Newly identified gene powerful predictor of colon cancer metastasis

Cancer Researchers at the Max Delbrck Center for Molecular Medicine (MDC) Berlin-Buch and the Charit Universitts Medizin Berlin (Germany) have identified a gene which enables them to predict for the first time with high probability if colon cancer is going to metastasize. Assistant Professor Dr. ...

Sibling study could lead to better treatments for inherited form of colon cancer

SALT LAKE CITYResearchers at Huntsman Cancer Institute (HCI) believe they may be one step closer to understanding how certain forms of colon cancer develop. In a study using siblings who have been diagnosed with colon cancer, scientists discovered similarities on a region of a particular chromo...

Breakthrough optical technology to assess colon cancer risk, accuracy

Researchers at NorthShore University HealthSystem (NorthShore) and Northwestern University have discovered that fiber optic technology can for the very first time effectively measure blood levels in the colonic lining (mucosa) in humans, thus having potential applications for analyzing risk of col...

'1-hit' event provides new opportunity for colon cancer prevention, say Fox Chase researchers

PHILADELPHIA (September 15, 2008) More than 30 years ago, Alfred Knudson Jr., M.D., Ph.D., revolutionized the field of cancer genetics by showing that a person must lose both their paternal and maternal copies of a particular class of cancer-inhibiting genes, called tumor-suppressor genes, in ord...

Researchers identify cancer-causing gene in many colon cancers

BOSTON--Demonstrating that despite the large number of cancer-causing genes already identified, many more remain to be found, scientists at Dana-Farber Cancer Institute have linked a previously unsuspected gene, CDK8, to colon cancer. The discovery of CDK8's role in cancer was made possible by ...

Early stage colon cancer characterized by inactivation of gatekeeper gene

The absence or inactivation of the RUNX3 gatekeeper gene paves the way for the growth and development of colon cancer, Singapore scientists report in the Sept. issue of the journal Cancer Cell . Previous studies have shown that RUNX3 plays a role in gastric, breast, lung and bladder cancers. ...

NCI grant launches clinical trials for colon cancer screening

EVANSTON, Ill. --- A Northwestern University biomedical engineer who has developed optical technology shown to be effective for the early detection of colon cancer has received a $7.5 million grant over five years from the National Cancer Institute to further study an instrument that potentially c...

Novel therapeutic strategy for colon cancer treatment

A team of scientists at the Genome Institute of Singapore (GIS), a research institute of the Asian city-state's Agency for Science, Technology and Research (A*STAR), and the University of California at San Francisco have developed a pharmacological approach to kill colon cancer cells. Genetic...

DNA methylation shown to promote development of colon tumors

CAMBRIDGE, Mass. (December 1, 2007) Damaged or defective genes have long been known to be the cause of some cancers. Over the past decade, however, scientists have discovered that even healthy genes can be switched on or off and can cause cancer without any changes in the underlying DNA sequencea...

$2.7 million awarded for metastatic colon cancer research

PHILADELPHIA Through the generous philanthropic support of the Littlefield 2000 Trust, the American Association for Cancer Research (AACR) is pleased to announce four recipients of the 2007 Jeannik M. Littlefield-AACR Grants for Metastatic Colon Cancer Research, totaling $2.7 million. Now in its ...

Genome update defines landscape of breast and colon cancers

One year after completing the first large-scale report sequencing breast and colon cancer genes, Johns Hopkins Kimmel Cancer Center scientists have studied the vast majority of protein-coding genes which now suggest a landscape dominated by genes that each are mutated in relatively few cancers. ...

Analysis of breast and colon cancer genes finds many areas of differences between tumors

Researchers from University Hospitals (UH) Ireland Cancer Center and Case Western Reserve University School of Medicine are part of a new national study that has analyzed more than 18,000 genes, including 5,000 previously unmapped genes, from breast and colorectal tumors. The study, published onl...

'Western' diet linked to increased risk of colon cancer recurrence

BOSTONColon cancer patients who eat a diet high in red meat, fatty products, refined grains, and desserts a so-called Western diet may be increasing their chance of disease relapse and early death, report researchers at Dana-Farber Cancer Institute. The study, published in the Aug. 15 issue o...

