302 in combination with other chemotherapy agents, eight of 12, or 67 percent, of patients wit...

First human gets new antibody aimed at hepatitis C virus

...fter transplant surgery to continue neutralizing any remaining virus. It is also possible, researchers theorize, that the antibody could be used in combination with new antiviral drugs for treatment in patients with newly diagnosed HCV infection. "There is still more work to be done, but we are encouraged by ...

UBC researchers find first-ever 'wanderlust gene' in tiny bony fish

...o move into different salinities a sort of 'wanderlust gene,' if you will instead of staying put and acclimatizing to the current salinity." "The combination of physical and behavioural traits could explain why the low-armour allele keeps turning up during marine sticklebacks' 'invasion' of freshwater habit...

DNA computation gets logical at the Weizmann Institute of Science

... and let the light shine. The tiny water drops containing the biomolecular data-bases were able to answer very intricate queries, and they lit up in a combination of colors representing the complex answers. ...

Urban water ecology at the ESA annual meeting

...d phosphorous could be toxic to them. Mosquito larvae, however, breathe air at the water's surface through a specialized siphon. Chaves says that this combination of an increase in food and a potential decline in predators could be the key to these mosquitoes' success. Larger mosquitoes tend to result from a l...

New hope for fisheries

...ment solutions are available to help rebuild fish stocks. They found that a combination of approaches, such as catch quotas and community management coupled with s...ine ecosystems and may collapse vulnerable species. That's why we require a combination of measures, including gear restrictions and closed areas, in order to meet...

UC San Diego engineer provides insights to decades-old DNA squabble

... has baffled scientists for more than three decades. Chromatin is a complex combination of DNA and proteins that makes up chromosomes. The function of chromatin is...and his collaborators suggest that the structure of chromatin is actually a combination of both of these models. Some researchers suggest that its structure is l...

Global curbs on overfishing are beginning to work

...lyse ecosystem recovery in 31 fisheries worldwide, 10 in detail, including Australia's Southern and Eastern Scalefish and Shark Fishery. She says a combination of management measures has been adopted in Australia's commonwealth fisheries in the past decade to reduce pressures on fishery ecosystems. These i...

Douglas-fir, geoducks make strange bedfellows in studying climate change

... time scales more than twice the length of the instrument measurements. "Each species brings its own 'perspective' of past climate, such that their combination provides a more accurate account," Black added. Results of the study are being published in the professional journal, Palaeogeography, Palaeoclimat...

Nanoparticle-delivered 'suicide' genes slowed ovarian tumor growth

... report in Cancer Research , a journal of the American Association for Cancer Research. Although early stage ovarian cancer can be treated with a combination of surgery followed by chemotherapy, there are currently no effective treatments for advanced ovarian cancer that has recurred after surgery and prima...

'Microfluidic palette' may paint clearer picture of biological processes

...s constant as long as flow rate into the system does not change. Overlapping the three gradients results in a blend of dye concentrations in which the combination of colors at one location is distinctly different from any other location. Similarly, if three separate drugs were injected into the palette where ...

Test helps in fight against lung infections and for treating other life-threatening infections

... the patient to hospital in an attempt to stabilize the patient prior to transplantation. A bioFILM PA™ test was ordered and consequently a new combination of antibiotics was administered. The lung transplant was conducted successfully and the patient has been symptom free for more than two years. ...

Indonesia Now Using MegaMatcher Biometric Technology in Integrated Passport Issuance System

...tralized biometric matching system that delivers fast and accurate processing of passport information. Neurotechnology's MegaMatcher provided the best combination of high degree of accuracy, identification of duplicate registrations, exemplary technical support and a low total cost of ownership. "Neurotec...

High-tech vehicle design boosts emergency rescue capacity

... in such a project, according to Strobel. "Our collaboration is a good example for the global market and normal at this time. The big advantage is the combination of know how." As a result of the success in the two-year EUREKA project, which finished in early 2008, the new technology should be starting in seri...

New drug may reduce heart attack damage

... treatment," Dr Bhindi said. "This drug not only structurally reduces heart attack size but it protects heart muscle function. Both those things in combination improve outcomes and give hope to patients." Dr Bhindi said the process was attractive because it is so selective. "The drug minimises potential...

SRI announces selection by the National Cancer Institute as a Chemical Biology Consortium center

...been successful in generating an extensive drug pipeline translating discoveries into beneficial treatments. SRI's drug discovery process, guided by a combination of biological screens and computational methods, will be a key component of the NCI Chemical Biology Consortium program. "SRI is proud to be select...

Skin-like tissue developed from human embryonic stem cells

... in vitro tissue engineering techniques to produce skin-like tissues that mimic the lining tissues found in the oral cavity," said Garlick. Using a combination of chemical nutrients and specialized surfaces for cell attachment, an hES cell line (H9) was directed to form two distinct specialized cell populatio...

Hush little baby... Linking genes, brain and behavior in children

...ing to a new report in Psychological Science , a journal of the Association for Psychological Science, children's temperament may be due in part to a combination of a certain gene and a specific pattern of brain activity. The pattern of brain activity in the frontal cortex of the brain has been associated wi...

Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case

...nd exploits the most comprehensive and advanced methods available in the art of signature verification. Automatic comparison is executed by a powerful combination of verifiers. In particular, the technology combines a human-like holistic analysis of signature segmentation with a subsequent analysis of the signa...

New technique can fast-track better ionic liquids for biomass pre-treatments

...ow in the process of evaluating other ionic liquids to discover the optimal combination of cost and performance." The results of this study were reported in the...e turned this "nuisance" into an effective tool. Using auto-fluorescence in combination with a variety of microscopy and spectroscopy techniques, they were able to...

Toward an explanation for Crohn's disease?

... the predisposition for Crohn's disease with both the NOD2 mutation and the presence of mycobacteria, but researchers must still determine the precise combination of these factors to understand how the disease develops. More research is required to establish a complete explanation. From this, it is expected ...

New way to make sensors that detect toxic chemicals

... sensor. "The human nose coordinates signals from hundreds of thousands of sensory neurons to identify chemicals," Beach said. "Here, we're using a combination of electrical responses to identify the signature of a toxic chemical." The key to making the sensor work is how the nickel oxide particles are mad...

Two dietary oils, two sets of benefits for older women with diabetes

...s in an effort to alter body composition is both achievable and affordable to postmenopausal women in the United States who are managing the difficult combination of obesity and diabetes," said Martha Belury, professor of human nutrition at Ohio State University and senior author of the study. Among the most...

GUMC discovery highlights new direction for drug discovery

...atients annually are diagnosed with the cancer, and they are treated with a combination of five different chemotherapy drugs. Between 60-70 percent of patients sur...ontrol gene transcription. "We believe that when RHA binds to EWS-FLI1, the combination becomes more powerful at turning genes on and off," says the study's first ...

Pitt team finds molecule that regulates heart size by using zebrafish screening model

...s well, Dr. Tsang said. For example, FGF2 has been used in treatment of chronic skin ulcers and following burn surgery in Japan. Thus, BCI alone or in combination with FGF2 might accelerate the healing process and improve wound repair. ...

Harvard scientists solve mystery about why HIV patients are more susceptible to TB infection

...that reduced their ability to ward off TB infection. "HIV and TB represent two of the most significant health challenges in human history and the combination of the two infections is particularly devastating because HIV dramatically increases the severity of TB infection," said John Wherry, Ph.D., Deputy Ed...

Ecological Society of America announces 2009 award recipients

...changes in a physical trait of a plant can affect overall plant community structure, which in turn drives the evolution of the trait. The paper uses a combination of theory, experiment and observation to bridge the fields of community ecology and quantitative genetics. Odum Education Award: Christine Flanag...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... several JIA subtypes, and add important information about what causes this group of diseases," he said. "We look forward to the day when we can use a combination of genetic and gene expression tests in the clinic to help us better diagnose and treat childhood arthritis." ...

Stanford researchers publish comprehensive model for medical device development

...cturing methods, and overall life cycle for products in the two sectors. "Drug-device differences underscore challenges associated with developing combination products, such as drug-eluting stents, which play an increasingly important role in healthcare innovation," says Pietzsch. "It is our aim to contribut...

ICSI or IVF: Babies born from frozen embryos do just as well

...ng outcomes. Interestingly, we did not see any clear difference in neonatal outcomes between the medicated and unmedicated groups. From our study, the combination of exposure to cryopreservation and medications or both did not significantly impair offspring outcome." The malformations ranged from heart defect...

First riser-drilling research operations undertaken

...sts. The scheduled drill site, the Kumano Basin, is a fore-arc basin of the Nankai Trough under the influence of the strong Kuroshio ocean current. In combination with inclement weather expected, due to passing typhoons, and riser drilling down to depths of more than 2,000 meters below surface, this phase of Nan...

CWRU receives $5 million from Ohio Third Frontier Commission

... develop a gene therapy approach to treating brain tumors. Jean Welter (CWRU) and Adam Lambert (Oakwood Laboratories) are teaming up to develop a combination product comprised of a drug and Oakwood's proprietary sustained release technology to treat arthritic disease. Eben Alsberg (CWRU) and Orthopedia...

Molecular typesetting -- proofreading without a proofreader

... "In fact, there is more than one identified mechanism for ensuring that genetic code is copied correctly. The challenge now is to find out through a combination of experimental biology and modelling which mechanism is dominant." ...

Parascript Signature Verification Technology Used by Moscow Law Firm to Detect Signature Fraud in $160,000 Debt Collection Case

...nd exploits the most comprehensive and advanced methods available in the art of signature verification. Automatic comparison is executed by a powerful combination of verifiers. In particular, the technology combines a human-like holistic analysis of signature segmentation with a subsequent analysis of the signa...
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