RNA interference stops colon cancer spread in mice

Using one of the newest and most powerful tools of biomedical science, University of Texas Medical Branch at Galveston (UTMB) researchers have scored a dramatic success in the battle against colorectal cancer. The scientists were the first to use what are known as "small interfering RNAs" to bloc...

Research Using Mouse Models Reveals A Novel Key Player In The Initiation Of Colon Cancer

Gastric and colorectal cancers account for more than 1 million deaths worldwide every year and several research groups have been working to identify the molecular events that result in the initiation and progression of these tumors. It has been established that interfering with the function of one ...

First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

Two compounds that zero in on cancer cells spreading throughout the body, while ignoring primary tumor cells, could someday give doctors a whole new weapon in the fight against tough-to-treat metastatic disease, according to Weill Medical College of Cornell University researchers. The compounds, ...

Pitt researchers find promising candidate protein for cancer prevention vaccines

...ne to boost response against MUC1, a protein that is abnormally produced in colon cancer and in precancerous polyps. The MUC1 colon cancer prevention vaccine is being tested in a clinical trial led by collea...

A crystal ball for brain cancer?

...ancer returned after chemotherapy and radiation, his UCLA doctor prescribed the off-label use of Avastin, a drug shown to quell cancers in the breast, colon and lung. One month later, McNabb's tumors had shrunk by 95 percent. Subsequent brain scans show no trace of his cancer at all. The former mara...

Cancer's distinctive pattern of gene expression could aid early screening and prevention

...kers in breast cancer and the aggressive adult brain tumor glioblastoma. Dr. Robertson, who also works in breast cancer and brain tumors as well as colon cancer, is finding patterns of genes that regulate healthy cell differentiation are shut off in cancers. "These are genes that may need to be active ...

New research finds possible genetic link to cause of pregnancy loss and disorders

... assistant professor of biochemistry and cellular and molecular biology at UT Knoxville, originally was studying the gene for a possible connection to colon cancer, when he found his lab mice showed strange fertility characteristics. "Where you would normally expect a female to have eight to 10 pups, th...

C. difficile spores spread superbug

... of 2009 saw a decline in incidence compared to the same period in 2008. The most severe complication is pseudomembranous colitis, an infection of the colon that can be lethal in patients with weakened immune systems. "What this research essentially provides," says Dr Fiona Cooke, working in the Depart...

2 Fred Hutchinson Cancer Research Center scientists receive Presidential Early Career Award

...tic approaches, she also studies vitamin D and calcium in the prevention of colon cancer, the second leading cause of cancer death in the United States. Pe...ntire genome and is currently conducting genomewide association studies for colon and breast cancer. The goal is to identify new genetic markers that can be ...

'Normal' cells far from cancer give nanosignals of trouble

... specimen required for testing. Using PWS, the researchers made another important discovery: the abnormalities found in the nanoarchitecture of the colon cells are the same abnormalities as those found in the pancreas and lung, illustrating commonality across three very different organs. The results ...

Colorectal cancer

...cer Institute estimates that, alone in the United States, 106,100 cases of colon cancer will occur and 49,920 patients will die both from colon and rectal cancer in 2009. Beginning in glands in the bowel lining, col...

Purple sweet potato means increased amount of anti-cancer components

...urring purple sweet potatoes, she said. The K-State researchers also wanted to see the specific effects of cyanidin and peonidin. Lim treated human colon cancer cells with low concentrations of the pigment derivatives and also studied the effects on the cell cycles. Cyanidin and peonidin showed signi...

Colon cancer screening technique shows continued promise in new study

... Recent clinical trials show that a new colon cancer screening technique created by Northwestern...ore successful than a colonoscopy in screening for colon cancer. The technique uses optical technology, ...ld detect the presence of growths elsewhere in the colon even though it just analyzed tissue from the base ...

Enzyme involved in inflammatory bowel disease discovered at Penn State College of Medicine

...and from healthy people. The amount of enzyme in the IBD patient's inflamed colon was significantly lower than that in normal colon sections. The researchers concluded that their findings strongly correlate ...

Caffeic acid inhibits colitis in a mouse model -- is a drug-metabolizing gene crucial?

...ociated with significant lessening of colitic damage, assessed by examining colon histopathology. In comparison with rutin, an anti-inflammatory flavonoid a... respect to their ability and mechanisms of inhibiting colitis, and perhaps colon cancer, because colitis increases risk for this disease". In summary, no...

First jaguar photo taken at Smithsonian Research Station in Panama

...st point. Barro Colorado Island in Gatun Lakepart of the Panama Canalis only 25 miles from Panama City on the Pacific end of the canal and the city of colon on the Atlantic end. Most of Panama's more than 3 million people live in these two cities. Two of the world's great biological hotspots meet in this a...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

...produce toxins A and B. The toxins cause damage to the GI tract lining in the colon, resulting in severe diarrhea, and may lead to perforation of the colon and/or death. Treatment of severe disease requires administration of additional antibiotics to kill the C. difficile bacteria, but because of the pe...

Burnham researchers present at 100th AACR Meeting

...mopreventative Effect of Ursodeoxycholic Acid by Activating Nuclear Receptor FXRα in Colorectal Cancer and Genetic Deletion of FXRα Promotes colon Tumorigenesis in ApcMin/+ Mice Adam Richardson, Ph.D., will present The Role of Pentose Phosphate Pathway in the Warburg Effect. ...

Skin cancer study uncovers new tumor suppressor gene

...ling skin after sunburns, cuts or other injuries. The MMP gene family has been associated with tumor growth in a variety of cancers, including breast, colon and melanoma. To explore the role of MMP genes in melanoma, the NHGRI researchers studied a bank of tumor and blood samples collected from 79 patie...

Suppressing cancer with a master control gene

...e of those genes, Atonal homolog 1 (ATOH1), causes colon cancer in mice. The gene regulates the last step i...tion to epithelial cells of the colon. Humans with colon cancer frequently have an inactivated ATOH1 gene, ...The researchers could reactivate the gene in human colon cancer cells grown in culture. This caused the tum...

Gene switch sites found mainly on 'shores,' not just 'islands' of the human genome

...ir colleagues searched for new methylated areas in colon tumors as well as normal colon tissue removed from 13 different cancer patients. ...hy cells. However, comparing the tumor and healthy colon cells' entire genomes, including CpG islands as we...

Physical activity may not be key to obesity epidemic

...mental health and mood, lowers blood pressure, improves cholesterol levels and reduces the risk of cardiovascular disease, diabetes, breast cancer and colon cancer. But Loyola research suggests that weight control might not be among the main benefits. People burn more calories when they exercise. But th...

Vitamins C and E and beta carotene again fail to reduce cancer risk in randomized controlled trial

...tive with respect to lowering cancer risk, there is valuable information uncovered that should not be overlooked. There was a trend for a reduction in colon cancer with vitamin E supplementation, which has been observed in other studies. Additionally, beta carotene use was associated with a modest excess o...

Tips from the American Journal of Pathology

..., 174:297-308 Inflammation Contributes to colon Cancer Researchers led by Dr. Brian Iritani a...n, Smad3, may therefore increase susceptibility to colon cancer. To examine whether Smad3 signaling contributes to development of colon cancer, Maggio-Price et al examined mice deficient...

Women double fruit, veggie intake with switch to Mediterranean diet plan

...ris also leading a study called Healthy Eating for colon Cancer Prevention, in which she and colleagues are...iterranean diet can have preventive effects in the colon in persons at increased colon cancer risk. The diet used in the newly published ...

GUMC researchers find gene function 'lost' in melanoma and glioblastoma

...were first discovered in 2005, and since then, deletions or mutations of the gene have been discovered in several cancer types, including those of the colon and lung. In this study, Waldman and his research team, which includes investigators from the National Cancer Institute, the University of Iowa and...

Washington University scientists first to sequence genome of cancer patient

... in genes that normally act to suppress tumor growth. One of these mutations is in the PTPRT tyrosine phosphatase gene, which is frequently altered in colon cancer. Four other mutated genes appear to be involved in molecular pathways that promote cancer growth. In particular, one mutation was found in a...